CA2876950C - Preparation of composition comprising gas microbubbles - Google Patents
Preparation of composition comprising gas microbubbles Download PDFInfo
- Publication number
- CA2876950C CA2876950C CA2876950A CA2876950A CA2876950C CA 2876950 C CA2876950 C CA 2876950C CA 2876950 A CA2876950 A CA 2876950A CA 2876950 A CA2876950 A CA 2876950A CA 2876950 C CA2876950 C CA 2876950C
- Authority
- CA
- Canada
- Prior art keywords
- gas
- inlet
- pipe
- protein solution
- microbubbles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/248—Reactors comprising multiple separated flow channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Accessories For Mixers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- General Preparation And Processing Of Foods (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12173606 | 2012-06-26 | ||
| EP12173606.0 | 2012-06-26 | ||
| PCT/EP2013/063218 WO2014001297A2 (en) | 2012-06-26 | 2013-06-25 | Preparation of composition comprising gas microbubbles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2876950A1 CA2876950A1 (en) | 2014-01-03 |
| CA2876950C true CA2876950C (en) | 2020-09-22 |
Family
ID=48699026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2876950A Active CA2876950C (en) | 2012-06-26 | 2013-06-25 | Preparation of composition comprising gas microbubbles |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10350314B2 (enExample) |
| EP (1) | EP2864033B1 (enExample) |
| JP (1) | JP6420761B2 (enExample) |
| KR (1) | KR102139393B1 (enExample) |
| CN (1) | CN104519989B (enExample) |
| AU (2) | AU2013283409B2 (enExample) |
| BR (1) | BR112014032254B1 (enExample) |
| CA (1) | CA2876950C (enExample) |
| DK (1) | DK2864033T3 (enExample) |
| ES (1) | ES2571481T3 (enExample) |
| IN (1) | IN2014DN10714A (enExample) |
| MX (1) | MX354719B (enExample) |
| RU (1) | RU2640078C2 (enExample) |
| WO (1) | WO2014001297A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2864033B1 (en) | 2012-06-26 | 2016-04-06 | GE Healthcare AS | Preparation of composition comprising gas microbubbles |
| NL2014178B1 (en) * | 2015-01-22 | 2017-01-05 | Tide Microfluidics B V | System and method for controlled manufacturing of mono-disperse microbubbles. |
| JP7104709B2 (ja) | 2016-10-11 | 2022-07-21 | トーマス・ジェファーソン・ユニバーシティ | 圧力測定のための非侵襲法 |
| JP7220567B2 (ja) * | 2017-02-10 | 2023-02-10 | キリンホールディングス株式会社 | スパージャー及び培養装置 |
| CN112808187B (zh) * | 2021-01-19 | 2023-05-30 | 浙江省林业科学研究院 | 一种生产气泡胶囊菌剂的自动化设备及方法 |
| US12345068B2 (en) | 2021-11-19 | 2025-07-01 | Sundance Spas, Inc. | Self-maintaining hot tub or spa |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
| US4957656A (en) | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
| US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US20080063603A1 (en) | 1990-04-02 | 2008-03-13 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| KR100191303B1 (ko) | 1991-09-17 | 1999-06-15 | 씨. 큐웨이 스티븐 | 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법 |
| HUT74827A (en) * | 1993-07-02 | 1997-02-28 | Molecular Biosystems Inc | Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents |
| US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
| AU722742B2 (en) * | 1993-07-02 | 2000-08-10 | Molecular Biosystems, Inc. | Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation |
| JPH0747251A (ja) | 1993-08-06 | 1995-02-21 | Toho Asechiren Kk | 混合ガス発生方法 |
| US5370955A (en) | 1993-09-27 | 1994-12-06 | Xerox Corporation | Electrophotographic elements with arylamine polycondensation polymers |
