JP2015520128A5 - - Google Patents
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- JP2015520128A5 JP2015520128A5 JP2015506351A JP2015506351A JP2015520128A5 JP 2015520128 A5 JP2015520128 A5 JP 2015520128A5 JP 2015506351 A JP2015506351 A JP 2015506351A JP 2015506351 A JP2015506351 A JP 2015506351A JP 2015520128 A5 JP2015520128 A5 JP 2015520128A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 20
- 208000008589 Obesity Diseases 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 229920000023 polynucleotide Polymers 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 239000000018 receptor agonist Substances 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 208000008466 Metabolic Disease Diseases 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 102000025873 GPCR, family 2, glucagon receptor Human genes 0.000 claims 2
- 108010063919 GPCR, family 2, glucagon receptor Proteins 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- 229960004666 Glucagon Drugs 0.000 claims 2
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N Glucagonum Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- PXZWGQLGAKCNKD-DPNMSELWSA-N MolPort-023-276-326 Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 PXZWGQLGAKCNKD-DPNMSELWSA-N 0.000 claims 2
- 101800001388 Oxyntomodulin Proteins 0.000 claims 2
- 102400000319 Oxyntomodulin Human genes 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000002068 genetic Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000008839 post-traumatic stress disease Diseases 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- DTHNMHAUYICORS-KTKZVXAJSA-N 107444-51-9 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
- 210000000577 Adipose Tissue Anatomy 0.000 claims 1
- 206010057666 Anxiety disease Diseases 0.000 claims 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 1
- 229940015047 Chorionic Gonadotropin Drugs 0.000 claims 1
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 claims 1
- 102100003818 GCG Human genes 0.000 claims 1
- 101710042131 GCG Proteins 0.000 claims 1
- 101700071595 GRZ1 Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 101700078733 ZGLP1 Proteins 0.000 claims 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001603 reducing Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Claims (32)
- ＧＬＰ−１／グルカゴンデュアル受容体アゴニストと、前記アゴニストのアミノ末端またはカルボキシ末端に結合した１〜５個の絨毛性ゴナドトロピンカルボキシ末端ペプチド（ＣＴＰ）とを含むＣＴＰ修飾ポリペプチド。
- 前記ＧＬＰ−１／グルカゴン受容体アゴニストがオキシントモジュリンであることを特徴とする請求項１に記載のＣＴＰ修飾ポリペプチド。
- 前記ＣＴＰ修飾ポリペプチドのアミノ酸配列が、配列番号９、１５、２５、２７、２９、配列番号２１の４〜１２２番目のアミノ酸配列、及び配列番号２３の１〜１１９番目のアミノ酸配列からなる群より選択されたアミノ酸配列を含むことを特徴とする請求項２に記載のＣＴＰ修飾ポリペプチド。
- 前記ＣＴＰ修飾ポリペプチドが、シグナルペプチドを含まないことを特徴とする請求項１または２に記載のＣＴＰ修飾ポリペプチド。
