JP2015506948A - 組換え毒素を含むクロストリジウム・ディフィシレに対するワクチン - Google Patents

組換え毒素を含むクロストリジウム・ディフィシレに対するワクチン Download PDF

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JP2015506948A
JP2015506948A JP2014554865A JP2014554865A JP2015506948A JP 2015506948 A JP2015506948 A JP 2015506948A JP 2014554865 A JP2014554865 A JP 2014554865A JP 2014554865 A JP2014554865 A JP 2014554865A JP 2015506948 A JP2015506948 A JP 2015506948A
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protein
seq
tcda
cdta
tcdb
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ヘインリツチズ，ジヨン・ヘンリー
ボドマー，ジーン−ルク
セコア，スーザン・リン
ゴーク，アーロン・ルデイー
キヤロアグイラー，イベツト
ジエンテイル，マリー−ピエール
ホートン，メラニー，エス
ミーゼイーウスキー，マシユー・ライアン
スキンナー，ジユリー，エム
ソンダーマイヤー，パウルス・ヤコブス・アントニウス
サブラマニアン，シヤムスンダー
ヘイイデンリエフケンス，カリン・フベルデイナ・アントニア・バン・デル
ワン，スー
シー，ジーンフー
ソコノスル，レイチエル・フローラ
ゾーマン，ジユリー，ケイ
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Merck Sharp and Dohme LLC
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
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  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014554865A 2012-01-27 2013-01-25 組換え毒素を含むクロストリジウム・ディフィシレに対するワクチン Pending JP2015506948A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261591631P 2012-01-27 2012-01-27
US61/591,631 2012-01-27
US201261596419P 2012-02-08 2012-02-08
US61/596,419 2012-02-08
US201261703754P 2012-09-20 2012-09-20
US61/703,754 2012-09-20
PCT/US2013/023189 WO2013112867A1 (en) 2012-01-27 2013-01-25 Vaccines against clostridium difficile comprising recombinant toxins

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JP2017026031A Division JP2017141226A (ja) 2012-01-27 2017-02-15 組換え毒素を含むクロストリジウム・ディフィシレに対するワクチン

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JP2017026031A Pending JP2017141226A (ja) 2012-01-27 2017-02-15 組換え毒素を含むクロストリジウム・ディフィシレに対するワクチン

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US (1) US9388394B2 (OSRAM)
EP (1) EP2807186A4 (OSRAM)
JP (2) JP2015506948A (OSRAM)
KR (1) KR20140117433A (OSRAM)
CN (1) CN104039816B (OSRAM)
AR (1) AR089797A1 (OSRAM)
AU (1) AU2013211973B2 (OSRAM)
BR (1) BR112014018432A8 (OSRAM)
CA (1) CA2856443A1 (OSRAM)
IN (1) IN2014CN04187A (OSRAM)
MX (1) MX351074B (OSRAM)
RU (1) RU2014134365A (OSRAM)
TW (1) TW201335178A (OSRAM)
WO (1) WO2013112867A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504993A (ja) * 2012-12-23 2016-02-18 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｃ．ディフィシルＣＤＴｂ及び／又はＣＤＴａタンパク質のエレメントを含む免疫原性組成物
JP2020509770A (ja) * 2017-03-15 2020-04-02 ノババックス，インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する免疫応答を誘導するための方法および組成物

