JP2015509522A5 - - Google Patents
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- Publication number
- JP2015509522A5 JP2015509522A5 JP2014560382A JP2014560382A JP2015509522A5 JP 2015509522 A5 JP2015509522 A5 JP 2015509522A5 JP 2014560382 A JP2014560382 A JP 2014560382A JP 2014560382 A JP2014560382 A JP 2014560382A JP 2015509522 A5 JP2015509522 A5 JP 2015509522A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- motomeko
- toxoid
- composition
- tlr agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 59
- 239000000556 agonist Substances 0.000 claims description 22
- 102000002689 Toll-like receptor Human genes 0.000 claims description 20
- 108020000411 Toll-like receptor Proteins 0.000 claims description 20
- 201000005702 Pertussis Diseases 0.000 claims description 14
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 12
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 12
- 229960000814 tetanus toxoid Drugs 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 8
- 230000002163 immunogen Effects 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 4
- 108010021711 pertactin Proteins 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- 229940032024 DPT vaccine Drugs 0.000 claims description 2
- 241000991587 Enterovirus C Species 0.000 claims description 2
- 101710154606 Hemagglutinin Proteins 0.000 claims description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 101710176177 Protein A56 Proteins 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000185 hemagglutinin Substances 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608398P | 2012-03-08 | 2012-03-08 | |
| US61/608,398 | 2012-03-08 | ||
| US201261697730P | 2012-09-06 | 2012-09-06 | |
| US61/697,730 | 2012-09-06 | ||
| PCT/EP2013/054672 WO2013132041A2 (en) | 2012-03-08 | 2013-03-08 | Adjuvanted formulations of booster vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017096343A Division JP2017132821A (ja) | 2012-03-08 | 2017-05-15 | 追加免疫ワクチンのアジュバント化された処方物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509522A JP2015509522A (ja) | 2015-03-30 |
| JP2015509522A5 true JP2015509522A5 (enExample) | 2016-04-21 |
| JP6345603B2 JP6345603B2 (ja) | 2018-06-20 |
Family
ID=47843287
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560382A Active JP6345603B2 (ja) | 2012-03-08 | 2013-03-08 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2017096343A Withdrawn JP2017132821A (ja) | 2012-03-08 | 2017-05-15 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2018194314A Pending JP2019001832A (ja) | 2012-03-08 | 2018-10-15 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2021015094A Active JP7295895B2 (ja) | 2012-03-08 | 2021-02-02 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2023045185A Pending JP2023085364A (ja) | 2012-03-08 | 2023-03-22 | 追加免疫ワクチンのアジュバント化された処方物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017096343A Withdrawn JP2017132821A (ja) | 2012-03-08 | 2017-05-15 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2018194314A Pending JP2019001832A (ja) | 2012-03-08 | 2018-10-15 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2021015094A Active JP7295895B2 (ja) | 2012-03-08 | 2021-02-02 | 追加免疫ワクチンのアジュバント化された処方物 |
| JP2023045185A Pending JP2023085364A (ja) | 2012-03-08 | 2023-03-22 | 追加免疫ワクチンのアジュバント化された処方物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9375471B2 (enExample) |
| EP (1) | EP2822581A2 (enExample) |
| JP (5) | JP6345603B2 (enExample) |
| CN (1) | CN104159602B (enExample) |
| AU (1) | AU2013229432A1 (enExample) |
| CA (1) | CA2866406A1 (enExample) |
| MX (1) | MX372965B (enExample) |
| RU (1) | RU2014140521A (enExample) |
