ES2546287T3 - Relaxina para uso en el tratamiento de la disnea asociada con la insuficiencia cardiaca aguda - Google Patents
Relaxina para uso en el tratamiento de la disnea asociada con la insuficiencia cardiaca aguda Download PDFInfo
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- ES2546287T3 ES2546287T3 ES09747740.0T ES09747740T ES2546287T3 ES 2546287 T3 ES2546287 T3 ES 2546287T3 ES 09747740 T ES09747740 T ES 09747740T ES 2546287 T3 ES2546287 T3 ES 2546287T3
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- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US12788908P | 2008-05-16 | 2008-05-16 | |
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US190545P | 2008-08-28 | ||
| US20124008P | 2008-12-08 | 2008-12-08 | |
| US201240P | 2008-12-08 | ||
| US16433309P | 2009-03-27 | 2009-03-27 | |
| US164333P | 2009-03-27 | ||
| PCT/US2009/044249 WO2009140659A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating dyspnea associated with acute heart failure |
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| ES2546287T3 true ES2546287T3 (es) | 2015-09-22 |
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| ZA (1) | ZA201007449B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2009246112B2 (en) * | 2008-05-16 | 2013-05-02 | Corthera, Inc. | Method of treating chronic heart failure |
| US8415301B2 (en) * | 2008-05-16 | 2013-04-09 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure by administering H2 relaxin |
| KR101800040B1 (ko) * | 2010-03-10 | 2017-11-21 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 릴랙신을 사용한 아쿠아포린의 조절 |
| JP5899213B2 (ja) | 2010-08-06 | 2016-04-06 | マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ | 腎機能不全のバイオマーカーとしてのパールカン |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| PE20140160A1 (es) * | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| AU2012280474A1 (en) * | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| WO2013059879A1 (en) * | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| JP6562632B2 (ja) * | 2012-02-14 | 2019-08-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現 |
| US9452973B2 (en) | 2012-05-04 | 2016-09-27 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| CN110840890A (zh) | 2012-10-26 | 2020-02-28 | 凯西制药公司 | 用于在心力衰竭中控制血压和减轻呼吸困难的方法 |
| CN105431145B (zh) | 2013-04-05 | 2019-12-10 | Sc医药品有限公司 | 用于呋塞米的皮下施用的药物制剂 |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| HK1226581A1 (zh) * | 2014-02-03 | 2017-09-29 | Novartis Ag | 用於输液器上的过滤器 |
| EP2946788A1 (en) * | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| JP6820748B2 (ja) * | 2014-06-13 | 2021-01-27 | ノバルティス アーゲー | Ｇｄｆ−１５を減少させるためのセレラキシンの使用 |
| US11161891B2 (en) | 2015-12-09 | 2021-11-02 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
| CN108697330B (zh) | 2016-02-12 | 2022-07-15 | 心脏起搏器股份公司 | 用于患者监视的系统和方法 |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| ES3041602T3 (en) | 2018-12-10 | 2025-11-13 | Sq Innovation Ag | Pharmaceutical compositions of furosemide and uses thereof |
| ES3058386T3 (es) | 2019-01-04 | 2026-03-10 | Sq Innovation Ag | Composiciones farmacéuticas de furosemida |
| EP3906020B1 (en) | 2019-01-04 | 2025-12-31 | SQ Innovation AG | Pharmaceutical compositions of torsemide and their uses |
| AU2020214314B2 (en) | 2019-01-31 | 2025-09-18 | Scpharmaceuticals Inc. | Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same |
| JP2025528469A (ja) | 2022-08-31 | 2025-08-28 | リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー． カーゲー | 免疫抑制薬及び処置方法 |
| EP4791358A1 (en) | 2023-09-15 | 2026-08-19 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Relaxin medication |
| CN121837268B (zh) * | 2026-03-12 | 2026-06-16 | 西安建筑科技大学 | 一种基于渐进性风险排序的尘肺病早期精细化筛查方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023321A (en) * | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| US5478807A (en) | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| CA2165781C (en) | 1993-06-21 | 2007-02-13 | Tim Breece | Process for producing relaxin |
| CA2145515A1 (en) * | 1993-07-27 | 1995-02-09 | Mario Bigazzi | Use of relaxin as therapeutic or preventing agent |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| ES2187667T3 (es) * | 1995-08-15 | 2003-06-16 | Connetics Corp | Uso de relaxina para estimular angiogenesis. |
| ATE362770T1 (de) * | 2000-02-09 | 2007-06-15 | Bas Medical Inc | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US7878978B2 (en) * | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| EP1729817B1 (en) * | 2004-03-30 | 2014-03-05 | Industry-Academic Cooperation Foundation | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
| US20060264367A1 (en) | 2005-05-21 | 2006-11-23 | Howard Florey Institute | Prevention of fibrosis following cardiac injury |
| WO2007008907A2 (en) * | 2005-07-11 | 2007-01-18 | Abbott Laboratories | Methods for determining how to treat congestive heart failure |
| CA2693651A1 (en) | 2007-07-12 | 2009-01-15 | Ronen Shemesh | Bioactive peptides and method of using same |
| AU2009246112B2 (en) | 2008-05-16 | 2013-05-02 | Corthera, Inc. | Method of treating chronic heart failure |
| US8415301B2 (en) * | 2008-05-16 | 2013-04-09 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure by administering H2 relaxin |
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- 2009-05-15 PL PL09747740T patent/PL2288373T3/pl unknown
- 2009-05-15 EP EP14167842.5A patent/EP2829280A1/en not_active Withdrawn
- 2009-05-15 HU HUE09747740A patent/HUE025483T2/en unknown
- 2009-05-15 SI SI200931246T patent/SI2288373T1/sl unknown
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- 2009-05-15 EP EP09747740.0A patent/EP2288373B1/en active Active
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