JP2015509909A5 - - Google Patents
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- Publication number
- JP2015509909A5 JP2015509909A5 JP2014543571A JP2014543571A JP2015509909A5 JP 2015509909 A5 JP2015509909 A5 JP 2015509909A5 JP 2014543571 A JP2014543571 A JP 2014543571A JP 2014543571 A JP2014543571 A JP 2014543571A JP 2015509909 A5 JP2015509909 A5 JP 2015509909A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- use according
- itc
- sulforaphane
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 8
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims 5
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 claims 3
- 229960005559 sulforaphane Drugs 0.000 claims 3
- 235000015487 sulforaphane Nutrition 0.000 claims 3
- IHQDGXUYTSZGOG-UHFFFAOYSA-N Erucin Chemical compound CSCCCCN=C=S IHQDGXUYTSZGOG-UHFFFAOYSA-N 0.000 claims 2
- -1 TP-225 Chemical compound 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002540 isothiocyanates Chemical class 0.000 claims 2
- ORJDDOBAOGKRJV-CQSZACIVSA-N (2S)-Pinocembrin Natural products C1([C@H]2CC(=O)C3=C(O)C=C(C=C3O2)OC)=CC=CC=C1 ORJDDOBAOGKRJV-CQSZACIVSA-N 0.000 claims 1
- ISZIRXMFUSQQOS-NDXORKPFSA-N (4bs,8ar,10as)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-9,10-dihydro-8ah-phenanthrene-2,6-dicarbonitrile Chemical compound C([C@@]1(CC2)C#C)=C(C#N)C(=O)C=C1[C@]1(C)[C@@H]2C(C)(C)C(=O)C(C#N)=C1 ISZIRXMFUSQQOS-NDXORKPFSA-N 0.000 claims 1
- KQJSQWZMSAGSHN-UHFFFAOYSA-N (9beta,13alpha,14beta,20alpha)-3-hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid Natural products CC12CCC3(C)C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C2=CC=C2C1=CC(=O)C(O)=C2C KQJSQWZMSAGSHN-UHFFFAOYSA-N 0.000 claims 1
- AQKDBFWJOPNOKZ-UHFFFAOYSA-N Celastrol Natural products CC12CCC3(C)C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C2=CC=C2C1=CC(=O)C(=O)C2C AQKDBFWJOPNOKZ-UHFFFAOYSA-N 0.000 claims 1
- ORJDDOBAOGKRJV-UHFFFAOYSA-N Dihydrotectochrysin Natural products O1C2=CC(OC)=CC(O)=C2C(=O)CC1C1=CC=CC=C1 ORJDDOBAOGKRJV-UHFFFAOYSA-N 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 1
- VDFOMVRWDSKWSL-UHFFFAOYSA-N Zerumbone Natural products CC1=C2CC(C)(C)C=C2C(=O)C(=CCC1)C VDFOMVRWDSKWSL-UHFFFAOYSA-N 0.000 claims 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- KQJSQWZMSAGSHN-JJWQIEBTSA-N celastrol Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)[C@](C)(C(O)=O)CC[C@]1(C)CC[C@]2(C)C4=CC=C1C3=CC(=O)C(O)=C1C KQJSQWZMSAGSHN-JJWQIEBTSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 229930003935 flavonoid Natural products 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 125000004383 glucosinolate group Chemical group 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- SQFSKOYWJBQGKQ-UHFFFAOYSA-N kaempferide Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 SQFSKOYWJBQGKQ-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000000050 nutritive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- ORJDDOBAOGKRJV-AWEZNQCLSA-N pinostrobin Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)OC)=CC=CC=C1 ORJDDOBAOGKRJV-AWEZNQCLSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940016667 resveratrol Drugs 0.000 claims 1
- 235000021283 resveratrol Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229930004725 sesquiterpene Natural products 0.000 claims 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 150000003436 stilbenoids Chemical class 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- YCGBUPXEBUFYFV-UHFFFAOYSA-N withaferin A Natural products CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(O)C6(C)C4CCC23C YCGBUPXEBUFYFV-UHFFFAOYSA-N 0.000 claims 1
- DBRXOUCRJQVYJQ-CKNDUULBSA-N withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 claims 1
- GIHNTRQPEMKFKO-SKTNYSRSSA-N zerumbone Chemical compound C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1 GIHNTRQPEMKFKO-SKTNYSRSSA-N 0.000 claims 1
- GIHNTRQPEMKFKO-UHFFFAOYSA-N zurembone Natural products CC1=CCC(C)(C)C=CC(=O)C(C)=CCC1 GIHNTRQPEMKFKO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562559P | 2011-11-22 | 2011-11-22 | |
| US61/562,559 | 2011-11-22 | ||
| US201161568721P | 2011-12-09 | 2011-12-09 | |
| US61/568,721 | 2011-12-09 | ||
