JP2016053040A5 - - Google Patents
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- Publication number
- JP2016053040A5 JP2016053040A5 JP2015201153A JP2015201153A JP2016053040A5 JP 2016053040 A5 JP2016053040 A5 JP 2016053040A5 JP 2015201153 A JP2015201153 A JP 2015201153A JP 2015201153 A JP2015201153 A JP 2015201153A JP 2016053040 A5 JP2016053040 A5 JP 2016053040A5
- Authority
- JP
- Japan
- Prior art keywords
- relaxin
- risk
- mortality
- composition
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003743 Relaxin Human genes 0.000 claims 8
- 108090000103 Relaxin Proteins 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 239000000902 placebo Substances 0.000 claims 7
- 229940068196 placebo Drugs 0.000 claims 7
- 206010007556 Cardiac failure acute Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 230000001631 hypertensive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12788908P | 2008-05-16 | 2008-05-16 | |
| US61/127,889 | 2008-05-16 | ||
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US61/190,545 | 2008-08-28 | ||
| US20124008P | 2008-12-08 | 2008-12-08 | |
| US61/201,240 | 2008-12-08 | ||
| US16433309P | 2009-03-27 | 2009-03-27 | |
| US61/164,333 | 2009-03-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014165276A Division JP5875646B2 (ja) | 2008-05-16 | 2014-08-14 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016053040A JP2016053040A (ja) | 2016-04-14 |
| JP2016053040A5 true JP2016053040A5 (enExample) | 2016-07-07 |
Family
ID=40834101
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509783A Expired - Fee Related JP5651586B2 (ja) | 2008-05-16 | 2009-05-15 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| JP2012200728A Expired - Fee Related JP5638044B2 (ja) | 2008-05-16 | 2012-09-12 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| JP2014165276A Expired - Fee Related JP5875646B2 (ja) | 2008-05-16 | 2014-08-14 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| JP2015201153A Pending JP2016053040A (ja) | 2008-05-16 | 2015-10-09 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509783A Expired - Fee Related JP5651586B2 (ja) | 2008-05-16 | 2009-05-15 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| JP2012200728A Expired - Fee Related JP5638044B2 (ja) | 2008-05-16 | 2012-09-12 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
| JP2014165276A Expired - Fee Related JP5875646B2 (ja) | 2008-05-16 | 2014-08-14 | 急性心不全に伴う呼吸困難のリラキシンによる治療 |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US8415301B2 (enExample) |
| EP (2) | EP2829280A1 (enExample) |
| JP (4) | JP5651586B2 (enExample) |
| CN (3) | CN102036679A (enExample) |
| AR (1) | AR071810A1 (enExample) |
| AU (1) | AU2009246114B2 (enExample) |
| BR (1) | BRPI0913011A2 (enExample) |
| CA (1) | CA2724540C (enExample) |
| CR (1) | CR11749A (enExample) |
| CY (1) | CY1116925T1 (enExample) |
| DK (1) | DK2288373T3 (enExample) |
| EA (2) | EA022948B1 (enExample) |
| ES (1) | ES2546287T3 (enExample) |
| GB (2) | GB2459983B (enExample) |
| HK (1) | HK1202054A1 (enExample) |
| HR (1) | HRP20150845T1 (enExample) |
| HU (1) | HUE025483T2 (enExample) |
| IL (3) | IL208992A (enExample) |
| MA (1) | MA32389B1 (enExample) |
| MX (1) | MX2010012450A (enExample) |
| MY (2) | MY159803A (enExample) |
| NZ (3) | NZ701038A (enExample) |
| PL (1) | PL2288373T3 (enExample) |
| PT (1) | PT2288373E (enExample) |
| SG (2) | SG191587A1 (enExample) |
| SI (1) | SI2288373T1 (enExample) |
| TW (1) | TWI386202B (enExample) |
| UA (1) | UA99953C2 (enExample) |
| WO (1) | WO2009140659A2 (enExample) |
| ZA (1) | ZA201007449B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009246112B2 (en) * | 2008-05-16 | 2013-05-02 | Corthera, Inc. | Method of treating chronic heart failure |
