SI2288373T1 - Relaksin za uporabo pri zdravljenju dispneje, povezane z akutnim srčnim popuščanjem - Google Patents

Relaksin za uporabo pri zdravljenju dispneje, povezane z akutnim srčnim popuščanjem

Info

Publication number
SI2288373T1
SI2288373T1 SI200931246T SI200931246T SI2288373T1 SI 2288373 T1 SI2288373 T1 SI 2288373T1 SI 200931246 T SI200931246 T SI 200931246T SI 200931246 T SI200931246 T SI 200931246T SI 2288373 T1 SI2288373 T1 SI 2288373T1
Authority
SI
Slovenia
Prior art keywords
relaxin
treating
heart failure
acute heart
dyspnea associated
Prior art date
Application number
SI200931246T
Other languages
English (en)
Inventor
Elaine Unemori
Sam L. Teichman
Gad Cotter
Dennis R. Stewart
Martha Jo Whitehouse
Original Assignee
Corthera, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corthera, Inc. filed Critical Corthera, Inc.
Publication of SI2288373T1 publication Critical patent/SI2288373T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200931246T 2008-05-16 2009-05-15 Relaksin za uporabo pri zdravljenju dispneje, povezane z akutnim srčnim popuščanjem SI2288373T1 (sl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US19054508P 2008-08-28 2008-08-28
US20124008P 2008-12-08 2008-12-08
US16433309P 2009-03-27 2009-03-27
PCT/US2009/044249 WO2009140659A2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure
EP09747740.0A EP2288373B1 (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure

Publications (1)

Publication Number Publication Date
SI2288373T1 true SI2288373T1 (sl) 2015-12-31

Family

ID=40834101

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931246T SI2288373T1 (sl) 2008-05-16 2009-05-15 Relaksin za uporabo pri zdravljenju dispneje, povezane z akutnim srčnim popuščanjem

Country Status (30)

Country Link
US (7) US8415301B2 (sl)
EP (2) EP2288373B1 (sl)
JP (4) JP5651586B2 (sl)
CN (3) CN106177914A (sl)
AR (1) AR071810A1 (sl)
AU (1) AU2009246114B2 (sl)
BR (1) BRPI0913011A2 (sl)
CA (1) CA2724540C (sl)
CR (1) CR11749A (sl)
CY (1) CY1116925T1 (sl)
DK (1) DK2288373T3 (sl)
EA (2) EA022948B1 (sl)
ES (1) ES2546287T3 (sl)
GB (2) GB2459983B (sl)
HK (5) HK1139051A1 (sl)
HR (1) HRP20150845T1 (sl)
HU (1) HUE025483T2 (sl)
IL (3) IL208992A (sl)
MA (1) MA32389B1 (sl)
MX (1) MX2010012450A (sl)
MY (2) MY159803A (sl)
NZ (3) NZ598709A (sl)
PL (1) PL2288373T3 (sl)
PT (1) PT2288373E (sl)
SG (2) SG10201609580YA (sl)
SI (1) SI2288373T1 (sl)
TW (1) TWI386202B (sl)
UA (1) UA99953C2 (sl)
WO (1) WO2009140659A2 (sl)
ZA (1) ZA201007449B (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102026649A (zh) * 2008-05-16 2011-04-20 科尔泰拉公司 治疗慢性心力衰竭的方法
AU2009246114B2 (en) * 2008-05-16 2013-01-31 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
AU2011224341B2 (en) 2010-03-10 2014-07-10 The University Of Florida Research Foundation, Inc. Modulating aquaporins with relaxin
EP2601532B1 (en) * 2010-08-06 2016-01-27 Mycartis N.V. Perlecan as a biomarker for renal dysfunction
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
MX346786B (es) * 2010-08-17 2017-03-31 Ambrx Inc Polipeptidos de relaxina modificados y sus usos.
MX2014000031A (es) * 2011-07-01 2014-07-09 Bayer Ip Gmbh Polipeptidos de fusion de relaxina y usos de los mismos.
AU2013202269A1 (en) * 2011-10-26 2013-05-16 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
EP3311830A1 (en) * 2012-02-14 2018-04-25 The Regents of The University of California Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
EP2844345B1 (en) 2012-05-04 2022-08-03 The United States of America, as Represented by The Secretary, Department of Health and Human Services Modulators of the relaxin receptor 1
JP6329957B2 (ja) 2012-10-26 2018-05-23 キエージィ ファーマチェウティチ エス．ペー．アー． 心不全において血圧を制御するためおよび呼吸困難を低減させるための方法
KR102266460B1 (ko) 2013-04-05 2021-06-17 에스씨파마슈티칼스 인코포레이티드 퓨로세마이드의 피하 투여용 약학 제형
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
MA39320A1 (fr) * 2014-02-03 2018-04-30 Novartis Ag Filtres pour perfuseurs
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
JP6820748B2 (ja) * 2014-06-13 2021-01-27 ノバルティス アーゲー Ｇｄｆ−１５を減少させるためのセレラキシンの使用
US11161891B2 (en) 2015-12-09 2021-11-02 The Scripps Research Institute Relaxin immunoglobulin fusion proteins and methods of use
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
SG11201907209QA (en) 2017-02-08 2019-09-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
US11246851B2 (en) 2019-01-04 2022-02-15 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
JP7465881B2 (ja) 2019-01-31 2024-04-11 エスシーファーマシューティカルズ インコーポレイテッド フロセミドの濃縮液体医薬製剤及びそれを投与する方法
WO2024047130A1 (en) 2022-08-31 2024-03-07 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Immunosuppressive medicament and method of treatment

