JP2015512645A5 - - Google Patents
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- Publication number
- JP2015512645A5 JP2015512645A5 JP2015504688A JP2015504688A JP2015512645A5 JP 2015512645 A5 JP2015512645 A5 JP 2015512645A5 JP 2015504688 A JP2015504688 A JP 2015504688A JP 2015504688 A JP2015504688 A JP 2015504688A JP 2015512645 A5 JP2015512645 A5 JP 2015512645A5
- Authority
- JP
- Japan
- Prior art keywords
- mutant
- polypeptide
- car
- fatty alcohol
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 73
- 102000004196 processed proteins & peptides Human genes 0.000 claims 73
- 108090000765 processed proteins & peptides Proteins 0.000 claims 73
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 42
- 230000035772 mutation Effects 0.000 claims 31
- 102220534644 Protein quaking_E20R_mutation Human genes 0.000 claims 28
- 102220289826 rs1555407420 Human genes 0.000 claims 24
- 150000002191 fatty alcohols Chemical class 0.000 claims 23
- 238000004113 cell culture Methods 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 108010053754 Aldehyde reductase Proteins 0.000 claims 2
- 102100027265 Aldo-keto reductase family 1 member B1 Human genes 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 108030002325 Carboxylate reductases Proteins 0.000 claims 1
- 102000005488 Thioesterase Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002192 fatty aldehydes Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102220242995 rs1555187010 Human genes 0.000 claims 1
- 102220017029 rs187218889 Human genes 0.000 claims 1
- 102220075807 rs202025584 Human genes 0.000 claims 1
- 102220095963 rs758112386 Human genes 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 108020002982 thioesterase Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619309P | 2012-04-02 | 2012-04-02 | |
| US61/619,309 | 2012-04-02 | ||
| PCT/US2013/035040 WO2013152052A2 (en) | 2012-04-02 | 2013-04-02 | Novel car enzymes and improved production of fatty alcohols |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512645A JP2015512645A (ja) | 2015-04-30 |
| JP2015512645A5 true JP2015512645A5 (cg-RX-API-DMAC7.html) | 2016-09-29 |
| JP6230594B2 JP6230594B2 (ja) | 2017-11-15 |
Family
ID=49237582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504688A Active JP6230594B2 (ja) | 2012-04-02 | 2013-04-02 | Ｃａｒ酵素、および改良された脂肪アルコール産生方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9340801B2 (cg-RX-API-DMAC7.html) |
| EP (6) | EP3385374B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6230594B2 (cg-RX-API-DMAC7.html) |
| KR (6) | KR101831331B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104704113B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013243602B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR112014024674B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2883064A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO7170148A2 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2786633T3 (cg-RX-API-DMAC7.html) |
| MX (2) | MX358177B (cg-RX-API-DMAC7.html) |
| MY (1) | MY170889A (cg-RX-API-DMAC7.html) |
| SI (1) | SI3385374T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013152052A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2796559B1 (en) * | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| MX379251B (es) * | 2012-04-02 | 2025-03-11 | Genomatica Inc | Producción mejorada de derivados de ácidos grasos. |
| KR101831331B1 (ko) * | 2012-04-02 | 2018-02-23 | 알이지 라이프 사이언시스, 엘엘씨 | Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 |
| WO2014026162A1 (en) | 2012-08-10 | 2014-02-13 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US10047383B2 (en) | 2013-03-15 | 2018-08-14 | Cargill, Incorporated | Bioproduction of chemicals |
| BR112015023473B1 (pt) * | 2013-03-15 | 2023-04-11 | Cargill, Incorporated | Microrganismo geneticamente modificado e método de produzir um produto |
| CN106795483A (zh) | 2013-07-19 | 2017-05-31 | 嘉吉公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| BR112017001105A2 (pt) | 2014-07-18 | 2018-07-24 | REG Life Sciences, LLC | produção microbiana de dióis graxos |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN105985987B (zh) * | 2015-03-02 | 2020-01-31 | 苏州安捷生物科技有限公司 | 一种生物法制备脂肪醇的方法 |
| WO2017161112A1 (en) * | 2016-03-17 | 2017-09-21 | Invista Technologies S.A R.L. | Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto |
| JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞 |
| KR102677413B1 (ko) | 2017-04-03 | 2024-06-24 | 게노마티카 인코포레이티드 | 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체 |
| EP3844179A4 (en) | 2018-08-31 | 2022-08-31 | Genomatica, Inc. | XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE |
| US12221644B2 (en) | 2018-08-31 | 2025-02-11 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| KR20230160398A (ko) | 2021-03-30 | 2023-11-23 | 아사히 가세이 가부시키가이샤 | 카르복실산 환원 활성을 갖는 재조합 폴리펩티드 |
| EP4493683A1 (en) | 2022-03-16 | 2025-01-22 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| EP0528881A4 (en) | 1990-04-24 | 1993-05-26 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US7056714B2 (en) * | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
| DE102004052115A1 (de) | 2004-10-26 | 2006-04-27 | Westfälische Wilhelms-Universität Münster | Mikroorganismen zur Herstellung von Fettsäureestern, Verfahren zu deren Herstellung und deren Verwendung |
| EP2194119A3 (en) | 2006-05-19 | 2010-09-22 | LS9, Inc. | Production of fatty acids and derivatives thereof |
| CA2678915C (en) | 2007-03-28 | 2019-04-09 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| CA2679085C (en) | 2007-05-22 | 2018-04-10 | Ls9, Inc. | Hydrocarbon-producing genes and methods of their use |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| WO2009085278A1 (en) | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
| CA3038491A1 (en) | 2008-10-07 | 2010-04-15 | REG Life Sciences, LLC | Bacterial host cells engineered to express a carboxylic acid reductase and a thioesterase |
| EP2796559B1 (en) * | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| US9175234B2 (en) | 2008-12-23 | 2015-11-03 | REG Life Sciences, LLC | Methods and compositions related to thioesterase enzymes |
| WO2010127318A2 (en) | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
| EP2432890B1 (en) * | 2009-05-22 | 2015-09-02 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| AU2010306785B2 (en) * | 2009-10-13 | 2016-01-14 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| US20110250663A1 (en) | 2010-04-08 | 2011-10-13 | Ls9, Inc. | Methods and compositions related to fatty alcohol biosynthetic enzymes |
| EP3702363A1 (en) * | 2011-04-01 | 2020-09-02 | Genomatica, Inc. | Fadr overexpressing bacterial cells for improved production of fatty acids and derivatives thereof |
| US9133487B2 (en) * | 2011-04-01 | 2015-09-15 | Genomatica, Inc. | Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto |
| US8617862B2 (en) * | 2011-06-22 | 2013-12-31 | Genomatica, Inc. | Microorganisms for producing propylene and methods related thereto |
| KR101831331B1 (ko) * | 2012-04-02 | 2018-02-23 | 알이지 라이프 사이언시스, 엘엘씨 | Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 |
-
2013
- 2013-04-02 KR KR1020147030704A patent/KR101831331B1/ko active Active
- 2013-04-02 KR KR1020207009760A patent/KR102282677B1/ko not_active Expired - Fee Related
- 2013-04-02 EP EP18160746.6A patent/EP3385374B1/en active Active
- 2013-04-02 SI SI201331706T patent/SI3385374T1/sl unknown
- 2013-04-02 EP EP13766728.3A patent/EP2834350B1/en active Active
- 2013-04-02 EP EP19212944.3A patent/EP3674399B1/en active Active
- 2013-04-02 MY MYPI2014002838A patent/MY170889A/en unknown
- 2013-04-02 ES ES18160746T patent/ES2786633T3/es active Active
- 2013-04-02 AU AU2013243602A patent/AU2013243602B2/en not_active Ceased
- 2013-04-02 KR KR1020177026945A patent/KR20170113710A/ko not_active Ceased
- 2013-04-02 CA CA2883064A patent/CA2883064A1/en active Pending
- 2013-04-02 MX MX2016013852A patent/MX358177B/es unknown
- 2013-04-02 ES ES13766728.3T patent/ES2613553T3/es active Active
- 2013-04-02 EP EP22202380.6A patent/EP4186974A1/en active Pending
- 2013-04-02 EP EP21191034.4A patent/EP3985108A1/en not_active Withdrawn
- 2013-04-02 CN CN201380026546.8A patent/CN104704113B/zh active Active
- 2013-04-02 BR BR112014024674-2A patent/BR112014024674B1/pt not_active IP Right Cessation
- 2013-04-02 BR BR122019026987-4A patent/BR122019026987B1/pt active IP Right Grant
- 2013-04-02 JP JP2015504688A patent/JP6230594B2/ja active Active
- 2013-04-02 KR KR1020217023277A patent/KR20210095226A/ko not_active Ceased
- 2013-04-02 WO PCT/US2013/035040 patent/WO2013152052A2/en not_active Ceased
- 2013-04-02 KR KR1020197005741A patent/KR102114841B1/ko not_active Expired - Fee Related
- 2013-04-02 US US14/390,350 patent/US9340801B2/en active Active
- 2013-04-02 EP EP16198810.0A patent/EP3153579B1/en not_active Not-in-force
- 2013-04-02 ES ES16198810.0T patent/ES2666157T3/es active Active
- 2013-04-02 MX MX2014011903A patent/MX343296B/es active IP Right Grant
- 2013-04-02 KR KR1020197017717A patent/KR102185762B1/ko not_active Expired - Fee Related
-
2014
- 2014-10-29 CO CO14240039A patent/CO7170148A2/es unknown
-
2016
- 2016-05-13 US US15/154,636 patent/US9758769B2/en active Active
- 2016-09-20 AU AU2016231497A patent/AU2016231497B2/en not_active Ceased
-
2017
- 2017-09-05 US US15/695,205 patent/US10301603B2/en active Active
-
2019
- 2019-05-16 US US16/414,550 patent/US11034937B2/en active Active
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