| PCT/US2012/066340 WO2013078371A2 (en) | 2011-11-22 | 2012-11-21 | Methods and compositions for reducing alcohol toxicity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509909A JP2015509909A (ja) | 2015-04-02 |
| JP2015509909A5 true JP2015509909A5 (enExample) | 2015-09-03 |
| JP6437823B2 JP6437823B2 (ja) | 2018-12-12 |
Family
ID=48470418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543571A Active JP6437823B2 (ja) | 2011-11-22 | 2012-11-21 | アルコール毒性低減のための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20150087702A1 (enExample) |
| EP (1) | EP2782583B1 (enExample) |
| JP (1) | JP6437823B2 (enExample) |
| KR (1) | KR102002147B1 (enExample) |
| CN (1) | CN104520311B (enExample) |
| WO (1) | WO2013078371A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105163728B (zh) * | 2013-04-05 | 2018-10-02 | 蜜纽康新西兰有限公司 | 包含蜂胶提取物的治疗性组合物和其用途 |
| CN103396348B (zh) * | 2013-08-21 | 2015-05-20 | 昆明龙津药业股份有限公司 | 蔊菜素的衍生物以及在制备抗癌药物中的应用 |
| JP6855157B2 (ja) * | 2014-10-06 | 2021-04-07 | 扶桑化学工業株式会社 | 水中動物用飼料、水中動物用発育向上剤、および、それらを用いた養殖魚の飼育方法 |
| WO2016168450A1 (en) | 2015-04-16 | 2016-10-20 | The Research Foundation For The State University Of New York | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis |
| CN105251025B (zh) * | 2015-11-11 | 2018-11-27 | 福州大学 | Aldh2基因在制备预防苯乙烯致遗传毒性药物中的应用 |
| JP2017195809A (ja) * | 2016-04-27 | 2017-11-02 | 佐々木食品工業株式会社 | アセトアルデヒドの代謝促進用食品組成物及びアセトアルデヒドの代謝促進剤 |
| CN107789612A (zh) * | 2016-08-31 | 2018-03-13 | 李镇坚 | 一种中药水果复合固体解酒糖及制备工艺 |
| JP6867823B2 (ja) * | 2017-02-13 | 2021-05-12 | サッポロビール株式会社 | アセトアルデヒドデヒドロゲナーゼ活性促進剤 |
| US10849938B2 (en) | 2017-09-13 | 2020-12-01 | ZBiotics Company | Gene expression system for probiotic microorganisms |
| CN107950726A (zh) * | 2017-11-27 | 2018-04-24 | 广州六顺生物科技有限公司 | 一种具有解酒护肝作用的凝胶糖果、制备方法和应用 |
| CN110101849B (zh) * | 2019-04-12 | 2023-11-10 | 暨南大学 | 一种酶催化解酒作用的组合物及其制备方法与应用 |
| CN110538173A (zh) * | 2019-08-20 | 2019-12-06 | 郑州大学第一附属医院 | 异硫氰酸酯类化合物在制备食管癌靶向药中的应用 |
| KR20220081351A (ko) * | 2019-10-10 | 2022-06-15 | 조브리어스 파르마 에이에스 | 개선된 숙취해소 조성물, 이의 제조 및 용도 |
| KR102460570B1 (ko) | 2020-02-18 | 2022-10-28 | 주식회사 피코엔텍 | 신규한 돌연변이 효모를 함유하는 아토피 억제 조성물 |
| CN111437280A (zh) * | 2020-04-29 | 2020-07-24 | 重庆燕盈生物科技有限公司 | 一种基于雷公藤红素的新用途及其应用 |
| CN118490676B (zh) * | 2024-07-18 | 2024-09-13 | 暨南大学 | 杨芽黄素在制备延缓卵巢衰老和/或修复损伤卵巢和/或重建卵巢功能药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5725895B1 (en) | 1995-09-15 | 2000-10-10 | Hopkins J School Of Medicine | Method of preparing food product from cruciferous seeds |
| KR20020014978A (ko) | 2000-08-19 | 2002-02-27 | 김기성 | 숙취제거 향의 조성물 |
| US20050271754A1 (en) * | 2004-06-07 | 2005-12-08 | Cochrane Patrick W | Composition for prevention or treatment of an alcohol hangover |
| RU2292899C2 (ru) * | 2004-06-29 | 2007-02-10 | Дмитрий Николаевич Мясников | Средство и способ профилактики и уменьшения неблагоприятных проявлений острой алкогольной интоксикации (варианты) и способ получения средства |
| KR100661032B1 (ko) * | 2005-04-19 | 2006-12-22 | 주식회사한국야쿠르트 | 간 기능 개선, 혈중 알코올 감소 및 항산화에 유효한조성물 |
| WO2007016955A1 (en) * | 2005-07-29 | 2007-02-15 | Matuschka-Greiffenclau Markus | Alcohol metabolism moderating composition |
| PL1909600T3 (pl) * | 2005-07-29 | 2012-09-28 | Tima Found | Kompozycja spowalniająca metabolizm alkoholu i ograniczająca ryzyko chorób wywołanych alkoholem |
| US20080311276A1 (en) * | 2007-06-12 | 2008-12-18 | Kraft Foods Holdings, Inc. | Production of Glucosinolates from Agricultural By-Products & Waste |
| MY160074A (en) * | 2008-01-24 | 2017-02-15 | Raptor Therapeutics Inc | Protopanaxadiol-type ginsenoside compositions and uses thereof |
| CN103202838A (zh) | 2013-04-16 | 2013-07-17 | 缪为民 | 一种具有肝脏保护作用的植物提取物组合物 |
-
2012
- 2012-11-21 WO PCT/US2012/066340 patent/WO2013078371A2/en not_active Ceased
- 2012-11-21 EP EP12851204.3A patent/EP2782583B1/en active Active
- 2012-11-21 US US14/358,712 patent/US20150087702A1/en not_active Abandoned
- 2012-11-21 KR KR1020147015619A patent/KR102002147B1/ko active Active
- 2012-11-21 CN CN201280066882.0A patent/CN104520311B/zh active Active
- 2012-11-21 JP JP2014543571A patent/JP6437823B2/ja active Active
-
2021
- 2021-09-07 US US17/467,795 patent/US20210401791A1/en not_active Abandoned
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