MX354719B - Preparacion de una composicion que comprende microburbujas de gas. - Google Patents

Preparacion de una composicion que comprende microburbujas de gas.

Info

Publication number
MX354719B
MX354719B MX2014015717A MX2014015717A MX354719B MX 354719 B MX354719 B MX 354719B MX 2014015717 A MX2014015717 A MX 2014015717A MX 2014015717 A MX2014015717 A MX 2014015717A MX 354719 B MX354719 B MX 354719B
Authority
MX
Mexico
Prior art keywords
preparation
composition
microbubbles
gas microbubbles
gas
Prior art date
Application number
MX2014015717A
Other languages
English (en)
Other versions
MX2014015717A (es
Inventor
Johannes Tokerud Ole
Kvaale Svein
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of MX2014015717A publication Critical patent/MX2014015717A/es
Publication of MX354719B publication Critical patent/MX354719B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Accessories For Mixers (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de medios de contraste de ultrasonido, particularmente a composiciones que comprenden microburbujas de gas, y más particularmente a microburbujas encapsuladas por proteínas. Las microburbujas producidas por el procedimiento de la invención tendrán una estrecha distribución de tamaño. La invención además se refiere a un aparato útil en el procedimiento de la invención.
MX2014015717A 2012-06-26 2013-06-25 Preparacion de una composicion que comprende microburbujas de gas. MX354719B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
MX2014015717A MX2014015717A (es) 2015-08-05
MX354719B true MX354719B (es) 2018-03-16

Family

ID=48699026

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015717A MX354719B (es) 2012-06-26 2013-06-25 Preparacion de una composicion que comprende microburbujas de gas.

Country Status (15)

Country Link
US (1) US10350314B2 (es)
EP (1) EP2864033B1 (es)
JP (1) JP6420761B2 (es)
KR (1) KR102139393B1 (es)
CN (1) CN104519989B (es)
AU (2) AU2013283409B2 (es)
BR (1) BR112014032254B1 (es)
CA (1) CA2876950C (es)
DK (1) DK2864033T3 (es)
ES (1) ES2571481T3 (es)
HK (1) HK1209381A1 (es)
IN (1) IN2014DN10714A (es)
MX (1) MX354719B (es)
RU (1) RU2640078C2 (es)
WO (1) WO2014001297A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013283409B2 (en) 2012-06-26 2017-06-08 Ge Healthcare As Preparation of composition comprising gas microbubbles
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
US11317888B2 (en) 2016-10-11 2022-05-03 Thomas Jefferson University Non-invasive method for pressure measurement
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
CZ286149B6 (cs) 1991-09-17 2000-01-12 Sonus Pharmaceuticals, Inc. Plynná prostředí pro zvýšení kontrastnosti obrazu, získaného ultrazvukem a způsob výběru plynů pro toto použití
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
PL312387A1 (en) * 1993-07-02 1996-04-15 Molecular Biosystems Inc Proteinous microbeads of encapsulated non-dissolving gas and method of making them and their application as ultrasonic visualisation medium
AU722742B2 (en) 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
CZ92497A3 (en) 1994-09-29 1997-08-13 Andaris Ltd Micro-particles of water soluble material intended for use in therapy or diagnosis, inhaling apparatus containing such particles and application of a therapeutical agent
WO1997029783A1 (en) 1996-02-19 1997-08-21 Nycomed Imaging A/S Improvements in or relating to contrast agents
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
AP885A (en) * 1996-10-21 2000-11-03 Nycomed Imaging As Ultrasonic visualisation using a gas containing contrast agent.
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
DE102005052973B4 (de) 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
JP4350058B2 (ja) 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005020727A1 (de) 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
CN101507908B (zh) * 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
AU2013283409B2 (en) 2012-06-26 2017-06-08 Ge Healthcare As Preparation of composition comprising gas microbubbles

Also Published As

Publication number Publication date
AU2013283409B2 (en) 2017-06-08
RU2640078C2 (ru) 2017-12-26
AU2013283409A1 (en) 2015-01-22
CA2876950C (en) 2020-09-22
EP2864033B1 (en) 2016-04-06
BR112014032254A2 (pt) 2017-06-27
CA2876950A1 (en) 2014-01-03
IN2014DN10714A (es) 2015-09-04
BR112014032254B1 (pt) 2022-11-01
AU2017216553A1 (en) 2017-09-07
MX2014015717A (es) 2015-08-05
US20150250904A1 (en) 2015-09-10
ES2571481T3 (es) 2016-05-25
US10350314B2 (en) 2019-07-16
WO2014001297A3 (en) 2014-10-02
JP6420761B2 (ja) 2018-11-07
KR20150024420A (ko) 2015-03-06
EP2864033A2 (en) 2015-04-29
AU2017216553B2 (en) 2019-06-27
HK1209381A1 (en) 2016-04-01
KR102139393B1 (ko) 2020-07-29
CN104519989A (zh) 2015-04-15
CN104519989B (zh) 2016-10-26
DK2864033T3 (en) 2016-05-17
WO2014001297A2 (en) 2014-01-03
JP2015524792A (ja) 2015-08-27
RU2014150473A (ru) 2016-08-20

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