JP2015172060A5 - - Google Patents
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- Publication number
- JP2015172060A5 JP2015172060A5 JP2015097888A JP2015097888A JP2015172060A5 JP 2015172060 A5 JP2015172060 A5 JP 2015172060A5 JP 2015097888 A JP2015097888 A JP 2015097888A JP 2015097888 A JP2015097888 A JP 2015097888A JP 2015172060 A5 JP2015172060 A5 JP 2015172060A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- chain
- methotrexate
- antibody
- humanized anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0817809A GB0817809D0 (en) | 2008-09-29 | 2008-09-29 | Agent for treating disease |
| GB0817811.3 | 2008-09-29 | ||
| GB0817810.5 | 2008-09-29 | ||
| GB0817811A GB0817811D0 (en) | 2008-09-29 | 2008-09-29 | Agent for treating disease |
| GB0817810A GB0817810D0 (en) | 2008-09-29 | 2008-09-29 | Agent for treating disease |
| GB0817809.7 | 2008-09-29 | ||
| EPPCT/EP2009/052809 | 2009-03-10 | ||
| PCT/EP2009/052811 WO2009124815A1 (en) | 2008-03-13 | 2009-03-10 | Agent for treating disease |
| PCT/EP2009/052810 WO2009112502A1 (en) | 2008-03-13 | 2009-03-10 | Agent for treating disease |
| EPPCT/EP2009/052811 | 2009-03-10 | ||
| PCT/EP2009/052809 WO2009121690A1 (en) | 2008-03-13 | 2009-03-10 | Agent for treating disease |
| EPPCT/EP2009/052810 | 2009-03-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528278A Division JP2012504110A (ja) | 2008-09-29 | 2009-08-31 | 疾患治療組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015172060A JP2015172060A (ja) | 2015-10-01 |
| JP2015172060A5 true JP2015172060A5 (https=) | 2016-04-21 |
| JP6154847B2 JP6154847B2 (ja) | 2017-06-28 |
Family
ID=41138980
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528278A Pending JP2012504110A (ja) | 2008-09-29 | 2009-08-31 | 疾患治療組成物 |
| JP2015097888A Expired - Fee Related JP6154847B2 (ja) | 2008-09-29 | 2015-05-13 | 疾患治療組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528278A Pending JP2012504110A (ja) | 2008-09-29 | 2009-08-31 | 疾患治療組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110229465A1 (https=) |
| JP (2) | JP2012504110A (https=) |
| KR (1) | KR20110061630A (https=) |
| CN (1) | CN102215867B (https=) |
| AU (1) | AU2009296078B2 (https=) |
| BR (1) | BRPI0919489A2 (https=) |
| CA (1) | CA2738598C (https=) |
| CR (1) | CR20110226A (https=) |
| DK (1) | DK2341937T3 (https=) |
| ES (1) | ES2528419T3 (https=) |
| IL (1) | IL211904A (https=) |
| MX (1) | MX2011003335A (https=) |
| PT (1) | PT2341937E (https=) |
| RU (1) | RU2531548C2 (https=) |
| SG (1) | SG194362A1 (https=) |
| WO (1) | WO2010034590A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| EP2260057B1 (en) * | 2008-03-13 | 2016-11-23 | Biotest AG | Anti-CD4 antibody dosage regimen for treating autoimmune disease |
| EP2265643B1 (en) * | 2008-03-13 | 2016-10-19 | Biotest AG | Dosing regimen for treating psoriasis and rheumatoid arthritis |
| RU2540013C2 (ru) * | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
| GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
| US20160158352A1 (en) * | 2013-07-10 | 2016-06-09 | The United States of America, as represented by the Secretary, Department of Health & Human Servic | Apoptotic cell-mediated induction of antigen specific regulatory t-cells for the therapy of autoimmune diseases in animals and humans |
| GB202017681D0 (en) * | 2020-11-09 | 2020-12-23 | T Balance Therapeutics Gmbh | Anti-CD4 antibody or fragment thereof for medical use |
| DE102020129648A1 (de) * | 2020-11-10 | 2022-05-12 | Leopold MTX GmbH | Pharmazeutische zusammensetzung |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| US20020099179A1 (en) * | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US7084260B1 (en) * | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| AU662891B2 (en) * | 1990-11-27 | 1995-09-21 | Biogen Idec Ma Inc. | Anti CD-4 antibodies blocking HIV-induced syncytia |
| US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| DE69427928T3 (de) * | 1993-03-05 | 2012-05-10 | Bayer Healthcare Llc | Humane monoklonale anti-TNF alpha Antikörper |
| EP0631783A1 (en) * | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives |
| US20020068057A1 (en) * | 1994-03-10 | 2002-06-06 | Marc Feldmann | Treatment of autoimmune and inflammatory disorders |
| US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
| DE19722888A1 (de) * | 1997-05-28 | 1998-12-03 | Thomas Prof Dr Huenig | Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten |
| DE60042785D1 (de) * | 1999-06-09 | 2009-10-01 | Immunomedics Inc | Immuntherapie von autoimmunerkrankungen durch die verwendung von b-zell spezifischen antikörpern |
| CA2410786A1 (en) * | 2000-06-02 | 2001-12-13 | Regents Of The University Of Minnesota | Immunotherapeutic method to prevent islet cell rejection |
| JP2004508420A (ja) * | 2000-09-18 | 2004-03-18 | アイデック ファーマスーティカルズ コーポレイション | B細胞枯渇抗体/免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法 |
| DE10050935A1 (de) * | 2000-10-11 | 2002-05-02 | Tegenero Gmbh | Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen |
| AU2002249958B2 (en) * | 2001-01-16 | 2007-11-08 | Vascular Therapies, Inc. | Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts |
| EP1372721A4 (en) * | 2001-03-07 | 2008-04-02 | Childrens Medical Center | METHOD FOR SCREENING PEPTIDE DISPLAY LIBRARIES WITH A MINIMUM DISPLAY |
| JP4660067B2 (ja) * | 2001-04-24 | 2011-03-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗血管新生剤とTNFαとを用いる組合せ療法 |
| US7541443B2 (en) * | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
| DK1451224T3 (da) * | 2001-12-04 | 2012-11-19 | Theramab Llc | Peptid eller protein, der indeholder en C´-D-sløjfe fra CD28-receptorfamilien |
| DE10212108A1 (de) * | 2002-03-13 | 2003-10-02 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung |
| DE10230223A1 (de) * | 2002-07-04 | 2004-01-22 | Tegenero Ag | Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern |
| US7501494B2 (en) * | 2003-01-15 | 2009-03-10 | United Biomedical, Inc. | Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection |
| EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| EP1613350B1 (en) * | 2003-04-09 | 2009-03-18 | Genentech, Inc. | Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor |
| GB0314461D0 (en) * | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| EP1600164A3 (de) * | 2003-09-22 | 2006-05-17 | TeGenero AG | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer Pharmazeutischen Zusammensetzung mit dosisabhängiger Wirkung |
| DE10352900A1 (de) * | 2003-11-11 | 2005-06-16 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von B-CLL |
| JPWO2006035876A1 (ja) * | 2004-09-29 | 2008-05-15 | 興和株式会社 | 関節リウマチの予防及び/又は治療薬 |
| DE102004063494A1 (de) * | 2004-12-23 | 2006-07-13 | Tegenero Ag | Antikörper |
| JP4730733B2 (ja) * | 2005-05-02 | 2011-07-20 | 国立大学法人京都大学 | 4型葉酸受容体の発現を指標とした制御性t細胞の検出方法、及び免疫賦活剤 |
| WO2007009064A2 (en) * | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| AU2006290433B2 (en) * | 2005-08-26 | 2012-06-07 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
| CA2645322A1 (en) * | 2006-03-16 | 2007-09-27 | Genentech, Inc. | Methods of treating lupus using cd4 antibodies |
| EP2260057B1 (en) | 2008-03-13 | 2016-11-23 | Biotest AG | Anti-CD4 antibody dosage regimen for treating autoimmune disease |
| EP2265643B1 (en) | 2008-03-13 | 2016-10-19 | Biotest AG | Dosing regimen for treating psoriasis and rheumatoid arthritis |
| RU2540013C2 (ru) * | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
| ES2351456B1 (es) * | 2009-06-24 | 2011-11-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro para el pronostico o prediccion de la respuesta por parte de pacientes con artritis reumatoide al tratamiento con agentes que reconocen el receptor de membrana cd20 de los linfocitos b |
-
2009
- 2009-08-31 BR BRPI0919489A patent/BRPI0919489A2/pt not_active IP Right Cessation
- 2009-08-31 KR KR1020117009215A patent/KR20110061630A/ko not_active Ceased
- 2009-08-31 JP JP2011528278A patent/JP2012504110A/ja active Pending
- 2009-08-31 PT PT97824007T patent/PT2341937E/pt unknown
- 2009-08-31 DK DK09782400.7T patent/DK2341937T3/en active
- 2009-08-31 ES ES09782400.7T patent/ES2528419T3/es active Active
- 2009-08-31 AU AU2009296078A patent/AU2009296078B2/en not_active Ceased
- 2009-08-31 CN CN200980143326.7A patent/CN102215867B/zh not_active Expired - Fee Related
- 2009-08-31 MX MX2011003335A patent/MX2011003335A/es active IP Right Grant
- 2009-08-31 WO PCT/EP2009/061210 patent/WO2010034590A1/en not_active Ceased
- 2009-08-31 SG SG2013070859A patent/SG194362A1/en unknown
- 2009-08-31 RU RU2011117293/10A patent/RU2531548C2/ru not_active IP Right Cessation
- 2009-08-31 CA CA2738598A patent/CA2738598C/en active Active
-
2011
- 2011-03-24 IL IL211904A patent/IL211904A/en not_active IP Right Cessation
- 2011-03-29 US US13/074,357 patent/US20110229465A1/en not_active Abandoned
- 2011-04-29 CR CR20110226A patent/CR20110226A/es not_active Application Discontinuation
-
2015
- 2015-05-13 JP JP2015097888A patent/JP6154847B2/ja not_active Expired - Fee Related
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