|
KR101699822B1
(ko)
|
2011-12-21 |
2017-01-25 |
노비라 테라퓨틱스, 인코포레이티드 |
B형 간염의 항바이러스성 제제
|
|
CN104245701A
(zh)
|
2012-04-03 |
2014-12-24 |
诺华有限公司 |
有酪氨酸激酶抑制剂的组合产品和其应用
|
|
AR092270A1
(es)
|
2012-08-28 |
2015-04-08 |
Janssen R&D Ireland |
Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
|
|
EP2890691B1
(en)
*
|
2012-08-31 |
2018-04-25 |
Principia Biopharma Inc. |
Benzimidazole derivatives as itk inhibitors
|
|
PT2961732T
(pt)
|
2013-02-28 |
2017-06-26 |
Janssen Sciences Ireland Uc |
Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
EA027068B1
(ru)
|
2013-04-03 |
2017-06-30 |
Янссен Сайенсиз Айрлэнд Юси |
Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
|
|
JP6441315B2
(ja)
|
2013-05-17 |
2018-12-19 |
ヤンセン・サイエンシズ・アイルランド・ユーシー |
スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用
|
|
JO3603B1
(ar)
|
2013-05-17 |
2020-07-05 |
Janssen Sciences Ireland Uc |
مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
|
|
US10450270B2
(en)
|
2013-07-25 |
2019-10-22 |
Janssen Sciences Ireland Uc |
Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
MX368158B
(es)
|
2013-10-23 |
2019-09-20 |
Janssen Sciences Ireland Uc |
Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
WO2015081463A1
(en)
*
|
2013-12-02 |
2015-06-11 |
Novartis Ag |
Egfr inhibitor forms
|
|
WO2015083059A1
(en)
*
|
2013-12-02 |
2015-06-11 |
Novartis Ag |
Forms of the egfr inhibitor
|
|
WO2015085482A1
(en)
*
|
2013-12-10 |
2015-06-18 |
Novartis Ag |
Egfr inhibitor forms
|
|
US10392349B2
(en)
|
2014-01-16 |
2019-08-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
MX2016009449A
(es)
|
2014-02-05 |
2016-10-13 |
Novira Therapeutics Inc |
Terapia de combinacion para el tratamiento de infecciones por virus de la hepatitis b (vhb).
|
|
EA035848B1
(ru)
|
2014-02-06 |
2020-08-20 |
Янссен Сайенсиз Айрлэнд Юси |
Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b
|
|
US9932329B2
(en)
|
2014-03-03 |
2018-04-03 |
Principia Biopharma, Inc. |
Benzimidazole derivatives as RLK and ITK inhibitors
|
|
SI3116909T1
(sl)
|
2014-03-14 |
2020-03-31 |
Novartis Ag |
Molekule protiteles na LAG-3 in njih uporaba
|
|
AU2015231215B2
(en)
|
2014-03-20 |
2019-07-18 |
Capella Therapeutics, Inc. |
Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
|
|
DK3119762T3
(da)
*
|
2014-03-20 |
2021-08-30 |
Capella Therapeutics Inc |
Benzimidazol-derivater som erbb-tyrosin-kinase-inhibitorer til behandlingen af kræft
|
|
WO2015145388A2
(en)
|
2014-03-27 |
2015-10-01 |
Novartis Ag |
Methods of treating colorectal cancers harboring upstream wnt pathway mutations
|
|
KR20170036037A
(ko)
*
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
|
CA2960824A1
(en)
*
|
2014-09-13 |
2016-03-17 |
Novartis Ag |
Combination therapies of alk inhibitors
|
|
JO3556B1
(ar)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
|
JP2017535528A
(ja)
|
2014-10-03 |
2017-11-30 |
ノバルティス アーゲー |
組み合わせ治療
|
|
WO2016055916A1
(en)
|
2014-10-06 |
2016-04-14 |
Novartis Ag |
Therapeutic combination for the treatment of cancer
