JP2015501843A5 - - Google Patents

Download PDF

Info

Publication number
JP2015501843A5
JP2015501843A5 JP2014547416A JP2014547416A JP2015501843A5 JP 2015501843 A5 JP2015501843 A5 JP 2015501843A5 JP 2014547416 A JP2014547416 A JP 2014547416A JP 2014547416 A JP2014547416 A JP 2014547416A JP 2015501843 A5 JP2015501843 A5 JP 2015501843A5
Authority
JP
Japan
Prior art keywords
mir
pharmaceutical composition
adenocarcinoma
cancer
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014547416A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015501843A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/069484 external-priority patent/WO2013090556A1/en
Publication of JP2015501843A publication Critical patent/JP2015501843A/ja
Publication of JP2015501843A5 publication Critical patent/JP2015501843A5/ja
Pending legal-status Critical Current

Links

JP2014547416A 2011-12-13 2012-12-13 miR−21およびmiR−29a、エキソソーム阻害、およびがん転移に関する方法および組成物 Pending JP2015501843A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161569862P 2011-12-13 2011-12-13
US61/569,862 2011-12-13
US201261644980P 2012-05-09 2012-05-09
US61/644,980 2012-05-09
PCT/US2012/069484 WO2013090556A1 (en) 2011-12-13 2012-12-13 Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis

Publications (2)

Publication Number Publication Date
JP2015501843A JP2015501843A (ja) 2015-01-19
JP2015501843A5 true JP2015501843A5 (OSRAM) 2016-01-21

Family

ID=48613170

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014547416A Pending JP2015501843A (ja) 2011-12-13 2012-12-13 miR−21およびmiR−29a、エキソソーム阻害、およびがん転移に関する方法および組成物

Country Status (7)

Country Link
US (2) US9481885B2 (OSRAM)
EP (1) EP2790735A4 (OSRAM)
JP (1) JP2015501843A (OSRAM)
CN (1) CN104619353A (OSRAM)
AU (1) AU2012352265B2 (OSRAM)
CA (1) CA2859430A1 (OSRAM)
WO (1) WO2013090556A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10036018B2 (en) 2014-03-10 2018-07-31 Carlo M. Croce Compositions and methods for treating cachexia
CN105316336B (zh) * 2015-10-20 2018-01-12 浙江大学 一种抑制Bid蛋白表达的miR‑29a模拟物及其应用
WO2017079983A1 (en) * 2015-11-13 2017-05-18 Amoigen Bioscience (Xiamen) Company Limited USES OF MICRORNA MIR-574-5p-BASED COMPOUNDS AS IMMUNOMODULATORS AND COMPOSITIONS THEREOF
US11243215B2 (en) 2016-01-14 2022-02-08 The Regents Of The University Of California 3D-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids
US20190040093A1 (en) * 2016-02-10 2019-02-07 Ymir Genomics Llc Bioparticle isolation and therapeutic application thereof
CA3015054A1 (en) * 2016-02-18 2017-08-24 Kyoto University Complex capable of inhibiting genetic function in exosome, and cancer proliferation and/or metastasis suppressor
US20180235936A1 (en) * 2017-02-17 2018-08-23 University Of Notre Dame Du Lac Cancer treatment methods
WO2018160699A1 (en) * 2017-03-01 2018-09-07 University Of Notre Dame Du Lac Biomarkers for diagnosis, prediction and/or prognosis of pancreatic cancer and uses thereof
CN107412250B (zh) * 2017-05-11 2019-03-05 南京北恒生物科技有限公司 miR-193a-3p的应用
CN115856300B (zh) * 2022-08-01 2024-06-21 南京大学 一种与肺癌相关的血浆外泌体蛋白标志物、抗体及其应用
CN116650513A (zh) * 2023-07-25 2023-08-29 中国农业大学 miR-29在制备调节细胞能量代谢和细胞干性的制剂中的应用