- 前記ＣＴＰ修飾ポリペプチドのアミノ酸配列が、配列番号９の２７〜１１９番目のアミノ酸配列、配列番号１５の２７〜１４７番目のアミノ酸配列、配列番号２１の３０〜１２２番目のアミノ酸配列、配列番号２３の２７〜１１９番目のアミノ酸配列、配列番号２５の２６〜１４７番目のアミノ酸配列、配列番号２７の２７〜１７５番目のアミノ酸配列、及び配列番号２９の２７〜２０３番目のアミノ酸配列からなる群より選択されたアミノ酸配列を含むことを特徴とする請求項２または４に記載のＣＴＰ修飾ポリペプチド。
- 少なくとも１つのＣＴＰのアミノ酸配列が、配列番号１および配列番号２からなる群より選択されることを特徴とする請求項１または２に記載のＣＴＰ修飾ポリペプチド。
- 少なくとも１つのＣＴＰがグリコシル化されていることを特徴とする請求項１〜６のいずれか一項に記載のＣＴＰ修飾ポリペプチド。
- 少なくとも１つのＣＴＰが短縮化されていることを特徴とする請求項１または２に記載のＣＴＰ修飾ポリペプチド。
- 少なくとも１つのＣＴＰが、リンカーを介して前記アゴニストに結合していることを特徴とする請求項１または２に記載のＣＴＰ修飾ポリペプチド。
- 前記リンカーがペプチド結合であることを特徴とする請求項９に記載のＣＴＰ修飾ポリペプチド。
- 請求項１〜１０のいずれか一項に記載のＣＴＰ修飾ポリペプチドを含む医薬組成物。
- 請求項１〜１０のいずれか一項に記載のＣＴＰ修飾ポリペプチドをコードするポリヌクレオチド。
- 前記ポリヌクレオチドのヌクレオチド配列が、配列番号８、１４、２０、２２、２４、２６、及び２８からなる群から選択されたヌクレオチド配列を含むことを特徴とする請求項１２に記載のポリヌクレオチド。
- 請求項１２または１３に記載のポリヌクレオチドを含む発現ベクター。
- 請求項１４に記載の発現ベクターを含む細胞または医薬組成物。
- 対象における耐糖性を誘導するための、対象における望ましくない体重増加を防止するための、対象における食物摂取を阻害、減少または抑制するための、対象における肥満を治療するための、対象におけるＩＩ型糖尿病を治療するための、または、対象における代謝性障害を治療するための医薬を製造するための、ＧＬＰ−１／グルカゴンデュアル受容体アゴニストと、前記アゴニストのアミノ末端またはカルボキシ末端に結合した１〜５個の絨毛性ゴナドトロピンカルボキシ末端ペプチド（ＣＴＰ）とを含むＣＴＰ修飾ポリペプチドの使用。
- 前記ＧＬＰ−１／グルカゴン受容体アゴニストがオキシントモジュリンであることを特徴とする請求項１６に記載の使用。
- 前記ＣＴＰ修飾ポリペプチドのアミノ酸配列が、配列番号９、１５、２５、２７、２９、配列番号２１の４〜１２２番目のアミノ酸配列、及び配列番号２３の１〜１１９番目のアミノ酸配列からなる群より選択されたアミノ酸配列を含むことを特徴とする請求項１７に記載の使用。
- 前記ＣＴＰ修飾ポリペプチドが、シグナルペプチドを含まないことを特徴とする請求項１６または１７に記載の使用。
- 前記ＣＴＰ修飾ポリペプチドのアミノ酸配列が、配列番号９の２７〜１１９番目のアミノ酸配列、配列番号１５の２７〜１４７番目のアミノ酸配列、配列番号２１の３０〜１２２番目のアミノ酸配列、配列番号２３の２７〜１１９番目のアミノ酸配列、配列番号２５の２６〜１４７番目のアミノ酸配列、配列番号２７の２７〜１７５番目のアミノ酸配列、及び配列番号２９の２７〜２０３番目のアミノ酸配列からなる群より選択されたアミノ酸配列を含むことを特徴とする請求項１７または１９に記載の使用。
- 少なくとも１つのＣＴＰのアミノ酸配列が、配列番号１および配列番号２からなる群より選択されることを特徴とする請求項１６または１７に記載の使用。
- 少なくとも１つのＣＴＰがグリコシル化されていることを特徴とする請求項１６〜２１のいずれか一項に記載の使用。
- 少なくとも１つのＣＴＰが短縮化されていることを特徴とする請求項１６または１７に記載の使用。
- 少なくとも１つのＣＴＰが、リンカーを介して前記アゴニストに結合していることを特徴とする請求項１６または１７に記載の使用。
- 前記リンカーがペプチド結合であることを特徴とする請求項２４に記載の使用。
- 前記体重増加が、前記対象に肥満を発生させるか、前記対象の心理状態に起因するか、または前記対象における肥満になりやすい遺伝的素因に起因することを特徴とする請求項１６に記載の使用。
- 前記心理状態が、うつ病、不安症、または心的外傷後ストレス障害（ＰＴＳＤ）であることを特徴とする請求項２６に記載の使用。
- 前記対象による食物摂取を阻害、減少または抑制することにより、前記対象に肥満が発生する可能性を減少させるようにしたことを特徴とする請求項１６に記載の使用。
- 前記対象が、肥満になりやすい遺伝的素因を有していることを特徴とする請求項１６、２６、または２８のいずれか一項に記載の使用。
- 肥満を治療することにより、前記対象の体重または体脂肪が減少するようにしたことを特徴とする請求項１６、２６、２８、または２９のいずれか一項に記載の使用。
- 前記代謝性障害が、糖尿病性ケトアシドーシス、真性糖尿病、またはそれらの組合せであることを特徴とする請求項１６に記載の使用。
- 前記代謝性障害が、前記対象におけるインスリンの欠乏とグルコースの過剰により生じることを特徴とする請求項１６に記載の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261635483P | 2012-04-19 | 2012-04-19 | |
| US61/635,483 | 2012-04-19 | ||
| PCT/IL2013/050332 WO2013157002A1 (en) | 2012-04-19 | 2013-04-17 | Long-acting oxyntomodulin variants and methods of producing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015520128A JP2015520128A (ja) | 2015-07-16 |
