JP2015505966A - 循環腫瘍細胞を特定するための装置、システム、及び方法 - Google Patents

循環腫瘍細胞を特定するための装置、システム、及び方法 Download PDF

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JP2015505966A
JP2015505966A JP2014546147A JP2014546147A JP2015505966A JP 2015505966 A JP2015505966 A JP 2015505966A JP 2014546147 A JP2014546147 A JP 2014546147A JP 2014546147 A JP2014546147 A JP 2014546147A JP 2015505966 A JP2015505966 A JP 2015505966A
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マリエンフェルド ゲルド
マリエンフェルド ゲルド
ピーター クーン
クーン ピーター
コラトカル アナンド
コラトカル アナンド
マリヌッチ デナ
マリヌッチ デナ
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Scripps Research Institute
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JP2014546147A 2011-12-09 2012-12-07 循環腫瘍細胞を特定するための装置、システム、及び方法 Pending JP2015505966A (ja)

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US201161568793P 2011-12-09 2011-12-09
US61/568,793 2011-12-09
PCT/US2012/068586 WO2013086428A1 (en) 2011-12-09 2012-12-07 Apparatus, system and method for identifying circulating tumor cells

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US (1) US20140329917A1 (https=)
EP (1) EP2788773A4 (https=)
JP (1) JP2015505966A (https=)
KR (1) KR20150008842A (https=)
CN (1) CN104428677A (https=)
AU (1) AU2012347526A1 (https=)
BR (1) BR112014013956A2 (https=)
CA (1) CA2858689A1 (https=)
EA (1) EA201491140A1 (https=)
HK (1) HK1201916A1 (https=)
IL (1) IL233007A0 (https=)
MX (1) MX2014006884A (https=)
SG (1) SG11201403041TA (https=)
WO (1) WO2013086428A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180019607A (ko) * 2016-07-25 2018-02-26 가부시끼가이샤 옵토니쿠스 세이미쯔 세포의 슬라이드 글래스 표본 제작 장치, 세포의 슬라이드 글래스 표본 제작 방법, 및 dna 또는 rna의 추출 방법
WO2018116465A1 (ja) * 2016-12-22 2018-06-28 日立化成株式会社 Her2陽性癌細胞の検出方法
JP2018136336A (ja) * 2018-04-19 2018-08-30 日立化成株式会社 標準細胞液
JP2021073437A (ja) * 2015-04-21 2021-05-13 ジェネンテック, インコーポレイテッド 前立腺がんの分析のための組成物及び方法
JP2021110664A (ja) * 2020-01-14 2021-08-02 学校法人杏林学園 癌被験体の予後を予測する方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1413874A1 (en) 2002-10-16 2004-04-28 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018569U1 (de) 2009-02-18 2017-09-26 Streck Inc. Konservierung zellfreier Nukleinsäuren
EP3045918B1 (en) 2009-10-21 2017-12-06 The Scripps Research Institute Method of using non-rare cells to detect rare cells
US9956281B2 (en) 2011-05-04 2018-05-01 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
US9396532B2 (en) * 2012-11-15 2016-07-19 Siemens Healthcare Diagnostics, Inc. Cell feature-based automatic circulating tumor cell detection
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
WO2015017046A1 (en) * 2013-07-31 2015-02-05 The Regents Of The University Of California Fluorescent imaging using a flatbed scanner
EP3502270B1 (en) * 2013-10-21 2020-03-18 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
WO2015112999A1 (en) * 2014-01-27 2015-07-30 Epic Sciences, Inc. Detection of prostate specific membrane antigen (psma) expression on circulating tumor cells (ctc)
EA201691496A1 (ru) 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток
EP3100052B1 (en) * 2014-01-30 2021-03-10 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
CN104062428B (zh) * 2014-07-09 2016-08-17 郑勤 一种检测循环肿瘤细胞的试剂盒
CN107208151A (zh) * 2014-12-10 2017-09-26 得克萨斯州大学系统董事会 使用基因组特异性探针的循环肿瘤和肿瘤干细胞检测
US20160178630A1 (en) * 2014-12-18 2016-06-23 Creatv Microtech, Inc. Methods for predicting overall survival of cancer patients based on numbers of circulating tumor cells
WO2016121574A1 (ja) * 2015-01-29 2016-08-04 コニカミノルタ株式会社 相互作用する分子を有する血中細胞の同時検出方法
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
CN107921277A (zh) * 2015-05-14 2018-04-17 伊利诺伊大学理事会 使用循环肿瘤细胞作为生物标志物来监测癌症疗法的功效的方法
WO2016207986A1 (ja) * 2015-06-24 2016-12-29 株式会社日立製作所 検査システム、検査装置、及び検査方法
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
EP4656715A3 (en) 2016-07-29 2026-02-25 Streck LLC Suspension composition for hematology analysis control
US9738937B1 (en) * 2017-03-31 2017-08-22 Cellmax, Ltd. Identifying candidate cells using image analysis
IT201700085439A1 (it) * 2017-07-26 2019-01-26 Tethis S P A Metodo di immobilizzazione di campioni biologici a scopo analitico e diagnostico
CN115119829B (zh) 2017-10-19 2024-07-12 斯特雷克股份有限公司 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物
CN109887542A (zh) * 2019-02-12 2019-06-14 嘉兴海云惠智医疗科技有限公司 一种基于云计算的肿瘤个体化基因检测智能解读系统
CN110146704A (zh) * 2019-03-28 2019-08-20 苏州举健生物科技有限公司 一种基于循环肿瘤细胞的用药及病理检测数据系统
CN111323362A (zh) * 2020-03-17 2020-06-23 宁波江丰生物信息技术有限公司 一种基于荧光切片的循环肿瘤细胞检测系统及检测方法
CN114092934A (zh) * 2020-07-31 2022-02-25 骏实生物科技(上海)有限公司 循环肿瘤细胞的分类方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526785A (ja) * 1998-08-07 2002-08-20 バイオジェネックス ラボラトリーズ 疎水性防壁によって規定された反応区域を有するスライド
JP2009500675A (ja) * 2005-07-08 2009-01-08 イコニシス インコーポレーテッド スライド堆積室
JP2009525468A (ja) * 2006-01-30 2009-07-09 ザ・スクリプス・リサーチ・インステイチユート 循環腫瘍細胞の検出方法および哺乳類対象における癌の診断方法
JP2010512508A (ja) * 2006-12-20 2010-04-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 量子ドットで染色された組織試料の定量的マルチ・スペクトル画像の分析
WO2011093927A1 (en) * 2010-01-27 2011-08-04 Duke University Biomarkers for circulating tumor cells