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4172124A (en) 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
US4608337A (en) 1980-11-07 1986-08-26 The Wistar Institute Human hybridomas and the production of human monoclonal antibodies by human hybridomas
US4701409A (en) 1984-11-15 1987-10-20 The Wistar Institute Detection of B-cell neoplasms
US4693975A (en) 1984-11-20 1987-09-15 The Wistar Institute Human hybridroma fusion partner for production of human monoclonal antibodies
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US5198338A (en) 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
EP0480970A1 (en) 1989-07-03 1992-04-22 Temple University - Of The Commonwealth System Higher Education Tcl-5 gene rearrangement involved in t-cell leukemia and melanoma
US5149628A (en) 1989-11-15 1992-09-22 Temple University Methods for detecting bcl-3 gene in human leukemias
US6040140A (en) 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5633135A (en) 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
WO1993012136A1 (en) 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
EP0667920B1 (en) 1992-10-29 2003-01-15 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
US5674682A (en) 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
GB9307754D0 (en) 1993-04-15 1993-06-02 Perry Robert E Diagnostic probes and therapeutic products
WO1994026930A1 (en) 1993-05-14 1994-11-24 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5985598A (en) 1994-10-27 1999-11-16 Thomas Jefferson University TCL-1 gene and protein and related methods and compositions
US7175995B1 (en) 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US5695944A (en) 1995-05-05 1997-12-09 Thomas Jefferson University Modulation of bcl-2 phosphorylation
US5567586A (en) 1995-05-18 1996-10-22 Thomas Jefferson University Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region
US6242212B1 (en) 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5928884A (en) 1996-02-09 1999-07-27 Croce; Carlo M. FHIT proteins and nucleic acids and methods based thereon
AU4003597A (en) 1996-09-04 1998-03-26 Howard Florey Institute Of Experimental Physiology And Medicine Methods of diagnosing and treating cancer
WO1998035707A1 (en) 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
WO1998045480A1 (en) 1997-04-04 1998-10-15 The Texas A & M University System Noninvasive detection of colonic biomarkers using fecal messenger rna
EP1025444B1 (en) 1997-10-21 2005-03-02 Cancer Research Technology Limited Determination of cellular growth abnormality
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
WO2000003685A2 (en) 1998-07-20 2000-01-27 Thomas Jefferson University Nitrilase homologs
US6255293B1 (en) 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
AU2869300A (en) 1999-02-05 2000-08-25 Uab Research Foundation, The Fiber receptor-independent system for the propagation of adenoviral vectors
JP2003508011A (ja) 1999-02-25 2003-03-04 トマス・ジエフアーソン・ユニバーシテイ ヒトfez1遺伝子である新規ガン抑制遺伝子に関する組成物、キットおよび方法
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
JP2003519463A (ja) 1999-03-15 2003-06-24 トーマス・ジェファーソン・ユニバーシティー TCL−1b遺伝子、蛋白質、それらに関連した方法およびそれらに関連する物質
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
WO2001007914A1 (en) 1999-07-26 2001-02-01 Childrens Hospital Los Angeles Research Institute Fenretinide increases antibody cellular toxicity
US7163801B2 (en) 1999-09-01 2007-01-16 The Burnham Institute Methods for determining the prognosis for cancer patients using tucan
US20040132017A1 (en) 1999-12-16 2004-07-08 Robert Richards Oxidoreductase gene associated with the fra16d fragile site
US20030206958A1 (en) 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
US6891031B2 (en) 2000-02-18 2005-05-10 The Regents Of The University Of California Coordinate cytokine regulatory sequences
WO2001068666A1 (en) 2000-03-14 2001-09-20 Thomas Jefferson University Tcl1 enhances akt kinase activity and mediates its nuclear translocation
