AR071810A1 - Metodo de tratamiento de la disnea asociada con la insuficiencia cardiaca aguda. relaxina h2. uso. - Google Patents
Metodo de tratamiento de la disnea asociada con la insuficiencia cardiaca aguda. relaxina h2. uso.Info
- Publication number
- AR071810A1 AR071810A1 ARP090101762A ARP090101762A AR071810A1 AR 071810 A1 AR071810 A1 AR 071810A1 AR P090101762 A ARP090101762 A AR P090101762A AR P090101762 A ARP090101762 A AR P090101762A AR 071810 A1 AR071810 A1 AR 071810A1
- Authority
- AR
- Argentina
- Prior art keywords
- acute
- relaxin
- heart failure
- decompensated
- human subject
- Prior art date
Links
- 206010007556 Cardiac failure acute Diseases 0.000 title abstract 5
- 102000003743 Relaxin Human genes 0.000 title abstract 4
- 108090000103 Relaxin Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 208000000059 Dyspnea Diseases 0.000 abstract 2
- 206010013975 Dyspnoeas Diseases 0.000 abstract 2
- 230000001154 acute effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940127088 antihypertensive drug Drugs 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035488 systolic blood pressure Effects 0.000 abstract 1
- 230000002861 ventricular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Metodos para reducir la descompensacion por intervencion aguda inclusive en los sujetos afectados con la insuficiencia cardiaca aguda descompensada. Metodos de tratamiento de la descompensacion card¡aca aguda mediante la administracion de una cantidad farmaceuticamente eficaz de relaxina. Reivindicacion 1: Una relaxina H2 con actividad farmaceutica caracterizada porque es para usar en un metodo para tratar la disnea en un sujeto humano. Reivindicacion 55: Uso de una relaxina H2 con actividad farmaceutica y una droga antihipertensiva caracterizado porque es en la fabricacion de un medicamento para tratar (a) la disnea en un sujeto humano; (b) la insuficiencia card¡aca aguda descompensada en un sujeto humano, donde el sujeto tiene insuficiencia cardiaca descompensada y una presion sangu¡nea sistolica de al menos 125 mm Hg; o (c) la insuficiencia cardiaca aguda descompensada en un sujeto humano, donde el sujeto tiene insuficiencia cardiaca aguda descompensada y una fraccion de eyeccion del ventr¡culo izquierdo de al menos 20%.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12788908P | 2008-05-16 | 2008-05-16 | |
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US20124008P | 2008-12-08 | 2008-12-08 | |
| US16433309P | 2009-03-27 | 2009-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071810A1 true AR071810A1 (es) | 2010-07-14 |
Family
ID=40834101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101762A AR071810A1 (es) | 2008-05-16 | 2009-05-15 | Metodo de tratamiento de la disnea asociada con la insuficiencia cardiaca aguda. relaxina h2. uso. |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US8415301B2 (es) |
| EP (2) | EP2829280A1 (es) |
| JP (4) | JP5651586B2 (es) |
| CN (3) | CN103212063B (es) |
| AR (1) | AR071810A1 (es) |
| AU (1) | AU2009246114B2 (es) |
| BR (1) | BRPI0913011A2 (es) |
| CA (1) | CA2724540C (es) |
| CR (1) | CR11749A (es) |
| CY (1) | CY1116925T1 (es) |
| DK (1) | DK2288373T3 (es) |
| EA (2) | EA022948B1 (es) |
| ES (1) | ES2546287T3 (es) |
| GB (2) | GB2462221B (es) |
| HK (5) | HK1139051A1 (es) |
| HR (1) | HRP20150845T1 (es) |
| HU (1) | HUE025483T2 (es) |
| IL (3) | IL208992A (es) |
| MA (1) | MA32389B1 (es) |
| MX (1) | MX2010012450A (es) |
| MY (2) | MY159803A (es) |
| NZ (3) | NZ589009A (es) |
| PL (1) | PL2288373T3 (es) |
| PT (1) | PT2288373E (es) |
| SG (2) | SG191587A1 (es) |
| SI (1) | SI2288373T1 (es) |
| TW (1) | TWI386202B (es) |
| UA (1) | UA99953C2 (es) |
| WO (1) | WO2009140659A2 (es) |
| ZA (1) | ZA201007449B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2288366A4 (en) * | 2008-05-16 | 2012-05-02 | Corthera Inc | METHOD FOR TREATING CHRONIC HEART FAILURE |
| EA022948B1 (ru) * | 2008-05-16 | 2016-03-31 | Кортера, Инк. | Лечение релаксином одышки, ассоциированной с острой сердечной недостаточностью |
