WO2013066835A3 - Compounds and methods - Google Patents

Compounds and methods Download PDF

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Publication number
WO2013066835A3
WO2013066835A3 PCT/US2012/062510 US2012062510W WO2013066835A3 WO 2013066835 A3 WO2013066835 A3 WO 2013066835A3 US 2012062510 W US2012062510 W US 2012062510W WO 2013066835 A3 WO2013066835 A3 WO 2013066835A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Application number
PCT/US2012/062510
Other languages
French (fr)
Other versions
WO2013066835A2 (en
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Peiling CHEN
Original Assignee
Glaxosmithkline Llc
Tempero Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc, Tempero Pharmaceuticals, Inc. filed Critical Glaxosmithkline Llc
Publication of WO2013066835A2 publication Critical patent/WO2013066835A2/en
Publication of WO2013066835A3 publication Critical patent/WO2013066835A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

The present invention relates to compounds that inhibit histone deacetylase (HDAC) enzymes, the preparation of these compounds or salts of said compound, the use of these compounds in the treatment of neurodegenerative diseases or conditions ameliorated by inhibition of HDAC activity and pharmaceutical compositions that are comprised of these compounds.
PCT/US2012/062510 2011-10-31 2012-10-30 Compounds and methods WO2013066835A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553490P 2011-10-31 2011-10-31
US61/553,490 2011-10-31
US201261596404P 2012-02-08 2012-02-08
US61/596,404 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066835A2 WO2013066835A2 (en) 2013-05-10
WO2013066835A3 true WO2013066835A3 (en) 2015-05-21

Family

ID=48193010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062510 WO2013066835A2 (en) 2011-10-31 2012-10-30 Compounds and methods

Country Status (1)

Country Link
WO (1) WO2013066835A2 (en)

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CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi
JP7428833B2 (en) 2020-02-25 2024-02-06 チョン クン ダン ファーマシューティカル コーポレイション 1,3,4-oxadiazole derivative compound as a histone deacetylase 6 inhibitor and a pharmaceutical composition containing the same

