JP6437823B2 - アルコール毒性低減のための方法および組成物 - Google Patents

アルコール毒性低減のための方法および組成物 Download PDF

Info

Publication number
JP6437823B2
JP6437823B2 JP2014543571A JP2014543571A JP6437823B2 JP 6437823 B2 JP6437823 B2 JP 6437823B2 JP 2014543571 A JP2014543571 A JP 2014543571A JP 2014543571 A JP2014543571 A JP 2014543571A JP 6437823 B2 JP6437823 B2 JP 6437823B2
Authority
JP
Japan
Prior art keywords
acetaldehyde
acetaldehyde dehydrogenase
subject
certain embodiments
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014543571A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015509909A (ja
JP2015509909A5 (enExample
Inventor
タラレイ ポール
タラレイ ポール
ユウスケ ウシダ
ユウスケ ウシダ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of JP2015509909A publication Critical patent/JP2015509909A/ja
Publication of JP2015509909A5 publication Critical patent/JP2015509909A5/ja
Application granted granted Critical
Publication of JP6437823B2 publication Critical patent/JP6437823B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014543571A 2011-11-22 2012-11-21 アルコール毒性低減のための方法および組成物 Active JP6437823B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161562559P 2011-11-22 2011-11-22
US61/562,559 2011-11-22
US201161568721P 2011-12-09 2011-12-09
US61/568,721 2011-12-09
PCT/US2012/066340 WO2013078371A2 (en) 2011-11-22 2012-11-21 Methods and compositions for reducing alcohol toxicity

Publications (3)

Publication Number Publication Date
JP2015509909A JP2015509909A (ja) 2015-04-02
JP2015509909A5 JP2015509909A5 (enExample) 2015-09-03
JP6437823B2 true JP6437823B2 (ja) 2018-12-12

Family

ID=48470418

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014543571A Active JP6437823B2 (ja) 2011-11-22 2012-11-21 アルコール毒性低減のための方法および組成物

Country Status (6)

Country Link
US (2) US20150087702A1 (enExample)
EP (1) EP2782583B1 (enExample)
JP (1) JP6437823B2 (enExample)
KR (1) KR102002147B1 (enExample)
CN (1) CN104520311B (enExample)
WO (1) WO2013078371A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105163728B (zh) * 2013-04-05 2018-10-02 蜜纽康新西兰有限公司 包含蜂胶提取物的治疗性组合物和其用途
CN103396348B (zh) * 2013-08-21 2015-05-20 昆明龙津药业股份有限公司 蔊菜素的衍生物以及在制备抗癌药物中的应用
JP6855157B2 (ja) * 2014-10-06 2021-04-07 扶桑化学工業株式会社 水中動物用飼料、水中動物用発育向上剤、および、それらを用いた養殖魚の飼育方法
WO2016168450A1 (en) 2015-04-16 2016-10-20 The Research Foundation For The State University Of New York Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis
CN105251025B (zh) * 2015-11-11 2018-11-27 福州大学 Aldh2基因在制备预防苯乙烯致遗传毒性药物中的应用
JP2017195809A (ja) * 2016-04-27 2017-11-02 佐々木食品工業株式会社 アセトアルデヒドの代謝促進用食品組成物及びアセトアルデヒドの代謝促進剤
CN107789612A (zh) * 2016-08-31 2018-03-13 李镇坚 一种中药水果复合固体解酒糖及制备工艺
JP6867823B2 (ja) * 2017-02-13 2021-05-12 サッポロビール株式会社 アセトアルデヒドデヒドロゲナーゼ活性促進剤
US10849938B2 (en) 2017-09-13 2020-12-01 ZBiotics Company Gene expression system for probiotic microorganisms
CN107950726A (zh) * 2017-11-27 2018-04-24 广州六顺生物科技有限公司 一种具有解酒护肝作用的凝胶糖果、制备方法和应用
CN110101849B (zh) * 2019-04-12 2023-11-10 暨南大学 一种酶催化解酒作用的组合物及其制备方法与应用
CN110538173A (zh) * 2019-08-20 2019-12-06 郑州大学第一附属医院 异硫氰酸酯类化合物在制备食管癌靶向药中的应用
KR20220081351A (ko) * 2019-10-10 2022-06-15 조브리어스 파르마 에이에스 개선된 숙취해소 조성물, 이의 제조 및 용도
KR102460570B1 (ko) 2020-02-18 2022-10-28 주식회사 피코엔텍 신규한 돌연변이 효모를 함유하는 아토피 억제 조성물
CN111437280A (zh) * 2020-04-29 2020-07-24 重庆燕盈生物科技有限公司 一种基于雷公藤红素的新用途及其应用
CN118490676B (zh) * 2024-07-18 2024-09-13 暨南大学 杨芽黄素在制备延缓卵巢衰老和/或修复损伤卵巢和/或重建卵巢功能药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725895B1 (en) 1995-09-15 2000-10-10 Hopkins J School Of Medicine Method of preparing food product from cruciferous seeds
KR20020014978A (ko) 2000-08-19 2002-02-27 김기성 숙취제거 향의 조성물
US20050271754A1 (en) * 2004-06-07 2005-12-08 Cochrane Patrick W Composition for prevention or treatment of an alcohol hangover
RU2292899C2 (ru) * 2004-06-29 2007-02-10 Дмитрий Николаевич Мясников Средство и способ профилактики и уменьшения неблагоприятных проявлений острой алкогольной интоксикации (варианты) и способ получения средства
KR100661032B1 (ko) * 2005-04-19 2006-12-22 주식회사한국야쿠르트 간 기능 개선, 혈중 알코올 감소 및 항산화에 유효한조성물
WO2007016955A1 (en) * 2005-07-29 2007-02-15 Matuschka-Greiffenclau Markus Alcohol metabolism moderating composition
PL1909600T3 (pl) * 2005-07-29 2012-09-28 Tima Found Kompozycja spowalniająca metabolizm alkoholu i ograniczająca ryzyko chorób wywołanych alkoholem
US20080311276A1 (en) * 2007-06-12 2008-12-18 Kraft Foods Holdings, Inc. Production of Glucosinolates from Agricultural By-Products & Waste
MY160074A (en) * 2008-01-24 2017-02-15 Raptor Therapeutics Inc Protopanaxadiol-type ginsenoside compositions and uses thereof
CN103202838A (zh) 2013-04-16 2013-07-17 缪为民 一种具有肝脏保护作用的植物提取物组合物