JP2004516002A (ja) 2000-04-11 2004-06-03 トーマス・ジェファーソン・ユニバーシティー Fhit欠損マウスにおけるミュア−トール様症候群
WO2001087958A2 (en) 2000-05-16 2001-11-22 Thomas Jefferson University CRYSTAL STRUCTURE OF WORM NitFhit REVEALS THAT A Nit TETRAMER BINDS TWO Fhit DIMERS
US7060811B2 (en) 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
WO2002064171A1 (en) 2001-02-12 2002-08-22 Thomas Jefferson University Adenoviral transduction of fragile histidine triad (fhit) into cancer cells
WO2002064172A2 (en) 2001-02-12 2002-08-22 Thomas Jefferson University Fhit gene therapy prevents tumor development in fhit-deficient mice
US20040033502A1 (en) 2001-03-28 2004-02-19 Amanda Williams Gene expression profiles in esophageal tissue
US20050176025A1 (en) 2001-05-18 2005-08-11 Sirna Therapeutics, Inc. RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
EP2428568B1 (en) 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Microrna molecules
US7371736B2 (en) 2001-11-07 2008-05-13 The Board Of Trustees Of The University Of Arkansas Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
US7455995B2 (en) 2001-11-09 2008-11-25 The Ohio State University Research Foundation BAALC expression as a diagnostic marker for acute leukemia
GB0128898D0 (en) 2001-12-03 2002-01-23 Biotech Res Ventures Pte Ltd Materials and methods relating to the stabilization and activation of a tumour suppressor protein
WO2003069853A1 (en) 2002-02-12 2003-08-21 Nokia Corporation Method for controlling data transmission, and data transmission system
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
EP1442143A4 (en) 2002-02-20 2005-02-16 Sirna Therapeutics Inc INHIBITION OF BCL2 GENE EXPRESSION MEDIATED BY RNA INTERFERENCE USING siNA (SHORT INTERFERING NUCLEIC ACID)
NZ535101A (en) 2002-03-08 2007-07-27 Eisai Co Ltd Macrocyclic compounds useful as pharmaceuticals
DK2261369T3 (da) 2002-03-13 2014-07-28 Genomic Health Inc Genekspressionsprofilering i biopsier af tumorvæv
JP2005522677A (ja) 2002-04-08 2005-07-28 シファーゲン バイオシステムズ, インコーポレイテッド 肝細胞癌の血清バイオマーカー
JP2005523712A (ja) 2002-04-29 2005-08-11 トマス ジェファソン ユニバーシティ 標的tcl1発現によりマウスでモデル化されたヒト慢性リンパ球性白血病
WO2003102215A2 (en) 2002-05-31 2003-12-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying and isolating stem cells and cancer stem cells
US20050260639A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
AU2003284083A1 (en) 2002-10-11 2004-05-04 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
US20050266443A1 (en) 2002-10-11 2005-12-01 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
CN1719973A (zh) 2002-11-13 2006-01-11 托马斯杰斐逊大学 用于癌症诊断和治疗的组合物和方法
CA2504605C (en) 2002-11-13 2016-01-19 Thomas Jefferson University Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2004071464A2 (en) 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
WO2004079013A1 (en) 2003-03-03 2004-09-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer
US7183384B2 (en) 2003-03-06 2007-02-27 A & G Pharmaceutical, Inc. Monoclonal antibody 7H11 reactive with human cancer
AU2004219595A1 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
WO2004098377A2 (en) 2003-05-02 2004-11-18 Thomas Jefferson University Methods and compositions for diagnosis and therapy of parkin-associated disorders
US20050069918A1 (en) 2003-05-29 2005-03-31 Francois Claret JAB1 as a prognostic marker and a therapeutic target for human cancer
EP2028270B9 (en) 2003-06-18 2012-04-25 Genelux Corporation Modified recombinant vaccinia viruses, uses thereof
EP2530157B1 (en) 2003-07-31 2016-09-28 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of miRNAs
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
US20050037362A1 (en) 2003-08-11 2005-02-17 Eppendorf Array Technologies, S.A. Detection and quantification of siRNA on microarrays
US8412541B2 (en) 2003-08-14 2013-04-02 Edda Technology, Inc. Method and system for intelligent qualitative and quantitative analysis for medical diagnosis
