JP2015513524A5 - - Google Patents
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- JP2015513524A5 JP2015513524A5 JP2014556075A JP2014556075A JP2015513524A5 JP 2015513524 A5 JP2015513524 A5 JP 2015513524A5 JP 2014556075 A JP2014556075 A JP 2014556075A JP 2014556075 A JP2014556075 A JP 2014556075A JP 2015513524 A5 JP2015513524 A5 JP 2015513524A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102100003735 CD44 Human genes 0.000 claims 5
- 101700078950 CD44 Proteins 0.000 claims 5
- 102100002013 CSPG4 Human genes 0.000 claims 5
- 101700026160 CSPG4 Proteins 0.000 claims 5
- 102000016611 Proteoglycans Human genes 0.000 claims 5
- 108010067787 Proteoglycans Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001225 therapeutic Effects 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 230000001472 cytotoxic Effects 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N Calicheamicin Chemical group C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- QTQAWLPCGQOSGP-DVKIRIBLSA-N [(3R,5R,6S,7R,8E,10R,11R,12E,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate Chemical compound N1C(=O)\C(C)=C\C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C\[C@@H](C)[C@H](O)[C@H](OC)C[C@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-DVKIRIBLSA-N 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000037240 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 claims 1
- 229960000977 trabectedin Drugs 0.000 claims 1
Claims (15)
- ＶＡＲ２ＣＳＡポリペプチドと、治療用または診断用エフェクター部分とを含む、コンジュゲートまたは融合タンパク質。
- ＶＡＲ２ＣＳＡポリペプチドが、
ａ）ＩＤ１、および
ｂ）ＤＢＬ２Ｘｂ
の連続するアミノ酸配列からなるタンパク質フラグメントであるか、
ａ）ＩＤ１、および
ｂ）ＤＢＬ２Ｘｂ
の連続するアミノ酸配列からなるタンパク質フラグメントを含む、請求項１に記載のコンジュゲート。 - フラグメントが、配列番号１の１〜５７７、配列番号３の１〜５９２、配列番号４の１〜５７９、配列番号５の１〜５７６、配列番号１０の１〜５８６、配列番号１１の１〜５７９、配列番号２９の１〜５６５、配列番号３４の１〜５８４、配列番号３６の１〜５６９、配列番号３７の１〜５７５、配列番号３８の１〜５９２、配列番号４１の１〜６０３、配列番号４３の１〜５８８、配列番号４４の１〜５６５、配列番号４５の１〜５８９、配列番号４８の１〜５７３、配列番号５３の１〜５８３、または配列番号５４の１〜５６９のいずれか一つのアミノ酸配列と少なくとも７０％の配列同一性を有するアミノ酸配列を含む、請求項２に記載のコンジュゲート。
- フラグメントが、配列番号１の５７８〜６４０、配列番号３の５９３〜６５６、配列番号４の５８０〜６４３、配列番号５の５７７〜６４０、配列番号１０の５８７〜６５０、配列番号１１の５８０〜６４３、配列番号２９の５６６〜６２８、配列番号３４の５８５〜６４７、配列番号３６の５７０〜６３２、配列番号３７の５７６〜６３９、配列番号３８の５９３〜６５５、配列番号４１の６０４〜６６７、配列番号４３の５８９〜６５２、配列番号４４の５６６〜６２８、配列番号４５の５９０〜６５３、配列番号４８の５７４〜６３７、配列番号５３の５８４〜６４６、または配列番号５４の５７０〜６３２のアミノ酸配列と少なくとも７０％の配列同一性を有するアミノ酸配列を含む、請求項２または３に記載のコンジュゲート。
- フラグメントが、配列番号２、６、８、９、１２、１３、１４、１５、１６、１７、１８、１９、２０、２１、２２、２３、２４、２５、２６、２７、２８、３０、３１、３２、３３、３５、３９、４０、４２、４６、４７、４９、５０、５１、または５２のアミノ酸配列と少なくとも７０％の配列同一性を有するアミノ酸配列を含む、請求項２〜４のいずれか一項に記載のコンジュゲート。
- 細胞毒性部分が、カリケアマイシン、オーリスタチン、ドキソルビシン、メイタンシノイド、タキソール、エクテイナシジン、ゲルダナマイシン、メトトレキサートおよびそれらの誘導体、細胞毒性タンパク質、ならびにそれらの機能的変異体、フラグメント、および組み合わせから選択される、請求項１〜５のいずれか一項に記載のコンジュゲート。
- 治療用または診断用エフェクター部分が抗炎症剤である、請求項１〜６のいずれか一項に記載のコンジュゲート。
- 治療用または診断用エフェクター部分が、ＣＳＰＧ４、ＣＤ４４、または他のプロテオグリカンである、請求項１〜７のいずれか一項に記載のコンジュゲート。
- 請求項１〜８のいずれか一項に記載のコンジュゲートを含む、組成物。
- 医薬または診断剤として使用するための、ＶＡＲ２ＣＳＡポリペプチド、または請求項１〜８のいずれか一項に記載のコンジュゲート。
- ＶＡＲ２ＣＳＡポリペプチド、または請求項１〜８のいずれか一項に記載のコンジュゲートを含む、医薬組成物。
- ＣＳＡの発現を伴う状態に関連する任意の適応症を処置するための、ＶＡＲ２ＣＳＡポリペプチド、または請求項１〜８のいずれか一項に記載のコンジュゲート。
- ＣＳＡの発現に関連する適応症または状態の診断および／または予後のための、体液および／または組織中のバイオマーカーとしての、ＶＡＲ２ＣＳＡポリペプチド、または請求項１〜８のいずれか一項に記載のコンジュゲートの使用。
- ＣＤ４４、および／またはＣＳＰＧ４、および／または他の任意のプロテオグリカンを発現する細胞を単離するための、ターゲティング部分としての、ＶＡＲ２ＣＳＡポリペプチド、または請求項８に記載のコンジュゲートの使用。
- 生物学的試料中の、ＣＤ４４、および／またはＣＳＰＧ４、および／または他の任意のプロテオグリカンを発現する細胞を単離および／または検出するための方法であって、
ａ）ＣＤ４４、および／またはＣＳＰＧ４、および／または他の任意のプロテオグリカンを発現する細胞を含む生物学的試料を取得すること；
ｂ）該生物学的試料を請求項１〜８のいずれか一項に記載のコンジュゲートと接触させること；および
ｃ）該ＣＤ４４、および／またはＣＳＰＧ４、および／または他の任意のプロテオグリカンを発現する細胞と該コンジュゲートとの複合体を精製、単離および／または検出すること
を含む、方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261596931P | 2012-02-09 | 2012-02-09 | |
| US61/596,931 | 2012-02-09 | ||
