AU2013283409B2 - Preparation of composition comprising gas microbubbles - Google Patents

Preparation of composition comprising gas microbubbles Download PDF

Info

Publication number
AU2013283409B2
AU2013283409B2 AU2013283409A AU2013283409A AU2013283409B2 AU 2013283409 B2 AU2013283409 B2 AU 2013283409B2 AU 2013283409 A AU2013283409 A AU 2013283409A AU 2013283409 A AU2013283409 A AU 2013283409A AU 2013283409 B2 AU2013283409 B2 AU 2013283409B2
Authority
AU
Australia
Prior art keywords
gas
protein
protein solution
heated
microbubbles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2013283409A
Other languages
English (en)
Other versions
AU2013283409A1 (en
Inventor
Svein Kvaale
Ole Johannes Tokerud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of AU2013283409A1 publication Critical patent/AU2013283409A1/en
Application granted granted Critical
Publication of AU2013283409B2 publication Critical patent/AU2013283409B2/en
Priority to AU2017216553A priority Critical patent/AU2017216553B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Accessories For Mixers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2013283409A 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles Active AU2013283409B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017216553A AU2017216553B2 (en) 2012-06-26 2017-08-18 Preparation of composition comprising gas microbubbles

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
EP12173606.0 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017216553A Division AU2017216553B2 (en) 2012-06-26 2017-08-18 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
AU2013283409A1 AU2013283409A1 (en) 2015-01-22
AU2013283409B2 true AU2013283409B2 (en) 2017-06-08

Family

ID=48699026

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013283409A Active AU2013283409B2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles
AU2017216553A Active AU2017216553B2 (en) 2012-06-26 2017-08-18 Preparation of composition comprising gas microbubbles

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017216553A Active AU2017216553B2 (en) 2012-06-26 2017-08-18 Preparation of composition comprising gas microbubbles

Country Status (14)

Country Link
US (1) US10350314B2 (enExample)
EP (1) EP2864033B1 (enExample)
JP (1) JP6420761B2 (enExample)
KR (1) KR102139393B1 (enExample)
CN (1) CN104519989B (enExample)
AU (2) AU2013283409B2 (enExample)
BR (1) BR112014032254B1 (enExample)
CA (1) CA2876950C (enExample)
DK (1) DK2864033T3 (enExample)
ES (1) ES2571481T3 (enExample)
IN (1) IN2014DN10714A (enExample)
MX (1) MX354719B (enExample)
RU (1) RU2640078C2 (enExample)
WO (1) WO2014001297A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2864033B1 (en) 2012-06-26 2016-04-06 GE Healthcare AS Preparation of composition comprising gas microbubbles
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
JP7104709B2 (ja) 2016-10-11 2022-07-21 トーマス・ジェファーソン・ユニバーシティ 圧力測定のための非侵襲法
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法
US12345068B2 (en) 2021-11-19 2025-07-01 Sundance Spas, Inc. Self-maintaining hot tub or spa

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US20120037232A1 (en) * 2009-04-09 2012-02-16 Zhigang Shen Microchannel double pipe device and usage thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
KR100191303B1 (ko) 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법
HUT74827A (en) * 1993-07-02 1997-02-28 Molecular Biosystems Inc Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
AU722742B2 (en) * 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
WO1996009814A1 (en) * 1994-09-29 1996-04-04 Andaris Limited Spray-dried microparticles as therapeutic vehicles
TR199801613T2 (xx) 1996-02-19 1998-11-23 Nycomed Imaging A/S Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler.
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
PL332820A1 (en) * 1996-10-21 1999-10-11 Nycomed Imaging As Improved contrast media
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
DE102005052973B4 (de) 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
JP4350058B2 (ja) 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005020727A1 (de) * 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
EP2864033B1 (en) 2012-06-26 2016-04-06 GE Healthcare AS Preparation of composition comprising gas microbubbles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US20120037232A1 (en) * 2009-04-09 2012-02-16 Zhigang Shen Microchannel double pipe device and usage thereof

Also Published As

Publication number Publication date
BR112014032254B1 (pt) 2022-11-01
EP2864033B1 (en) 2016-04-06
RU2640078C2 (ru) 2017-12-26
MX354719B (es) 2018-03-16
RU2014150473A (ru) 2016-08-20
AU2017216553A1 (en) 2017-09-07
HK1209381A1 (en) 2016-04-01
MX2014015717A (es) 2015-08-05
CN104519989B (zh) 2016-10-26
BR112014032254A2 (pt) 2017-06-27
ES2571481T3 (es) 2016-05-25
AU2017216553B2 (en) 2019-06-27
WO2014001297A3 (en) 2014-10-02
CA2876950C (en) 2020-09-22
US20150250904A1 (en) 2015-09-10
IN2014DN10714A (enExample) 2015-09-04
KR20150024420A (ko) 2015-03-06
JP2015524792A (ja) 2015-08-27
DK2864033T3 (en) 2016-05-17
US10350314B2 (en) 2019-07-16
KR102139393B1 (ko) 2020-07-29
JP6420761B2 (ja) 2018-11-07
AU2013283409A1 (en) 2015-01-22
CA2876950A1 (en) 2014-01-03
EP2864033A2 (en) 2015-04-29
CN104519989A (zh) 2015-04-15
WO2014001297A2 (en) 2014-01-03

Similar Documents

Publication Publication Date Title
AU2017216553B2 (en) Preparation of composition comprising gas microbubbles
Zhang et al. CO 2 foam properties and the stabilizing mechanism of sodium bis (2-ethylhexyl) sulfosuccinate and hydrophobic nanoparticle mixtures
US8783941B2 (en) Method of ultrasonically treating a substance
AU683485B2 (en) Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
Melich et al. Preparation and characterization of perfluorocarbon microbubbles using Shirasu Porous Glass (SPG) membranes
NO176871B (no) Fremgangsmåte ved lydbölgepåvirkning for kontinuerlig fremstilling av et stabilt ultralyd-avbildningsmiddel
CN112210087B (zh) 一种水包水Pickering乳液及其制备方法
WO2016050224A1 (zh) 一种脂质气泡的制备方法
Chen et al. Engineering the echogenic properties of microfluidic microbubbles using mixtures of recombinant protein and amphiphilic copolymers
HK1209381B (en) Preparation of composition comprising gas microbubbles
AU2013255952B2 (en) Method for filling a container with a foamable composition
CN104689348A (zh) 包含至少两种充气微泡的造影剂及其制备方法和应用
JP2009208035A (ja) 微細粒状体の製造方法
Suslick et al. Sonochemical preparation of protein microspheres
YUYAMA et al. Fabrication of Cyanoacrylate Hollow Particles using Microbubble Generation Technique
Lopes Preparation of Gas-filled Porous microparticles (GPPs) and Microbubbles (MBs) by PGSS method
Betz et al. Microfluidic Formation of Hydrogel Microparticles for Drug Delivery

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)