WO2005020795A2 (en) 2003-08-25 2005-03-10 The Johns Hopkins University Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differntial gene expression analysis
WO2005028648A1 (ja) 2003-09-22 2005-03-31 Aichi Prefecture リンパ腫の病型および予後診断方法
EP1670955A2 (en) 2003-09-22 2006-06-21 Rosetta Inpharmatics LLC. Synthetic lethal screen using rna interference
US20070054849A1 (en) 2003-09-24 2007-03-08 Oncotherapy Science, Inc. Method for diagnosing hepatocellular carcinomas
US20050186589A1 (en) 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
US20050164252A1 (en) 2003-12-04 2005-07-28 Yeung Wah Hin A. Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell
DE602004031881D1 (de) 2003-12-19 2011-04-28 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
JP4120002B2 (ja) 2004-01-07 2008-07-16 愛知県 miRNAを用いた癌の予後判定方法、癌の遺伝子治療ベクター及び癌治療用医薬組成物
US20050256072A1 (en) 2004-02-09 2005-11-17 University Of Massachusetts Dual functional oligonucleotides for use in repressing mutant gene expression
EP2295604B1 (en) 2004-02-09 2015-04-08 Thomas Jefferson University Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features
CA2556435C (en) 2004-02-13 2014-08-12 The Rockefeller University Anti-microrna oligonucleotide molecules
CN101088089A (zh) 2004-02-23 2007-12-12 鹿特丹伊拉斯姆斯大学医疗中心 通过基因表达图形对急性粒细胞性白血病进行分类、诊断和预后
WO2005094263A2 (en) 2004-03-23 2005-10-13 Pintex Pharmaceuticals, Inc. Methods of determining the prognosis and treatment of subjects with colon cancer
US20060134639A1 (en) 2004-04-06 2006-06-22 Huffel Christophe V Method for the determination of cellular transcriptional regulation
US7365058B2 (en) 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
CA2585525A1 (en) 2004-04-20 2005-11-03 Genaco Biomedical Products, Inc. Method for detecting ncrna
CA2566519C (en) 2004-05-14 2020-04-21 Rosetta Genomics Ltd. Micrornas and uses thereof
US7888010B2 (en) 2004-05-28 2011-02-15 Asuragen, Inc. Methods and compositions involving microRNA
US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
JP2008505104A (ja) 2004-07-01 2008-02-21 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 免疫抑制性エキソソーム
US20060037088A1 (en) 2004-08-13 2006-02-16 Shulin Li Gene expression levels as predictors of chemoradiation response of cancer
EP1797183B1 (en) 2004-09-02 2012-08-01 Yale University Regulation of oncogenes by micrornas
US7642348B2 (en) 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
US7592441B2 (en) 2004-10-04 2009-09-22 Rosetta Genomics Ltd Liver cancer-related nucleic acids
FR2877350B1 (fr) 2004-11-03 2010-08-27 Centre Nat Rech Scient IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE
EP2808389A1 (en) * 2004-11-12 2014-12-03 Asuragen, Inc. Methods and compositions involving MIRNA and MIRNA inhibitor molecules
EP1662259A1 (en) 2004-11-25 2006-05-31 Cellzome Ag Use of Eph receptor inhibitors for the treatment of neurodegenerative diseases
CA2590768A1 (en) 2004-12-14 2006-06-22 Alnylam Pharmaceuticals, Inc. Rnai modulation of mll-af4 and uses thereof
US20060185027A1 (en) 2004-12-23 2006-08-17 David Bartel Systems and methods for identifying miRNA targets and for altering miRNA and target expression
EP1838870A2 (en) 2004-12-29 2007-10-03 Exiqon A/S NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs
US8071306B2 (en) 2005-01-25 2011-12-06 Merck Sharp & Dohme Corp. Methods for quantitating small RNA molecules
DE602006016739D1 (de) 2005-01-25 2010-10-21 Rosetta Inpharmatics Llc Verfahren zur quantifizierung kleiner rna-moleküle
EP1856286A2 (en) 2005-02-11 2007-11-21 Wisconsin Alumni Research Foundation Mir-155 assay
MX2007009889A (es) 2005-02-23 2007-09-07 Genentech Inc Alargar el tiempo hasta la progresion de la enfermedad o la supervivencia de los pacientes de cancer.
US20070065840A1 (en) 2005-03-23 2007-03-22 Irena Naguibneva Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
GB2425311A (en) 2005-04-15 2006-10-25 Ist Superiore Sanita Micro RNA against kit protein
EP2631292A3 (en) 2005-04-29 2013-11-20 The Rockefeller University Human microRNAs and methods for inhibiting same
US8071559B2 (en) 2005-05-02 2011-12-06 Cold Spring Harbor Laboratory Compositions and methods for cancer diagnosis and treatment
US20090209621A1 (en) 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070065844A1 (en) 2005-06-08 2007-03-22 Massachusetts Institute Of Technology Solution-based methods for RNA expression profiling
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
CN102533966B (zh) 2005-08-01 2014-03-12 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
WO2007021896A2 (en) 2005-08-10 2007-02-22 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro rna and uses thereof
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
CN103028120B (zh) 2005-09-12 2015-08-12 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
US20090270484A1 (en) 2005-10-05 2009-10-29 The Ohio State University Research Foundation WWOX Vectors and Uses in Treatment of Cancer
US20070092882A1 (en) 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US7390792B2 (en) 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
US20100286044A1 (en) 2005-12-29 2010-11-11 Exiqon A/S Detection of tissue origin of cancer
JP5490413B2 (ja) 2006-01-05 2014-05-14 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常
ES2508893T3 (es) 2006-01-05 2014-10-16 The Ohio State University Research Foundation Métodos basados en microARN para el diagnóstico de cánceres de estómago
ES2554531T3 (es) 2006-01-05 2015-12-21 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
WO2007084486A2 (en) 2006-01-13 2007-07-26 Battelle Memorial Institute Animal model for assessing copd-related diseases
EP2371971B1 (en) 2006-03-20 2013-11-27 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
US20090324618A1 (en) 2006-03-24 2009-12-31 Armstrong Scott A Novel signature self renewal gene expression programs
AU2007233155B2 (en) 2006-03-29 2012-04-26 Scitech Development Llc Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
WO2007112754A2 (en) * 2006-04-03 2007-10-11 Santaris Pharma A/S Pharmaceutical compositions comprising anti-mirna antisense oligonucleotides
CA2650026C (en) 2006-04-24 2013-01-22 The Ohio State University Research Foundation Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice
DK2038432T3 (en) 2006-06-30 2017-04-03 Rosetta Genomics Ltd METHOD OF DETECTING AND QUANTIFYING A TARGET NUCLEIC ACID GENERATED BY RT-PCR BY MIRNA
EP2369017B8 (en) 2006-07-13 2014-03-12 The Ohio State University Research Foundation Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases
CA2661354C (en) 2006-08-30 2012-12-18 The Regents Of The University Of Michigan New small molecule inhibitors of mdm2 and the uses thereof
US20080193943A1 (en) 2006-09-05 2008-08-14 Abbott Laboratories Companion diagnostic assays for cancer therapy
EP2145001A2 (en) 2006-09-19 2010-01-20 Asuragen, Inc. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
CA2663878A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-200 regulated genes and pathways as targets for therapeutic intervention
US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
JP5520605B2 (ja) 2006-09-19 2014-06-11 アシュラジェン インコーポレイテッド 膵臓疾患で差次的に発現されるマイクロrnaおよびその使用
JP2008086201A (ja) 2006-09-29 2008-04-17 Gifu Prefecture Kenkyu Kaihatsu Zaidan マイクロrna生成の検出方法と癌の診断・治療およびマイクロrna生成調整剤
WO2008054828A2 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
CN101316935B (zh) 2006-11-28 2012-02-29 博奥生物有限公司 一种用于诊断食道癌的芯片
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
WO2008070082A2 (en) 2006-12-04 2008-06-12 The Johns Hopkins University Stem-progenitor cell specific micro-ribonucleic acids and uses thereof
GB0624302D0 (en) 2006-12-05 2007-01-17 Istituto Superiore Di Sanito Micro RNA
WO2008073920A2 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
AU2007333106A1 (en) 2006-12-08 2008-06-19 Asuragen, Inc. miR-20 regulated genes and pathways as targets for therapeutic intervention
CA2671299A1 (en) 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
CN101622350A (zh) 2006-12-08 2010-01-06 奥斯瑞根公司 作为干预治疗靶标的miR-126调控基因和通路
