JP2015518901A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015518901A5 JP2015518901A5 JP2015516245A JP2015516245A JP2015518901A5 JP 2015518901 A5 JP2015518901 A5 JP 2015518901A5 JP 2015516245 A JP2015516245 A JP 2015516245A JP 2015516245 A JP2015516245 A JP 2015516245A JP 2015518901 A5 JP2015518901 A5 JP 2015518901A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- cancer cells
- inactivated
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 17
- 210000004881 tumor cell Anatomy 0.000 claims 11
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100036848 C-C motif chemokine 20 Human genes 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims 1
- 101000665442 Homo sapiens Serine/threonine-protein kinase TBK1 Proteins 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 claims 1
- UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 claims 1
- 108700014844 flt3 ligand Proteins 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657574P | 2012-06-08 | 2012-06-08 | |
| US61/657,574 | 2012-06-08 | ||
| PCT/US2013/044744 WO2013185052A1 (en) | 2012-06-08 | 2013-06-07 | Compostions and methods for cancer immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518901A JP2015518901A (ja) | 2015-07-06 |
| JP2015518901A5 true JP2015518901A5 (enExample) | 2016-07-28 |
| JP6257607B2 JP6257607B2 (ja) | 2018-01-10 |
Family
ID=49712686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516245A Expired - Fee Related JP6257607B2 (ja) | 2012-06-08 | 2013-06-07 | 癌免疫療法のための組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9770467B2 (enExample) |
| EP (1) | EP2858722B8 (enExample) |
| JP (1) | JP6257607B2 (enExample) |
| KR (1) | KR20150022996A (enExample) |
| CN (1) | CN104507538B (enExample) |
| AU (1) | AU2013271375B2 (enExample) |
| CA (1) | CA2876150A1 (enExample) |
| IN (1) | IN2014MN02492A (enExample) |
| NZ (1) | NZ702392A (enExample) |
| SG (2) | SG10201610251PA (enExample) |
| WO (1) | WO2013185052A1 (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ702392A (en) | 2012-06-08 | 2017-03-31 | Aduro Biotech | Compositions and methods for cancer immunotherapy |
| WO2014093936A1 (en) | 2012-12-13 | 2014-06-19 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| RU2015129030A (ru) * | 2012-12-19 | 2017-01-26 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Фармацевтическое направленное воздействие на путь передачи сигнала циклических динуклеотидов млекопитающих |
| MX374828B (es) | 2013-04-29 | 2025-03-06 | Memorial Sloan Kettering Cancer Center | Composiciones y metodos para alterar la señalizacion del segundo mensajero. |
| US20140329889A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| JP6400082B2 (ja) * | 2013-05-18 | 2018-10-03 | アデュロ バイオテック，インコーポレイテッド | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| JP2016526532A (ja) * | 2013-06-14 | 2016-09-05 | インターベット インターナショナル ベー． フェー． | ＧｐＧオリゴデオキシヌクレオチドおよびサイクリックｄｉ‐ＧＭＰを含む医薬組成物 |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
| PE20211760A1 (es) | 2013-10-18 | 2021-09-07 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma) que comprenden grupos carboxilicos y una region de enlazador modificada, agentes formadores de imagenes y agentes farmaceuticos que los comprenden |
| WO2015108595A1 (en) * | 2014-01-15 | 2015-07-23 | Nikolai Khodarev | Anti-tumor therapy |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| CN103908468B (zh) * | 2014-04-21 | 2017-02-08 | 上海捌加壹医药科技有限公司 | 环二核苷酸cGAMP在制备抗肿瘤药物中的应用 |
| US10450341B2 (en) | 2014-06-04 | 2019-10-22 | Glaxosmithkline Intellectual Property Development Limited | Cyclic di-nucleotides as modulators of STING |
| CA2958771A1 (en) * | 2014-09-08 | 2016-03-17 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer |
| US10010607B2 (en) | 2014-09-16 | 2018-07-03 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response |
