JP2015500887A - Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 - Google Patents

Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 Download PDF

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Publication number
JP2015500887A
JP2015500887A JP2014548994A JP2014548994A JP2015500887A JP 2015500887 A JP2015500887 A JP 2015500887A JP 2014548994 A JP2014548994 A JP 2014548994A JP 2014548994 A JP2014548994 A JP 2014548994A JP 2015500887 A JP2015500887 A JP 2015500887A
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compound
compound according
selectin
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haloalkyl
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JP2015500887A5 (https=
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ジョン エル． マニャーニ，
ジョン エル． マニャーニ，
アルン ケイ． サーカー，
アルン ケイ． サーカー，
ミュン−ギ ベク，
ミュン−ギ ベク，
フランク イー． ザ サード アンダーソン，
フランク イー． ザ サード アンダーソン，
ヤンホン リ，
ヤンホン リ，
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グリコミメティクス， インコーポレイテッド
グリコミメティクス， インコーポレイテッド
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Publication of JP2015500887A publication Critical patent/JP2015500887A/ja
Publication of JP2015500887A5 publication Critical patent/JP2015500887A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/62—Metallic pigments or fillers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2014548994A 2011-12-22 2012-12-21 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法 Withdrawn JP2015500887A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161579646P 2011-12-22 2011-12-22
US61/579,646 2011-12-22
US201261583547P 2012-01-05 2012-01-05
US61/583,547 2012-01-05
US201261704424P 2012-09-21 2012-09-21
US201261704399P 2012-09-21 2012-09-21
US61/704,424 2012-09-21
US61/704,399 2012-09-21
US201261734924P 2012-12-07 2012-12-07
US61/734,924 2012-12-07
PCT/US2012/071519 WO2013096926A1 (en) 2011-12-22 2012-12-21 E-selectin antagonist compounds, compositions, and methods of use

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2015212564A Division JP2016020392A (ja) 2011-12-22 2015-10-29 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174991A Division JP2018035166A (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174990A Division JP6366150B2 (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法

Publications (2)

Publication Number Publication Date
JP2015500887A true JP2015500887A (ja) 2015-01-08
JP2015500887A5 JP2015500887A5 (https=) 2015-12-17

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JP2014548994A Withdrawn JP2015500887A (ja) 2011-12-22 2012-12-21 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2015212564A Pending JP2016020392A (ja) 2011-12-22 2015-10-29 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174991A Withdrawn JP2018035166A (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174990A Active JP6366150B2 (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2018244868A Withdrawn JP2019048891A (ja) 2011-12-22 2018-12-27 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法

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JP2015212564A Pending JP2016020392A (ja) 2011-12-22 2015-10-29 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174991A Withdrawn JP2018035166A (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2017174990A Active JP6366150B2 (ja) 2011-12-22 2017-09-12 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2018244868A Withdrawn JP2019048891A (ja) 2011-12-22 2018-12-27 Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法

Country Status (17)

Country Link
US (6) US9109002B2 (https=)
EP (2) EP3296310A1 (https=)
JP (5) JP2015500887A (https=)
KR (1) KR102055958B1 (https=)
CN (1) CN104039805B (https=)
AU (1) AU2012358150B2 (https=)
BR (1) BR112014014547B1 (https=)
CA (1) CA2858099C (https=)
CY (1) CY1119794T1 (https=)
DK (1) DK2794626T6 (https=)
ES (1) ES2655443T7 (https=)
HU (1) HUE036253T2 (https=)
LT (1) LT2794626T (https=)
PL (1) PL2794626T6 (https=)
PT (1) PT2794626T (https=)
SI (1) SI2794626T1 (https=)
WO (1) WO2013096926A1 (https=)

Cited By (4)

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JP2016020392A (ja) * 2011-12-22 2016-02-04 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンアンタゴニスト化合物、組成物および使用方法
JP2018533586A (ja) * 2015-11-03 2018-11-15 グリコミメティクス， インコーポレイテッド がん幹細胞を標的にし、そして侵襲性がんを処置するための抗体
JP2020510054A (ja) * 2017-03-15 2020-04-02 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンアンタゴニストとしてのガラクトピラノシル−シクロヘキシル誘導体
JP2021504403A (ja) * 2017-11-30 2021-02-15 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用

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WO2014070991A2 (en) * 2012-10-31 2014-05-08 Glycomimetics, Inc. E-selectin antagonist compounds and methods of use
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
US20170296566A9 (en) * 2013-09-30 2017-10-19 Glycomimetics, Inc. Methods and compositions for treating and/or preventing mucositis
DE102013112915A1 (de) 2013-11-22 2015-05-28 Universitätsklinikum Hamburg-Eppendorf (UKE) DNA-Aptamere, die E- und P-Selektine spezifisch binden
WO2015109049A1 (en) * 2014-01-17 2015-07-23 Glycomimetics, Inc. E-selectin antagonists modified by macrocycle formation to the galactose
ES2754549T3 (es) * 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
WO2016164394A1 (en) * 2015-04-08 2016-10-13 Glycomimetics, Inc. 2-halo-galactose-containing selectin antagonists
US20160331775A1 (en) * 2015-05-14 2016-11-17 The Regents Of The University Of Michigan E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk
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WO2017151708A1 (en) * 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
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US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
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US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
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WO2020219419A1 (en) 2019-04-24 2020-10-29 Glycomimetics, Inc. Multimeric pan–selectin antagonists
CN114340736A (zh) 2019-04-24 2022-04-12 糖模拟物有限公司 E-选择蛋白、半乳凝素-3和/或cxcr4趋化因子受体的半乳糖-连接的多聚体糖模拟物抑制剂
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EP4017863A1 (en) 2019-08-20 2022-06-29 GlycoMimetics, Inc. Process for preparing an e-selectin inhibitor intermediate
US20230147312A1 (en) 2020-03-27 2023-05-11 Glycomimetics, Inc. Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
CN115666584A (zh) 2020-05-31 2023-01-31 糖模拟物有限公司 用于减少癌细胞负荷和保护正常血细胞生成的化合物和方法
CN116033907A (zh) * 2020-06-14 2023-04-28 糖模拟物有限公司 经由e-选择素靶向克服微环境介导的抗性的组合物和方法
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US9796745B2 (en) 2017-10-24
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