IL208992A - Use of h2 relaxin active pharmacist in the manufacture of drugs for the treatment of shortness of breath related to acute heart failure and decompensatory acute heart failure - Google Patents
Use of h2 relaxin active pharmacist in the manufacture of drugs for the treatment of shortness of breath related to acute heart failure and decompensatory acute heart failureInfo
- Publication number
- IL208992A IL208992A IL208992A IL20899210A IL208992A IL 208992 A IL208992 A IL 208992A IL 208992 A IL208992 A IL 208992A IL 20899210 A IL20899210 A IL 20899210A IL 208992 A IL208992 A IL 208992A
- Authority
- IL
- Israel
- Prior art keywords
- heart failure
- acute
- relaxin
- medicaments
- manufacture
- Prior art date
Links
- 206010007556 Cardiac failure acute Diseases 0.000 title abstract 3
- 102000003743 Relaxin Human genes 0.000 title abstract 2
- 108090000103 Relaxin Proteins 0.000 title abstract 2
- 208000000059 Dyspnea Diseases 0.000 title 1
- 206010013975 Dyspnoeas Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 2
- 230000000747 cardiac effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12788908P | 2008-05-16 | 2008-05-16 | |
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US20124008P | 2008-12-08 | 2008-12-08 | |
| US16433309P | 2009-03-27 | 2009-03-27 | |
| PCT/US2009/044249 WO2009140659A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating dyspnea associated with acute heart failure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL208992A0 IL208992A0 (en) | 2011-01-31 |
| IL208992A true IL208992A (en) | 2013-09-30 |
Family
ID=40834101
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL208992A IL208992A (en) | 2008-05-16 | 2010-10-28 | Use of h2 relaxin active pharmacist in the manufacture of drugs for the treatment of shortness of breath related to acute heart failure and decompensatory acute heart failure |
| IL228244A IL228244A (en) | 2008-05-16 | 2013-09-02 | Pharmaceutically active human h2 relaxin for use as a medicament for treating dyspnea associated with acute heart failure |
| IL247351A IL247351A0 (en) | 2008-05-16 | 2016-08-18 | A pharmaceutically active human H2 relaxin for use as a drug in the treatment of dyspnea associated with severe heart failure |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL228244A IL228244A (en) | 2008-05-16 | 2013-09-02 | Pharmaceutically active human h2 relaxin for use as a medicament for treating dyspnea associated with acute heart failure |
| IL247351A IL247351A0 (en) | 2008-05-16 | 2016-08-18 | A pharmaceutically active human H2 relaxin for use as a drug in the treatment of dyspnea associated with severe heart failure |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US8053411B2 (enExample) |
| EP (2) | EP2288373B1 (enExample) |
| JP (4) | JP5651586B2 (enExample) |
| CN (3) | CN103212063B (enExample) |
| AR (1) | AR071810A1 (enExample) |
| AU (1) | AU2009246114B2 (enExample) |
| BR (1) | BRPI0913011A2 (enExample) |
| CA (1) | CA2724540C (enExample) |
| CR (1) | CR11749A (enExample) |
| CY (1) | CY1116925T1 (enExample) |
| DK (1) | DK2288373T3 (enExample) |
| EA (2) | EA022948B1 (enExample) |
| ES (1) | ES2546287T3 (enExample) |
| GB (2) | GB2462221B (enExample) |
| HK (1) | HK1202054A1 (enExample) |
| HR (1) | HRP20150845T1 (enExample) |
| HU (1) | HUE025483T2 (enExample) |
| IL (3) | IL208992A (enExample) |
| MA (1) | MA32389B1 (enExample) |
| MX (1) | MX2010012450A (enExample) |
| MY (2) | MY159803A (enExample) |
| NZ (3) | NZ701038A (enExample) |
| PL (1) | PL2288373T3 (enExample) |
| PT (1) | PT2288373E (enExample) |
| SG (2) | SG191587A1 (enExample) |
| SI (1) | SI2288373T1 (enExample) |
| TW (1) | TWI386202B (enExample) |
| UA (1) | UA99953C2 (enExample) |
| WO (1) | WO2009140659A2 (enExample) |
| ZA (1) | ZA201007449B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140659A2 (en) * | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure |
