JP2015522623A5 - - Google Patents

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Publication number
JP2015522623A5
JP2015522623A5 JP2015523282A JP2015523282A JP2015522623A5 JP 2015522623 A5 JP2015522623 A5 JP 2015522623A5 JP 2015523282 A JP2015523282 A JP 2015523282A JP 2015523282 A JP2015523282 A JP 2015523282A JP 2015522623 A5 JP2015522623 A5 JP 2015522623A5
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JP
Japan
Prior art keywords
difluoro
methyl
hydroxy
oxopyrrolidin
alkyl
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JP2015523282A
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English (en)
Japanese (ja)
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JP6141430B2 (ja
JP2015522623A (ja
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Priority claimed from PCT/US2013/051261 external-priority patent/WO2014015246A1/en
Publication of JP2015522623A publication Critical patent/JP2015522623A/ja
Publication of JP2015522623A5 publication Critical patent/JP2015522623A5/ja
Application granted granted Critical
Publication of JP6141430B2 publication Critical patent/JP6141430B2/ja
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JP2015523282A 2012-07-19 2013-07-19 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物 Active JP6141430B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673514P 2012-07-19 2012-07-19
US61/673,514 2012-07-19
US201361793929P 2013-03-15 2013-03-15
US61/793,929 2013-03-15
PCT/US2013/051261 WO2014015246A1 (en) 2012-07-19 2013-07-19 Difluorolactam compositions for ep4-mediated osteo related diseases and conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017091147A Division JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Publications (3)

Publication Number Publication Date
JP2015522623A JP2015522623A (ja) 2015-08-06
JP2015522623A5 true JP2015522623A5 (enExample) 2016-09-23
JP6141430B2 JP6141430B2 (ja) 2017-06-07

Family

ID=48916211

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015523282A Active JP6141430B2 (ja) 2012-07-19 2013-07-19 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2017091147A Active JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2019096736A Pending JP2019163300A (ja) 2012-07-19 2019-05-23 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017091147A Active JP6766008B2 (ja) 2012-07-19 2017-05-01 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物
JP2019096736A Pending JP2019163300A (ja) 2012-07-19 2019-05-23 Ep4介在性骨関連疾患及び病態用ジフルオロラクタム組成物

Country Status (20)

Country Link
US (8) US9440919B2 (enExample)
EP (4) EP3175852B1 (enExample)
JP (3) JP6141430B2 (enExample)
KR (2) KR102151578B1 (enExample)
CN (4) CN107802623B (enExample)
AU (3) AU2013292356B2 (enExample)
CA (2) CA2879506C (enExample)
CY (1) CY1118929T1 (enExample)
DK (2) DK2875022T3 (enExample)
ES (3) ES2610428T3 (enExample)
HR (1) HRP20170045T1 (enExample)
HU (2) HUE031190T2 (enExample)
IL (3) IL236636A (enExample)
LT (1) LT2875022T (enExample)
NZ (2) NZ704178A (enExample)
PH (1) PH12015500111A1 (enExample)
PL (1) PL2875022T3 (enExample)
PT (2) PT3175852T (enExample)
SI (1) SI2875022T1 (enExample)
WO (2) WO2014015247A1 (enExample)

Families Citing this family (8)

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CA2879506C (en) * 2012-07-19 2020-10-27 Cayman Chemical Company, Inc. Difluorolactam compositions for ep4-mediated osteo related diseases and conditions
BR112015023080A2 (pt) 2013-03-15 2017-07-18 Cayman Chemical Co Inc composto, composição farmacêutica, e, método para tratamento de doenças
EP2970234B1 (en) 2013-03-15 2018-07-18 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
AU2014290512A1 (en) 2013-07-19 2015-11-12 Cayman Chemical Company, Inc. Methods, systems, and compositions for promoting bone growth
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
CN106699604B (zh) * 2017-01-09 2019-01-01 四川同晟生物医药有限公司 一种沙库比曲及其中间体的制备方法
EP3446661B1 (en) 2017-08-21 2021-12-29 Cook Medical Technologies LLC Braided stent crown geometry and flare

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