| US11236139B2 (en) * | 2014-11-05 | 2022-02-01 | The Regents Of The University Of California | Combination immunotherapy |
| JP6762030B2 (ja) * | 2014-11-20 | 2020-09-30 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Ｔｈ１誘導性アジュバントおよびその用途 |
| PL3233882T3 (pl) | 2014-12-16 | 2020-04-30 | Kayla Therapeutics | Fluorowane cykliczne dinukleotydy do indukcji cytokin |
| WO2016096577A1 (en) * | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CA3256526A1 (en) | 2015-02-11 | 2025-10-30 | The Johns Hopkins University | Bacteria over-expressing c-di-amp and therapeutic methods |
| KR102873947B1 (ko) * | 2015-05-07 | 2025-10-22 | 베이롤 칼리지 오브 메드신 | 수지상 세포 면역요법 |
| CN108137641B (zh) | 2015-08-13 | 2022-04-01 | 默沙东公司 | 作为sting激动剂的环状双核苷酸化合物 |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| CN106540255A (zh) * | 2015-09-18 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用 |
| CN106540254A (zh) * | 2015-09-22 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 环二核苷酸cGAMP及其衍生物是潜在免疫佐剂 |
| CN106540253A (zh) * | 2015-09-24 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | cGAMP及其衍生物在制备抗肿瘤疫苗中的应用 |
| CN105367617A (zh) * | 2015-09-25 | 2016-03-02 | 武汉品生科技有限公司 | 一种基于环二腺核苷酸的衍生物、tat多肽及其在一型干扰素小分子中抑制剂的应用 |
| RU2020113165A (ru) | 2015-12-03 | 2020-06-09 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
| PT3402801T (pt) | 2016-01-11 | 2025-10-23 | Innate Tumor Immunity Inc | Dinucleótidos cíclicos para o tratamento de condições associadas à atividade de sting, tal como cancro |
| CN106544319A (zh) * | 2016-01-24 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法 |
| US20190105381A1 (en) * | 2016-03-16 | 2019-04-11 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for treating cancer |
| HUE060396T2 (hu) * | 2016-03-18 | 2023-02-28 | Immune Sensor Llc | Ciklikus DI-nukleotid vegyületek és azok felhasználási módszerei |
| MX2018012266A (es) | 2016-04-07 | 2019-05-30 | Glaxosmithkline Ip Dev Ltd | Amidas heterociclicas como moduladores de proteinas. |
| HUE058932T2 (hu) | 2016-04-07 | 2022-09-28 | Glaxosmithkline Ip Dev Ltd | Fehérjemodulátorokként hasznos heterociklikus amidok |
| EP3448393A1 (en) | 2016-04-25 | 2019-03-06 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
| JP7100227B2 (ja) | 2016-07-06 | 2022-07-13 | エフ－スター・セラピューティクス・インコーポレイテッド | 疾患の治療のための化合物、組成物、および方法 |
| EP3922279B8 (en) | 2016-08-30 | 2025-02-12 | Dana-Farber Cancer Institute, Inc. | Drug delivery compositions and uses thereof |
| EA037513B1 (ru) * | 2016-09-17 | 2021-04-06 | ИММЬЮН СЕНСОР, ЭлЭлСи | Циклические динуклеотидные соединения и способы их применения |
| RS62410B1 (sr) | 2016-10-04 | 2021-10-29 | Merck Sharp & Dohme | Benzo[b]tiofenska jedinjenja kao agonisti sting |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| KR101889181B1 (ko) * | 2016-12-19 | 2018-08-16 | 주식회사 포스코 | 굽힘성 및 신장플랜지성이 우수한 고장력강 및 이의 제조방법 |
| CN110461334A (zh) * | 2016-12-22 | 2019-11-15 | 马福制药公司 | 增强或增加i型ifn产生的组合物和方法 |
| MX2019009070A (es) | 2017-02-01 | 2019-10-30 | Modernatx Inc | Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion. |
| US20200055883A1 (en) * | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| CA3053568A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents, The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| KR20200028392A (ko) * | 2017-06-12 | 2020-03-16 | 유니버시티 오브 마이애미 | 질환의 치료를 위한 sting-의존성 활성화제 |
| US11969499B2 (en) | 2017-06-16 | 2024-04-30 | William Marsh Rice University | Hydrogel delivery of sting immunotherapy for treatment cancer |
| CA3071538A1 (en) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene sting agonists for cancer treatment |
| MA49773A (fr) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| EP3675859A4 (en) | 2017-08-31 | 2021-06-30 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF A DISEASE |
