|
US3975399A
(en)
|
1974-08-06 |
1976-08-17 |
E. I. Du Pont De Nemours And Company |
1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
|
|
ZA747723B
(en)
*
|
1974-12-11 |
1976-11-24 |
Pfizer |
11-desoxy-15-substituted-omega-pentanor prostaglandins
|
|
US4154949A
(en)
|
1974-12-11 |
1979-05-15 |
Pfizer Inc. |
11-Desoxy-15-substituted-ω-pentanor prostaglandins
|
|
IT1037126B
(it)
*
|
1975-03-14 |
1979-11-10 |
Erba Carlo Spa |
13.4 deidro ii desossi prosta glandine
|
|
DE2517771A1
(de)
|
1975-04-18 |
1976-10-28 |
Schering Ag |
Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
|
|
DE2528664A1
(de)
|
1975-06-27 |
1977-01-13 |
Hoechst Ag |
Pyrrolidone und verfahren zu ihrer herstellung
|
|
CA1085859A
(en)
|
1975-06-27 |
1980-09-16 |
Wilhelm Bartmann |
Pyrrolidones and process for their manufacture
|
|
DE2619638A1
(de)
|
1976-05-04 |
1977-11-17 |
Hoechst Ag |
Pyrrolidone und verfahren zu ihrer herstellung
|
|
US4268522A
(en)
|
1976-06-14 |
1981-05-19 |
Pfizer Inc. |
13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof
|
|
US4177346A
(en)
|
1976-08-06 |
1979-12-04 |
Pfizer Inc. |
1,5-Disubstituted-2-pyrrolidones
|
|
DE2729960A1
(de)
*
|
1977-06-30 |
1979-01-18 |
Schering Ag |
Neue acetylenprostaglandine und verfahren zu ihrer herstellung
|
|
US4320136A
(en)
|
1980-08-11 |
1982-03-16 |
E. I. Du Pont De Nemours And Company |
8-Aza-16,16-difluoroprostanoids
|
|
JPS58124778A
(ja)
|
1982-01-20 |
1983-07-25 |
Toray Ind Inc |
５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
|
|
US4456613A
(en)
|
1982-12-27 |
1984-06-26 |
E. I. Du Pont De Nemours And Company |
6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
|
|
GB8329559D0
(en)
|
1983-11-04 |
1983-12-07 |
Erba Farmitalia |
Furyl derivatives of 16-substituted prostaglandins preparations
|
|
DE3886936T2
(de)
|
1987-10-16 |
1994-04-28 |
Toray Industries |
2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLEN 2-PGI-DERIVATE, VERFAHREN ZUR HERSTELLUNG UND DEREN VERWENDUNG.
|
|
JPH0662599B2
(ja)
*
|
1987-10-16 |
1994-08-17 |
東レ株式会社 |
２，５，６，７―テトラノル―４，８―インタ―ｍ―フェニレンＰＧＩ２誘導体ならびにその製造法および用途
|
|
DE3835162A1
(de)
*
|
1988-10-13 |
1990-04-19 |
Schering Ag |
(1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
|
|
US7196054B1
(en)
|
1990-11-27 |
2007-03-27 |
The American National Red Cross |
Methods for treating wound tissue and forming a supplemented fibrin matrix
|
|
CA2093836A1
(en)
|
1992-04-24 |
1993-10-25 |
Wayne Gombotz |
Biodegradable tgf-.beta. delivery system for bone regeneration
|
|
JP3388867B2
(ja)
|
1994-03-31 |
2003-03-24 |
株式会社東芝 |
宛名領域検出装置および宛名領域検出方法
|
|
WO1996014335A1
(en)
|
1994-11-07 |
1996-05-17 |
The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services |
Cartilage-derived morphogenetic proteins
|
|
US7517539B1
(en)
|
1996-10-16 |
2009-04-14 |
Etex Corporation |
Method of preparing a poorly crystalline calcium phosphate and methods of its use
|
|
US20020098222A1
(en)
|
1997-03-13 |
2002-07-25 |
John F. Wironen |
Bone paste
|
|
ZA984040B
(en)
|
1997-05-15 |
1998-11-20 |
Ono Pharmaceutical Co |
Benzenesulfonamide compounds
|
|
US6043275A
(en)
|
1998-04-16 |
2000-03-28 |
Ono Pharmaceutical Co., Ltd. |
3,7-dithiaprostanoic acid derivative
|
|
TWI249520B
(en)
|
1998-07-15 |
2006-02-21 |
Ono Pharmaceutical Co |
5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
|
|
US6894175B1
(en)
|
1999-08-04 |
2005-05-17 |
The Procter & Gamble Company |
2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
|
|
TWI247606B
(en)
|
1999-11-24 |
2006-01-21 |
Ono Pharmaceutical Co |
Treating agent for osteopenic diseases
|
|
AP2002002555A0
(en)
|
1999-12-22 |
2002-06-30 |
Pfizer Prod Inc |
EP4 Receptor selective agonists in the treatment of osteoporosis.