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KR20140048235A (en) * 2011-07-08 2014-04-23 노파르티스 아게 Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
JP6556146B2 (en) * 2014-08-26 2019-08-07 武田薬品工業株式会社 Heterocyclic compounds
JP6805172B2 (en) * 2015-05-07 2020-12-23 シーエイチディーアイ ファウンデーション，インコーポレーテッド Histone deacetylase inhibitors and compositions and methods of their use
JP6671456B2 (en) 2015-07-17 2020-03-25 武田薬品工業株式会社 Heterocyclic compounds
JPWO2017014170A1 (en) * 2015-07-17 2018-04-26 武田薬品工業株式会社 Heterocyclic compounds
JP6560436B2 (en) 2015-07-27 2019-08-14 チョン クン ダン ファーマシューティカル コーポレーション 1,3,4-oxadiazolesulfonamide derivative compound as histone deacetylase 6 inhibitor and pharmaceutical composition containing the same
PL3328844T3 (en) 2015-07-27 2020-07-27 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same
CA2993918C (en) * 2015-07-27 2020-09-29 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
ES2903214T3 (en) * 2015-08-04 2022-03-31 Chong Kun Dang Pharmaceutical Corp Compounds derived from 1,3,4-oxadiazole as inhibitors of histone deacetylase 6 and the pharmaceutical composition comprising them
EP3342772A4 (en) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited Heterocyclic compound
SI3356358T1 (en) 2015-10-02 2020-09-30 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
US10501425B2 (en) 2015-10-02 2019-12-10 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
DK3362445T3 (en) 2015-10-12 2023-02-27 Chong Kun Dang Pharmaceutical Corp OXADIAZOLAMINDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6-INHIBITORS AND THE PHARMACEUTICAL COMPOSITION THEREOF
AU2016349662A1 (en) * 2015-11-05 2018-05-17 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
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AR106679A1 (en) 2015-11-13 2018-02-07 Basf Se OXADIAZOLS REPLACED TO FIGHT FITOPATHOGEN FUNGI
CA3003946A1 (en) 2015-11-19 2017-05-26 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN108289448B (en) 2015-12-02 2021-10-22 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
WO2017103223A1 (en) * 2015-12-18 2017-06-22 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
CN108430980B (en) * 2015-12-22 2022-09-02 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
UY37062A (en) 2016-01-08 2017-08-31 Syngenta Participations Ag DERIVATIVES OF ARYL OXADIAZOL FUNGICIDAS
CN108779109B (en) 2016-03-15 2022-03-11 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
WO2017162868A1 (en) 2016-03-24 2017-09-28 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
RU2018138748A (en) 2016-04-11 2020-05-12 Басф Се SUBSTITUTED OXADIAZOLES FOR FIGHTING PHYTOPATHOGENIC MUSHROOMS
JP2019516670A (en) 2016-04-12 2019-06-20 シンジェンタ パーティシペーションズ アーゲー Microbicidal oxadiazole derivative
BR112018074943B1 (en) 2016-06-03 2022-07-26 Syngenta Participations Ag OXADIAZOLE DERIVED COMPOUNDS MICROBIOCIDES, AGROCHEMICAL COMPOSITION, METHOD TO CONTROL OR PREVENT THE INFESTATION OF USEFUL PLANTS BY PHYTOPATOGENIC MICROORGANISMS AND USE OF SUCH COMPOUNDS
AU2017277354A1 (en) 2016-06-09 2018-12-06 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2017222951A1 (en) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
WO2018202491A1 (en) * 2017-05-04 2018-11-08 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
AR112221A1 (en) 2017-07-05 2019-10-02 Fmc Corp FUNGICIDE OXADIAZOLES, COMPOSITION THAT INCLUDE THEM AND A METHOD TO CONTROL PHYTO DISEASES THAT USE THEM
JP7135007B2 (en) 2017-07-31 2022-09-12 武田薬品工業株式会社 heterocyclic compound
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
WO2019038042A1 (en) 2017-08-21 2019-02-28 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
WO2019219464A1 (en) 2018-05-15 2019-11-21 Basf Se Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
KR102316234B1 (en) 2018-07-26 2021-10-22 주식회사 종근당 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same
JP7451569B2 (en) 2019-05-31 2024-03-18 チョン クン ダン ファーマシューティカル コーポレーション 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitors, and pharmaceutical compositions containing the same
CN114846012B (en) 2019-09-27 2024-01-26 武田药品工业株式会社 2-isoindole-1, 3, 4-oxadiazole derivatives useful as HDAC6 inhibitors
CA3165424A1 (en) 2019-12-20 2021-06-24 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
JP2023509452A (en) 2020-01-03 2023-03-08 バーグ エルエルシー Polycyclic Amides as UBE2K Modulators to Treat Cancer
TW202226947A (en) 2020-08-18 2022-07-16 印度商皮埃企業有限公司 Novel heterocyclic compounds for combating phytopathogenic fungi
UY39755A (en) 2021-05-05 2022-11-30 Pi Industries Ltd NEW CONDENSED HETEROCYCLIC COMPOUNDS TO COMBAT PHYTOPATHOGENIC FUNGI.
CA3229931A1 (en) * 2021-08-31 2023-03-09 Nina Ha Compositions for preventing or treating charcot-marie-tooth disease (cmt)
TW202339760A (en) * 2022-01-28 2023-10-16 韓商鐘根堂股份有限公司 Compositions for preventing or treating heart failure (hf)
KR20230160194A (en) * 2022-05-16 2023-11-23 주식회사 종근당 Compositions for preventing or treating idiopathic pulmonary fibrosis(IPF)

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WO1997030047A1 (en) * 1996-02-17 1997-08-21 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
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US20100280083A1 (en) * 2007-12-25 2010-11-04 Kissei Pharmaceutical Co., Ltd. Novel catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition
US20110077252A1 (en) * 2007-08-07 2011-03-31 Sanjay Kumar Pyridyl derivatives, their preparation and use
WO2011088181A1 (en) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods

Patent Citations (6)

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WO1997030047A1 (en) * 1996-02-17 1997-08-21 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
US20040082585A1 (en) * 2001-10-03 2004-04-29 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
US20110077252A1 (en) * 2007-08-07 2011-03-31 Sanjay Kumar Pyridyl derivatives, their preparation and use
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WO2011088181A1 (en) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi
JP7428833B2 (en) 2020-02-25 2024-02-06 チョン クン ダン ファーマシューティカル コーポレイション 1,3,4-oxadiazole derivative compound as a histone deacetylase 6 inhibitor and a pharmaceutical composition containing the same

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