| MX336145B (es) * | 2008-05-16 | 2016-01-08 | Corthera Inc | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
| US20130053318A1 (en) | 2010-03-10 | 2013-02-28 | Parry Laura | Modulating aquaporins with relaxin |
| EP2601532B1 (en) * | 2010-08-06 | 2016-01-27 | Mycartis N.V. | Perlecan as a biomarker for renal dysfunction |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| SMT201900495T1 (it) | 2010-08-17 | 2019-11-13 | Ambrx Inc | Polipeptidi di relaxina modificati e loro usi |
| US9382305B2 (en) * | 2011-07-01 | 2016-07-05 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| WO2013059879A1 (en) * | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| PT2814513T (pt) * | 2012-02-14 | 2018-03-02 | Univ California | Entrega sistémica e expressão regulada de genes parácrinos para doenças cardiovasculares e outras doenças |
| ES2929283T3 (es) | 2012-05-04 | 2022-11-28 | Us Health | Moduladores del receptor de relaxina 1 |
| EA030354B1 (ru) * | 2012-10-26 | 2018-07-31 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Способ уменьшения диспноэ у пациента с острой сердечной недостаточностью |
| US9884039B2 (en) | 2013-04-05 | 2018-02-06 | Scpharmaceuticals Inc. | Pharmaceutical formulations for subcutaneous administration of furosemide |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| SG11201605273XA (en) * | 2014-02-03 | 2016-08-30 | Novartis Ag | Filters for infusion sets |
| EP2946788A1 (en) * | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
| BR112016028833A2 (pt) * | 2014-06-13 | 2017-08-22 | Novartis Ag | uso de serelaxinaa para reduzir gdf-15 |
| PT3387019T (pt) | 2015-12-09 | 2022-01-14 | Scripps Research Inst | Proteínas de fusão de imunoglobulina de relaxina e métodos de uso |
| WO2017139164A1 (en) | 2016-02-12 | 2017-08-17 | Cardiac Pacemakers, Inc. | Systems and methods for patient monitoring |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| US11832970B2 (en) | 2017-07-26 | 2023-12-05 | Cardiac Pacemakers, Inc. | Worsening heart failure stratification |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| US12403120B2 (en) | 2018-12-10 | 2025-09-02 | Sq Innovation Ag | Pharmaceutical compositions of furosemide and uses thereof |
| EP3906019B1 (en) | 2019-01-04 | 2025-11-26 | SQ Innovation AG | Pharmaceutical compositions of furosemide |
| EP3906020B1 (en) | 2019-01-04 | 2025-12-31 | SQ Innovation AG | Pharmaceutical compositions of torsemide and their uses |
| CA3128033A1 (en) | 2019-01-31 | 2020-08-06 | Scpharmaceuticals Inc. | Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same |
| AU2023332056A1 (en) | 2022-08-31 | 2025-03-13 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Immunosuppressive medicament and method of treatment |
| WO2025056188A1 (en) | 2023-09-15 | 2025-03-20 | Relaxera Pharmazeutische Gmbh & Co. Kg | Relaxin medication |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| US5166191A (en) | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| EP0707650B1 (en) * | 1993-06-21 | 2003-05-21 | Genentech, Inc. | Process for producing human relaxin |
| WO1995003822A2 (en) * | 1993-07-27 | 1995-02-09 | Mario Bigazzi | Use of relaxin as therapeutic or preventing agent |
| US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| DE69624925T2 (de) | 1995-08-15 | 2003-09-04 | Connetics Corp., Palo Alto | Verwendung von relaxin zur stimulierung der angiogenese |
| DE60128540T2 (de) | 2000-02-09 | 2008-01-31 | Bas Medical, Inc., San Mateo | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| WO2006075819A1 (en) * | 2004-03-30 | 2006-07-20 | Industry-Academic Cooperation Foundation, Yonsei University | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
| US20060264367A1 (en) | 2005-05-21 | 2006-11-23 | Howard Florey Institute | Prevention of fibrosis following cardiac injury |
| US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
| AU2008273813B2 (en) | 2007-07-12 | 2013-06-13 | Compugen Ltd. | Bioactive peptides and method of using same |