|
|
US20010056060A1
(en)
|
2000-02-07 |
2001-12-27 |
Cameron Kimberly O. |
Treatment of osteoporsis with EP2/EP4 receptor selective agonists
|
|
AU2001290250A1
(en)
|
2000-09-21 |
2002-04-02 |
Ono Pharmaceutical Co. Ltd. |
Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
|
|
EA200300379A1
(ru)
*
|
2000-11-27 |
2003-08-28 |
Пфайзер Продактс Инк. |
Селективные агонисты рецептора ep4 в лечении остеопороза
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
JP2004521954A
(ja)
|
2001-07-16 |
2004-07-22 |
エフ．ホフマン−ラ ロシュ アーゲー |
Ｅｐ４受容体作用薬としてのプロスタグランジン類似体
|
|
PL215425B1
(pl)
|
2001-07-16 |
2013-12-31 |
Ono Pharmaceutical Co |
Pochodna pirolidonu, srodek farmaceutyczny zawierajacy te pochodna i jej zastosowanie
|
|
CN1863768A
(zh)
*
|
2001-07-16 |
2006-11-15 |
霍夫曼-拉罗奇有限公司 |
作为ep4受体激动剂的前列腺素类似物
|
|
JP4273407B2
(ja)
|
2001-07-23 |
2009-06-03 |
小野薬品工業株式会社 |
Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤
|
|
AU2002340282B2
(en)
|
2001-10-23 |
2007-08-09 |
Merck Serono Sa |
Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors
|
|
WO2003047417A2
(en)
|
2001-12-03 |
2003-06-12 |
Merck & Co., Inc. |
Ep4 receptor agonist, compositions and methods thereof
|
|
AU2002346562A1
(en)
*
|
2001-12-03 |
2003-06-17 |
Merck & Co., Inc. |
Method for treating ocular hypertension
|
|
AU2003211574A1
(en)
|
2002-03-05 |
2003-09-16 |
Ono Pharmaceutical Co., Ltd. |
8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
|
|
ATE336247T1
(de)
|
2002-03-18 |
2006-09-15 |
Pfizer Prod Inc |
Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten
|
|
EP1490055A1
(en)
|
2002-03-18 |
2004-12-29 |
Pfizer Products Inc. |
Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
|
|
US7326426B2
(en)
|
2002-03-29 |
2008-02-05 |
Ethicon, Inc. |
Compositions and medical devices utilizing bioabsorbable liquid polymers
|
|
US6573294B1
(en)
|
2002-05-14 |
2003-06-03 |
Allergan, Inc. |
8-azaprostaglandin analogs as agents for lowering intraocular pressure
|
|
EP1513589B1
(en)
|
2002-06-06 |
2010-11-10 |
Merck Frosst Canada Ltd. |
1,5-disubstituted pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma
|
|
AU2003237520B2
(en)
|
2002-06-10 |
2009-01-08 |
Laboratoires Serono Sa |
Gamma lactams as prostaglandin agonists and use thereof
|
|
WO2004037786A2
(en)
|
2002-10-25 |
2004-05-06 |
Merck Frosst Canada & Co. |
2-pyrrolidones as ep4 receptor agonists
|
|
WO2004065365A1
(ja)
|
2003-01-21 |
2004-08-05 |
Ono Pharmaceutical Co., Ltd. |
８−アザプロスタグランジン誘導体およびその医薬用途
|
|
JP4662926B2
(ja)
|
2003-03-03 |
2011-03-30 |
メルク セローノ ソシエテ アノニム |
プロスタグランジン作動薬としてのγ−ラクタム誘導体
|
|
US7163920B2
(en)
|
2003-09-30 |
2007-01-16 |
Ethicon, Inc. |
Peptide with osteogenic activity
|
|
MXPA06006810A
(es)
|
2003-12-17 |
2006-08-23 |
Pfizer Prod Inc |
Tratamiento de afecciones que se presentan con un nivel bajo de masa osea por terapia de combinacion continua con agonistas selectivos del receptor de prostaglandina ep4 y un estrogeno.