| WO2019051488A1 (en) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2019069270A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | GENERATOR STIMULATOR MODULATORS (STING) INTERFERON |
| WO2019069269A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | INTERFERON GENE STIMULATOR MODULATORS USEFUL IN THE TREATMENT OF HIV |
| CN107619438B (zh) * | 2017-10-11 | 2021-12-03 | 广州云启科技有限公司 | 新型环二核苷酸受体及其激动剂或抑制剂筛选的方法和试剂盒 |
| CN109694397B (zh) * | 2017-10-23 | 2021-08-31 | 上海弘翊生物科技有限公司 | 环状二核苷酸化合物、其制备方法和应用 |
| KR20200098511A (ko) | 2017-11-10 | 2020-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 조절제 화합물, 및 제조 및 사용 방법 |
| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| WO2019125974A1 (en) | 2017-12-20 | 2019-06-27 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| MX2020009796A (es) | 2018-03-23 | 2021-01-15 | Codiak Biosciences Inc | Vesiculas extracelulares que comprenden agonista de estimulador de genes de interferon (sting). |
| EP3774764A1 (en) | 2018-04-03 | 2021-02-17 | Merck Sharp&Dohme Corp. | Benzothiophenes and related compounds as sting agonists |
| US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202014193A (zh) | 2018-05-03 | 2020-04-16 | 捷克科學院有機化學與生物化學研究所 | 包含碳環核苷酸之2’3’－環二核苷酸 |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| WO2020014127A1 (en) | 2018-07-10 | 2020-01-16 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
| CA3099904A1 (en) | 2018-08-16 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Salts of compounds and crystals thereof |
| MA53438A (fr) | 2018-08-24 | 2021-09-15 | Codiak Biosciences Inc | Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées |
| EP3874068A4 (en) * | 2018-11-02 | 2022-08-17 | The Regents of the University of California | METHODS OF DIAGNOSIS AND TREATMENT OF CANCER USING NON-HUMAN NUCLEIC ACIDS |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US12318403B2 (en) | 2019-03-07 | 2025-06-03 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′-cyclic dinucleotides and prodrugs thereof |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| PH12021552223A1 (en) | 2019-03-21 | 2022-05-30 | Codiak Biosciences Inc | Extracellular vesicles for vaccine delivery |
| EP3941528A1 (en) | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Extracellular vesicle conjugates and uses thereof |
| TW202104214A (zh) | 2019-04-05 | 2021-02-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 化合物 |
| MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
| JP7621974B2 (ja) | 2019-05-09 | 2025-01-27 | アリゴス セラピューティクス インコーポレイテッド | Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物 |
| EP3994158A1 (en) | 2019-07-03 | 2022-05-11 | Codiak BioSciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| EP4017592A1 (en) * | 2019-08-21 | 2022-06-29 | The Scripps Research Institute | Monocyclic agonists of stimulator of interferon genes sting |
| WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
| AU2020351729A1 (en) | 2019-09-25 | 2022-04-21 | Lonza Sales Ag | STING agonist comprising exosomes combined with IL-12 displaying exosomes for treating a tumour |
| BR112022005614A2 (pt) | 2019-09-25 | 2022-07-12 | Codiak Biosciences Inc | Composições de vesícula extracelular |
| US20230241089A1 (en) | 2019-09-25 | 2023-08-03 | Codiak Biosciences, Inc. | Sting agonist comprising exosomes for treating neuroimmunological disorders |
| US20230103726A1 (en) | 2019-09-25 | 2023-04-06 | Codiak Biosciences, Inc. | Methods of producing extracellular vesicles |
| WO2021119753A1 (en) | 2019-12-18 | 2021-06-24 | Ctxt Pty Limited | Compounds |
| EP4075980B1 (en) | 2019-12-18 | 2025-07-23 | Stinginn LLC | Substituted 1,2, 4-triazoles and methods of use |
| US12251449B2 (en) | 2019-12-19 | 2025-03-18 | William Marsh Rice University | Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase |
| EP4117717A1 (en) | 2020-03-13 | 2023-01-18 | Codiak BioSciences, Inc. | Extracellular vesicles for treating neurological disorders |
| AU2021236763A1 (en) | 2020-03-20 | 2022-10-06 | Lonza Sales Ag | Extracellular vesicles for therapy |
| KR20230002680A (ko) * | 2020-04-15 | 2023-01-05 | 스태튼스 세룸 인스티튜트 | 병원성 감염의 예방 또는 조기 치료 용도의 리포솜 조성물 |
| WO2021216572A1 (en) | 2020-04-20 | 2021-10-28 | Massachusetts Institute Of Technology | Lipid compositions for delivery of sting agonist compounds and uses thereof |
| US11897888B1 (en) | 2020-04-30 | 2024-02-13 | Stinginn Llc | Small molecular inhibitors of sting signaling compositions and methods of use |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| JP7072604B2 (ja) * | 2020-06-23 | 2022-05-20 | アンスティテュ・クリー | 環状ジヌクレオチドを含むウイルス粒子を調製する方法及びがんを治療するための前記粒子の使用 |
| CN111956797B (zh) * | 2020-07-10 | 2022-05-13 | 清华大学 | 新型疫苗佐剂及其在新冠肺炎疫苗和其他疫苗中的应用 |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| US20240082389A1 (en) | 2020-09-23 | 2024-03-14 | Lonza Sales Ag | Methods of producing extracellular vesicles |
| IL302390A (en) | 2020-11-09 | 2023-06-01 | Takeda Pharmaceuticals Co | Drug antibody conjugates |
| WO2022118043A1 (en) * | 2020-12-03 | 2022-06-09 | Enara Bio Limited | Novel protein-ligand complex |
| EP4326769A1 (en) | 2021-04-20 | 2024-02-28 | Institut Curie | Compositions and methods for use in immunotherapy |
| EP4326321A1 (en) | 2021-04-20 | 2024-02-28 | Institut Curie | Compositions and methods for use in immunotherapy |
| WO2023056468A1 (en) | 2021-09-30 | 2023-04-06 | Codiak Biosciences, Inc. | Extracellular vesicle comprising cholesterol tagged sting-agonist |
| WO2024086799A2 (en) * | 2022-10-20 | 2024-04-25 | Northwestern University | Lipid nanoparticles and methods of using the same for treating cell proliferative diseases and disorders |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9110808D0 (en) | 1991-05-17 | 1991-07-10 | Retroscreen Ltd | Aids vaccine and method for its production |
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| US5637483A (en) | 1991-10-04 | 1997-06-10 | Whitehead Institute For Biomedical Research | Irradiated tumor cell vaccine engineered to express GM-CSF |
| US5904920A (en) | 1991-10-04 | 1999-05-18 | Whitehead Institute For Biomedical Research | Regulation of systemic immune responses utilizing cytokines and antigens |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US6033674A (en) | 1995-12-28 | 2000-03-07 | Johns Hopkins University School Of Medicine | Method of treating cancer with a tumor cell line having modified cytokine expression |
| US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
| EP1053301B1 (en) | 1998-02-02 | 2004-04-21 | The Johns Hopkins University School Of Medicine | A universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use |
| RU2238279C2 (ru) | 1999-02-15 | 2004-10-20 | Ниппон Синяку Ко., Лтд. | Полинуклеотид с укороченной цепью и способ его получения |
| US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
| WO2000076497A1 (en) | 1999-06-14 | 2000-12-21 | Cancer Research Ventures Limited | Cancer therapy |
| US6635677B2 (en) * | 1999-08-13 | 2003-10-21 | Case Western Reserve University | Methoxyamine combinations in the treatment of cancer |
| AU2001290860A1 (en) | 2000-09-21 | 2002-04-02 | The Regents Of The University Of California | Spas-1 cancer antigen |
| WO2002059575A2 (en) | 2001-01-23 | 2002-08-01 | The Trustees Of Princeton University, Princeton University | Method and apparatus for analysis of biological solutions |
| TW200303759A (en) * | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| US20040197312A1 (en) * | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