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023321A (en) 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
US5166191A (en) * 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
US5478807A (en) 1991-08-19 1995-12-26 Genentech, Inc. Use of relaxin in the treatment of bradycardia
JP3954091B2 (ja) 1993-06-21 2007-08-08 ジェネンテック・インコーポレーテッド リラキシンの製造方法
CA2145515A1 (en) 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US5811395A (en) 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
ATE228004T1 (de) 1995-08-15 2002-12-15 Connetics Corp Verwendung von relaxin zur stimulierung der angiogenese
US6723702B2 (en) 2000-02-09 2004-04-20 Ras Medical, Inc. Use of relaxin treat diseases related to vasoconstriction
DE10155843A1 (de) * 2000-11-16 2003-01-30 Immundiagnostik Ag Verfahren zur Prognose und Diagnose von Herzinsuffizienz
US20050113286A1 (en) 2002-03-18 2005-05-26 Schreiner George F. Methods for treating congestive heart failure
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
CN1968717B (zh) * 2004-03-30 2013-08-21 延世大学教产学协力团 含有松弛素基因的基因送递系统和使用松弛素的药物组合物
US20060264367A1 (en) 2005-05-21 2006-11-23 Howard Florey Institute Prevention of fibrosis following cardiac injury
WO2007008907A2 (en) 2005-07-11 2007-01-18 Abbott Laboratories Methods for determining how to treat congestive heart failure
US8492329B2 (en) 2007-07-12 2013-07-23 Compugen Ltd. Bioactive peptides and methods of using same
AU2009246114B2 (en) * 2008-05-16 2013-01-31 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
CN102026649A (zh) 2008-05-16 2011-04-20 科尔泰拉公司 治疗慢性心力衰竭的方法

Also Published As

Publication number Publication date
AR071810A1 (es) 2010-07-14
HK1139051A1 (en) 2010-09-10
NZ598709A (en) 2013-09-27
WO2009140659A2 (en) 2009-11-19
CA2724540C (en) 2014-07-08
JP2016053040A (ja) 2016-04-14
GB2462221B (en) 2010-09-01
CN103212063A (zh) 2013-07-24
CR11749A (es) 2011-02-11
NZ701038A (en) 2016-01-29
GB2462221A (en) 2010-02-03
SG191587A1 (en) 2013-07-31
CY1116925T1 (el) 2017-04-05
EA022948B1 (ru) 2016-03-31
TWI386202B (zh) 2013-02-21
ZA201007449B (en) 2011-06-29
CN103212063B (zh) 2015-07-22
BRPI0913011A2 (pt) 2019-09-03
UA99953C2 (uk) 2012-10-25
GB0918132D0 (en) 2009-12-02
ES2546287T3 (es) 2015-09-22
WO2009140659A3 (en) 2010-07-22
EP2829280A1 (en) 2015-01-28
US20150320834A1 (en) 2015-11-12
HRP20150845T1 (hr) 2015-11-06
AU2009246114B2 (en) 2013-01-31
JP2011520918A (ja) 2011-07-21
PT2288373E (pt) 2015-10-19
HK1202054A1 (en) 2015-09-18
US20120040902A1 (en) 2012-02-16
US20100048475A1 (en) 2010-02-25
JP5651586B2 (ja) 2015-01-14
CA2724540A1 (en) 2009-11-19
AU2009246114A1 (en) 2009-11-19
JP2015013870A (ja) 2015-01-22
GB2459983A (en) 2009-11-18
US9579363B2 (en) 2017-02-28
SG10201609580YA (en) 2016-12-29
US20120040903A1 (en) 2012-02-16
US8372809B2 (en) 2013-02-12
GB2459983B (en) 2010-04-28
HK1140693A1 (en) 2010-10-22
HUE025483T2 (en) 2016-02-29
US9066916B2 (en) 2015-06-30
MY159803A (en) 2017-02-15
EA201001771A1 (ru) 2011-06-30
MX2010012450A (es) 2011-03-21
US8415301B2 (en) 2013-04-09
IL228244A (en) 2016-10-31
CN102036679A (zh) 2011-04-27
US20130116181A1 (en) 2013-05-09
EP2288373B1 (en) 2015-06-24
IL247351A0 (en) 2016-09-29
TW200948353A (en) 2009-12-01
CN106177914A (zh) 2016-12-07
JP5875646B2 (ja) 2016-03-02
US8053411B2 (en) 2011-11-08
EA201500552A1 (ru) 2016-07-29
JP2013040174A (ja) 2013-02-28
HK1151229A1 (en) 2012-01-27
JP5638044B2 (ja) 2014-12-10
DK2288373T3 (en) 2015-09-28
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
MY158327A (en) 2016-09-30
US9205132B2 (en) 2015-12-08
IL208992A0 (en) 2011-01-31
HK1187550A1 (zh) 2014-04-11
IL208992A (en) 2013-09-30
US20130210730A1 (en) 2013-08-15
PL2288373T3 (pl) 2015-11-30
US20170151311A1 (en) 2017-06-01
EP2288373A2 (en) 2011-03-02
GB0908432D0 (en) 2009-06-24

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