|
|
US7169807B2
(en)
|
2004-04-09 |
2007-01-30 |
Allergan, Inc. |
10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
|
|
EP1782829A1
(en)
|
2004-08-10 |
2007-05-09 |
Ono Pharmaceutical Co., Ltd. |
Preventive and/or remedy for hyperkalemia containing ep4 agonist
|
|
US7858610B2
(en)
|
2004-08-10 |
2010-12-28 |
Ono Pharmaceutical Co., Ltd. |
Preventive and/or remedy for lower urinary tract diseases containing EP4 agonist
|
|
US20060039949A1
(en)
|
2004-08-20 |
2006-02-23 |
Nycz Jeffrey H |
Acetabular cup with controlled release of an osteoinductive formulation
|
|
US20060057184A1
(en)
|
2004-09-16 |
2006-03-16 |
Nycz Jeffrey H |
Process to treat avascular necrosis (AVN) with osteoinductive materials
|
|
US7621963B2
(en)
|
2005-04-13 |
2009-11-24 |
Ebi, Llc |
Composite bone graft material
|
|
KR101465994B1
(ko)
|
2005-05-27 |
2014-11-27 |
로이어 바이오메디칼 인코포레이티드 |
생체재흡수성 중합체 매트릭스 및 이의 제조방법과 사용방법
|
|
ES2402651T3
(es)
|
2005-09-09 |
2013-05-07 |
Agnovos Healthcare, Llc |
Cemento sustituto de injerto óseo de material compuesto y artículos producidos del mismo
|
|
KR20060013354A
(ko)
|
2005-12-09 |
2006-02-09 |
(주)코리아 본 뱅크 |
인산칼슘계 시멘트 첨가에 의해 개질된 탈회골 기질의 개발
|
|
US20070232660A1
(en)
|
2006-04-04 |
2007-10-04 |
Allergan, Inc. |
Therapeutic and delivery methods of prostaglandin ep4 agonists
|
|
CN101686985A
(zh)
|
2007-05-08 |
2010-03-31 |
国立大学法人浜松医科大学 |
含有ep4激动剂的细胞毒性t细胞的活化剂
|
|
CN101821279A
(zh)
|
2007-08-15 |
2010-09-01 |
赛特凯恩蒂克公司 |
某些化学个体、组合物和方法
|
|
EP2215084B1
(en)
|
2007-10-23 |
2016-09-28 |
Allergan, Inc. |
Therapeutic substituted lactams
|
|
US20090112332A1
(en)
|
2007-10-31 |
2009-04-30 |
Alexis Paul Shelokov |
Bone graft and bone graft substitutes with antibiotics for sustained, localized release of antibiotics for reducing postoperative surgical wound infection in spinal and other bone surgery
|
|
WO2011127149A1
(en)
|
2010-04-06 |
2011-10-13 |
University Of Utah Research Foundation |
Controlled release combination biomaterials
|
|
US8685432B2
(en)
|
2008-03-25 |
2014-04-01 |
University Of Utah Research Foundation |
Controlled release tissue graft combination biomaterials
|
|
US9314545B2
(en)
|
2008-04-15 |
2016-04-19 |
Life Science Enterprises, Inc. |
Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement
|
|
WO2010011599A2
(en)
|
2008-07-22 |
2010-01-28 |
Osteogenex Inc. |
Pimethixene derivatives for promoting bone growth
|
|
WO2010025135A2
(en)
|
2008-08-28 |
2010-03-04 |
Osteogenex Inc. |
Trimeprazine and ethopropazine derivatives for promoting bone growth
|
|
US9320761B2
(en)
|
2008-12-18 |
2016-04-26 |
Vivex Biomedical, Inc. |
Bone induction system and methods
|
|
WO2011003058A1
(en)
|
2009-07-03 |
2011-01-06 |
Concert Pharmaceuticals, Inc. |
Prostacyclin derivatives
|
|
US9107983B2
(en)
|
2010-10-27 |
2015-08-18 |
Warsaw Orthopedic, Inc. |
Osteoconductive matrices comprising statins
|
|
EP2638008B1
(en)
*
|
2010-11-10 |
2015-07-01 |
Actelion Pharmaceuticals Ltd |
Lactam derivatives useful as orexin receptor antagonists
|
|
WO2012068135A1
(en)
|
2010-11-15 |
2012-05-24 |
Zimmer Orthobiologics, Inc. |
Bone void fillers
|
|
US20120283293A1
(en)
|
2011-05-06 |
2012-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of neuroprotection involving Prostaglandin E2 EP4 (PGE2 EP4) receptor activation
|
|
US9682065B2
(en)
|
2011-08-02 |
2017-06-20 |
Ono Pharmaceutical Co., Ltd. |
Left ventricular diastolic function improving agent
|
|
US20170260173A1
(en)
|
2012-07-19 |
2017-09-14 |
Myometrics, Llc |
Difluorolactam compositions for ep4-mediated osteo related diseases and condtions
|
|
EP2875022B1
(en)
|
2012-07-19 |
2016-10-12 |
Cayman Chemical Company, Incorporated |
Difluorolactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated disease and conditions
|
|
PT2989098T
(pt)
|
2013-03-15 |
2017-08-16 |
Cayman Chemical Co Inc |
Compostos de lactama como agonistas selectivos do receptor ep4 para uso no tratamento de doenças e condições mediadas por ep4
|
|
WO2014144610A1
(en)
|
2013-03-15 |
2014-09-18 |
Cayman Chemical Company, Inc. |
Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
|
|
WO2014144500A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Cayman Chemical Company, Inc. |
Methods of synthesizing a difluorolactam analog
|
|
CN105392505A
(zh)
|
2013-07-19 |
2016-03-09 |
开曼化学股份有限公司 |
用于促进骨生长的方法、系统和组合物
|
|
JP6062599B1
(ja)
|
2015-08-03 |
2017-01-18 |
株式会社ｓｉｚｅｂｏｏｋ |
携帯情報装置、寸法測定方法、および寸法測定プログラム
|