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE047085T2 (hu) 2011-04-22 2020-04-28 Wyeth Llc Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai
CA2858519A1 (en) * 2011-12-08 2013-06-13 Novartis Ag Clostridium difficile toxin-based vaccine
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
WO2014197651A1 (en) * 2013-06-05 2014-12-11 Tufts University Atoxic recombinant holotoxins of clostridium difficile as immunogens
SG11201510166YA (en) 2013-06-14 2016-01-28 Sanofi Pasteur Inc Compositions and methods of immunizing against c. difficile
LT3160500T (lt) * 2014-06-25 2019-10-25 Glaxosmithkline Biologicals Sa Clostridium difficile imunogeninė kompozicija
JP2017212882A (ja) * 2014-10-10 2017-12-07 学校法人 名城大学 アセチルエステラーゼ及びその利用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
MX2017014666A (es) 2015-05-15 2018-02-09 Sanofi Pasteur Inc Metodos de inmunización contra clostridium difficile.
TW201718627A (zh) * 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
AU2017227978B2 (en) 2016-03-02 2022-03-10 Merz Pharma Gmbh & Co. Kgaa Composition comprising botulinum toxin
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN110088300A (zh) * 2016-12-14 2019-08-02 默沙东公司 与对靶向艰难梭菌毒素b的治疗的响应相关的人类遗传标志物
US10668140B2 (en) 2017-02-24 2020-06-02 University Of South Floirida Non-toxigenic Clostridium difficile spores for use in oral vaccination
US10555992B2 (en) 2017-05-31 2020-02-11 University Of South Florida Immunogenic proteins against clostridium difficile
BR112019024412A2 (pt) 2017-06-09 2020-07-14 Hipra Scientific, S.L.U. Usos de composição imunogênica e de vacina compreendendo toxóides de clostridium difficile para tratar e/ou prevenir doença causada por clostridium sp, composiçãoimunogênica e vacina compreendendo toxóides de c. difficile e c. perfringens, processo para preparar a dita vacina, bem como kit de vacinação que compreende a dita composição imunogênica
US11952601B2 (en) 2017-06-20 2024-04-09 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum toxin with increased duration of effect
EP3649143B1 (en) 2017-07-06 2022-08-31 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with increased duration of effect
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
TW202035437A (zh) * 2018-10-17 2020-10-01 陳啟彰 預防艱難梭菌（clostridium difficile）感染的免疫原性組合物及方法
CN110041437B (zh) * 2019-04-29 2020-12-25 中国兽医药品监察所 一种无毒性破伤风毒素和诺维梭菌α毒素重组融合蛋白
CN110607314B (zh) * 2019-10-31 2022-09-23 四川农业大学 一种TcdB RBD基因、重组RBD蛋白和应用
CN112442472B (zh) * 2020-11-30 2023-05-26 四川大学华西医院 抗艰难梭菌的重组乳酸乳球菌、活载体疫苗及其制备方法
CN118613492A (zh) * 2022-01-30 2024-09-06 西湖大学 Tfpi结合多肽及其用途
JP2023134918A (ja) * 2022-03-15 2023-09-28 株式会社荏原製作所 研磨方法および研磨装置
WO2025029561A2 (en) * 2023-07-28 2025-02-06 University Of South Florida Vaccine containing rbd2 of cdtb component from binary toxin cdt of clostridioides difficile

