JP2015514793A - 局所スプレー組成物およびそれを送達するためのシステム - Google Patents
局所スプレー組成物およびそれを送達するためのシステム Download PDFInfo
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- JP2015514793A JP2015514793A JP2015507512A JP2015507512A JP2015514793A JP 2015514793 A JP2015514793 A JP 2015514793A JP 2015507512 A JP2015507512 A JP 2015507512A JP 2015507512 A JP2015507512 A JP 2015507512A JP 2015514793 A JP2015514793 A JP 2015514793A
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Abstract
Description
局所組成物を作製するための取り組みが開示されている。米国特許出願公開第2004/105873号、同第2005/208003号および同第2007/276033号において、水および油溶性原料を加えた局所製剤が開示されている。
a)液体乳化剤であって、3.0から7.0までのHLBを有する液体乳化剤と、
b)皮膚有益剤と
を含む組成物であって、スプレー可能であり、500から4200cpsまでの粘度および約22から約33mN/mまでの表面張力を有する、組成物を対象とする。
a)30から55%のヘッドスペースを持ち、5.2から10.7バール(75から155psi)に加圧されることができるパッケージと、
b)出口挿入物であって、少なくとも1つのチャネル、渦流室および開口部を有する出口挿入物と、
c)本発明の第一の態様の組成物と
を備え、渦流室が0.5mmから2.0mmまでの直径を有し、開口部が0.15mmから0.4mmまでの直径を有し、かつチャネルが開口部直径よりも3から9倍大きい長さおよび開口部直径よりも0.7から5倍長い幅を有し、さらに、開口部直径対渦流室直径(d/D)が0.45未満である、システムを対象とする。
(1)パルミチン酸イソプロピル、イソステアリン酸イソプロピル、ミリスチン酸イソプロピル、イソノナン酸イソノニル、ミリスチン酸オレイル、ステアリン酸オレイルおよびオレイン酸オレイルのような、10から20個までの炭素原子を有する脂肪酸のアルケニルまたはアルキルエステル、
(2)エトキシ化脂肪アルコールの脂肪酸エステル等のエーテル−エステル、
(3)エチレングリコールモノ−およびジ−脂肪酸エステル、ジエチレングリコールモノ−およびジ−脂肪酸エステル、ポリエチレングリコール(200〜6000)モノ−およびジ−脂肪酸エステル、プロピレングリコールモノ−およびジ−脂肪酸エステル、ポリプロピレングリコール2000モノオレエート、ポリプロピレングリコール2000モノステアレート、エトキシ化プロピレングリコールモノステアレート、グリセリルモノ−およびジ−脂肪酸エステル、ポリグリセロールポリ−脂肪エステル、エトキシ化グリセリルモノステアレート、1,3−ブチレングリコールモノステアレート、1,3−ブチレングリコールジステアレート、ポリオキシエチレンポリオール脂肪酸エステル、ソルビタン脂肪酸エステル、ならびにポリオキシエチレンソルビタン脂肪酸エステル等の多価アルコールエステル、
(4)蜜ロウ、鯨ロウ、ミリスチン酸ミリスチル、ステアリン酸ステアリル等のロウエステル、ならびに
(5) 大豆ステロールおよびコレステロール脂肪酸エステルがその例である、ステロールエステル。
[実施例2]
実施例1の組成物を、本発明において記述されている通りのバルブパッケージ上の市販の袋に充填した。パッケージを充填し、約8.3バール(120psi)に加圧した。熟練したパネリストは、製品(約二(2)秒のスプレー噴射、三(3)グラムの製品)を自分の前腕に腕から約10cmの距離から適用した。すべてのパネリストが、本発明のシステムは卓越した均質な製品を望ましいパターンで生み出したと満場一致で結論付けた。パネリストはまた、本発明において本発明のシステムから送達される製品は、従来のローションよりも適用するのが速くかつ容易であり、組成物はごくわずかしか擦らずに容易に皮膚に吸収されたとも結論付けた。
実施例1において調製された本発明のシステム内の組成物を、垂直な基質の異なる領域に約10cmの距離からスプレーした(約三(3)グラムの実施例2において記述されている通りの製品)。組成物を、ここでも垂直な基質に同じ方式で適用された商業的に販売されているスプレー保湿剤(固体乳化剤を含む)と比較した。すべてのパネリストが、本発明のシステムを介して適用されたスプレー組成物は、より均等かつ制御されており、適用から約三十(30)分後、いかなる製品の流れも示さなかったと結論付けた。固体乳化剤で制御する、商業的に販売されている製品は、適用時に著しく流れた。
Claims (11)
- a)液体乳化剤であって、3.0から7.0までのHLBを有する前記液体乳化剤と、
b)皮膚有益剤と
を含む組成物であって、
スプレー可能であり、500から4200cpsまでの粘度および22から33mN/mまでの表面張力を有する、組成物。 - 前記液体乳化システムが、3.5から6.5までのHLBを有する、請求項1に記載の組成物。
- スプレー可能であり、バルブパッケージ上の袋から適用されることができる、請求項1または2に記載の組成物。
- 前記皮膚有益が、サンスクリーン剤、皮膚美白剤、老化防止剤、保湿剤、サンレスタンニング剤またはそれらの混合物である、請求項1から3のいずれか一項に記載の組成物。