| JP2015520128A5 true JP2015520128A5 (ja) | 2016-06-16 |
Family
ID=49383021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015506351A Pending JP2015520128A (ja) | 2012-04-19 | 2013-04-17 | 長時間作用性オキシントモジュリン変異体とその作製方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9522945B2 (ja) |
| EP (1) | EP2838552A4 (ja) |
| JP (1) | JP2015520128A (ja) |
| KR (1) | KR20150008137A (ja) |
| CN (1) | CN104487082A (ja) |
| AU (1) | AU2013250711A1 (ja) |
| BR (1) | BR112014025951A2 (ja) |
| CA (1) | CA2870650A1 (ja) |
| CL (1) | CL2014002791A1 (ja) |
| CO (1) | CO7200249A2 (ja) |
| EA (1) | EA201491898A1 (ja) |
| HK (1) | HK1207564A1 (ja) |
| IL (1) | IL235184A0 (ja) |
| MX (1) | MX2014012625A (ja) |
| MY (1) | MY167814A (ja) |
| PE (1) | PE20142405A1 (ja) |
| SG (1) | SG11201406671RA (ja) |
| WO (1) | WO2013157002A1 (ja) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
| LT2718318T (lt) | 2011-06-10 | 2018-10-25 | Hanmi Science Co., Ltd. | Nauji oksintomodulino dariniai ir farmacinė kompozicija, apimanti šiuos darinius, nutukimo gydymui |
| HUE042585T2 (hu) | 2011-06-17 | 2019-07-29 | Hanmi Science Co Ltd | Oxintomodulint és immunglobulin-fragmentumot tartalmazó konjugátum és alkalmazása |
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- 2013-04-17 BR BR112014025951A patent/BR112014025951A2/pt not_active IP Right Cessation
- 2013-04-17 EP EP13778848.5A patent/EP2838552A4/en not_active Withdrawn
- 2013-04-17 EA EA201491898A patent/EA201491898A1/ru unknown
- 2013-04-17 CN CN201380032217.4A patent/CN104487082A/zh active Pending
- 2013-04-17 SG SG11201406671RA patent/SG11201406671RA/en unknown
- 2013-04-17 WO PCT/IL2013/050332 patent/WO2013157002A1/en active Application Filing
- 2013-04-17 AU AU2013250711A patent/AU2013250711A1/en not_active Abandoned
- 2013-04-17 MX MX2014012625A patent/MX2014012625A/es unknown
- 2013-04-17 KR KR1020147032422A patent/KR20150008137A/ko not_active Application Discontinuation
- 2013-04-17 JP JP2015506351A patent/JP2015520128A/ja active Pending
- 2013-04-17 US US14/395,441 patent/US9522945B2/en active Active
- 2013-04-17 PE PE2014001683A patent/PE20142405A1/es not_active Application Discontinuation
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2014
- 2014-10-16 CL CL2014002791A patent/CL2014002791A1/es unknown
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- 2014-11-11 CO CO14249267A patent/CO7200249A2/es unknown
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2015
- 2015-08-24 HK HK15108167.3A patent/HK1207564A1/xx unknown
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2016
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