CN104519989B - 制备包含气体微泡的组合物 - Google Patents

制备包含气体微泡的组合物 Download PDF

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Publication number
CN104519989B
CN104519989B CN201380033735.8A CN201380033735A CN104519989B CN 104519989 B CN104519989 B CN 104519989B CN 201380033735 A CN201380033735 A CN 201380033735A CN 104519989 B CN104519989 B CN 104519989B
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CN
China
Prior art keywords
gas
protein solution
inlet
feed
heated
Prior art date
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CN201380033735.8A
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English (en)
Chinese (zh)
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CN104519989A (zh
Inventor
S.克瓦勒
O.J.托克鲁德
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GE Healthcare AS
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GE Healthcare AS
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Publication of CN104519989A publication Critical patent/CN104519989A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Accessories For Mixers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201380033735.8A 2012-06-26 2013-06-25 制备包含气体微泡的组合物 Active CN104519989B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
EP12173606.0 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
CN104519989A CN104519989A (zh) 2015-04-15
CN104519989B true CN104519989B (zh) 2016-10-26

Family

ID=48699026

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380033735.8A Active CN104519989B (zh) 2012-06-26 2013-06-25 制备包含气体微泡的组合物

Country Status (14)

Country Link
US (1) US10350314B2 (enExample)
EP (1) EP2864033B1 (enExample)
JP (1) JP6420761B2 (enExample)
KR (1) KR102139393B1 (enExample)
CN (1) CN104519989B (enExample)
AU (2) AU2013283409B2 (enExample)
BR (1) BR112014032254B1 (enExample)
CA (1) CA2876950C (enExample)
DK (1) DK2864033T3 (enExample)
ES (1) ES2571481T3 (enExample)
IN (1) IN2014DN10714A (enExample)
MX (1) MX354719B (enExample)
RU (1) RU2640078C2 (enExample)
WO (1) WO2014001297A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2864033B1 (en) 2012-06-26 2016-04-06 GE Healthcare AS Preparation of composition comprising gas microbubbles
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
JP7104709B2 (ja) 2016-10-11 2022-07-21 トーマス・ジェファーソン・ユニバーシティ 圧力測定のための非侵襲法
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法
US12345068B2 (en) 2021-11-19 2025-07-01 Sundance Spas, Inc. Self-maintaining hot tub or spa

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
KR100191303B1 (ko) 1991-09-17 1999-06-15 씨. 큐웨이 스티븐 기체상의 초음파 조영제 및 초음파 조영제로서 사용하기 위한 기체를 선택하는 방법
HUT74827A (en) * 1993-07-02 1997-02-28 Molecular Biosystems Inc Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
AU722742B2 (en) * 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
WO1996009814A1 (en) * 1994-09-29 1996-04-04 Andaris Limited Spray-dried microparticles as therapeutic vehicles
TR199801613T2 (xx) 1996-02-19 1998-11-23 Nycomed Imaging A/S Kontrast ajanlar�nda ya da bunlarla ilgili iyile�tirmeler.
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
PL332820A1 (en) * 1996-10-21 1999-10-11 Nycomed Imaging As Improved contrast media
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
DE102005052973B4 (de) 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
JP4350058B2 (ja) 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005020727A1 (de) * 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
CN101507908B (zh) * 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
EP2864033B1 (en) 2012-06-26 2016-04-06 GE Healthcare AS Preparation of composition comprising gas microbubbles

Also Published As

Publication number Publication date
BR112014032254B1 (pt) 2022-11-01
EP2864033B1 (en) 2016-04-06
RU2640078C2 (ru) 2017-12-26
MX354719B (es) 2018-03-16
RU2014150473A (ru) 2016-08-20
AU2017216553A1 (en) 2017-09-07
HK1209381A1 (en) 2016-04-01
MX2014015717A (es) 2015-08-05
BR112014032254A2 (pt) 2017-06-27
ES2571481T3 (es) 2016-05-25
AU2017216553B2 (en) 2019-06-27
WO2014001297A3 (en) 2014-10-02
CA2876950C (en) 2020-09-22
US20150250904A1 (en) 2015-09-10
IN2014DN10714A (enExample) 2015-09-04
KR20150024420A (ko) 2015-03-06
JP2015524792A (ja) 2015-08-27
AU2013283409B2 (en) 2017-06-08
DK2864033T3 (en) 2016-05-17
US10350314B2 (en) 2019-07-16
KR102139393B1 (ko) 2020-07-29
JP6420761B2 (ja) 2018-11-07
AU2013283409A1 (en) 2015-01-22
CA2876950A1 (en) 2014-01-03
EP2864033A2 (en) 2015-04-29
CN104519989A (zh) 2015-04-15
WO2014001297A2 (en) 2014-01-03

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