JP5651586B2 - 急性心不全に伴う呼吸困難のリラキシンによる治療 - Google Patents

急性心不全に伴う呼吸困難のリラキシンによる治療 Download PDF

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Publication number
JP5651586B2
JP5651586B2 JP2011509783A JP2011509783A JP5651586B2 JP 5651586 B2 JP5651586 B2 JP 5651586B2 JP 2011509783 A JP2011509783 A JP 2011509783A JP 2011509783 A JP2011509783 A JP 2011509783A JP 5651586 B2 JP5651586 B2 JP 5651586B2
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Prior art keywords
relaxin
day
heart failure
subject
acute
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Japanese (ja)
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JP2011520918A5 (enExample
JP2011520918A (ja
Inventor
ウネモリ,エライネ
タイクマン,サム,エル.
コッター,ガッド
スチュアート,デニス,アール.
ホワイトハウス,マーサ,ジョー
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コーセラ,インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011509783A 2008-05-16 2009-05-15 急性心不全に伴う呼吸困難のリラキシンによる治療 Expired - Fee Related JP5651586B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US61/127,889 2008-05-16
US19054508P 2008-08-28 2008-08-28
US61/190,545 2008-08-28
US20124008P 2008-12-08 2008-12-08
US61/201,240 2008-12-08
US16433309P 2009-03-27 2009-03-27
US61/164,333 2009-03-27
PCT/US2009/044249 WO2009140659A2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012200728A Division JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療

Publications (3)

Publication Number Publication Date
JP2011520918A JP2011520918A (ja) 2011-07-21
JP2011520918A5 JP2011520918A5 (enExample) 2012-11-01
JP5651586B2 true JP5651586B2 (ja) 2015-01-14

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JP2011509783A Expired - Fee Related JP5651586B2 (ja) 2008-05-16 2009-05-15 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2012200728A Expired - Fee Related JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2014165276A Expired - Fee Related JP5875646B2 (ja) 2008-05-16 2014-08-14 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2015201153A Pending JP2016053040A (ja) 2008-05-16 2015-10-09 急性心不全に伴う呼吸困難のリラキシンによる治療

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012200728A Expired - Fee Related JP5638044B2 (ja) 2008-05-16 2012-09-12 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2014165276A Expired - Fee Related JP5875646B2 (ja) 2008-05-16 2014-08-14 急性心不全に伴う呼吸困難のリラキシンによる治療
JP2015201153A Pending JP2016053040A (ja) 2008-05-16 2015-10-09 急性心不全に伴う呼吸困難のリラキシンによる治療

Country Status (30)

Country Link
US (7) US8415301B2 (enExample)
EP (2) EP2829280A1 (enExample)
JP (4) JP5651586B2 (enExample)
CN (3) CN102036679A (enExample)
AR (1) AR071810A1 (enExample)
AU (1) AU2009246114B2 (enExample)
BR (1) BRPI0913011A2 (enExample)
CA (1) CA2724540C (enExample)
CR (1) CR11749A (enExample)
CY (1) CY1116925T1 (enExample)
DK (1) DK2288373T3 (enExample)
EA (2) EA022948B1 (enExample)
ES (1) ES2546287T3 (enExample)
GB (2) GB2459983B (enExample)
HK (1) HK1202054A1 (enExample)
HR (1) HRP20150845T1 (enExample)
HU (1) HUE025483T2 (enExample)
IL (3) IL208992A (enExample)
MA (1) MA32389B1 (enExample)
MX (1) MX2010012450A (enExample)
MY (2) MY159803A (enExample)
NZ (3) NZ701038A (enExample)
PL (1) PL2288373T3 (enExample)
PT (1) PT2288373E (enExample)
SG (2) SG191587A1 (enExample)
SI (1) SI2288373T1 (enExample)
TW (1) TWI386202B (enExample)
UA (1) UA99953C2 (enExample)
WO (1) WO2009140659A2 (enExample)
ZA (1) ZA201007449B (enExample)