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3830721A1 (de) * 1988-09-09 1990-03-22 Michael Dr Menton In labors, insbesondere in medizinischen labors, zu verwendender objekttraeger
CN2265982Y (zh) * 1996-05-20 1997-10-29 中国农业大学 平底方槽型细胞显微操作载片
US8192994B2 (en) * 1998-02-10 2012-06-05 Angros Lee H Method of applying a biological specimen to an analytic plate
CN2377532Y (zh) * 1999-06-10 2000-05-10 中国人民解放军第二军医大学 微量荧光细胞计数板
US20020187485A1 (en) * 2000-10-25 2002-12-12 Jakobsen Mogens Hausteen Open substrate platforms suitable for analysis of biomolecules
US7943093B2 (en) * 2001-12-12 2011-05-17 Erie Scientific Company Cover slip
WO2008151278A1 (en) * 2007-06-05 2008-12-11 Nanopoint, Inc. Cell tray systems and methods
CN201184866Y (zh) * 2008-02-26 2009-01-21 强实贸易(上海)有限公司 定量细胞计数系统装置
US8860938B2 (en) * 2008-10-21 2014-10-14 Chemometec A/S Apparatus and methods for analysing fluorescent particles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526785A (ja) * 1998-08-07 2002-08-20 バイオジェネックス ラボラトリーズ 疎水性防壁によって規定された反応区域を有するスライド
JP2009500675A (ja) * 2005-07-08 2009-01-08 イコニシス インコーポレーテッド スライド堆積室
JP2009525468A (ja) * 2006-01-30 2009-07-09 ザ・スクリプス・リサーチ・インステイチユート 循環腫瘍細胞の検出方法および哺乳類対象における癌の診断方法
JP2010512508A (ja) * 2006-12-20 2010-04-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 量子ドットで染色された組織試料の定量的マルチ・スペクトル画像の分析
WO2011093927A1 (en) * 2010-01-27 2011-08-04 Duke University Biomarkers for circulating tumor cells

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021073437A (ja) * 2015-04-21 2021-05-13 ジェネンテック, インコーポレイテッド 前立腺がんの分析のための組成物及び方法
JP7022191B2 (ja) 2015-04-21 2022-02-17 ジェネンテック, インコーポレイテッド 前立腺がんの分析のための組成物及び方法
KR20180019607A (ko) * 2016-07-25 2018-02-26 가부시끼가이샤 옵토니쿠스 세이미쯔 세포의 슬라이드 글래스 표본 제작 장치, 세포의 슬라이드 글래스 표본 제작 방법, 및 dna 또는 rna의 추출 방법
KR102064049B1 (ko) 2016-07-25 2020-01-08 가부시끼가이샤 옵토니쿠스 세이미쯔 세포의 슬라이드 글래스 표본 제작 방법
WO2018116465A1 (ja) * 2016-12-22 2018-06-28 日立化成株式会社 Her2陽性癌細胞の検出方法
JP2018136336A (ja) * 2018-04-19 2018-08-30 日立化成株式会社 標準細胞液
JP2021110664A (ja) * 2020-01-14 2021-08-02 学校法人杏林学園 癌被験体の予後を予測する方法

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SG11201403041TA (en) 2014-08-28
MX2014006884A (es) 2015-06-02
KR20150008842A (ko) 2015-01-23
IL233007A0 (en) 2014-07-31
CN104428677A (zh) 2015-03-18
CA2858689A1 (en) 2013-06-13
EP2788773A1 (en) 2014-10-15
BR112014013956A2 (pt) 2017-06-13
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AU2012347526A1 (en) 2014-07-10
EA201491140A1 (ru) 2014-11-28

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