|
US3975399A
(en)
|
1974-08-06 |
1976-08-17 |
E. I. Du Pont De Nemours And Company |
1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
|
|
ZA747723B
(en)
*
|
1974-12-11 |
1976-11-24 |
Pfizer |
11-desoxy-15-substituted-omega-pentanor prostaglandins
|
|
US4154949A
(en)
|
1974-12-11 |
1979-05-15 |
Pfizer Inc. |
11-Desoxy-15-substituted-ω-pentanor prostaglandins
|
|
IT1037126B
(it)
|
1975-03-14 |
1979-11-10 |
Erba Carlo Spa |
13.4 deidro ii desossi prosta glandine
|
|
DE2517771A1
(de)
|
1975-04-18 |
1976-10-28 |
Schering Ag |
Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
|
|
DE2528664A1
(de)
|
1975-06-27 |
1977-01-13 |
Hoechst Ag |
Pyrrolidone und verfahren zu ihrer herstellung
|
|
CA1085859A
(en)
|
1975-06-27 |
1980-09-16 |
Wilhelm Bartmann |
Pyrrolidones and process for their manufacture
|
|
DE2619638A1
(de)
|
1976-05-04 |
1977-11-17 |
Hoechst Ag |
Pyrrolidone und verfahren zu ihrer herstellung
|
|
US4268522A
(en)
|
1976-06-14 |
1981-05-19 |
Pfizer Inc. |
13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof
|
|
US4177346A
(en)
|
1976-08-06 |
1979-12-04 |
Pfizer Inc. |
1,5-Disubstituted-2-pyrrolidones
|
|
DE2729960A1
(de)
*
|
1977-06-30 |
1979-01-18 |
Schering Ag |
Neue acetylenprostaglandine und verfahren zu ihrer herstellung
|
|
US4320136A
(en)
|
1980-08-11 |
1982-03-16 |
E. I. Du Pont De Nemours And Company |
8-Aza-16,16-difluoroprostanoids
|
|
JPS58124778A
(ja)
*
|
1982-01-20 |
1983-07-25 |
Toray Ind Inc |
5,6,7−トリノル−4,8−インタ−m−フエニレンPGI↓2誘導体
|
|
US4456613A
(en)
|
1982-12-27 |
1984-06-26 |
E. I. Du Pont De Nemours And Company |
6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
|
|
GB8329559D0
(en)
*
|
1983-11-04 |
1983-12-07 |
Erba Farmitalia |
Furyl derivatives of 16-substituted prostaglandins preparations
|
|
JPH0662599B2
(ja)
*
|
1987-10-16 |
1994-08-17 |
東レ株式会社 |
2,5,6,7―テトラノル―4,8―インタ―m―フェニレンPGI2誘導体ならびにその製造法および用途
|
|
EP0365678B1
(en)
|
1987-10-16 |
1994-01-05 |
Toray Industries, Inc. |
2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
|
|
DE3835162A1
(de)
*
|
1988-10-13 |
1990-04-19 |
Schering Ag |
(1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
|
|
US7208179B1
(en)
|
1990-11-27 |
2007-04-24 |
The American National Red Cross |
Methods for treating disease and forming a supplemented fibrin matrix
|
|
CA2093836A1
(en)
|
1992-04-24 |
1993-10-25 |
Wayne Gombotz |
Biodegradable tgf-.beta. delivery system for bone regeneration
|
|
JP3388867B2
(ja)
|
1994-03-31 |
2003-03-24 |
株式会社東芝 |
宛名領域検出装置および宛名領域検出方法
|
|
WO1996014335A1
(en)
|
1994-11-07 |
1996-05-17 |
The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services |
Cartilage-derived morphogenetic proteins
|
|
US7517539B1
(en)
|
1996-10-16 |
2009-04-14 |
Etex Corporation |
Method of preparing a poorly crystalline calcium phosphate and methods of its use
|
|
US20020098222A1
(en)
|
1997-03-13 |
2002-07-25 |
John F. Wironen |
Bone paste
|
|
ZA984040B
(en)
|
1997-05-15 |
1998-11-20 |
Ono Pharmaceutical Co |
Benzenesulfonamide compounds
|
|
US6043275A
(en)
|
1998-04-16 |
2000-03-28 |
Ono Pharmaceutical Co., Ltd. |
3,7-dithiaprostanoic acid derivative
|
|
TWI249520B
(en)
|
1998-07-15 |
2006-02-21 |
Ono Pharmaceutical Co |
5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
|
|
US6894175B1
(en)
|
1999-08-04 |
2005-05-17 |
The Procter & Gamble Company |
2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
|
|
TWI247606B
(en)
|
1999-11-24 |
2006-01-21 |
Ono Pharmaceutical Co |
Treating agent for osteopenic diseases
|
|
WO2001046140A1
(en)
|
1999-12-22 |
2001-06-28 |
Pfizer Products Inc. |
Ep4 receptor selective agonists in the treatment of osteoporosis
|
|
US20010056060A1
(en)
|
2000-02-07 |
2001-12-27 |
Cameron Kimberly O. |