| US20130053318A1 (en) | 2010-03-10 | 2013-02-28 | Parry Laura | Modulating aquaporins with relaxin |
| EP2601532B1 (en) | 2010-08-06 | 2016-01-27 | Mycartis N.V. | Perlecan as a biomarker for renal dysfunction |
| SG10201506443TA (en) | 2010-08-17 | 2015-10-29 | Ambrx Inc | Modified relaxin polypeptides and their uses |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| MX2014000031A (es) * | 2011-07-01 | 2014-07-09 | Bayer Ip Gmbh | Polipeptidos de fusion de relaxina y usos de los mismos. |
| AU2013202269A1 (en) * | 2011-10-26 | 2013-05-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| PL2814513T3 (pl) * | 2012-02-14 | 2018-06-29 | The Regents Of The University Of California | Układowe dostarczanie i regulowana ekspresja genów parakrynnych w chorobach sercowo-naczyniowych i innych stanach |
| EP2844345B1 (en) | 2012-05-04 | 2022-08-03 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Modulators of the relaxin receptor 1 |
| CA2889584C (en) | 2012-10-26 | 2018-08-14 | The Medicines Company | Methods for controlling blood pressure and reducing dyspnea in heart failure |
| EP3799869A1 (en) | 2013-04-05 | 2021-04-07 | ScPharmaceuticals Inc. | Pharmaceutical formulations for subcutaneous administration of furosemide |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| EA201691562A2 (ru) * | 2014-02-03 | 2017-01-30 | Новартис Аг | Фильтры для инфузионных наборов |
| EP2946788A1 (en) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| JP6820748B2 (ja) * | 2014-06-13 | 2021-01-27 | ノバルティス アーゲー | Ｇｄｆ−１５を減少させるためのセレラキシンの使用 |
| US11161891B2 (en) | 2015-12-09 | 2021-11-02 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| CN108697330B (zh) | 2016-02-12 | 2022-07-15 | 心脏起搏器股份公司 | 用于患者监视的系统和方法 |
| MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| CN113271923A (zh) | 2019-01-04 | 2021-08-17 | Sq创新股份公司 | 呋塞米的药物组合物及其用途 |
| MX2021009084A (es) | 2019-01-31 | 2021-10-26 | Scpharmaceuticals Inc | Formulaciones farmaceuticas liquidas concentradas de furosemida y metodos para administrar las mismas. |
| WO2024047130A1 (en) | 2022-08-31 | 2024-03-07 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Immunosuppressive medicament and method of treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023321A (en) * | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| CA2165781C (en) * | 1993-06-21 | 2007-02-13 | Tim Breece | Process for producing relaxin |
| CA2145515A1 (en) | 1993-07-27 | 1995-02-09 | Mario Bigazzi | Use of relaxin as therapeutic or preventing agent |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| EP0845992B1 (en) * | 1995-08-15 | 2002-11-20 | Connetics Corporation | Use of relaxin for promoting angiogenesis |
| DE60128540T2 (de) | 2000-02-09 | 2008-01-31 | Bas Medical, Inc., San Mateo | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| JP4764872B2 (ja) * | 2004-03-30 | 2011-09-07 | インダストリー−アカデミック コオペレイション ファウンデーション，ヨンセイ ユニバーシティ | リラクシン遺伝子を含む遺伝子伝達システム及びリラクシンを用いた薬剤学的組成物 |
| US20060264367A1 (en) * | 2005-05-21 | 2006-11-23 | Howard Florey Institute | Prevention of fibrosis following cardiac injury |
| WO2007008907A2 (en) * | 2005-07-11 | 2007-01-18 | Abbott Laboratories | Methods for determining how to treat congestive heart failure |
| JP5355561B2 (ja) | 2007-07-12 | 2013-11-27 | コンピュゲン エルティーディー． | 生物活性ペプチドおよびその使用方法 |
| EP2288366A4 (en) | 2008-05-16 | 2012-05-02 | Corthera Inc | METHOD FOR TREATING CHRONIC HEART FAILURE |
| EA022948B1 (ru) * | 2008-05-16 | 2016-03-31 | Кортера, Инк. | Лечение релаксином одышки, ассоциированной с острой сердечной недостаточностью |
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2009
- 2009-05-15 EA EA201001771A patent/EA022948B1/ru not_active IP Right Cessation
- 2009-05-15 CA CA2724540A patent/CA2724540C/en not_active Expired - Fee Related
- 2009-05-15 NZ NZ589009A patent/NZ589009A/en not_active IP Right Cessation
- 2009-05-15 DK DK09747740.0T patent/DK2288373T3/en active
- 2009-05-15 TW TW098116328A patent/TWI386202B/zh not_active IP Right Cessation
