JP2015505471A5 - - Google Patents
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- Publication number
- JP2015505471A5 JP2015505471A5 JP2014555522A JP2014555522A JP2015505471A5 JP 2015505471 A5 JP2015505471 A5 JP 2015505471A5 JP 2014555522 A JP2014555522 A JP 2014555522A JP 2014555522 A JP2014555522 A JP 2014555522A JP 2015505471 A5 JP2015505471 A5 JP 2015505471A5
- Authority
- JP
- Japan
- Prior art keywords
- acetolactate
- microorganism
- butanediol
- producing
- converting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 26
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 claims 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 15
- 102000004190 Enzymes Human genes 0.000 claims 15
- 108090000790 Enzymes Proteins 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 14
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 14
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 108010000700 Acetolactate synthase Proteins 0.000 claims 8
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 8
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 8
- 108010084631 acetolactate decarboxylase Proteins 0.000 claims 8
- 238000012239 gene modification Methods 0.000 claims 8
- 230000005017 genetic modification Effects 0.000 claims 8
- 235000013617 genetically modified food Nutrition 0.000 claims 8
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 claims 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 4
- 101100072559 Bacillus subtilis (strain 168) alsS gene Proteins 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 4
- 101710088194 Dehydrogenase Proteins 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
- 108010036467 butanediol dehydrogenase Proteins 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 238000000855 fermentation Methods 0.000 claims 4
- 230000004151 fermentation Effects 0.000 claims 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 4
- 229960000310 isoleucine Drugs 0.000 claims 4
- 108010084715 isopropanol dehydrogenase (NADP) Proteins 0.000 claims 4
- 229940049920 malate Drugs 0.000 claims 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- 239000004474 valine Substances 0.000 claims 4
- 241000193403 Clostridium Species 0.000 claims 3
- 241001656809 Clostridium autoethanogenum Species 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 2
- 241001171821 Clostridium coskatii Species 0.000 claims 1
- 241000186566 Clostridium ljungdahlii Species 0.000 claims 1
- 241001611023 Clostridium ragsdalei Species 0.000 claims 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 150000003138 primary alcohols Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019002184A JP6898365B2 (ja) | 2012-01-31 | 2019-01-09 | 組換え微生物およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261593269P | 2012-01-31 | 2012-01-31 | |
| US61/593,269 | 2012-01-31 | ||
| PCT/NZ2013/000012 WO2013115659A2 (en) | 2012-01-31 | 2013-01-31 | Recombinant microorganisms and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019002184A Division JP6898365B2 (ja) | 2012-01-31 | 2019-01-09 | 組換え微生物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505471A JP2015505471A (ja) | 2015-02-23 |
| JP2015505471A5 true JP2015505471A5 (cg-RX-API-DMAC10.html) | 2016-03-10 |
| JP6512825B2 JP6512825B2 (ja) | 2019-05-15 |
Family
ID=48905994
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555522A Active JP6512825B2 (ja) | 2012-01-31 | 2013-01-31 | 組換え微生物およびその使用方法 |
| JP2019002184A Active JP6898365B2 (ja) | 2012-01-31 | 2019-01-09 | 組換え微生物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019002184A Active JP6898365B2 (ja) | 2012-01-31 | 2019-01-09 | 組換え微生物およびその使用方法 |
Country Status (13)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2710117B1 (en) * | 2012-01-31 | 2016-04-27 | Lanzatech New Zealand Limited | Recombinant microorganisms and methods of use thereof |
| DK3047028T5 (da) * | 2013-09-22 | 2024-10-14 | Lanzatech Nz Inc | Fermenteringsfremgangsmåde |
| US20150152445A1 (en) * | 2013-12-03 | 2015-06-04 | Lanzatech New Zealand Limited | Microorganisms and methods for the production of ketones |