| US8415301B2 (en) * | 2008-05-16 | 2013-04-09 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure by administering H2 relaxin |
| KR101800040B1 (ko) * | 2010-03-10 | 2017-11-21 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 릴랙신을 사용한 아쿠아포린의 조절 |
| JP5899213B2 (ja) | 2010-08-06 | 2016-04-06 | マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ | 腎機能不全のバイオマーカーとしてのパールカン |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| PE20140160A1 (es) * | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| AU2012280474A1 (en) * | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| WO2013059879A1 (en) * | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| JP6562632B2 (ja) * | 2012-02-14 | 2019-08-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| US9452973B2 (en) | 2012-05-04 | 2016-09-27 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| CN110840890A (zh) | 2012-10-26 | 2020-02-28 | 凯西制药公司 | 用于在心力衰竭中控制血压和减轻呼吸困难的方法 |
| CN105431145B (zh) | 2013-04-05 | 2019-12-10 | Sc医药品有限公司 | 用于呋塞米的皮下施用的药物制剂 |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| HK1226581A1 (zh) * | 2014-02-03 | 2017-09-29 | Novartis Ag | 用於输液器上的过滤器 |
| EP2946788A1 (en) * | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| JP6820748B2 (ja) * | 2014-06-13 | 2021-01-27 | ノバルティス アーゲー | Ｇｄｆ−１５を減少させるためのセレラキシンの使用 |
| US11161891B2 (en) | 2015-12-09 | 2021-11-02 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| CN108697330B (zh) | 2016-02-12 | 2022-07-15 | 心脏起搏器股份公司 | 用于患者监视的系统和方法 |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| ES3041602T3 (en) | 2018-12-10 | 2025-11-13 | Sq Innovation Ag | Pharmaceutical compositions of furosemide and uses thereof |
| ES3058386T3 (es) | 2019-01-04 | 2026-03-10 | Sq Innovation Ag | Composiciones farmacéuticas de furosemida |
| EP3906020B1 (en) | 2019-01-04 | 2025-12-31 | SQ Innovation AG | Pharmaceutical compositions of torsemide and their uses |
| AU2020214314B2 (en) | 2019-01-31 | 2025-09-18 | Scpharmaceuticals Inc. | Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same |
| JP2025528469A (ja) | 2022-08-31 | 2025-08-28 | リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー． カーゲー | 免疫抑制薬及び処置方法 |
| EP4791358A1 (en) | 2023-09-15 | 2026-08-19 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Relaxin medication |
| CN121837268B (zh) * | 2026-03-12 | 2026-06-16 | 西安建筑科技大学 | 一种基于渐进性风险排序的尘肺病早期精细化筛查方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023321A (en) * | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| US5478807A (en) | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| CA2165781C (en) | 1993-06-21 | 2007-02-13 | Tim Breece | Process for producing relaxin |
| CA2145515A1 (en) * | 1993-07-27 | 1995-02-09 | Mario Bigazzi | Use of relaxin as therapeutic or preventing agent |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| ES2187667T3 (es) * | 1995-08-15 | 2003-06-16 | Connetics Corp | Uso de relaxina para estimular angiogenesis. |
| ATE362770T1 (de) * | 2000-02-09 | 2007-06-15 | Bas Medical Inc | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US7878978B2 (en) * | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| EP1729817B1 (en) * | 2004-03-30 | 2014-03-05 | Industry-Academic Cooperation Foundation | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
| US20060264367A1 (en) | 2005-05-21 | 2006-11-23 | Howard Florey Institute | Prevention of fibrosis following cardiac injury |
| WO2007008907A2 (en) * | 2005-07-11 | 2007-01-18 | Abbott Laboratories | Methods for determining how to treat congestive heart failure |
| CA2693651A1 (en) | 2007-07-12 | 2009-01-15 | Ronen Shemesh | Bioactive peptides and method of using same |
| AU2009246112B2 (en) | 2008-05-16 | 2013-05-02 | Corthera, Inc. | Method of treating chronic heart failure |
