JP2015500288A5 - - Google Patents

Info

Publication number

JP2015500288A5

JP2015500288A5 JP2014546010A JP2014546010A JP2015500288A5 JP 2015500288 A5 JP2015500288 A5 JP 2015500288A5 JP 2014546010 A JP2014546010 A JP 2014546010A JP 2014546010 A JP2014546010 A JP 2014546010A JP 2015500288 A5 JP2015500288 A5 JP 2015500288A5

Authority

JP

Japan

Prior art keywords

titania

nanotubes

titanium substrate

nanotube film

titania nanotube

Prior art date

2012-12-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 74
• 239000002071 nanotube Substances 0.000 claims description 45
• 238000000034 method Methods 0.000 claims description 22
• RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 20
• 229910052719 titanium Inorganic materials 0.000 claims description 20
• 239000010936 titanium Substances 0.000 claims description 20
• 239000000758 substrate Substances 0.000 claims description 19
• 238000007743 anodising Methods 0.000 claims description 8
• 238000005530 etching Methods 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims 5
• 229940124597 therapeutic agent Drugs 0.000 claims 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• 239000002775 capsule Substances 0.000 claims 4
• 239000002904 solvent Substances 0.000 claims 4
• DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
• 102000006992 Interferon-alpha Human genes 0.000 claims 2
• 108010047761 Interferon-alpha Proteins 0.000 claims 2
• 238000000137 annealing Methods 0.000 claims 2
• 238000010438 heat treatment Methods 0.000 claims 2
• DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims 1
• YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims 1
• HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 claims 1
• 108010011459 Exenatide Proteins 0.000 claims 1
• 102000001690 Factor VIII Human genes 0.000 claims 1
• 108010054218 Factor VIII Proteins 0.000 claims 1
• 102000002265 Human Growth Hormone Human genes 0.000 claims 1
• 108010000521 Human Growth Hormone Proteins 0.000 claims 1
• 239000000854 Human Growth Hormone Substances 0.000 claims 1
• 102000003996 Interferon-beta Human genes 0.000 claims 1
• 108090000467 Interferon-beta Proteins 0.000 claims 1
• 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims 1
• 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 claims 1
• 108700025316 aldesleukin Proteins 0.000 claims 1
• 229960005310 aldesleukin Drugs 0.000 claims 1
• 229950001863 bapineuzumab Drugs 0.000 claims 1
• 238000000708 deep reactive-ion etching Methods 0.000 claims 1
• 238000009792 diffusion process Methods 0.000 claims 1
• 229960001519 exenatide Drugs 0.000 claims 1
• 229960000301 factor viii Drugs 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 claims 1
• 229960001318 fondaparinux Drugs 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• -1 halogen ions Chemical class 0.000 claims 1
• 229960001388 interferon-beta Drugs 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• 229920000166 polytrimethylene carbonate Polymers 0.000 claims 1
• RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 1
• 229960001534 risperidone Drugs 0.000 claims 1
• 229960004532 somatropin Drugs 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1