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
PE20171067A1
(es)
|
2014-10-14 |
2017-07-24 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
|
WO2016145102A1
(en)
|
2015-03-10 |
2016-09-15 |
Aduro Biotech, Inc. |
Compositions and methods for activating "stimulator of interferon gene" -dependent signalling
|
|
WO2016149581A1
(en)
|
2015-03-19 |
2016-09-22 |
Novira Therapeutics, Inc. |
Azocane and azonane derivatives and methods of treating hepatitis b infections
|
|
CN107849022A
(zh)
|
2015-04-10 |
2018-03-27 |
亚瑞克西斯制药公司 |
取代的喹唑啉化合物和其使用方法
|
|
EP3283462B1
(en)
|
2015-04-15 |
2020-12-02 |
Araxes Pharma LLC |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
|
CN108012529A
(zh)
*
|
2015-05-15 |
2018-05-08 |
诺华股份有限公司 |
治疗egfr突变的癌症的方法
|
|
CN107847448A
(zh)
*
|
2015-05-22 |
2018-03-27 |
诺华股份有限公司 |
药物组合物
|
|
WO2017004383A1
(en)
|
2015-06-30 |
2017-01-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of egfr and methods of use thereof
|
|
US10875876B2
(en)
|
2015-07-02 |
2020-12-29 |
Janssen Sciences Ireland Uc |
Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
JP6878405B2
(ja)
|
2015-07-29 |
2021-05-26 |
ノバルティス アーゲー |
Ｐｄ−１に対する抗体分子を含む組み合わせ治療
|
|
EP3317301B1
(en)
|
2015-07-29 |
2021-04-07 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
|
AU2016298823A1
(en)
*
|
2015-07-29 |
2018-02-08 |
Novartis Ag |
Combination of PD-1 antagonist with an EGFR inhibitor
|
|
WO2017049069A1
(en)
*
|
2015-09-18 |
2017-03-23 |
Merck Patent Gmbh |
Heteroaryl compounds as irak inhibitors and uses thereof
|
|
US10590108B2
(en)
|
2015-09-23 |
2020-03-17 |
Capella Therapeutics, Inc. |
Benzimidazoles for use in the treatment of cancer and inflammatory diseases
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058792A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10975071B2
(en)
|
2015-09-28 |
2021-04-13 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
AU2016330964B2
(en)
|
2015-09-29 |
2021-04-01 |
Novira Therapeutics, Inc. |
Crystalline forms of a hepatitis B antiviral agent
|
|
CR20180234A
(es)
|
2015-11-03 |
2018-09-11 |
Janssen Biotech Inc |
Anticuerpos que se unen especificamente a pd-1 y sus usos
|
|
US10414757B2
(en)
|
2015-11-16 |
2019-09-17 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
|
|
JP2019503349A
(ja)
|
2015-12-17 |
2019-02-07 |
ノバルティス アーゲー |
Ｐｄ−１に対する抗体分子およびその使用
|
|
AU2017247806B2
(en)
*
|
2016-04-07 |
2019-11-14 |
Glaxosmithkline Intellectual Property Development Limited |
Heterocyclic amides useful as protein modulators
|
|
US20190167694A1
(en)
|
2016-04-08 |
2019-06-06 |
Novartis Ag |
New therapeutics uses
|
|
SG11201808949SA
(en)
|
2016-04-15 |
2018-11-29 |
Novira Therapeutics Inc |
Combinations and methods comprising a capsid assembly inhibitor
|
|
US20170321285A1
(en)
*
|
2016-05-03 |
2017-11-09 |
The Texas A&M University System |
Nlrc5 as a biomarker for cancer patients and a target for cancer therapy
|
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
CN107663170B
(zh)
*
|
2016-07-29 |
2020-02-11 |