Treatment of osteoporsis with EP2/EP4 receptor selective agonists
|
|
WO2002024647A1
(en)
|
2000-09-21 |
2002-03-28 |
Ono Pharmaceutical Co., Ltd. |
Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
|
|
SI1339678T1
(sl)
*
|
2000-11-27 |
2007-12-31 |
Pfizer Prod Inc |
Selektivni agonisti EP4 receptorja pri zdravljenju osteoporoze
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
AU2002328855B2
(en)
*
|
2001-07-16 |
2005-11-24 |
F. Hoffmann-La Roche Ag |
Prostaglandin Analogues As EP4 Receptor Agonists
|
|
AU2002328338C1
(en)
|
2001-07-16 |
2009-01-08 |
Ono Pharmaceutical Co., Ltd |
2 pyrrolidone derivatives as prostanoid agonists
|
|
CN1863768A
(zh)
*
|
2001-07-16 |
2006-11-15 |
霍夫曼-拉罗奇有限公司 |
作为ep4受体激动剂的前列腺素类似物
|
|
KR100826866B1
(ko)
|
2001-07-23 |
2008-05-06 |
오노 야꾸힝 고교 가부시키가이샤 |
Ep4 아고니스트를 유효 성분으로 하는 골량 저하질환의 치료제
|
|
US7410991B2
(en)
|
2001-10-23 |
2008-08-12 |
Laboratoires Serono S.A. |
Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors
|
|
CA2466751A1
(en)
|
2001-12-03 |
2003-06-12 |
Merck And Co., Inc. |
Ep4 receptor agonist, compositions and methods thereof
|
|
AU2002346562A1
(en)
*
|
2001-12-03 |
2003-06-17 |
Merck & Co., Inc. |
Method for treating ocular hypertension
|
|
JP4547912B2
(ja)
|
2002-03-05 |
2010-09-22 |
小野薬品工業株式会社 |
8−アザプロスタグランジン誘導体化合物およびその化合物を有効成分として含有する薬剤
|
|
ATE336247T1
(de)
|
2002-03-18 |
2006-09-15 |
Pfizer Prod Inc |
Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten
|
|
EP1490055A1
(en)
|
2002-03-18 |
2004-12-29 |
Pfizer Products Inc. |
Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
|
|
US7326426B2
(en)
|
2002-03-29 |
2008-02-05 |
Ethicon, Inc. |
Compositions and medical devices utilizing bioabsorbable liquid polymers
|
|
US6573294B1
(en)
|
2002-05-14 |
2003-06-03 |
Allergan, Inc. |
8-azaprostaglandin analogs as agents for lowering intraocular pressure
|
|
WO2003103604A2
(en)
|
2002-06-01 |
2003-12-18 |
Applied Research Systems Ars Holding N.V |
Gamma lactams as prostaglandin agonists and use thereof
|
|
EP1513589B1
(en)
|
2002-06-06 |
2010-11-10 |
Merck Frosst Canada Ltd. |
1,5-disubstituted pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma
|
|
JP2006505572A
(ja)
|
2002-10-25 |
2006-02-16 |
メルク フロスト カナダ アンド カンパニー |
Ep4受容体アゴニストとしての2−ピロリドン
|
|
EP1586564B1
(en)
|
2003-01-21 |
2012-11-28 |
Ono Pharmaceutical Co., Ltd. |
8-azaprostaglandin derivatives and medicinal uses thereof
|
|
WO2004078103A2
(en)
*
|
2003-03-03 |
2004-09-16 |
Applied Research Systems Ars Holding N.V. |
G-lactam derivatives as prostaglandin agonists
|
|
US7163920B2
(en)
|
2003-09-30 |
2007-01-16 |
Ethicon, Inc. |
Peptide with osteogenic activity
|
|
CA2549935A1
(en)
|
2003-12-17 |
2005-07-07 |
Pfizer Products Inc. |
Treatment of conditions that present with low bone mass by continuous combination therapy with selective prostaglandin ep4 receptor agonists and an estrogen
|
|
US7169807B2
(en)
|
2004-04-09 |
2007-01-30 |
Allergan, Inc. |
10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
|
|
EP1782830A4
(en)
|
2004-08-10 |
2009-07-29 |
Ono Pharmaceutical Co |
PREVENTION AND / OR REMEDY FOR LOWER URINARY TRACT DISEASES CONTAINING AN EP4 AGONIST
|
|
JPWO2006016695A1
(ja)
|
2004-08-10 |
2008-05-01 |
小野薬品工業株式会社 |
Ep4アゴニストを含有してなる高カリウム血症の予防および/または治療剤
|
|
US20060039949A1
(en)
|
2004-08-20 |
2006-02-23 |
Nycz Jeffrey H |
Acetabular cup with controlled release of an osteoinductive formulation
|
|
US20060057184A1
(en)
|
2004-09-16 |
2006-03-16 |
Nycz Jeffrey H |
Process to treat avascular necrosis (AVN) with osteoinductive materials
|
|
US7621963B2
(en)
|
2005-04-13 |
2009-11-24 |
Ebi, Llc |
Composite bone graft material
|
|
WO2006130455A2
(en)
|
2005-05-27 |
2006-12-07 |