| WO2005030186A2 (en) | 2003-07-28 | 2005-04-07 | Univ Maryland | Method for attenuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
| EP1682173A4 (en) | 2003-10-15 | 2007-10-31 | Medimmune Inc | EPHA2 VACCINE ON LISTERIA BASE |
| EP1677765A1 (en) | 2003-10-24 | 2006-07-12 | Alza Corporation | Preparation of lipid particles |
| JP4931798B2 (ja) | 2004-03-15 | 2012-05-16 | ケイ．アール． カラオリス，デイヴィッド | 免疫、炎症または神経保護応答のための方法 |
| US7592326B2 (en) * | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
| EP1888790A2 (en) | 2005-05-06 | 2008-02-20 | The Regents of the University of California | Microfluidic system for identifying or sizing individual particles passing through a channel |
| US20070059683A1 (en) | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
| EP1782826A1 (en) | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| ES2548240T3 (es) | 2005-12-01 | 2015-10-15 | Pronai Therapeutics, Inc. | Terapias para el cáncer y composiciones farmacéuticas usadas en las mismas |
| US20080076778A1 (en) | 2006-09-05 | 2008-03-27 | Bipar Sciences, Inc. | Methods for designing parp inhibitors and uses thereof |
| WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| JP2011529708A (ja) * | 2008-08-04 | 2011-12-15 | ユニバーシティ オブ マイアミ | 自然免疫応答の調節因子ｓｔｉｎｇ（インターフェロン遺伝子の刺激因子） |
| US8840881B2 (en) | 2008-08-28 | 2014-09-23 | Aduro Gvax Inc. | Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer |
| ES2481040T3 (es) | 2008-12-09 | 2014-07-29 | Coley Pharmaceutical Group, Inc. | Oligonucleótidos inmunoestimulantes |
| CA2754896C (en) | 2009-03-09 | 2017-11-28 | Molecular Express, Inc. | Methods and compositions for liposomal formulation of antigens and uses thereof |
| US8414630B2 (en) | 2009-03-10 | 2013-04-09 | Marc Evan Richelsoph | Active bone screw |
| PT2437753T (pt) | 2009-06-05 | 2016-11-23 | Infectious Disease Res Inst | Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos |
| WO2011003025A1 (en) | 2009-07-01 | 2011-01-06 | Rutgers, The State University Of New Jersey | Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof |
| US8771933B2 (en) | 2009-10-06 | 2014-07-08 | Massachusetts Institute Of Technology | Continuous-flow deformability-based cell separation |
| US20110293558A1 (en) | 2010-03-22 | 2011-12-01 | Massachusetts Institute Of Technology | Material properties of t cells and related methods and compositions |
| CA2798074A1 (en) * | 2010-04-27 | 2011-11-03 | The Johns Hopkins University | Immunogenic compositions and methods for treating neoplasia |
| US8450293B2 (en) | 2010-08-10 | 2013-05-28 | Rutgers, The State University Of New Jersey | Synthesis and characterization of C8 analogs of c-di-GMP |
| SMT201800444T1 (it) | 2010-11-17 | 2018-09-13 | Aduro Biotech Inc | Metodi e composizioni per indurre una risposta immunitaria contro egfrviii |
| US9061048B2 (en) | 2010-12-15 | 2015-06-23 | The Regents Of The University Of California | Cyclic di-AMP induction of type I interferon |
| EP2655392B1 (en) | 2010-12-22 | 2018-04-18 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| JP5990256B2 (ja) | 2011-04-15 | 2016-09-07 | ザ ユニバーシティ オブ ブリティッシュ コロンビアＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｂｒｉｔｉｓｈ Ｃｏｌｕｍｂｉａ | 粒子分離の方法および装置 |
| WO2013086331A1 (en) | 2011-12-07 | 2013-06-13 | President And Fellows Of Harvard College | High efficiency di-nucleotide cyclase |
| KR20150004416A (ko) | 2012-04-30 | 2015-01-12 | 글렌 엔. 바버 | 면역 반응의 조절 |
| NZ702392A (en) | 2012-06-08 | 2017-03-31 | Aduro Biotech | Compositions and methods for cancer immunotherapy |
| US9090646B2 (en) | 2012-12-05 | 2015-07-28 | Rutgers, The State University Of New Jersey | Biotinylated compounds |
| WO2014093936A1 (en) * | 2012-12-13 | 2014-06-19 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| RU2015129030A (ru) | 2012-12-19 | 2017-01-26 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Фармацевтическое направленное воздействие на путь передачи сигнала циклических динуклеотидов млекопитающих |