| WO2015116874A1 (en) * | 2014-01-30 | 2015-08-06 | Lanzatech New Zealand Limited | Recombinant microorganisms and methods of use thereof |
| KR102308556B1 (ko) * | 2014-08-11 | 2021-10-07 | 란자테크 뉴질랜드 리미티드 | 변경된 일산화탄소 탈수소효소(codh) 활성을 가지는 유전자 조작된 박테리아 |
| AU2015360786B2 (en) * | 2014-12-08 | 2021-10-21 | Lanzatech Nz, Inc. | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
| WO2017037897A1 (ja) * | 2015-09-02 | 2017-03-09 | 積水化学工業株式会社 | 組換え細胞、組換え細胞の製造方法、並びに、１，４－ブタンジオールの生産方法 |
| JP6905518B2 (ja) | 2015-10-13 | 2021-07-21 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| CN108603178A (zh) * | 2016-01-06 | 2018-09-28 | 株式会社西化学 | Co水合酶以及使用其产生甲酸的方法 |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11505809B2 (en) * | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| US20190233816A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| CN113490748A (zh) * | 2019-02-25 | 2021-10-08 | 西北大学 | 来源于梭菌属提取物的无细胞蛋白质合成平台 |
| CN111089914A (zh) * | 2019-11-07 | 2020-05-01 | 河北首朗新能源科技有限公司 | 微生物发酵生产乙醇中代谢物的高效液相检测方法 |
| CN111154683B (zh) * | 2020-01-19 | 2022-05-13 | 南京工业大学 | 一种食甲基丁酸杆菌的优化培养方法及其应用 |
| CN111220762A (zh) * | 2020-03-24 | 2020-06-02 | 河北首朗新能源科技有限公司 | 一种乙醇梭菌蛋白中有机物的含量的检测方法及应用 |
| CN114144513A (zh) * | 2020-04-29 | 2022-03-04 | 朗泽科技有限公司 | 从气态底物发酵生产β-酮己二酸盐 |
| JP2023520257A (ja) * | 2020-06-06 | 2023-05-16 | ランザテク，インコーポレイテッド | アセトラクテートデカルボキシラーゼ遺伝子座位でのノックインを有する微生物 |
| TW202212566A (zh) * | 2020-09-25 | 2022-04-01 | 美商朗澤科技有限公司 | 重組微生物及其用途 |
| CN113234653B (zh) * | 2021-04-22 | 2022-10-04 | 中国科学院青岛生物能源与过程研究所 | 一种提高合成气发酵产乙醇含量的突变株和利用突变株的应用 |
| US20240117393A1 (en) | 2022-09-30 | 2024-04-11 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
| CN115960808A (zh) * | 2022-11-24 | 2023-04-14 | 苏州聚维元创生物科技有限公司 | 一种敲除基因的重组大肠杆菌及其构建方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5437631B2 (ja) * | 2005-07-01 | 2014-03-12 | ザ ユニバーシティー オブ フロリダ リサーチ ファンデーション インク | エタノール産生のための組み換えホスト細胞及び培地 |
| WO2008013996A2 (en) | 2006-07-27 | 2008-01-31 | Gevo Inc. | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
| DE102007048277A1 (de) * | 2007-10-08 | 2009-04-09 | Agraferm Technologies Ag | Verfahren und Vorrichtung zur mikrobiellen Herstellung eines bestimmten Produktes und Methan |
| KR101375029B1 (ko) * | 2007-11-13 | 2014-03-14 | 란자테크 뉴질랜드 리미티드 | 신규 세균 및 이의 이용 방법 |
| US8119378B2 (en) | 2008-03-12 | 2012-02-21 | Lanzatech New Zealand Limited | Microbial alcohol production process |
| AU2009258344B2 (en) * | 2008-06-09 | 2013-11-07 | Lanzatech Nz, Inc. | Production of butanediol by anaerobic microbial fermentation |
| DE102009002583A1 (de) | 2009-04-23 | 2010-10-28 | Evonik Degussa Gmbh | Zellen und Verfahren zur Herstellung von Aceton |
| US8143037B2 (en) * | 2010-03-19 | 2012-03-27 | Coskata, Inc. | Ethanologenic Clostridium species, Clostridium coskatii |
| BR112013003644B1 (pt) * | 2010-07-28 | 2020-11-17 | Lanzatech New Zealand Limited | isolado biologicamente puro de uma bactéria clostridium autoethanogenum |
| EP2710117B1 (en) * | 2012-01-31 | 2016-04-27 | Lanzatech New Zealand Limited | Recombinant microorganisms and methods of use thereof |
-
2013
- 2013-01-31 EP EP13743087.2A patent/EP2710117B1/en active Active
- 2013-01-31 WO PCT/NZ2013/000012 patent/WO2013115659A2/en not_active Ceased
- 2013-01-31 AU AU2013215706A patent/AU2013215706B2/en not_active Ceased
- 2013-01-31 ES ES13743087.2T patent/ES2583203T3/es active Active
- 2013-01-31 CN CN201380018640.9A patent/CN104395455B/zh active Active
- 2013-01-31 MY MYPI2014002189A patent/MY165103A/en unknown
- 2013-01-31 EA EA201491418A patent/EA031093B1/ru not_active IP Right Cessation
- 2013-01-31 BR BR112014018844-0A patent/BR112014018844B1/pt active IP Right Grant
- 2013-01-31 KR KR1020137032065A patent/KR101511639B1/ko active Active
- 2013-01-31 JP JP2014555522A patent/JP6512825B2/ja active Active
- 2013-01-31 CA CA2862790A patent/CA2862790C/en active Active
- 2013-01-31 US US13/876,563 patent/US9057071B2/en active Active
-
2014
- 2014-08-11 ZA ZA2014/05858A patent/ZA201405858B/en unknown
-
2015
- 2015-05-04 US US14/703,222 patent/US9297026B2/en active Active
-
2019
- 2019-01-09 JP JP2019002184A patent/JP6898365B2/ja active Active
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