JP2015514402A5 - - Google Patents
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- Publication number
- JP2015514402A5 JP2015514402A5 JP2015503888A JP2015503888A JP2015514402A5 JP 2015514402 A5 JP2015514402 A5 JP 2015514402A5 JP 2015503888 A JP2015503888 A JP 2015503888A JP 2015503888 A JP2015503888 A JP 2015503888A JP 2015514402 A5 JP2015514402 A5 JP 2015514402A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- virus
- modified oligonucleotide
- group
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims description 29
- 239000002773 nucleotide Substances 0.000 claims description 26
- 125000003729 nucleotide group Chemical group 0.000 claims description 24
- 239000000758 substrate Substances 0.000 claims description 18
- 108091093088 Amplicon Proteins 0.000 claims description 15
- 241000700605 Viruses Species 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical class 0.000 claims description 14
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 241000711549 Hepacivirus C Species 0.000 claims description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000000523 sample Substances 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 241000710886 West Nile virus Species 0.000 claims description 7
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims description 6
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 4
- 241000725619 Dengue virus Species 0.000 claims description 4
- 241000710831 Flavivirus Species 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 238000003205 genotyping method Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 238000012163 sequencing technique Methods 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052697 platinum Inorganic materials 0.000 claims description 3
- 230000003612 virological effect Effects 0.000 claims description 3
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000237858 Gastropoda Species 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000002796 nucleotidyl group Chemical group 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 241000710781 Flaviviridae Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 241000710924 Togaviridae Species 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1253122 | 2012-04-04 | ||
| FR1253122A FR2989089B1 (fr) | 2012-04-04 | 2012-04-04 | Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques |
| PCT/EP2013/057150 WO2013150122A1 (fr) | 2012-04-04 | 2013-04-04 | Oligonucleotides modifies compenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514402A JP2015514402A (ja) | 2015-05-21 |
| JP2015514402A5 true JP2015514402A5 (enExample) | 2016-04-07 |
| JP6175489B2 JP6175489B2 (ja) | 2017-08-02 |
Family
ID=48128279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503888A Active JP6175489B2 (ja) | 2012-04-04 | 2013-04-04 | チオール官能基を含む修飾オリゴヌクレオチドおよび核酸検出のためのこれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20150232957A1 (enExample) |
| EP (1) | EP2859008B1 (enExample) |
| JP (1) | JP6175489B2 (enExample) |
| KR (1) | KR102186143B1 (enExample) |
| AU (1) | AU2013244900B2 (enExample) |
| BR (1) | BR112014024601B1 (enExample) |
| CA (1) | CA2868926C (enExample) |
| EA (1) | EA029907B1 (enExample) |
| ES (1) | ES2624993T3 (enExample) |
| FR (1) | FR2989089B1 (enExample) |
| IN (1) | IN2014DN08170A (enExample) |
| WO (1) | WO2013150122A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017218293A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| WO2018204420A1 (en) | 2017-05-02 | 2018-11-08 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| JP7282379B2 (ja) * | 2017-08-22 | 2023-05-29 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| US20200263163A1 (en) * | 2017-09-25 | 2020-08-20 | Haystack Sciences Corporation | Multinomial encoding for oligonucleotide-directed combinatorial chemistry |
| EP4305198A1 (en) | 2021-03-09 | 2024-01-17 | Etablissement Français du Sang | Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041183A (ja) * | 1983-08-16 | 1985-03-04 | 三菱電機株式会社 | 入場管理装置 |
| IE922292A1 (en) * | 1991-07-15 | 1993-01-27 | Jolla Pharma | Modified phosphorous intermediates for providing functional¹groups on the 5' end of oligonucleotides |
| JPH0641183A (ja) * | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
| DE10163836A1 (de) * | 2001-12-22 | 2003-07-10 | Friz Biochem Gmbh | Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren |
| US7371585B2 (en) * | 2003-12-31 | 2008-05-13 | Genencor International, Inc. | Membranes incorporating recognition moieties |
| US7167395B1 (en) | 2005-07-13 | 2007-01-23 | Infineon Technologies Flash Gmbh & Co. Kg | Non-volatile semiconductor memory |
| AU2006330464A1 (en) | 2005-12-23 | 2007-07-05 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for genotyping HCV |
| FR2989086B1 (fr) | 2012-04-04 | 2017-03-24 | Centre Nat De La Rech Scient (Cnrs) | Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies |
-
2012
- 2012-04-04 FR FR1253122A patent/FR2989089B1/fr active Active
-
2013
- 2013-04-04 ES ES13716756.5T patent/ES2624993T3/es active Active
- 2013-04-04 KR KR1020147027987A patent/KR102186143B1/ko active Active
- 2013-04-04 JP JP2015503888A patent/JP6175489B2/ja active Active
- 2013-04-04 EP EP13716756.5A patent/EP2859008B1/fr active Active
- 2013-04-04 BR BR112014024601-7A patent/BR112014024601B1/pt active IP Right Grant
- 2013-04-04 US US14/390,748 patent/US20150232957A1/en not_active Abandoned
- 2013-04-04 IN IN8170DEN2014 patent/IN2014DN08170A/en unknown
- 2013-04-04 CA CA2868926A patent/CA2868926C/fr active Active
- 2013-04-04 WO PCT/EP2013/057150 patent/WO2013150122A1/fr not_active Ceased
- 2013-04-04 AU AU2013244900A patent/AU2013244900B2/en not_active Ceased
- 2013-04-04 EA EA201491821A patent/EA029907B1/ru not_active IP Right Cessation
-
2019
- 2019-02-08 US US16/271,581 patent/US11390643B2/en active Active
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