AU2013229432A1 - Adjuvanted formulations of booster vaccines - Google Patents
Adjuvanted formulations of booster vaccines Download PDFInfo
- Publication number
- AU2013229432A1 AU2013229432A1 AU2013229432A AU2013229432A AU2013229432A1 AU 2013229432 A1 AU2013229432 A1 AU 2013229432A1 AU 2013229432 A AU2013229432 A AU 2013229432A AU 2013229432 A AU2013229432 A AU 2013229432A AU 2013229432 A1 AU2013229432 A1 AU 2013229432A1
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- Australia
- Prior art keywords
- composition
- toxoid
- alkyl
- tlr agonist
- pertussis
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- C—CHEMISTRY; METALLURGY
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
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Landscapes
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| US20120177681A1 (en) | 2010-09-01 | 2012-07-12 | Manmohan Singh | Formulation of immunopotentiators |
| TR201811280T4 (tr) | 2011-03-02 | 2018-08-27 | Glaxosmithkline Biologicals Sa | Düşük antijen ve/ veya adjuvan dozları olan karma aşılar. |
| JP2014525429A (ja) * | 2011-09-01 | 2014-09-29 | ノバルティス アーゲー | Staphylococcusaureus抗原のアジュバント添加処方物 |
| EP2822581A2 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Adjuvanted formulations of dtp booster vaccines |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US20150086592A1 (en) | 2013-09-25 | 2015-03-26 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
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Family Cites Families (109)
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| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
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| US5059258A (en) | 1989-08-23 | 1991-10-22 | Aluminum Company Of America | Phosphonic/phosphinic acid bonded to aluminum hydroxide layer |
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| AU685443B2 (en) | 1993-03-23 | 1998-01-22 | Smithkline Beecham Biologicals (Sa) | Vaccine compositions containing 3-O deacylated monophosphoryl lipid A |
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| ES2283012T3 (es) | 1996-01-04 | 2007-10-16 | Novartis Vaccines And Diagnostics, Inc. | Bacterioferritina de helicobacter pylori. |
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| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6630161B1 (en) | 1998-05-07 | 2003-10-07 | Ribi Immunochem Research, Inc. | Adjuvant composition and methods for its use |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| US20030130212A1 (en) | 1999-01-14 | 2003-07-10 | Rossignol Daniel P. | Administration of an anti-endotoxin drug by intravenous infusion |
| US6551600B2 (en) | 1999-02-01 | 2003-04-22 | Eisai Co., Ltd. | Immunological adjuvant compounds compositions and methods of use thereof |
| DE10012370A1 (de) * | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
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| FR2827605B1 (fr) | 2001-07-20 | 2004-07-16 | Pf Medicament | Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| GB0211118D0 (en) | 2002-05-15 | 2002-06-26 | Polonelli Luciano | Vaccines |
| CA2493690C (en) | 2002-06-13 | 2011-11-08 | New York University | Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases |
| SI2353608T1 (sl) | 2002-10-11 | 2020-12-31 | Glaxosmithkline Biologicals Sa | Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam |
| US7818252B2 (en) | 2003-02-20 | 2010-10-19 | Gilat Satellite Networks, Ltd | Enforcement of network service level agreements |
| SI1644389T1 (sl) | 2003-06-16 | 2011-06-30 | Acad Of Science Czech Republic | Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi |
| CN1812809A (zh) | 2003-06-26 | 2006-08-02 | 希龙公司 | 用于沙眼衣原体的免疫原性组合物 |
| US7771726B2 (en) | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
| CA2557353A1 (en) | 2004-03-02 | 2005-09-15 | Chiron Corporation | Immunogenic compositions for chlamydia pneunomiae |
| GB0405787D0 (en) | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
| EP1732384A4 (en) | 2004-03-31 | 2008-04-23 | Univ New York State Res Found | NOVEL SYNTHETIC C-GLYCOLIPIDES, THEIR SYNTHESIS AND USE FOR THE TREATMENT OF INFECTIONS, CANCER AND AUTOIMMUNE DISEASES |
| BRPI0509606B1 (pt) | 2004-04-05 | 2019-01-15 | Pah Usa 15 Llc | emulsões de óleo-em-água microfluidizadas e composições para vacinas |
| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| NZ599345A (en) | 2005-02-18 | 2013-07-26 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic Escherichia Coli |
| EP1866319B1 (en) | 2005-04-01 | 2011-11-23 | The Regents of The University of California | Phosphono-pent-2-en-1-yl nucleosides and analogs |
| EP1891096A2 (en) | 2005-05-12 | 2008-02-27 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions for chlamydia trachomatis |
| EP2201961B1 (en) | 2005-06-27 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯 |
| TW200801003A (en) | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| EP1939201A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| US20090118263A1 (en) | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
| EP1939198A4 (en) | 2005-09-22 | 2012-02-15 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| EP1939200A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| TW200745114A (en) | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| AR056591A1 (es) | 2005-10-28 | 2007-10-10 | Vaxinnate Corp | Polipeptidos ligandos para receptor 4 simil toll (tlr4) |
| CN102755645A (zh) | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US8481057B2 (en) | 2005-12-22 | 2013-07-09 | Novartis Vaccines & Diagnostics Srl | Chlamydial antigens |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| MX2008010611A (es) | 2006-02-17 | 2008-11-12 | Pfizer Ltd | Derivados de 3-desazapurina como moduladores de receptores similares a toll. |
| WO2007109812A2 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
| ATE539079T1 (de) | 2006-03-23 | 2012-01-15 | Novartis Ag | Imidazochinoxalinverbindungen als immunmodulatoren |
| JP2009542645A (ja) | 2006-07-05 | 2009-12-03 | アストラゼネカ・アクチエボラーグ | Tlr7のモジュレーターとして作用する8−オキソアデニン誘導体 |
| AU2007269557B2 (en) | 2006-07-07 | 2013-11-07 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
| GB0616306D0 (en) * | 2006-08-16 | 2006-09-27 | Novartis Ag | Vaccines |
| JP2010500399A (ja) | 2006-08-16 | 2010-01-07 | ノバルティス アーゲー | 尿路病原性大腸菌由来の免疫原 |
| SI2097102T1 (sl) | 2006-09-07 | 2012-09-28 | Glaxosmithkline Biolog Sa | Kombinirano cepivo, ki ima zmanjšane količine antigena za poliovirus |
| WO2008043774A1 (en) | 2006-10-12 | 2008-04-17 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
| WO2008047174A1 (en) | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| GB0622282D0 (en) | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| HRP20110115T1 (hr) | 2007-02-19 | 2011-03-31 | Glaxosmithkline Llc | Derivati purina kao imunomodulatori |
| PE20081887A1 (es) | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
| PL2155743T3 (pl) | 2007-05-08 | 2013-01-31 | Astrazeneca Ab | Imidazochinoliny o właściwościach immunomodulacyjnych |
| CA2688268A1 (en) * | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
| EP2188280B1 (en) | 2007-08-03 | 2011-03-09 | Pfizer Limited | Imidazopyridinones |
| CA2702871A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| NZ586439A (en) | 2007-12-24 | 2012-10-26 | Novartis Ag | Method for peforming an immunodiffusion assay (SRID) for influenza hemagglutinin antigen based on desorbing the antigen from the aluminium adjuvant salt |
| US8092813B1 (en) | 2007-12-28 | 2012-01-10 | Novartis Ag | Polychlorinated biphenyls and squalene-containing adjuvants |
| DK2268618T3 (en) | 2008-03-03 | 2015-08-17 | Novartis Ag | Compounds and compositions as TLR aktivitetsmodulatorer |
| HRP20131139T1 (hr) | 2008-03-24 | 2014-01-03 | 4Sc Discovery Gmbh | Novi supstituirani imidazokinolini |
| AU2009266940A1 (en) | 2008-07-01 | 2010-01-07 | Emory University | Synergistic induction of humoral and cellular immunity by combinatorial activation of toll-like receptors |
| PT2313111E (pt) | 2008-08-01 | 2013-12-05 | Ventirx Pharmaceuticals Inc | Formulações de agonista de receptor do tipo toll e seus usos |
| CN102257149B (zh) | 2008-08-28 | 2013-12-25 | 诺华股份有限公司 | 由超产酵母生产角鲨烯 |
| TWM352127U (en) | 2008-08-29 | 2009-03-01 | Bestac Advanced Material Co Ltd | Polishing pad |
| TW201639852A (zh) | 2008-12-09 | 2016-11-16 | 吉李德科學股份有限公司 | 用於製備可用作類鐸受體調節劑之化合物的中間體化合物 |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| EP2398821B1 (en) | 2009-02-17 | 2017-08-30 | GlaxoSmithKline Biologicals S.A. | Inactivated dengue virus vaccine with aluminium-free adjuvant |
