ZA747723B - 11-desoxy-15-substituted-omega-pentanor prostaglandins - Google Patents

11-desoxy-15-substituted-omega-pentanor prostaglandins

Info

Publication number
ZA747723B
ZA747723B ZA747723A ZA747723A ZA747723B ZA 747723 B ZA747723 B ZA 747723B ZA 747723 A ZA747723 A ZA 747723A ZA 747723 A ZA747723 A ZA 747723A ZA 747723 B ZA747723 B ZA 747723B
Authority
ZA
South Africa
Prior art keywords
pentanor
desoxy
prostaglandins
omega
substituted
Prior art date
Application number
ZA747723A
Inventor
Michael Ross Johnson
Ross Johnson Michael
Thomas Ken Schaaf
Ken Schaaf Thomas
James Frederick Eggler
Frederick Eggler James
Jasjit Singh Bindra
Singh Bindra Jasjit
Hans-Jurgen Ernst Hess
Ernst Hess Hans-Jurgen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IE1622/75A priority Critical patent/IE42010B1/en
Priority to AU83317/75A priority patent/AU496309B2/en
Priority to GB3082875A priority patent/GB1453558A/en
Priority to CH971175A priority patent/CH598916A5/xx
Priority to IL7547815A priority patent/IL47815A/en
Priority to NL7509273A priority patent/NL7509273A/en
Priority to US05/601,955 priority patent/US4246004A/en
Priority to IT7526056A priority patent/IT1040335B/en
Priority to ES440211A priority patent/ES440211A1/en
Priority to FR7525110A priority patent/FR2281810A1/en
Priority to DE19752536090 priority patent/DE2536090A1/en
Priority to SE7509071A priority patent/SE412336B/en
Priority to IN1594/CAL/75A priority patent/IN142195B/en
Priority to JP50099028A priority patent/JPS5152592A/en
Priority to AR260017A priority patent/AR211917A1/en
Priority to CA233,434A priority patent/CA1047770A/en
Priority to BR7505192*A priority patent/BR7505192A/en
Publication of ZA747723B publication Critical patent/ZA747723B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
ZA747723A 1974-08-15 1974-12-04 11-desoxy-15-substituted-omega-pentanor prostaglandins ZA747723B (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IE1622/75A IE42010B1 (en) 1974-08-15 1975-07-21 Abrasive products
AU83317/75A AU496309B2 (en) 1975-07-23 Abrasive products
GB3082875A GB1453558A (en) 1974-08-15 1975-07-23 Abrasive products
CH971175A CH598916A5 (en) 1974-08-15 1975-07-25
IL7547815A IL47815A (en) 1974-08-15 1975-07-25 Abrasive bodies and tools and their manufacture
NL7509273A NL7509273A (en) 1974-08-15 1975-08-04 GRINDING OBJECTS.
US05/601,955 US4246004A (en) 1974-08-15 1975-08-04 Method of making a segmented cup grinding wheel
IT7526056A IT1040335B (en) 1974-08-15 1975-08-04 ABRASIVE PRODUCTS
ES440211A ES440211A1 (en) 1974-08-15 1975-08-12 Method of making a segmented cup grinding wheel
FR7525110A FR2281810A1 (en) 1974-08-15 1975-08-12 ABRASIVE PRODUCTS
DE19752536090 DE2536090A1 (en) 1974-08-15 1975-08-13 ABRASIVE BODIES AND METHOD FOR ITS MANUFACTURING
SE7509071A SE412336B (en) 1974-08-15 1975-08-13 GRINDING TOOL AND PROCEDURE FOR MANUFACTURING A GOOD TOOL
IN1594/CAL/75A IN142195B (en) 1974-08-15 1975-08-14
JP50099028A JPS5152592A (en) 1974-08-15 1975-08-14 Kensakukoguno kensakububunno seisakunimochiiru segumentooyobi segumentootsukuruhohonarabini kensakukoguotsukuruhoho
AR260017A AR211917A1 (en) 1974-08-15 1975-08-14 PART TO BE USED IN THE MANUFACTURE OF AN ABRASIVE TOOL AND METHOD OF MANUFACTURING IT
CA233,434A CA1047770A (en) 1974-08-15 1975-08-14 Abrasive products
BR7505192*A BR7505192A (en) 1974-08-15 1975-08-14 SEGMENT, PROCESS FOR ITS PRODUCTION, ABRASIVE TOOL PRODUCED WITH APPLICATION OF THE SUCH SEGMENT, AND PROCESS TO PRODUCE said TOOL