- 前記組成物中の前記乳化剤が、液体乳化剤から本質的になる、請求項1から4のいずれか一項に記載の組成物。
- 前記組成物中の前記乳化剤が、液体乳化剤からなる、請求項1から4のいずれか一項に記載の組成物。
- a)30から55%のヘッドスペースを持ち、5.2から10.7バール(75から155psi)に加圧されることができるパッケージと、
b)出口挿入物であって、少なくとも1つのチャネル、渦流室および開口部を有する前記出口挿入物と、
c)本発明の第一の態様の組成物と
を備え、前記渦流室が0.5mmから2.0mmまでの直径を有し、前記開口部が0.15mmから0.4mmまでの直径を有し、かつ前記チャネルが前記開口部直径よりも3.0から9倍大きい長さおよび前記開口部直径よりも0.7から5倍長い幅を有し、さらに、前記開口部直径対渦流室直径(d/D)が0.45未満である、システム。 - 前記液体乳化剤が、非ポリマー性のポリヒドロキシル化された脂肪酸、ポリマー性のポリヒドロキシル化された脂肪酸、または両方を含む、請求項7に記載のシステム。
- 前記開口部が直径dを有し、前記渦流室が直径Dを有し、ここで、(d/D)が0.25から0.4までである、請求項7または8に記載のシステム。
- 前記組成物が保湿組成物である、請求項7から9のいずれか一項に記載のシステム。
- 前記組成物が香料をさらに含む、請求項7から10のいずれか一項に記載のシステム。
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US13/457,767 | 2012-04-27 | ||
US13/457,767 US8857741B2 (en) | 2012-04-27 | 2012-04-27 | Topical spray composition and system for delivering the same |
PCT/EP2013/058466 WO2013160338A2 (en) | 2012-04-27 | 2013-04-24 | Topical spray composition and system for delivering the same |
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US (2) | US8857741B2 (ja) |
EP (2) | EP3025762A1 (ja) |
JP (1) | JP6317731B2 (ja) |
CN (2) | CN104394938A (ja) |
AU (1) | AU2013254754B2 (ja) |
BR (1) | BR112014026357A2 (ja) |
CA (1) | CA2870227C (ja) |
EA (1) | EA026502B1 (ja) |
ES (1) | ES2571478T3 (ja) |
IN (1) | IN2014MN02038A (ja) |
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JP2004107226A (ja) * | 2002-09-13 | 2004-04-08 | Kao Corp | 乳化組成物 |
JP2008540091A (ja) * | 2005-05-25 | 2008-11-20 | ザ プロクター アンド ギャンブル カンパニー | 可撓性ノズル挿入物を有するスプレーヘッド |
JP2011514338A (ja) * | 2008-02-25 | 2011-05-06 | シグナム バイオサイエンシーズ, インコーポレイテッド | 脂質修飾システイン含有ペプチドを含むペプチドを利用するための局所用組成物および方法 |
JP2009292734A (ja) * | 2008-06-02 | 2009-12-17 | Shiseido Co Ltd | 水中油型乳化皮膚化粧料 |
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WO2013160338A3 (en) | 2014-07-24 |
IN2014MN02038A (ja) | 2015-10-09 |
ES2571478T3 (es) | 2016-05-25 |
US20140374508A1 (en) | 2014-12-25 |
US8857741B2 (en) | 2014-10-14 |
BR112014026357A2 (pt) | 2017-06-27 |
EA026502B1 (ru) | 2017-04-28 |
EP2841170B1 (en) | 2016-04-06 |
AU2013254754B2 (en) | 2016-01-28 |
CA2870227C (en) | 2020-10-20 |
AU2013254754A1 (en) | 2014-11-27 |
JP6317731B2 (ja) | 2018-04-25 |
CN104394938A (zh) | 2015-03-04 |
EA201491689A1 (ru) | 2015-04-30 |
WO2013160338A2 (en) | 2013-10-31 |
CA2870227A1 (en) | 2013-10-31 |
NZ701450A (en) | 2016-07-29 |
US20130284824A1 (en) | 2013-10-31 |
US9751097B2 (en) | 2017-09-05 |
CN109288726A (zh) | 2019-02-01 |
EP2841170A2 (en) | 2015-03-04 |
EP3025762A1 (en) | 2016-06-01 |
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