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AU2009246112B2 (en) * 2008-05-16 2013-05-02 Corthera, Inc. Method of treating chronic heart failure
US8415301B2 (en) * 2008-05-16 2013-04-09 Corthera, Inc. Method of treating dyspnea associated with acute heart failure by administering H2 relaxin
KR101800040B1 (ko) * 2010-03-10 2017-11-21 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 릴랙신을 사용한 아쿠아포린의 조절
JP5899213B2 (ja) 2010-08-06 2016-04-06 マイカーティス エヌ.ヴェ.MyCartis NV 腎機能不全のバイオマーカーとしてのパールカン
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
PE20140160A1 (es) * 2010-08-17 2014-02-08 Ambrx Inc Polipeptidos de relaxina modificados y sus usos
AU2012280474A1 (en) * 2011-07-01 2014-01-16 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
WO2013059879A1 (en) * 2011-10-26 2013-05-02 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
JP6562632B2 (ja) * 2012-02-14 2019-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現
US9452973B2 (en) 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1
CN110840890A (zh) 2012-10-26 2020-02-28 凯西制药公司 用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN105431145B (zh) 2013-04-05 2019-12-10 Sc医药品有限公司 用于呋塞米的皮下施用的药物制剂
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
HK1226581A1 (zh) * 2014-02-03 2017-09-29 Novartis Ag 用於输液器上的过滤器
EP2946788A1 (en) * 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
JP6820748B2 (ja) * 2014-06-13 2021-01-27 ノバルティス アーゲー Gdf−15を減少させるためのセレラキシンの使用
US11161891B2 (en) 2015-12-09 2021-11-02 The Scripps Research Institute Relaxin immunoglobulin fusion proteins and methods of use
CN108697330B (zh) 2016-02-12 2022-07-15 心脏起搏器股份公司 用于患者监视的系统和方法
SG10201912034UA (en) 2017-02-08 2020-02-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (zh) * 2017-08-18 2017-11-10 温州医科大学附属第医院 一种保护慢性心衰肾功能的药物组合物
ES3041602T3 (en) 2018-12-10 2025-11-13 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
ES3058386T3 (es) 2019-01-04 2026-03-10 Sq Innovation Ag Composiciones farmacéuticas de furosemida
EP3906020B1 (en) 2019-01-04 2025-12-31 SQ Innovation AG Pharmaceutical compositions of torsemide and their uses
AU2020214314B2 (en) 2019-01-31 2025-09-18 Scpharmaceuticals Inc. Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
JP2025528469A (ja) 2022-08-31 2025-08-28 リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー. カーゲー 免疫抑制薬及び処置方法
EP4791358A1 (en) 2023-09-15 2026-08-19 Relaxera Pharmazeutische Gesellschaft mbH & Co. KG Relaxin medication
CN121837268B (zh) * 2026-03-12 2026-06-16 西安建筑科技大学 一种基于渐进性风险排序的尘肺病早期精细化筛查方法

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US5811395A (en) * 1995-06-07 1998-09-22 Medical University Of South Carolina Relaxin analogs and derivatives methods and uses thereof
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US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
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AU2009246112B2 (en) 2008-05-16 2013-05-02 Corthera, Inc. Method of treating chronic heart failure
US8415301B2 (en) * 2008-05-16 2013-04-09 Corthera, Inc. Method of treating dyspnea associated with acute heart failure by administering H2 relaxin

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Publication number Publication date
MY159803A (en) 2017-02-15
US20150320834A1 (en) 2015-11-12
IL228244A (en) 2016-10-31
NZ701038A (en) 2016-01-29
PL2288373T3 (pl) 2015-11-30
HK1187550A1 (zh) 2014-04-11
TW200948353A (en) 2009-12-01
EP2288373B1 (en) 2015-06-24
US8053411B2 (en) 2011-11-08
MA32389B1 (fr) 2011-06-01
NZ589009A (en) 2012-05-25
HK1151229A1 (en) 2012-01-27
WO2009140659A3 (en) 2010-07-22
CA2724540A1 (en) 2009-11-19
HK1139051A1 (en) 2010-09-10
GB2459983A (en) 2009-11-18
EP2829280A1 (en) 2015-01-28
GB2462221A (en) 2010-02-03
CN106177914A (zh) 2016-12-07
EA022948B1 (ru) 2016-03-31
JP2016053040A (ja) 2016-04-14
BRPI0913011A2 (pt) 2019-09-03
HUE025483T2 (en) 2016-02-29
US9579363B2 (en) 2017-02-28
UA99953C2 (uk) 2012-10-25
ES2546287T3 (es) 2015-09-22
US9066916B2 (en) 2015-06-30
AU2009246114B2 (en) 2013-01-31
US20130116181A1 (en) 2013-05-09
SG191587A1 (en) 2013-07-31
MX2010012450A (es) 2011-03-21
AR071810A1 (es) 2010-07-14
MY158327A (en) 2016-09-30
DK2288373T3 (en) 2015-09-28
SI2288373T1 (sl) 2015-12-31
CR11749A (es) 2011-02-11
CA2724540C (en) 2014-07-08
US20120040903A1 (en) 2012-02-16
TWI386202B (zh) 2013-02-21
IL208992A0 (en) 2011-01-31
US8372809B2 (en) 2013-02-12
HK1202054A1 (en) 2015-09-18
PT2288373E (pt) 2015-10-19
CN102036679A (zh) 2011-04-27
US9205132B2 (en) 2015-12-08
GB0908432D0 (en) 2009-06-24
HK1140693A1 (en) 2010-10-22
US20120040902A1 (en) 2012-02-16
US20130210730A1 (en) 2013-08-15
HRP20150845T1 (hr) 2015-11-06
US8415301B2 (en) 2013-04-09
SG10201609580YA (en) 2016-12-29
IL247351A0 (en) 2016-09-29
WO2009140659A2 (en) 2009-11-19
NZ598709A (en) 2013-09-27
GB2459983B (en) 2010-04-28
EA201500552A1 (ru) 2016-07-29
CN103212063B (zh) 2015-07-22
EP2288373A2 (en) 2011-03-02
EA201001771A1 (ru) 2011-06-30
GB2462221B (en) 2010-09-01
AU2009246114A1 (en) 2009-11-19
JP2015013870A (ja) 2015-01-22
IL208992A (en) 2013-09-30
CY1116925T1 (el) 2017-04-05
JP5638044B2 (ja) 2014-12-10
US20100048475A1 (en) 2010-02-25
GB0918132D0 (en) 2009-12-02
JP2011520918A (ja) 2011-07-21
JP2013040174A (ja) 2013-02-28
US20170151311A1 (en) 2017-06-01
ZA201007449B (en) 2011-06-29
CN103212063A (zh) 2013-07-24
JP5875646B2 (ja) 2016-03-02

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