| MX336145B (es) | 2008-05-16 | 2016-01-08 | Corthera Inc | Metodo para el tratamiento de insuficiencia cardiaca cronica. |
| WO2009140659A2 (en) * | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of treating dyspnea associated with acute heart failure |
-
2009
- 2009-05-15 WO PCT/US2009/044249 patent/WO2009140659A2/en not_active Ceased
- 2009-05-15 HU HUE09747740A patent/HUE025483T2/en unknown
- 2009-05-15 MX MX2010012450A patent/MX2010012450A/es active IP Right Grant
- 2009-05-15 JP JP2011509783A patent/JP5651586B2/ja not_active Expired - Fee Related
- 2009-05-15 AU AU2009246114A patent/AU2009246114B2/en not_active Ceased
- 2009-05-15 PL PL09747740T patent/PL2288373T3/pl unknown
- 2009-05-15 US US12/467,214 patent/US8053411B2/en not_active Expired - Fee Related
- 2009-05-15 DK DK09747740.0T patent/DK2288373T3/en active
- 2009-05-15 UA UAA201012879A patent/UA99953C2/uk unknown
- 2009-05-15 ES ES09747740.0T patent/ES2546287T3/es active Active
- 2009-05-15 GB GB0918132A patent/GB2462221B/en not_active Expired - Fee Related
- 2009-05-15 GB GB0908432A patent/GB2459983B/en not_active Expired - Fee Related
- 2009-05-15 EP EP09747740.0A patent/EP2288373B1/en active Active
- 2009-05-15 US US12/992,356 patent/US8415301B2/en not_active Expired - Fee Related
- 2009-05-15 BR BRPI0913011A patent/BRPI0913011A2/pt not_active IP Right Cessation
- 2009-05-15 TW TW098116328A patent/TWI386202B/zh not_active IP Right Cessation
- 2009-05-15 EA EA201001771A patent/EA022948B1/ru not_active IP Right Cessation
- 2009-05-15 CN CN201310127326.6A patent/CN103212063B/zh not_active Expired - Fee Related
- 2009-05-15 NZ NZ701038A patent/NZ701038A/en not_active IP Right Cessation
- 2009-05-15 NZ NZ598709A patent/NZ598709A/xx not_active IP Right Cessation
- 2009-05-15 SG SG2013038260A patent/SG191587A1/en unknown
- 2009-05-15 CA CA2724540A patent/CA2724540C/en not_active Expired - Fee Related
- 2009-05-15 NZ NZ589009A patent/NZ589009A/en not_active IP Right Cessation
- 2009-05-15 SG SG10201609580YA patent/SG10201609580YA/en unknown
- 2009-05-15 EA EA201500552A patent/EA201500552A1/ru unknown
- 2009-05-15 CN CN2009801177504A patent/CN102036679A/zh active Pending
- 2009-05-15 EP EP14167842.5A patent/EP2829280A1/en not_active Withdrawn
- 2009-05-15 AR ARP090101762A patent/AR071810A1/es unknown
- 2009-05-15 HR HRP20150845TT patent/HRP20150845T1/hr unknown
- 2009-05-15 PT PT97477400T patent/PT2288373E/pt unknown
- 2009-05-15 MY MYPI2010005049A patent/MY159803A/en unknown
- 2009-05-15 SI SI200931246T patent/SI2288373T1/sl unknown
- 2009-05-15 CN CN201610565105.0A patent/CN106177914A/zh active Pending
-
2010
- 2010-10-19 ZA ZA2010/07449A patent/ZA201007449B/en unknown
- 2010-10-22 CR CR11749A patent/CR11749A/es unknown
- 2010-10-28 IL IL208992A patent/IL208992A/en not_active IP Right Cessation
- 2010-12-10 MA MA33418A patent/MA32389B1/fr unknown
-
2011
- 2011-05-30 HK HK15102533.3A patent/HK1202054A1/en unknown
- 2011-09-23 US US13/242,012 patent/US8372809B2/en not_active Expired - Fee Related
-
2012
- 2012-09-12 JP JP2012200728A patent/JP5638044B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-04 US US13/734,301 patent/US9066916B2/en not_active Expired - Fee Related
- 2013-03-05 US US13/784,963 patent/US9205132B2/en not_active Expired - Fee Related
- 2013-09-02 IL IL228244A patent/IL228244A/en not_active IP Right Cessation
- 2013-11-28 MY MYPI2013004312A patent/MY158327A/en unknown
-
2014
- 2014-08-14 JP JP2014165276A patent/JP5875646B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-28 US US14/723,701 patent/US9579363B2/en not_active Expired - Fee Related
- 2015-09-18 CY CY20151100824T patent/CY1116925T1/el unknown
- 2015-10-09 JP JP2015201153A patent/JP2016053040A/ja active Pending
-
2016
- 2016-08-18 IL IL247351A patent/IL247351A0/en unknown
-
2017
- 2017-01-23 US US15/412,447 patent/US20170151311A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |