CN103998536B - 用于药物递送的具有二氧化钛纳米管膜的装置 - Google Patents
用于药物递送的具有二氧化钛纳米管膜的装置 Download PDFInfo
- Publication number
- CN103998536B CN103998536B CN201280059539.3A CN201280059539A CN103998536B CN 103998536 B CN103998536 B CN 103998536B CN 201280059539 A CN201280059539 A CN 201280059539A CN 103998536 B CN103998536 B CN 103998536B
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- CN
- China
- Prior art keywords
- titania nanotube
- titania
- titanium
- nanotube film
- based material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/26—Anodisation of refractory metals or alloys based thereon
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/34—Anodisation of metals or alloys not provided for in groups C25D11/04 - C25D11/32
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
- C25D5/48—After-treatment of electroplated surfaces
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
- C25D5/48—After-treatment of electroplated surfaces
- C25D5/50—After-treatment of electroplated surfaces by heat-treatment
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Composite Materials (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Carbon And Carbon Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566810P | 2011-12-05 | 2011-12-05 | |
| US61/566,810 | 2011-12-05 | ||
| PCT/US2012/067868 WO2013085951A1 (en) | 2011-12-05 | 2012-12-05 | Device having titania nanotube membrane for drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103998536A CN103998536A (zh) | 2014-08-20 |
| CN103998536B true CN103998536B (zh) | 2017-09-15 |
Family
ID=48574812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280059539.3A Active CN103998536B (zh) | 2011-12-05 | 2012-12-05 | 用于药物递送的具有二氧化钛纳米管膜的装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9814867B2 (enExample) |
| EP (1) | EP2788439A4 (enExample) |
| JP (2) | JP6564187B2 (enExample) |
| KR (1) | KR102055772B1 (enExample) |
| CN (1) | CN103998536B (enExample) |
| WO (1) | WO2013085951A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP6564187B2 (ja) * | 2011-12-05 | 2019-08-21 | ナノ プレシジョン メディカル インコーポレイテッドNano Precision Medical, Inc. | チタニアナノチューブ膜を有する、薬物送達用デバイス |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| US9770412B2 (en) | 2014-01-23 | 2017-09-26 | Nano Precision Medical, Inc. | Implant device for drug delivery |
| KR101458486B1 (ko) * | 2014-02-26 | 2014-11-07 | 재단법인대구경북과학기술원 | 다공성 한방침 및 이의 제조방법 |
| WO2021173770A1 (en) | 2020-02-28 | 2021-09-02 | Nano Precision Medical, Inc. | Polymeric stabilizing agents for implantable drug delivery devices |
| US12071516B2 (en) | 2014-09-04 | 2024-08-27 | Nano Precision Medical, Inc. | Polymeric stabilizing formulations |
| WO2016037128A1 (en) * | 2014-09-04 | 2016-03-10 | Nano Precision Medical, Inc. | Polymeric stabilizing formulations |
| US20230022463A1 (en) * | 2014-11-02 | 2023-01-26 | Nano Precision Medical, Inc. | Implantable medical devices for extended release of therapeutic agents |
| EP3212170B1 (en) * | 2014-11-02 | 2025-07-09 | Nano Precision Medical, Inc. | Implantable medical devices for extended release of therapeutic agents |
| WO2016123027A1 (en) * | 2015-01-26 | 2016-08-04 | Nano Precision Medical, Inc. | Apparatus and method for promoting fluid uptake into an implant |
| US20160367677A1 (en) * | 2015-06-19 | 2016-12-22 | Board Of Regents, The University Of Texas System | Lipid nanodiscs and nanorods as modulators of clotting factor function in vivo |
| WO2017218354A1 (en) | 2016-06-13 | 2017-12-21 | Nano Precision Medical, Inc. | Drug delivery device |
| WO2018067535A1 (en) | 2016-10-04 | 2018-04-12 | Nano Precision Medical, Inc. | Implant delivery system with hydration promotor capability |
| KR101946703B1 (ko) * | 2017-03-10 | 2019-04-29 | 성균관대학교산학협력단 | 친수성의 나노 필름 구조물을 이용한 무동력 액츄에이터 및 상기 무동력 액츄에이터를 제작하는 방법 |
| EP3760241B1 (en) | 2018-03-01 | 2024-04-17 | Titanium Textiles AG | Tension-free titanium metal warp knit fabric for surgically shaping soft tissues |
| MX2020009107A (es) | 2018-03-01 | 2022-10-25 | Titanium Textiles Ag | Matriz de titanio a base de una tela tejida por urdimbre metálica libre de tensión para la regeneración guiada del tejido. |
| CN109692695B (zh) * | 2018-12-27 | 2022-02-01 | 东北大学 | 一种近红外光响应型纳米二氧化钛复合材料及其制备方法 |
| CN109686594B (zh) * | 2019-01-18 | 2020-11-24 | 三峡大学 | 钴基双金属硫化物负极材料的制备方法及其应用 |
| WO2022010846A1 (en) | 2020-07-08 | 2022-01-13 | Nano Precision Medical, Inc. | Methods to control the rate of release of therapeutic agents from implantable devices |
| WO2023107950A1 (en) * | 2021-12-06 | 2023-06-15 | Case Western Reserve University | Implant medical devices |
| WO2023235302A1 (en) | 2022-06-01 | 2023-12-07 | Nano Precision Medical, Inc. | Devices, methods and formulations to control release of therapeutic agents from implantable devices |
| WO2023235298A1 (en) | 2022-06-01 | 2023-12-07 | Nano Precision Medical, Inc. | Methods and devices to control release of therapeutic agents from implantable devices |
| CA3255297A1 (en) * | 2022-06-03 | 2023-12-07 | Nano Prec Medical Inc | DEVICES AND METHODS TO IMPROVE THE BIOAVAILABILITY OF THERAPEUTIC AGENTS |
| KR20250156699A (ko) | 2023-01-06 | 2025-11-03 | 나노 프리시전 메디컬, 인코포레이티드 | Glp-1 작용제를 위한 제형, 디바이스 및 방법 |
| WO2025147462A1 (en) | 2024-01-04 | 2025-07-10 | Nano Precision Medical, Inc. | Implantable devices, formulations and methods for body weight management |
| WO2025147459A1 (en) | 2024-01-04 | 2025-07-10 | Nano Precision Medical, Inc. | Stabilization of peptides and proteins in implantable devices and formulations |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101191248A (zh) * | 2006-12-01 | 2008-06-04 | 西南交通大学 | 在钛基底材料表面制备二氧化钛纳米管阵列层的方法 |
| CN101550581A (zh) * | 2009-04-03 | 2009-10-07 | 西北有色金属研究院 | 一种双通大面积TiO2纳米管阵列膜的制备方法 |
| CN101717984A (zh) * | 2009-11-05 | 2010-06-02 | 兰州大学 | 一种二氧化钛纳米管薄膜的制备方法 |
| CN101896643A (zh) * | 2007-07-26 | 2010-11-24 | 宾州研究基金会 | 高度有序的二氧化钛纳米管阵列 |
| CN102220616A (zh) * | 2011-05-26 | 2011-10-19 | 东南大学 | 二氧化钛纳米管阵列的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0883788A (ja) * | 1994-09-14 | 1996-03-26 | Oki Electric Ind Co Ltd | ドライエッチング方法 |
| ES2205462T3 (es) | 1997-03-31 | 2004-05-01 | Alza Corporation | Sistema de suministro por dufusion, implantable. |