| PCT/EP2013/052557 WO2013117705A1 (en) | 2012-02-09 | 2013-02-08 | Targeting of chondroitin sulfate glycans |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017232702A Division JP2018076333A (ja) | 2012-02-09 | 2017-12-04 | コンドロイチン硫酸グリカンのターゲティング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513524A JP2015513524A (ja) | 2015-05-14 |
| JP2015513524A5 true JP2015513524A5 (ja) | 2016-02-25 |
| JP6517018B2 JP6517018B2 (ja) | 2019-05-22 |
Family
ID=47714079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556075A Active JP6517018B2 (ja) | 2012-02-09 | 2013-02-08 | コンドロイチン硫酸グリカンのターゲティング |
| JP2017232702A Pending JP2018076333A (ja) | 2012-02-09 | 2017-12-04 | コンドロイチン硫酸グリカンのターゲティング |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017232702A Pending JP2018076333A (ja) | 2012-02-09 | 2017-12-04 | コンドロイチン硫酸グリカンのターゲティング |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11787844B2 (ja) |
| EP (1) | EP2812024B1 (ja) |
| JP (2) | JP6517018B2 (ja) |
| CN (1) | CN104136041B (ja) |
| AU (1) | AU2013217986B2 (ja) |
| BR (1) | BR112014018630A2 (ja) |
| CA (1) | CA2861051C (ja) |
| DK (1) | DK2812024T3 (ja) |
| EA (1) | EA031876B1 (ja) |
| ES (1) | ES2676029T3 (ja) |
| IL (1) | IL233594B (ja) |
| PL (1) | PL2812024T3 (ja) |
| SG (2) | SG11201403988WA (ja) |
| WO (1) | WO2013117705A1 (ja) |
| ZA (1) | ZA201405187B (ja) |
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| EP2968440B1 (en) | 2013-03-15 | 2019-06-05 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
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| EP3086815B1 (en) | 2013-12-27 | 2022-02-09 | Zymeworks Inc. | Sulfonamide-containing linkage systems for drug conjugates |
| WO2015095952A1 (en) * | 2013-12-27 | 2015-07-02 | The Centre For Drug Research And Development | Var2csa-drug conjugates |
| JP6246030B2 (ja) * | 2014-03-12 | 2017-12-13 | 東芝メディカルシステムズ株式会社 | 病理染色装置及び病理染色方法 |
| EP4029873A1 (en) | 2014-09-17 | 2022-07-20 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| CA2977434A1 (en) * | 2015-02-26 | 2016-09-01 | Var2 Pharmaceuticals Aps | Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems |
| GB2561755A (en) * | 2015-11-26 | 2018-10-24 | Guangzhou Cas Lamvac Biotech Co Ltd | Anti-placenta-chondroitin-sulfate chimeric antigen receptor and application thereof |
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| CN114075298B (zh) * | 2022-01-07 | 2022-04-29 | 广州中科蓝华生物科技有限公司 | 一种索烃化的var2csa重组蛋白及其制备方法和应用 |
| WO2023148398A1 (en) * | 2022-02-07 | 2023-08-10 | Var2 Pharmaceuticals Aps | Antibodies and antibody fragments and analogues specific for chondroitin sulfate |
| CN116874578A (zh) * | 2022-12-09 | 2023-10-13 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院 中山大学肿瘤研究所) | 一种var2csa重组蛋白及其制备方法和应用 |
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2013
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- 2013-02-08 WO PCT/EP2013/052557 patent/WO2013117705A1/en active Application Filing
- 2013-02-08 EP EP13704077.0A patent/EP2812024B1/en active Active
- 2013-02-08 CN CN201380008730.XA patent/CN104136041B/zh active Active
- 2013-02-08 ES ES13704077.0T patent/ES2676029T3/es active Active
- 2013-02-08 JP JP2014556075A patent/JP6517018B2/ja active Active
- 2013-02-08 SG SG11201403988WA patent/SG11201403988WA/en unknown
- 2013-02-08 US US14/376,295 patent/US11787844B2/en active Active
- 2013-02-08 AU AU2013217986A patent/AU2013217986B2/en active Active
- 2013-02-08 CA CA2861051A patent/CA2861051C/en active Active
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- 2013-02-08 BR BR112014018630A patent/BR112014018630A2/pt not_active Application Discontinuation
- 2013-02-08 EA EA201491494A patent/EA031876B1/ru not_active IP Right Cessation
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- 2014-07-10 IL IL233594A patent/IL233594B/en unknown
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