- 2009-05-15 US US12/992,356 patent/US8415301B2/en not_active Expired - Fee Related
- 2009-05-15 WO PCT/US2009/044249 patent/WO2009140659A2/en active Application Filing
- 2009-05-15 CN CN201310127326.6A patent/CN103212063B/zh not_active Expired - Fee Related
- 2009-05-15 NZ NZ701038A patent/NZ701038A/en not_active IP Right Cessation
- 2009-05-15 AU AU2009246114A patent/AU2009246114B2/en not_active Ceased
- 2009-05-15 MX MX2010012450A patent/MX2010012450A/es active IP Right Grant
- 2009-05-15 EA EA201500552A patent/EA201500552A1/ru unknown
- 2009-05-15 NZ NZ598709A patent/NZ598709A/xx not_active IP Right Cessation
- 2009-05-15 SI SI200931246T patent/SI2288373T1/sl unknown
- 2009-05-15 EP EP14167842.5A patent/EP2829280A1/en not_active Withdrawn
- 2009-05-15 PT PT97477400T patent/PT2288373E/pt unknown
- 2009-05-15 EP EP09747740.0A patent/EP2288373B1/en active Active
- 2009-05-15 SG SG2013038260A patent/SG191587A1/en unknown
- 2009-05-15 BR BRPI0913011A patent/BRPI0913011A2/pt not_active IP Right Cessation
- 2009-05-15 AR ARP090101762A patent/AR071810A1/es unknown
- 2009-05-15 ES ES09747740.0T patent/ES2546287T3/es active Active
- 2009-05-15 PL PL09747740T patent/PL2288373T3/pl unknown
- 2009-05-15 SG SG10201609580YA patent/SG10201609580YA/en unknown
- 2009-05-15 HU HUE09747740A patent/HUE025483T2/en unknown
- 2009-05-15 CN CN2009801177504A patent/CN102036679A/zh active Pending
- 2009-05-15 MY MYPI2010005049A patent/MY159803A/en unknown
- 2009-05-15 US US12/467,214 patent/US8053411B2/en not_active Expired - Fee Related
- 2009-05-15 UA UAA201012879A patent/UA99953C2/uk unknown
- 2009-05-15 JP JP2011509783A patent/JP5651586B2/ja not_active Expired - Fee Related
- 2009-05-15 CN CN201610565105.0A patent/CN106177914A/zh active Pending
- 2009-05-15 GB GB0918132A patent/GB2462221B/en not_active Expired - Fee Related
- 2009-05-15 GB GB0908432A patent/GB2459983B/en not_active Expired - Fee Related
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2010
- 2010-05-18 HK HK10104896.5A patent/HK1139051A1/xx not_active IP Right Cessation
- 2010-07-28 HK HK10107238.5A patent/HK1140693A1/xx not_active IP Right Cessation
- 2010-10-19 ZA ZA2010/07449A patent/ZA201007449B/en unknown
- 2010-10-22 CR CR11749A patent/CR11749A/es unknown
- 2010-10-28 IL IL208992A patent/IL208992A/en not_active IP Right Cessation
- 2010-12-10 MA MA33418A patent/MA32389B1/fr unknown
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2011
- 2011-05-30 HK HK11105324.3A patent/HK1151229A1/xx not_active IP Right Cessation
- 2011-05-30 HK HK15102533.3A patent/HK1202054A1/xx unknown
- 2011-09-23 US US13/242,012 patent/US8372809B2/en not_active Expired - Fee Related
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2012
- 2012-09-12 JP JP2012200728A patent/JP5638044B2/ja not_active Expired - Fee Related
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2013
- 2013-01-04 US US13/734,301 patent/US9066916B2/en not_active Expired - Fee Related
- 2013-03-05 US US13/784,963 patent/US9205132B2/en not_active Expired - Fee Related
- 2013-09-02 IL IL228244A patent/IL228244A/en not_active IP Right Cessation
- 2013-11-28 MY MYPI2013004312A patent/MY158327A/en unknown
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2014
- 2014-01-23 HK HK14100736.3A patent/HK1187550A1/zh not_active IP Right Cessation
- 2014-08-14 JP JP2014165276A patent/JP5875646B2/ja not_active Expired - Fee Related
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2015
- 2015-05-28 US US14/723,701 patent/US9579363B2/en not_active Expired - Fee Related
- 2015-08-10 HR HRP20150845TT patent/HRP20150845T1/hr unknown
- 2015-09-18 CY CY20151100824T patent/CY1116925T1/el unknown
- 2015-10-09 JP JP2015201153A patent/JP2016053040A/ja active Pending
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2016
- 2016-08-18 IL IL247351A patent/IL247351A0/en unknown
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2017
- 2017-01-23 US US15/412,447 patent/US20170151311A1/en not_active Abandoned
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