Royer Biomedical, Inc. |
Bioresorbable polymer matrices and methods of making and using the same
|
|
CA2619469C
(en)
|
2005-09-09 |
2015-03-03 |
Wright Medical Technology, Inc. |
Composite bone graft cement comprising calcium sulfate dihydrate and brushite
|
|
KR20060013354A
(ko)
|
2005-12-09 |
2006-02-09 |
(주)코리아 본 뱅크 |
인산칼슘계 시멘트 첨가에 의해 개질된 탈회골 기질의 개발
|
|
US20070232660A1
(en)
|
2006-04-04 |
2007-10-04 |
Allergan, Inc. |
Therapeutic and delivery methods of prostaglandin ep4 agonists
|
|
US8507545B2
(en)
|
2007-05-08 |
2013-08-13 |
National University Corporation, Hamamatsu University School Of Medicine |
Cytotoxic T cell activator comprising EP4 agonist
|
|
EP2195328A4
(en)
|
2007-08-15 |
2011-06-15 |
Cytokinetics Inc |
PARTICULAR CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
|
|
EP2215084B1
(en)
|
2007-10-23 |
2016-09-28 |
Allergan, Inc. |
Therapeutic substituted lactams
|
|
US20090112332A1
(en)
|
2007-10-31 |
2009-04-30 |
Alexis Paul Shelokov |
Bone graft and bone graft substitutes with antibiotics for sustained, localized release of antibiotics for reducing postoperative surgical wound infection in spinal and other bone surgery
|
|
US8685432B2
(en)
|
2008-03-25 |
2014-04-01 |
University Of Utah Research Foundation |
Controlled release tissue graft combination biomaterials
|
|
WO2011127149A1
(en)
|
2010-04-06 |
2011-10-13 |
University Of Utah Research Foundation |
Controlled release combination biomaterials
|
|
KR101692911B1
(ko)
|
2008-04-15 |
2017-01-17 |
라이프 사이언스 엔터프라이즈 |
칼슘 포스페이트 혼합 골 시멘트를 이용한 척추의 최소 침습적 치료방법
|
|
US20100021524A1
(en)
|
2008-07-22 |
2010-01-28 |
Osteogenex Inc. |
Pimethixene derivatives for promoting bone growth
|
|
WO2010025135A2
(en)
|
2008-08-28 |
2010-03-04 |
Osteogenex Inc. |
Trimeprazine and ethopropazine derivatives for promoting bone growth
|
|
US9320761B2
(en)
|
2008-12-18 |
2016-04-26 |
Vivex Biomedical, Inc. |
Bone induction system and methods
|
|
WO2011003058A1
(en)
|
2009-07-03 |
2011-01-06 |
Concert Pharmaceuticals, Inc. |
Prostacyclin derivatives
|
|
US9107983B2
(en)
|
2010-10-27 |
2015-08-18 |
Warsaw Orthopedic, Inc. |
Osteoconductive matrices comprising statins
|
|
JP5847830B2
(ja)
*
|
2010-11-10 |
2016-01-27 |
アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd |
オレキシン受容体拮抗薬として有用なラクタム誘導体
|
|
AU2011329054B2
(en)
|
2010-11-15 |
2015-05-28 |
Zimmer Orthobiologics, Inc. |
Bone void fillers
|
|
US20120283293A1
(en)
|
2011-05-06 |
2012-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of neuroprotection involving Prostaglandin E2 EP4 (PGE2 EP4) receptor activation
|
|
BR112014002377A2
(pt)
|
2011-08-02 |
2017-02-21 |
Ono Pharmaceutical Co |
agente intensificador da função diastólica do ventrículo esquerdo
|
|
CA2879506C
(en)
*
|
2012-07-19 |
2020-10-27 |
Cayman Chemical Company, Inc. |
Difluorolactam compositions for ep4-mediated osteo related diseases and conditions
|
|
US20170260173A1
(en)
|
2012-07-19 |
2017-09-14 |
Myometrics, Llc |
Difluorolactam compositions for ep4-mediated osteo related diseases and condtions
|
|
EP2970234B1
(en)
|
2013-03-15 |
2018-07-18 |
Cayman Chemical Company, Inc. |
Methods of synthesizing a difluorolactam analog
|
|
US9676712B2
(en)
|
2013-03-15 |
2017-06-13 |
Cayman Chemical Company, Inc. |
Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
|
|
BR112015023080A2
(pt)
|
2013-03-15 |
2017-07-18 |
Cayman Chemical Co Inc |
composto, composição farmacêutica, e, método para tratamento de doenças
|
|
AU2014290512A1
(en)
|
2013-07-19 |
2015-11-12 |
Cayman Chemical Company, Inc. |
Methods, systems, and compositions for promoting bone growth
|
|
WO2017022045A1
(ja)
|
2015-08-03 |
2017-02-09 |
株式会社sizebook |
携帯情報装置、寸法測定方法、および寸法測定プログラム
|