Also Published As

Publication number Publication date
CN104520311A (zh) 2015-04-15
JP2015509909A (ja) 2015-04-02
US20150087702A1 (en) 2015-03-26
CN104520311B (zh) 2018-03-13
EP2782583A2 (en) 2014-10-01
US20210401791A1 (en) 2021-12-30
WO2013078371A3 (en) 2014-12-04
KR20140106549A (ko) 2014-09-03
KR102002147B1 (ko) 2019-07-19
EP2782583A4 (en) 2016-04-13
EP2782583B1 (en) 2019-09-25
WO2013078371A2 (en) 2013-05-30

Similar Documents

Publication Publication Date Title
JP6437823B2 (ja) アルコール毒性低減のための方法および組成物
JP6591748B2 (ja) 自閉症の処置のための方法および組成物
Krajka-Kuźniak et al. Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines
Speciale et al. Nutritional antioxidants and adaptive cell responses: an update
Calabrese et al. Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
Kumar et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
Li et al. Reduction of aging-induced oxidative stress and activation of autophagy by bilberry anthocyanin supplementation via the AMPK–mTOR signaling pathway in aged female rats
KR102090836B1 (ko) 세포 정제를 촉진하기 위한 경구 제제
M. de Figueiredo et al. The anti-oxidant properties of isothiocyanates: a review
US12369611B2 (en) Compositions and method for treating and preventing complications of obesity
Kaiser et al. Capsaicinoids: Occurrence, chemistry, biosynthesis, and biological effects
Liu et al. Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats
Hwang et al. Isodihydrocapsiate stimulates plasma glucose uptake by activation of AMP-activated protein kinase
Park et al. Beta-lapachone attenuates immobilization-induced skeletal muscle atrophy in mice
KR101352932B1 (ko) Ｐｒｘ3 를 표적으로 하는 스트레스 장애 치료제 및 이의 스크리닝 방법
JP2023554187A (ja) 身体運動パフォーマンスを改善するため方法
Kshatriya In Vivo Effects of Raspberry Ketone (4-(4-Hydroxyphenyl)-Butan-2-One) as a Supplement for Weight Loss in Mice
Pathak Modifying Acetylation in Skeletal Muscle to Improve Health-and Life-Span
WO2024231542A1 (en) Lipolytic and antiadipogenic coumarin derivatives
JP2024534971A (ja) セロリ種子抽出物を有効成分として含む筋力弱化関連疾患の予防、改善または治療用組成物
Gomaa et al. TIME-DEPENDENT EFFECT OF ALLYL ISOTHIOCYANATE ON SOME METABOLIC PARAMETERS IN RATS
Yang Anti-obesity effect of sulforaphane involves inhibition of HDAC8 but not Nrf2
Williams The acute impact of a single dose of resveratrol on insulin sensitivity, whole body fat oxidation, and intracellular signaling in skeletal muscle and adipose tissue in overweight and obese men
Agrawal Obesity, Metabolic

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150710

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150710

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160524

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160824

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161024

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170510

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20170622

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20170818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180919

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181115

R150 Certificate of patent or registration of utility model

Ref document number: 6437823

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250