| US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
| WO1996009814A1 (en) * | 1994-09-29 | 1996-04-04 | Andaris Limited | Spray-dried microparticles as therapeutic vehicles |
| TR199801613T2 (xx) | 1996-02-19 | 1998-11-23 | Nycomed Imaging A/S | Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler. |
| US5976501A (en) | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
| PL332820A1 (en) * | 1996-10-21 | 1999-10-11 | Nycomed Imaging As | Improved contrast media |
| JP3693276B2 (ja) | 1998-09-17 | 2005-09-07 | 東京瓦斯株式会社 | 温度差を有する気液を配管上で混合するための装置 |
| AR035779A1 (es) | 2001-02-06 | 2004-07-14 | Genetics Inst Llc | Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos |
| DE102005052973B4 (de) | 2004-11-09 | 2014-11-20 | Denso Corporation | Doppelwandiges Rohr und Herstellungsverfahren dafür |
| JP4350058B2 (ja) | 2004-11-09 | 2009-10-21 | 株式会社デンソー | 冷媒用二重管 |
| DE102005020727A1 (de) * | 2005-05-04 | 2006-11-09 | Dr.Ing.H.C. F. Porsche Ag | Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager |
| CN101130094A (zh) * | 2007-09-06 | 2008-02-27 | 上海新兴医药股份有限公司 | 一种超声造影剂及其制备方法 |
| CN101507908B (zh) * | 2009-04-09 | 2010-12-01 | 北京化工大学 | 微通道套管式装置及其应用 |
| EP2864033B1 (en) | 2012-06-26 | 2016-04-06 | GE Healthcare AS | Preparation of composition comprising gas microbubbles |
-
2013
- 2013-06-25 EP EP13731334.2A patent/EP2864033B1/en active Active
- 2013-06-25 BR BR112014032254-6A patent/BR112014032254B1/pt active IP Right Grant
- 2013-06-25 ES ES13731334T patent/ES2571481T3/es active Active
- 2013-06-25 RU RU2014150473A patent/RU2640078C2/ru active
- 2013-06-25 JP JP2015519044A patent/JP6420761B2/ja active Active
- 2013-06-25 IN IN10714DEN2014 patent/IN2014DN10714A/en unknown
- 2013-06-25 CA CA2876950A patent/CA2876950C/en active Active
- 2013-06-25 WO PCT/EP2013/063218 patent/WO2014001297A2/en not_active Ceased
- 2013-06-25 AU AU2013283409A patent/AU2013283409B2/en active Active
- 2013-06-25 US US14/579,905 patent/US10350314B2/en active Active
- 2013-06-25 CN CN201380033735.8A patent/CN104519989B/zh active Active
- 2013-06-25 DK DK13731334.2T patent/DK2864033T3/en active
- 2013-06-25 KR KR1020157001732A patent/KR102139393B1/ko active Active
- 2013-06-25 MX MX2014015717A patent/MX354719B/es active IP Right Grant
-
2017
- 2017-08-18 AU AU2017216553A patent/AU2017216553B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014032254B1 (pt) | 2022-11-01 |
| EP2864033B1 (en) | 2016-04-06 |
| RU2640078C2 (ru) | 2017-12-26 |
| MX354719B (es) | 2018-03-16 |
| RU2014150473A (ru) | 2016-08-20 |
| AU2017216553A1 (en) | 2017-09-07 |
| HK1209381A1 (en) | 2016-04-01 |
| MX2014015717A (es) | 2015-08-05 |
| CN104519989B (zh) | 2016-10-26 |
| BR112014032254A2 (pt) | 2017-06-27 |
| ES2571481T3 (es) | 2016-05-25 |
| AU2017216553B2 (en) | 2019-06-27 |
| WO2014001297A3 (en) | 2014-10-02 |
| US20150250904A1 (en) | 2015-09-10 |
| IN2014DN10714A (enExample) | 2015-09-04 |
| KR20150024420A (ko) | 2015-03-06 |
| JP2015524792A (ja) | 2015-08-27 |
| AU2013283409B2 (en) | 2017-06-08 |
| DK2864033T3 (en) | 2016-05-17 |
| US10350314B2 (en) | 2019-07-16 |
| KR102139393B1 (ko) | 2020-07-29 |
| JP6420761B2 (ja) | 2018-11-07 |
| AU2013283409A1 (en) | 2015-01-22 |
| CA2876950A1 (en) | 2014-01-03 |
| EP2864033A2 (en) | 2015-04-29 |
| CN104519989A (zh) | 2015-04-15 |
| WO2014001297A2 (en) | 2014-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180614 |