| MX374828B (es) | 2013-04-29 | 2025-03-06 | Memorial Sloan Kettering Cancer Center | Composiciones y metodos para alterar la señalizacion del segundo mensajero. |
| US20140329889A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| JP6400082B2 (ja) | 2013-05-18 | 2018-10-03 | アデュロ バイオテック，インコーポレイテッド | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
-
2013
- 2013-06-07 NZ NZ702392A patent/NZ702392A/en not_active IP Right Cessation
- 2013-06-07 SG SG10201610251PA patent/SG10201610251PA/en unknown
- 2013-06-07 WO PCT/US2013/044744 patent/WO2013185052A1/en not_active Ceased
- 2013-06-07 KR KR1020157000522A patent/KR20150022996A/ko not_active Ceased
- 2013-06-07 CA CA2876150A patent/CA2876150A1/en not_active Abandoned
- 2013-06-07 CN CN201380037917.2A patent/CN104507538B/zh not_active Expired - Fee Related
- 2013-06-07 JP JP2015516245A patent/JP6257607B2/ja not_active Expired - Fee Related
- 2013-06-07 AU AU2013271375A patent/AU2013271375B2/en not_active Ceased
- 2013-06-07 EP EP13799826.6A patent/EP2858722B8/en not_active Not-in-force
- 2013-06-07 IN IN2492MUN2014 patent/IN2014MN02492A/en unknown
- 2013-06-07 SG SG11201407875UA patent/SG11201407875UA/en unknown
- 2013-06-07 US US13/912,960 patent/US9770467B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015518901A5 (enExample) | ||
| JP2016503029A5 (enExample) | ||
| EP3708185A3 (en) | Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (cll) | |
| MX419719B (es) | Linfocitos infiltrantes de tumores remanentes y metodos de preparacion y uso de los mismos. | |
| MX389568B (es) | Péptidos y uso de los mismos en inmunoterapia contra varios tumores, tales como cáncer de pulmón, que incluye cáncer de pulmón de células no pequeñas (nsclc) | |
| PH12021551208A1 (en) | Novel immunotherapy against several tumors, such as lung cancer, including nsclc | |
| NZ702392A (en) | Compositions and methods for cancer immunotherapy | |
| MX2016014711A (es) | Inmunoterapia novedosa contra varios tumores de la sangre, con la leucemia mielogena aguda (lma). | |
| BR112017008972A2 (pt) | peptídeos e combinações de peptídeos para uso em imunoterapia contra carcinoma hepatocelular (hcc) e outros cânceres | |
| MX2020011696A (es) | Formulacion arn para inmunoterapia. | |
| MX391015B (es) | Composiciones de nanoparticulas y usos de las mismas | |
| JP2016531927A5 (enExample) | ||
| HRP20191972T1 (hr) | Pripravci i postupci za aktiviranje signalizacije ovisne o "stimulatoru gena interferona" | |
| JP2016520057A5 (enExample) | ||
| HK1218860A1 (zh) | 卵巢癌疫苗及接种方法 | |
| SG11202102290RA (en) | Herv-k-derived antigens as shared tumor antigens for anti-cancer vaccine | |
| WO2020023776A3 (en) | Compositions and methods for inhibiting cancers and viruses | |
| WO2017041092A3 (en) | Anti-survivin antibodies for cancer therapy | |
| Ni et al. | Treatment of hepatic cancer in mice by beta-elemene combined DC/Dribble vaccine: an immune mechanism research | |
| MX2020011791A (es) | Nuevos peptidos y nueva combinacion de peptidos para el uso en la inmunoterapia contra el carcinoma hepatocelular (chc) y otros tipos de cancer. | |
| AR118181A2 (es) | Inmunoterapia contra diversos tumores como el cáncer de pulmón, incluido el carcinoma de pulmón amicrocítico (nsclc) | |
| WO2015193729A3 (en) | Combination aroma and magnetotherapy device and methods of use | |
| LI et al. | BCG HSP70 gene transfection and its effect on immunogenicity of murine lymphocytic leukemia | |
| Li et al. | Future perspectives and challenges in the development of an antitumor vaccine based on heat shock protein gp96-peptide complex | |
| EA202090816A3 (ru) | Новый метод иммунотерапии нескольких видов опухолей, таких как рак легкого, включая нмрл |