US20090175827A1 (en) 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
CN105256004A (zh) 2007-01-31 2016-01-20 俄亥俄州立大学研究基金会 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
EP2126078B2 (en) 2007-02-27 2023-01-04 Rosetta Genomics Ltd Composition and methods for modulating cell proliferation and cell death
WO2008113758A1 (en) 2007-03-16 2008-09-25 Covalx Ag Direct mass spectrometric analysis of drug candidates targeting protein complexes
AU2008237036A1 (en) 2007-04-10 2008-10-16 Dcb-Usa Llc Predicting post-treatment survival in cancer patients with microRNAs
CA2685840C (en) 2007-04-30 2016-12-13 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
US20090005336A1 (en) 2007-05-08 2009-01-01 Zhiguo Wang Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions
US20090131354A1 (en) 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008154098A2 (en) 2007-06-07 2008-12-18 Wisconsin Alumni Research Foundation Reagents and methods for mirna expression analysis and identification of cancer biomarkers
AU2008261951A1 (en) 2007-06-08 2008-12-18 Asuragen, Inc. miR-34 regulated genes and pathways as targets for therapeutic intervention
CN105950706A (zh) 2007-06-08 2016-09-21 由卫生与公众服务部代表的美利坚合众国政府 确定肝细胞癌亚型和检测肝癌干细胞的方法
AU2008266014B2 (en) 2007-06-15 2013-06-06 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing
WO2009015357A1 (en) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
NZ583024A (en) * 2007-07-31 2012-04-27 Regents The Univeristy Of Texas System Board Of An agonist of miR-29a, miR-29b or miR-29c that prevents tissue fibrosis and uses thereof
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
EP2173908B1 (en) 2007-08-03 2016-01-06 The Ohio State University Research Foundation Ultraconserved regions encoding ncrnas
WO2009026487A1 (en) 2007-08-22 2009-02-26 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
US20090061424A1 (en) 2007-08-30 2009-03-05 Sigma-Aldrich Company Universal ligation array for analyzing gene expression or genomic variations
EP2183393B1 (en) 2007-09-06 2014-06-11 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
US20090239818A1 (en) 2007-09-07 2009-09-24 Cheng Jin Q Effective treatment of ovarian cancer using triciribine and related compounds
BRPI0816852A2 (pt) * 2007-09-14 2017-06-06 Univ Ohio State Res Found método de diagnosticar ou prognosticar doença ou desordem em sujeito, biomarcador, método para determinar e/ou prever se sujeito tem diferenciação da desordem, biomarcador para desordem pulmonar, método para diagnosticar se sujeito tem, ou está em risco de desenvolver doença ou desordem, método de inibir a proliferação de doença ou desordem e método para identificar agente terapêutico do câncer.
EP2208499A4 (en) 2007-10-03 2011-12-28 Kyowa Hakko Kirin Co Ltd NUCLEIC ACID FOR REGULATING CELL PROLIFERATION
ES2406686T3 (es) 2007-10-04 2013-06-07 Santaris Pharma A/S Micromirs
CA2702241A1 (en) 2007-10-11 2009-04-16 The Ohio State University Research Foundation Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas
CN103898069A (zh) 2007-10-26 2014-07-02 俄亥俄州立大学研究基金会 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途
EP2217248B1 (en) * 2007-10-29 2016-11-30 Regulus Therapeutics Inc. Targeting micrornas for the treatment of liver cancer
US20090123933A1 (en) 2007-11-12 2009-05-14 Wake Forest University Health Sciences Microrna biomarkers in lupus
US8575121B2 (en) 2007-11-12 2013-11-05 The United States of America as represented by the Secetary of the Department of Health and Human Services Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
AU2008329755A1 (en) 2007-11-30 2009-06-04 The Ohio State University Research Foundation MicroRNA expression profiling and targeting in peripheral blood in lung cancer
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
CN101215560B (zh) 2007-12-26 2010-09-29 暨南大学 一种具有抗白血病作用的miR-21反义寡核苷酸及其应用
ES2936256T3 (es) 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
EP2260110B1 (en) 2008-02-08 2014-11-12 Asuragen, INC. miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS
EP2096171A1 (en) * 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
EP2799557B1 (en) 2008-02-28 2016-09-07 The Ohio State University Research Foundation MiR-32 antagonists for increasing responsiveness of prostate cancer to apoptosis
US20110034538A1 (en) 2008-02-28 2011-02-10 The Ohio State University Research Foundation MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer
JP2011516033A (ja) 2008-02-28 2011-05-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 急性骨髄性性白血病(aml)における細胞遺伝学および予後と関連するマイクロrnaシグネチャーおよびその使用
CA2717026A1 (en) 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof
CA2717169A1 (en) 2008-03-01 2009-09-17 Abraxis Bioscience, Llc Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas
EP2268832A2 (en) 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
EP2271757A2 (en) 2008-03-26 2011-01-12 Asuragen, INC. Compositions and methods related to mir-16 and therapy of prostate cancer
WO2009131887A2 (en) 2008-04-24 2009-10-29 Merck & Co., Inc. Methods of using mir210 as a biomarker for hypoxia and as a therapeutic agent for treating cancer
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
WO2009147525A1 (en) 2008-06-04 2009-12-10 Karolinska Institutet Innovations Ab Skin cancer associated micrornas
WO2009149418A2 (en) 2008-06-06 2009-12-10 Asuragen, Inc. Novel compositions for the in vivo delivery of rnai agents
JP5745401B2 (ja) 2008-06-11 2015-07-08 アメリカ合衆国 肝細胞癌についての予測マーカーとしてのMiR−26ファミリーの使用および療法に対する反応性
US20100021734A1 (en) 2008-07-22 2010-01-28 Covalent Materials Corporation Ceramic particles and producing method thereof
KR101031305B1 (ko) * 2008-07-23 2011-04-29 국립암센터 마이크로rna-21 저해제를 포함하는 방사선 민감성증진용 조성물
ES2541442T3 (es) 2008-08-01 2015-07-20 Roche Innovation Center Copenhagen A/S Modulación mediada por microARN de factores estimulantes de colonias
KR20110039381A (ko) * 2008-08-04 2011-04-15 이데라 파마슈티칼즈, 인코포레이티드 안티센스 올리고누클레오티드에 의한 톨-유사 수용체 7 발현의 조절
EP2323677A4 (en) 2008-08-12 2013-01-09 Univ Ohio State Res Found MICRO-RNA BASED COMPOSITIONS AND METHODS OF DIAGNOSIS, FORECAST AND TREATMENT OF MULTIPLE MYELOMA
AU2009289822B2 (en) 2008-09-04 2015-04-30 Ventana Medical Systems, Inc. Method for prediction of the progression risk of tumors
US20100179213A1 (en) 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
WO2010059779A1 (en) 2008-11-21 2010-05-27 The Ohio State University Research Foundation Tcl1 AS A TRANSCRIPTIONAL REGULATOR
US20110275534A1 (en) 2008-12-05 2011-11-10 The Ohio State University MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform
CA2753562A1 (en) * 2009-02-26 2010-09-02 The Ohio State University Research Foundation Micrornas in never-smokers and related materials and methods
US8431530B2 (en) * 2009-06-12 2013-04-30 Morehouse School Of Medicine Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
US20110136124A1 (en) 2009-09-23 2011-06-09 Wilson Roa Microrna expression profiles associated with lung cancer
JP2013509430A (ja) 2009-10-28 2013-03-14 リヴィジョン セラピューティクス,インク. レチンアミドによる皮膚癌の予防
US20120219958A1 (en) 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
EP2354246A1 (en) 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
CN102844661B (zh) 2010-02-11 2014-06-25 香港理工大学 胃癌的生物标志物及其应用
CA2802738A1 (en) 2010-06-24 2011-12-29 The Ohio State University Chronic lymphocytic leukemia modeled in mouse by targeted mir-29 expression
EP2600871A2 (en) 2010-08-04 2013-06-12 The Ohio State University Methods for impairing the p53/hdm2 auto-regulatory loop in multiple myeloma development using mir-192, mir-194 and mir-215
CN102146412B (zh) * 2011-01-11 2012-10-03 中山大学 一种小分子非编码RNA 基因hsa-miR-29b 及其应用
US20130017964A1 (en) 2011-01-11 2013-01-17 Croce Carlo M Methods to Identify Chronic Lymphocytic Leukemia Disease Progression
WO2012122239A1 (en) 2011-03-07 2012-09-13 The Ohio State University MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER

Similar Documents

Publication Publication Date Title
JP2015501843A5 (OSRAM)
Pisignano et al. Going circular: history, present, and future of circRNAs in cancer
Hu et al. Emerging landscape of circular RNAs in lung cancer
Qi et al. Highly sensitive detection of multiple microRNAs by high-performance liquid chromatography coupled with long and short probe-based recycling amplification
Li et al. MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival
Van Roosbroeck et al. miRNAs and long noncoding RNAs as biomarkers in human diseases
Hamidi-Asl et al. A review on the electrochemical biosensors for determination of microRNAs
CA2805247C (en) Nanopore-facilitated single molecule detection of nucleic acids
Liu et al. Graphene fluorescence switch-based cooperative amplification: a sensitive and accurate method to detection microRNA
JP2010538610A5 (OSRAM)
EP3916106A1 (en) Method of determining the risk of developing breast cancer
Sheervalilou et al. Electrochemical nano-biosensors as novel approach for the detection of lung cancer-related MicroRNAs
Wang et al. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data
Li et al. microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization
JP2010529857A5 (OSRAM)
Xu et al. miRNA: The nemesis of gastric cancer
JP2010516291A5 (OSRAM)
Marcinkowska et al. Copy number variation of microRNA genes in the human genome
WO2011076142A1 (en) Compositions and methods for microrna expession profiling in plasma of colorectal cancer
Wijesinghe et al. Single-molecule sensor for high-confidence detection of miRNA
EP2514434A3 (en) MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
JP2014527807A5 (OSRAM)
Chatterjee et al. MicroRNAs in cancer: challenges and opportunities in early detection, disease monitoring, and therapeutic agents
Wang et al. miRNA interplay: Mechanisms and therapeutic interventions in cancer
WO2015007293A1 (en) Stem-loop silver nanocluster probes for mirna detection