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094970A1 (en) * 2009-02-20 2010-08-26 Health Protection Agency Antibodies to clostridium difficile toxins
US20110053244A1 (en) * 2009-08-27 2011-03-03 Oyler George A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
WO2011068953A2 (en) * 2009-12-02 2011-06-09 Tufts University Atoxic recombinant holotoxins of clostridium difficile as immunogens
US20120070859A1 (en) * 2010-09-17 2012-03-22 The Board Of Regents Of The University Of Oklahoma Bacterial cells, optimized nucleotide sequences and methods for improved expression of recombinant clostridium difficile toxin b
WO2012143902A1 (en) * 2011-04-22 2012-10-26 Wyeth Llc Compositions relating to a mutant clostridium difficile toxin and methods thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919665A (en) * 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
WO1998059053A1 (en) 1997-06-20 1998-12-30 Queen Mary & Westfield College Immonogenic fragments of toxin a of clostridium difficile
US6969520B2 (en) 1997-10-20 2005-11-29 Acambis Inc. Active immunization against clostridium difficile disease
US6214341B1 (en) 1997-10-20 2001-04-10 Oravax Passive immunization against Clostridium difficile disease
CA2365914A1 (en) 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
AU2003299527A1 (en) 2002-06-17 2004-06-07 Jimmy D. Ballard Mutant of clostridium difficile toxin b and methods of use
AU2004304770B2 (en) 2003-12-08 2010-05-06 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties by small oligonucleotide-based compounds
JP4588763B2 (ja) 2004-02-06 2010-12-01 ユニバーシティー オブ マサチューセッツ クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ）毒素に対する抗体およびその使用
US7470674B2 (en) 2005-11-07 2008-12-30 Idera Pharmaceuticals, Inc. Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
MX2008012651A (es) * 2006-03-30 2009-03-06 Embrex Inc Procedimientos y composiciones para vacunacion de aves de corral.
DK2396652T3 (da) * 2009-02-11 2018-01-29 Cedars Sinai Medical Center Diagnose af inflammatorisk tarmsyndrom baseret på cytoletalt udspilende toksin
WO2011060431A2 (en) 2009-11-16 2011-05-19 University Of Maryland Baltimore Multivalent live vector vaccine against clostridium difficile-associated disease
GB0921288D0 (en) * 2009-12-04 2010-01-20 Health Prot Agency Therapies for preventing or suppressing clostridium difficile infection
HUE033342T2 (en) 2010-09-03 2017-11-28 Valneva Austria Gmbh Isolated polypeptide of the toxin a and toxin b proteins of c. difficile and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094970A1 (en) * 2009-02-20 2010-08-26 Health Protection Agency Antibodies to clostridium difficile toxins
US20110053244A1 (en) * 2009-08-27 2011-03-03 Oyler George A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
WO2011068953A2 (en) * 2009-12-02 2011-06-09 Tufts University Atoxic recombinant holotoxins of clostridium difficile as immunogens
US20120070859A1 (en) * 2010-09-17 2012-03-22 The Board Of Regents Of The University Of Oklahoma Bacterial cells, optimized nucleotide sequences and methods for improved expression of recombinant clostridium difficile toxin b
WO2012143902A1 (en) * 2011-04-22 2012-10-26 Wyeth Llc Compositions relating to a mutant clostridium difficile toxin and methods thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BARTH, H. ET AL., MICROBIOL. MOL. BIOL. REV., vol. 68, JPN6016043794, 2004, pages 373 - 402, ISSN: 0003439820 *
BUSCH, C. ET AL., J. BIOL. CHEM., vol. 273, JPN6016043788, 1998, pages 19566 - 19572, ISSN: 0003439818 *
EGERER, M. ET AL., J. BIOL. CHEM., vol. 282, no. 35, JPN6016043783, 2007, pages 25314 - 25321, ISSN: 0003439815 *
GULKE, I. ET AL., INFECT. IMMUN., vol. 69, JPN6016043785, 2001, pages 6004 - 6011, ISSN: 0003439816 *
JANK, T. ET AL., J. BIOL. CHEM., vol. 282, JPN6016043782, 2007, pages 35222 - 35231, ISSN: 0003439814 *
VOTH, D.E. AND BALLARD, J.D., CLIN. MICROBIOL. REV., vol. 18, JPN6016043787, 2005, pages 247 - 263, ISSN: 0003439817 *
WANG, H. ET AL., INFECT. IMMUN., vol. 80, JPN6016043791, 12 May 2012 (2012-05-12), pages 2678 - 2688, ISSN: 0003439819 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504993A (ja) * 2012-12-23 2016-02-18 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｃ．ディフィシルＣＤＴｂ及び／又はＣＤＴａタンパク質のエレメントを含む免疫原性組成物
JP2020509770A (ja) * 2017-03-15 2020-04-02 ノババックス，インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する免疫応答を誘導するための方法および組成物
JP7149285B2 (ja) 2017-03-15 2022-10-06 ノババックス，インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する免疫応答を誘導するための方法および組成物
JP2022179543A (ja) * 2017-03-15 2022-12-02 ノババックス，インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する免疫応答を誘導するための方法および組成物
JP7397145B2 (ja) 2017-03-15 2023-12-12 ノババックス，インコーポレイテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する免疫応答を誘導するための方法および組成物
US11938179B2 (en) 2017-03-15 2024-03-26 Novavax, Inc. Methods and compositions for inducing immune responses against Clostridium difficile

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BR112014018432A2 (OSRAM) 2017-06-20
US20150044250A1 (en) 2015-02-12
AU2013211973A1 (en) 2014-06-12
RU2014134365A (ru) 2016-03-20
KR20140117433A (ko) 2014-10-07
MX351074B (es) 2017-09-28
AR089797A1 (es) 2014-09-17
JP2017141226A (ja) 2017-08-17
EP2807186A1 (en) 2014-12-03
CN104039816A (zh) 2014-09-10
MX2014009106A (es) 2014-11-10
CA2856443A1 (en) 2013-08-01
US9388394B2 (en) 2016-07-12
WO2013112867A1 (en) 2013-08-01
BR112014018432A8 (pt) 2017-07-11
CN104039816B (zh) 2018-02-09
IN2014CN04187A (OSRAM) 2015-07-17
EP2807186A4 (en) 2016-01-27
TW201335178A (zh) 2013-09-01
AU2013211973B2 (en) 2017-10-12

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