广东东阳光药业有限公司 |
制备贝西沙星中间体化合物的方法
|
|
CA2939286A1
(en)
*
|
2016-08-17 |
2018-02-17 |
Pharmascience Inc. |
Spirocyclic containing compounds and pharmaceutical uses thereof
|
|
CN110036010A
(zh)
|
2016-09-29 |
2019-07-19 |
亚瑞克西斯制药公司 |
Kras g12c突变蛋白的抑制剂
|
|
CN110312711A
(zh)
|
2016-10-07 |
2019-10-08 |
亚瑞克西斯制药公司 |
作为ras抑制剂的杂环化合物及其使用方法
|
|
CN110234773B
(zh)
*
|
2016-12-13 |
2024-07-02 |
匹兹堡大学联邦系统高等教育 |
治疗含融合基因的癌症的方法
|
|
EP3573970A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
WO2018140512A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
CN110382482A
(zh)
|
2017-01-26 |
2019-10-25 |
亚瑞克西斯制药公司 |
稠合的杂-杂二环化合物及其使用方法
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
CN106946779A
(zh)
*
|
2017-02-13 |
2017-07-14 |
广州仁恒医药科技股份有限公司 |
一种r‑3‑氨基‑六氢氮杂*的制备方法
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
EP3630747A1
(en)
|
2017-05-25 |
2020-04-08 |
Araxes Pharma LLC |
Quinazoline derivatives as modulators of mutant kras, hras or nras
|
|
TW201906832A
(zh)
|
2017-05-25 |
2019-02-16 |
美商亞瑞克西斯製藥公司 |
用於癌症治療之化合物及其使用方法
|
|
CN110869358A
(zh)
|
2017-05-25 |
2020-03-06 |
亚瑞克西斯制药公司 |
Kras的共价抑制剂
|
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
|
|
MA49457A
(fr)
|
2017-06-22 |
2020-04-29 |
Novartis Ag |
Molécules d'anticorps se liant à cd73 et leurs utilisations
|
|
WO2018235056A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER
|
|
JP2020524694A
(ja)
|
2017-06-22 |
2020-08-20 |
ノバルティス アーゲー |
がんの処置における使用のためのＩＬ−１β結合性抗体
|
|
RU2020108191A
(ru)
|
2017-08-03 |
2021-09-03 |
Новартис Аг |
Терапевтическая комбинация ингибитора тирозинкиназы egfr третьего поколения и ингибиторa циклин-d-киназы
|
|
SG11201913249SA
(en)
|
2017-08-03 |
2020-02-27 |
Novartis Ag |
Therapeutic combination of a third-generation egfr tyrosine kinase inhibitor and a raf inhibitor
|
|
CN109721605B
(zh)
*
|
2017-10-31 |
2022-03-11 |
维眸生物科技（上海）有限公司 |
一种免疫细胞迁徙抑制剂
|
|
RU2020121458A
(ru)
|
2017-11-30 |
2021-12-30 |
Новартис Аг |
Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения
|
|
JP7313364B2
(ja)
*
|
2018-02-21 |
2023-07-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｅｇｆｒ阻害剤としての新たなベンズイミダゾール化合物および誘導体
|
|
CA3090125A1
(en)
|
2018-03-14 |
2019-09-19 |
Janssen Sciences Ireland Unlimited Company |
Capsid assembly modulator dosing regimen
|
|
JP7399872B2
(ja)
|
2018-04-18 |
2023-12-18 |
ノバルティス アーゲー |
Ｃｎｓ転移の治療に使用するためのナザルチニブ
|
|
RU2762557C1
(ru)
|
2018-04-26 |
2021-12-21 |
Пфайзер Инк. |
Производные 2-аминопиридина или 2-аминопиримидина в качестве циклинзависимых ингибиторов киназы
|
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
CN112384531B
(zh)
|
2018-06-01 |
2024-05-14 |
诺华股份有限公司 |
针对bcma的结合分子及其用途
|
|
EP3897613A1
(en)
|
2018-12-21 |
2021-10-27 |
Novartis AG |
Use of il-1beta binding antibodies
|
|
CN109369620B
(zh)
*
|
2018-12-22 |
2020-04-14 |
山东大学 |
吡啶类化合物及其制备方法与抗胃癌应用
|
|
US11096931B2
(en)
|
2019-02-22 |
2021-08-24 |
Janssen Sciences Ireland Unlimited Company |
Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
|
|
CN111747950B
(zh)
*
|
2019-03-29 |