| WO2003024357A2 (en) | 2001-09-14 | 2003-03-27 | Martin Francis J | Microfabricated nanopore device for sustained release of therapeutic agent |
| US20050118229A1 (en) * | 2003-10-21 | 2005-06-02 | Imedd, Inc. | Implantable drug delivery device for sustained release of therapeutic agent |
| KR100937167B1 (ko) * | 2007-06-05 | 2010-01-15 | 재단법인서울대학교산학협력재단 | 나노 포어 어레이를 이용한 나노 구조체의 제조방법 |
| WO2009114719A2 (en) * | 2008-03-13 | 2009-09-17 | Richmond Chemical Corporation | Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus |
| KR101043584B1 (ko) * | 2008-08-20 | 2011-06-22 | 한국과학기술원 | 질소 원자가 선택적으로 도핑된 TiO2-xNx 나노튜브 및 그의 제조방법 |
| KR101063761B1 (ko) * | 2008-11-19 | 2011-09-08 | 경원대학교 산학협력단 | 마개가 형성된 나노튜브를 제조하는 방법 및 이에 의해 제조된 나노튜브 |
| US20100213046A1 (en) * | 2009-01-06 | 2010-08-26 | The Penn State Research Foundation | Titania nanotube arrays, methods of manufacture, and photocatalytic conversion of carbon dioxide using same |
| EP2405967B1 (en) * | 2009-03-12 | 2020-09-23 | Delpor, Inc. | Implantable device for long-term delivery of drugs |
| US20100269894A1 (en) * | 2009-04-28 | 2010-10-28 | Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada | Titanium dioxide nanotubes and their use in photovoltaic devices |
| NL2003250C2 (en) * | 2009-07-20 | 2011-01-24 | Metal Membranes Com B V | Method for producing a membrane and such membrane. |
| JP2011111660A (ja) * | 2009-11-27 | 2011-06-09 | National Institute Of Advanced Industrial Science & Technology | チタニアナノチューブアレイ及びその形成方法 |
| JP6564187B2 (ja) * | 2011-12-05 | 2019-08-21 | ナノ プレシジョン メディカル インコーポレイテッドNano Precision Medical, Inc. | チタニアナノチューブ膜を有する、薬物送達用デバイス |
-
2012
- 2012-12-05 JP JP2014546010A patent/JP6564187B2/ja active Active
- 2012-12-05 WO PCT/US2012/067868 patent/WO2013085951A1/en not_active Ceased
- 2012-12-05 CN CN201280059539.3A patent/CN103998536B/zh active Active
- 2012-12-05 US US14/362,554 patent/US9814867B2/en active Active
- 2012-12-05 EP EP12854742.9A patent/EP2788439A4/en active Pending
- 2012-12-05 KR KR1020147018695A patent/KR102055772B1/ko active Active
-
2018
- 2018-01-26 JP JP2018011874A patent/JP2018109236A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101191248A (zh) * | 2006-12-01 | 2008-06-04 | 西南交通大学 | 在钛基底材料表面制备二氧化钛纳米管阵列层的方法 |
| CN101896643A (zh) * | 2007-07-26 | 2010-11-24 | 宾州研究基金会 | 高度有序的二氧化钛纳米管阵列 |
| CN101550581A (zh) * | 2009-04-03 | 2009-10-07 | 西北有色金属研究院 | 一种双通大面积TiO2纳米管阵列膜的制备方法 |
| CN101717984A (zh) * | 2009-11-05 | 2010-06-02 | 兰州大学 | 一种二氧化钛纳米管薄膜的制备方法 |
| CN102220616A (zh) * | 2011-05-26 | 2011-10-19 | 东南大学 | 二氧化钛纳米管阵列的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US9814867B2 (en) | 2017-11-14 |
| KR20140106660A (ko) | 2014-09-03 |
| US20140371687A1 (en) | 2014-12-18 |
| CN103998536A (zh) | 2014-08-20 |
| JP2018109236A (ja) | 2018-07-12 |
| EP2788439A1 (en) | 2014-10-15 |
| WO2013085951A1 (en) | 2013-06-13 |
| KR102055772B1 (ko) | 2019-12-13 |
| JP6564187B2 (ja) | 2019-08-21 |
| EP2788439A4 (en) | 2015-09-02 |
| JP2015500288A (ja) | 2015-01-05 |
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