| CA3154626A1 (en) | 2009-04-14 | 2010-10-21 | Glaxosmithkline Biologicals S.A. | Compositions for immunising against staphylococcus aureus |
| US8609106B2 (en) | 2009-06-01 | 2013-12-17 | Novartis Ag | Combinations of pneumococcal RrgB clades |
| EP2440245B1 (en) | 2009-06-10 | 2017-12-06 | GlaxoSmithKline Biologicals SA | Benzonaphthyridine-containing vaccines |
| CN104650241A (zh) | 2009-08-27 | 2015-05-27 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| TWI445708B (zh) * | 2009-09-02 | 2014-07-21 | Irm Llc | 作為tlr活性調節劑之化合物及組合物 |
| EP2498815A4 (en) | 2009-11-09 | 2014-03-19 | Nat Jewish Health | VACCINE COMPOSITION |
| KR101616735B1 (ko) | 2009-12-03 | 2016-04-29 | 노파르티스 아게 | 백신 보조제 제조 중의 친수성 여과 |
| JP5820390B2 (ja) | 2009-12-03 | 2015-11-24 | ノバルティス アーゲー | エマルジョンの微小流動化中および/または均質化中における成分の循環 |
| RS52565B (sr) | 2009-12-03 | 2013-04-30 | Novartis Ag | Metod interakcije i komore sa povratnim pritiskom za mikrofluidizaciju |
| EP2549990A1 (en) | 2010-03-23 | 2013-01-30 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2011130379A1 (en) | 2010-04-13 | 2011-10-20 | Novartis Ag | Benzonapthyridine compositions and uses thereof |
| BR112012028711B1 (pt) | 2010-05-12 | 2020-12-01 | Novartis Ag | método para a fabricação de uma emulsão de óleo em água e método para a preparação de um kit de vacina |
| GB201009676D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009671D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| GB201009673D0 (en) | 2010-06-10 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel process |
| US20120177681A1 (en) | 2010-09-01 | 2012-07-12 | Manmohan Singh | Formulation of immunopotentiators |
| US9618508B2 (en) | 2010-12-14 | 2017-04-11 | Glaxosmithkline Biologicals Sa | Flow cytometry analysis of materials adsorbed to metal salts |
| TR201811280T4 (tr) | 2011-03-02 | 2018-08-27 | Glaxosmithkline Biologicals Sa | Düşük antijen ve/ veya adjuvan dozları olan karma aşılar. |
| JP2014525429A (ja) | 2011-09-01 | 2014-09-29 | ノバルティス アーゲー | Staphylococcusaureus抗原のアジュバント添加処方物 |
| EP2822586A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of streptococcus pneumoniae antigens |
| US20150030630A1 (en) | 2012-03-07 | 2015-01-29 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
| SI2822947T1 (sl) | 2012-03-07 | 2016-10-28 | Glaxosmithkline Biologicals S.A. | Argininske soli TLR7 agonista |
| EP2822581A2 (en) * | 2012-03-08 | 2015-01-14 | Novartis AG | Adjuvanted formulations of dtp booster vaccines |
| AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
| CA2888721A1 (en) | 2012-10-25 | 2014-05-01 | Glaxosmithkline Biologicals Sa | Nicotinamide as adjuvant |
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2013
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- 2013-03-08 AU AU2013229432A patent/AU2013229432A1/en not_active Abandoned
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- 2013-03-08 CA CA2866406A patent/CA2866406A1/en not_active Abandoned
- 2013-03-08 RU RU2014140521A patent/RU2014140521A/ru not_active Application Discontinuation
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- 2013-03-08 US US13/790,948 patent/US9375471B2/en active Active
- 2013-03-08 WO PCT/EP2013/054672 patent/WO2013132041A2/en not_active Ceased
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2016
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2017
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2018
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2021
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| WO2013132041A2 (en) | 2013-09-12 |
| US20160263216A1 (en) | 2016-09-15 |
| MX372965B (es) | 2020-04-01 |
| JP2015509522A (ja) | 2015-03-30 |
| JP2017132821A (ja) | 2017-08-03 |
| MX2014010417A (es) | 2014-09-22 |
| JP2023085364A (ja) | 2023-06-20 |
| EP2822581A2 (en) | 2015-01-14 |
| JP2019001832A (ja) | 2019-01-10 |
| CN104159602A (zh) | 2014-11-19 |
| US20180177871A1 (en) | 2018-06-28 |
| JP2021088564A (ja) | 2021-06-10 |
| CA2866406A1 (en) | 2013-09-12 |
| JP7295895B2 (ja) | 2023-06-21 |
| US9375471B2 (en) | 2016-06-28 |
| RU2014140521A (ru) | 2016-04-27 |
| US9931399B2 (en) | 2018-04-03 |
| US10842868B2 (en) | 2020-11-24 |
| CN104159602B (zh) | 2017-10-24 |
| WO2013132041A3 (en) | 2014-04-10 |
| US20130236492A1 (en) | 2013-09-12 |
| JP6345603B2 (ja) | 2018-06-20 |
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