2024-01-23 |
深圳福沃药业有限公司 |
用于治疗癌症的嘧啶衍生物
|
|
EP3966205A1
(en)
|
2019-05-06 |
2022-03-16 |
Janssen Sciences Ireland Unlimited Company |
Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
|
|
WO2020260252A1
(en)
|
2019-06-24 |
2020-12-30 |
Boehringer Ingelheim International Gmbh |
New macrocyclic compounds and derivatives as egfr inhibitors
|
|
JP2022548881A
(ja)
|
2019-09-18 |
2022-11-22 |
ノバルティス アーゲー |
Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
|
|
EP4045506A4
(en)
*
|
2019-10-15 |
2023-08-30 |
Aucentra Therapeutics Pty Ltd |
4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-N-(PYRIDIN-3-YL)PYRIMIDINE-2-AMINE DERIVATIVES FOR TREATMENT OF PROLIFERATIVE DISEASES AND CONDITIONS
|
|
KR102267662B1
(ko)
*
|
2019-11-19 |
2021-06-22 |
한국화학연구원 |
벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
CA3179994A1
(en)
|
2020-05-08 |
2021-11-11 |
Novartis Ag |
Pharmaceutical combination comprising tno155 and nazartinib
|
|
KR20210142553A
(ko)
*
|
2020-05-18 |
2021-11-25 |
웰마커바이오 주식회사 |
Ron 돌연변이와 관련된 소세포 폐암 예방 또는 치료용 약학 조성물 및 이를 이용한 방법
|
|
WO2021235812A1
(ko)
*
|
2020-05-18 |
2021-11-25 |
웰마커바이오 주식회사 |
Ron 돌연변이와 관련된 비소세포 폐암 예방 또는 치료용 약학 조성물 및 이를 이용한 방법
|
|
WO2021235813A1
(ko)
*
|
2020-05-18 |
2021-11-25 |
웰마커바이오 주식회사 |
Ron 돌연변이와 관련된 췌장암 예방 또는 치료용 약학 조성물 및 이를 이용한 방법
|
|
US20210369709A1
(en)
|
2020-05-27 |
2021-12-02 |
Astrazeneca Ab |
EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER
|
|
CN113880804A
(zh)
*
|
2020-07-01 |
2022-01-04 |
微境生物医药科技(上海)有限公司 |
新型苯并咪唑化合物
|
|
WO2022081478A1
(en)
*
|
2020-10-12 |
2022-04-21 |
Dana-Farber Cancer Institute, Inc. |
Covalent egfr inhibitors and methods of use thereof
|
|
CN116507627A
(zh)
|
2020-11-02 |
2023-07-28 |
勃林格殷格翰国际有限公司 |
作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物
|
|
IL302569A
(en)
|
2020-11-06 |
2023-07-01 |
Novartis Ag |
CD19 binding molecules and their uses
|
|
WO2022242712A1
(zh)
*
|
2021-05-21 |
2022-11-24 |
深圳市塔吉瑞生物医药有限公司 |
取代的大环化合物及包含该化合物的组合物及其用途
|
|
CN117479943A
(zh)
|
2021-06-15 |
2024-01-30 |
基因泰克公司 |
组合疗法中的egfr抑制剂和perk活化剂及其用于治疗癌症的用途
|
|
WO2023069959A1
(en)
*
|
2021-10-18 |
2023-04-27 |
Dana-Farber Cancer Institute, Inc. |
Covalent egfr inhibitors and methods of use thereof
|
|
KR102572664B1
(ko)
*
|
2022-02-07 |
2023-08-30 |
주식회사 인터엠 |
오디오 클록 조정 및 이를 이용한 네트워크 기반 전관 방송
|
|
US20240116926A1
(en)
|
2022-04-28 |
2024-04-11 |
Astrazeneca Ab |
Heteroaromatic compounds
|
|
WO2023209090A1
(en)
|
2022-04-28 |
2023-11-02 |
Astrazeneca Ab |
Bicyclic heteroaromatic compounds and their application in the treatment of cancer
|
|
WO2023209088A1
(en)
|
2022-04-28 |
2023-11-02 |
Astrazeneca Ab |
Bicyclic heteroaromatic compounds and their use in the treatment of cancer
|
|
WO2023209084A1
(en)
|
2022-04-28 |
2023-11-02 |
Astrazeneca Ab |
Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer
|
|
WO2023244587A1
(en)
*
|
2022-06-14 |
2023-12-21 |
Genzyme Corporation |
Methods of making tolebrutinib
|
|
TW202416963A
(zh)
*
|
2022-09-02 |
2024-05-01 |
大陸商迪哲（江蘇）醫藥股份有限公司 |
Ｅｇｆｒ抑制劑及其用途
|