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53167674A 1974-12-11 1974-12-11

Publications (1)

Publication Number Publication Date
ZA747723B true ZA747723B (en) 1976-11-24

Family

ID=24118594

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA747723A ZA747723B (en) 1974-08-15 1974-12-04 11-desoxy-15-substituted-omega-pentanor prostaglandins

Country Status (21)

Country Link
JP (3) JPS51125257A (en)
AT (1) AT351185B (en)
BE (1) BE836564A (en)
CH (1) CH610302A5 (en)
CS (3) CS194745B2 (en)
DD (3) DD129783A5 (en)
DE (1) DE2555210A1 (en)
DK (1) DK559975A (en)
ES (1) ES443421A1 (en)
FI (1) FI753475A (en)
FR (1) FR2293923A1 (en)
GB (3) GB1508170A (en)
GR (1) GR60310B (en)
IE (1) IE43815B1 (en)
IL (2) IL48617A0 (en)
LU (1) LU73997A1 (en)
NL (1) NL166015C (en)
NO (1) NO754195L (en)
NZ (1) NZ179502A (en)
SE (1) SE7513602L (en)
ZA (1) ZA747723B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486540A (en) * 1993-10-28 1996-01-23 Allergan, Inc. Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
EP1114816A4 (en) * 1998-09-14 2002-09-04 Ono Pharmaceutical Co $g(v)-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
BRPI0619492A2 (en) * 2005-12-07 2011-10-04 Univ Ramot jasmonate chemical derivatives, pharmaceutical compositions and methods of use
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
PL2875022T3 (en) 2012-07-19 2017-06-30 Cayman Chemical Company, Incorporated Difluorolactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated disease and conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO143741C (en) * 1972-07-13 1981-04-08 Pfizer ANALOGY PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE PROSTAGLAND CONNECTIONS OF THE E AND F SERIES

Also Published As

Publication number Publication date
GB1508170A (en) 1978-04-19
IE43815B1 (en) 1981-06-03
DK559975A (en) 1976-06-12
NL166015C (en) 1981-06-15
GR60310B (en) 1978-05-08
GB1508169A (en) 1978-04-19
AT351185B (en) 1979-07-10
DE2555210A1 (en) 1976-06-16
JPS52102258A (en) 1977-08-27
NO754195L (en) 1976-06-14
FR2293923A1 (en) 1976-07-09
DD129649A5 (en) 1978-02-01
LU73997A1 (en) 1976-11-11
ATA941675A (en) 1978-12-15
ES443421A1 (en) 1977-04-16
CS194746B2 (en) 1979-12-31
NZ179502A (en) 1979-01-11
BE836564A (en) 1976-06-11
SE7513602L (en) 1976-06-14
NL7514446A (en) 1976-06-15
CS194733B2 (en) 1979-12-31
IL48617A0 (en) 1976-02-29
JPS52102270A (en) 1977-08-27
JPS51125257A (en) 1976-11-01
GB1508168A (en) 1978-04-19
AU8736275A (en) 1977-10-13
FI753475A (en) 1976-06-12
CS194745B2 (en) 1979-12-31
DD125828A5 (en) 1977-05-18
NL166015B (en) 1981-01-15
CH610302A5 (en) 1979-04-12
IL56863A0 (en) 1979-05-31
FR2293923B1 (en) 1979-02-23
IE43815L (en) 1976-06-11
DD129783A5 (en) 1978-02-08

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