| WO (1) | WO2013132041A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077613A1 (en) | 2008-12-09 | 2010-07-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| SG178954A1 (en) * | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CN103313725B (zh) | 2010-09-01 | 2016-06-29 | 诺华有限公司 | 免疫增强剂吸附不溶性金属离子 |
| KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
| CN104093418A (zh) * | 2011-09-01 | 2014-10-08 | 诺华股份有限公司 | 金黄色葡萄球菌抗原的含佐剂制剂 |
| AU2013229432A1 (en) * | 2012-03-08 | 2014-10-16 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| US9017698B2 (en) | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EA037818B1 (ru) | 2014-03-26 | 2021-05-25 | Глаксосмитклайн Байолоджикалс С.А. | Мутантные стафилококковые антигены |
| EP4140485A1 (en) | 2014-07-11 | 2023-03-01 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
| EA201790369A1 (ru) | 2014-09-16 | 2017-10-31 | Джилид Сайэнс, Инк. | Твердые формы модулятора толл-подобного рецептора |
| MX2018014086A (es) * | 2016-05-16 | 2019-09-18 | Infectious Disease Res Inst | Formulacion que contiene agonista tlr y metodos de uso. |
| CN113395977A (zh) * | 2018-12-05 | 2021-09-14 | 圣诺菲·帕斯图尔公司 | 百日咳加强疫苗 |
| WO2025240361A1 (en) * | 2024-05-13 | 2025-11-20 | The Board Of Trustees Of The Leland Stanford Junior University | Enpp1 and/or enpp3 inhibitors |
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| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2011130379A1 (en) | 2010-04-13 | 2011-10-20 | Novartis Ag | Benzonapthyridine compositions and uses thereof |
| CN105125488A (zh) | 2010-05-12 | 2015-12-09 | 诺华股份有限公司 | 制备鲨烯的改良方法 |
| GB201009673D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009676D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009671D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| CN103313725B (zh) | 2010-09-01 | 2016-06-29 | 诺华有限公司 | 免疫增强剂吸附不溶性金属离子 |
| US9618508B2 (en) | 2010-12-14 | 2017-04-11 | Glaxosmithkline Biologicals Sa | Flow cytometry analysis of materials adsorbed to metal salts |
| KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
| CN104093418A (zh) | 2011-09-01 | 2014-10-08 | 诺华股份有限公司 | 金黄色葡萄球菌抗原的含佐剂制剂 |
| CN104582726A (zh) | 2012-03-07 | 2015-04-29 | 诺华股份有限公司 | 狂犬病病毒免疫原的含佐剂制剂 |
| LT2822947T (lt) | 2012-03-07 | 2016-10-10 | Glaxosmithkline Biologicals Sa | Tlr7 agonisto arginino druskos |
| EP2822586A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of streptococcus pneumoniae antigens |
| AU2013229432A1 (en) | 2012-03-08 | 2014-10-16 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| US20150258190A1 (en) | 2012-10-25 | 2015-09-17 | Novartis Ag | Nicotinamide as adjuvant |
-
2013
- 2013-03-08 AU AU2013229432A patent/AU2013229432A1/en not_active Abandoned
- 2013-03-08 EP EP13708155.0A patent/EP2822581A2/en not_active Withdrawn
- 2013-03-08 CN CN201380012817.4A patent/CN104159602B/zh active Active
- 2013-03-08 MX MX2014010417A patent/MX372965B/es active IP Right Grant
- 2013-03-08 US US13/790,948 patent/US9375471B2/en active Active
- 2013-03-08 WO PCT/EP2013/054672 patent/WO2013132041A2/en not_active Ceased
- 2013-03-08 JP JP2014560382A patent/JP6345603B2/ja active Active
- 2013-03-08 CA CA2866406A patent/CA2866406A1/en not_active Abandoned
- 2013-03-08 RU RU2014140521A patent/RU2014140521A/ru not_active Application Discontinuation
-
2016
- 2016-05-24 US US15/163,592 patent/US9931399B2/en active Active
-
2017
- 2017-05-15 JP JP2017096343A patent/JP2017132821A/ja not_active Withdrawn
-
2018
- 2018-02-26 US US15/905,483 patent/US10842868B2/en active Active
- 2018-10-15 JP JP2018194314A patent/JP2019001832A/ja active Pending
-
2021
- 2021-02-02 JP JP2021015094A patent/JP7295895B2/ja active Active
-
2023
- 2023-03-22 JP JP2023045185A patent/JP2023085364A/ja active Pending
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