| US8415301B2 (en) * | 2008-05-16 | 2013-04-09 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure by administering H2 relaxin |
-
2009
- 2009-05-15 US US12/992,356 patent/US8415301B2/en not_active Expired - Fee Related
- 2009-05-15 GB GB0908432A patent/GB2459983B/en not_active Expired - Fee Related
- 2009-05-15 US US12/467,214 patent/US8053411B2/en not_active Expired - Fee Related
- 2009-05-15 TW TW098116328A patent/TWI386202B/zh not_active IP Right Cessation
- 2009-05-15 BR BRPI0913011A patent/BRPI0913011A2/pt not_active IP Right Cessation
- 2009-05-15 PL PL09747740T patent/PL2288373T3/pl unknown
- 2009-05-15 EP EP14167842.5A patent/EP2829280A1/en not_active Withdrawn
- 2009-05-15 HU HUE09747740A patent/HUE025483T2/en unknown
- 2009-05-15 SI SI200931246T patent/SI2288373T1/sl unknown
- 2009-05-15 CA CA2724540A patent/CA2724540C/en not_active Expired - Fee Related
- 2009-05-15 NZ NZ701038A patent/NZ701038A/en not_active IP Right Cessation
- 2009-05-15 SG SG2013038260A patent/SG191587A1/en unknown
- 2009-05-15 DK DK09747740.0T patent/DK2288373T3/en active
- 2009-05-15 EP EP09747740.0A patent/EP2288373B1/en active Active
- 2009-05-15 ES ES09747740.0T patent/ES2546287T3/es active Active
- 2009-05-15 JP JP2011509783A patent/JP5651586B2/ja not_active Expired - Fee Related
- 2009-05-15 EA EA201001771A patent/EA022948B1/ru not_active IP Right Cessation
- 2009-05-15 SG SG10201609580YA patent/SG10201609580YA/en unknown
- 2009-05-15 MY MYPI2010005049A patent/MY159803A/en unknown
- 2009-05-15 PT PT97477400T patent/PT2288373E/pt unknown
- 2009-05-15 WO PCT/US2009/044249 patent/WO2009140659A2/en not_active Ceased
- 2009-05-15 CN CN2009801177504A patent/CN102036679A/zh active Pending
- 2009-05-15 UA UAA201012879A patent/UA99953C2/uk unknown
- 2009-05-15 EA EA201500552A patent/EA201500552A1/ru unknown
- 2009-05-15 NZ NZ598709A patent/NZ598709A/xx not_active IP Right Cessation
- 2009-05-15 AR ARP090101762A patent/AR071810A1/es unknown
- 2009-05-15 CN CN201310127326.6A patent/CN103212063B/zh not_active Expired - Fee Related
- 2009-05-15 GB GB0918132A patent/GB2462221B/en not_active Expired - Fee Related
- 2009-05-15 HR HRP20150845TT patent/HRP20150845T1/hr unknown
- 2009-05-15 MX MX2010012450A patent/MX2010012450A/es active IP Right Grant
- 2009-05-15 CN CN201610565105.0A patent/CN106177914A/zh active Pending
- 2009-05-15 AU AU2009246114A patent/AU2009246114B2/en not_active Ceased
- 2009-05-15 NZ NZ589009A patent/NZ589009A/en not_active IP Right Cessation
-
2010
- 2010-10-19 ZA ZA2010/07449A patent/ZA201007449B/en unknown
- 2010-10-22 CR CR11749A patent/CR11749A/es unknown
- 2010-10-28 IL IL208992A patent/IL208992A/en not_active IP Right Cessation
- 2010-12-10 MA MA33418A patent/MA32389B1/fr unknown
-
2011
- 2011-05-30 HK HK15102533.3A patent/HK1202054A1/en unknown
- 2011-09-23 US US13/242,012 patent/US8372809B2/en not_active Expired - Fee Related
-
2012
- 2012-09-12 JP JP2012200728A patent/JP5638044B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-04 US US13/734,301 patent/US9066916B2/en not_active Expired - Fee Related
- 2013-03-05 US US13/784,963 patent/US9205132B2/en not_active Expired - Fee Related
- 2013-09-02 IL IL228244A patent/IL228244A/en not_active IP Right Cessation
- 2013-11-28 MY MYPI2013004312A patent/MY158327A/en unknown
-
2014
- 2014-08-14 JP JP2014165276A patent/JP5875646B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-28 US US14/723,701 patent/US9579363B2/en not_active Expired - Fee Related
- 2015-09-18 CY CY20151100824T patent/CY1116925T1/el unknown
- 2015-10-09 JP JP2015201153A patent/JP2016053040A/ja active Pending
-
2016
- 2016-08-18 IL IL247351A patent/IL247351A0/en unknown
-
2017
- 2017-01-23 US US15/412,447 patent/US20170151311A1/en not_active Abandoned
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