JP2015078230A5 - - Google Patents
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- Publication number
- JP2015078230A5 JP2015078230A5 JP2015006124A JP2015006124A JP2015078230A5 JP 2015078230 A5 JP2015078230 A5 JP 2015078230A5 JP 2015006124 A JP2015006124 A JP 2015006124A JP 2015006124 A JP2015006124 A JP 2015006124A JP 2015078230 A5 JP2015078230 A5 JP 2015078230A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- following formula
- acceptable salt
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16881399P | 1999-12-03 | 1999-12-03 | |
| US60/168,813 | 1999-12-03 | ||
| US20571900P | 2000-05-19 | 2000-05-19 | |
| US60/205,719 | 2000-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011153911A Division JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015078230A JP2015078230A (ja) | 2015-04-23 |
| JP2015078230A5 true JP2015078230A5 (https=) | 2015-12-24 |
| JP5963894B2 JP5963894B2 (ja) | 2016-08-03 |
Family
ID=26864475
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541459A Expired - Lifetime JP4993649B2 (ja) | 1999-12-03 | 2000-12-04 | ホスホネート化合物 |
| JP2011153911A Withdrawn JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
| JP2014002881A Expired - Lifetime JP5963787B2 (ja) | 1999-12-03 | 2014-01-10 | ホスホネート化合物 |
| JP2015006124A Expired - Lifetime JP5963894B2 (ja) | 1999-12-03 | 2015-01-15 | ホスホネート化合物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541459A Expired - Lifetime JP4993649B2 (ja) | 1999-12-03 | 2000-12-04 | ホスホネート化合物 |
| JP2011153911A Withdrawn JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
| JP2014002881A Expired - Lifetime JP5963787B2 (ja) | 1999-12-03 | 2014-01-10 | ホスホネート化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (14) | US6716825B2 (https=) |
| EP (1) | EP1233770B1 (https=) |
| JP (4) | JP4993649B2 (https=) |
| KR (1) | KR20020073342A (https=) |
| CN (1) | CN1414854B (https=) |
| AT (1) | ATE385797T1 (https=) |
| AU (3) | AU785355B2 (https=) |
| BR (1) | BR0016058A (https=) |
| CA (2) | CA2747954C (https=) |
| CY (1) | CY1107927T1 (https=) |
| DE (1) | DE60038038T2 (https=) |
| DK (2) | DK1914237T3 (https=) |
| ES (2) | ES2300281T3 (https=) |
| HK (1) | HK1050627B (https=) |
| MX (1) | MXPA02005490A (https=) |
| PT (2) | PT1233770E (https=) |
| RU (1) | RU2258707C2 (https=) |
| WO (1) | WO2001039724A2 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| DE60038038T2 (de) * | 1999-12-03 | 2009-02-12 | The Regents of The University of California at San Diego, La Jolla | Phosphonatverbindungen |
| WO2002102813A1 (en) * | 2001-06-20 | 2002-12-27 | Merck Frosst Canada & Co. | Aryldifluoromethylphosphonic acids for treatment of diabetes |
| FR2837490B1 (fr) * | 2002-03-21 | 2009-04-17 | Univ Paris 13 | Nouveaux derives de bisphosphonates, leurs preparations et utilisations |
| EP1406910B1 (fr) * | 2001-07-16 | 2010-01-13 | Universite Paris 13 | Procedes de preparation de derives de bisphosphonates |
| US7488496B2 (en) | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
| AU2003219999A1 (en) * | 2002-03-06 | 2003-09-22 | Lifizz, Inc. | Effervescent compositions comprising bisphosphonates and methods related thereto |
| AU2003231765B9 (en) * | 2002-04-26 | 2010-01-28 | Gilead Sciences, Inc. | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such |
| RU2309747C2 (ru) * | 2002-09-18 | 2007-11-10 | Михаил Владимирович Кутушов | Применение 2-хлорэтилфосфоновой кислоты и ее солей в качестве противоопухолевого средства |
| AU2003901813A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Pharmaceutical derivatives |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| WO2004096287A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7273716B2 (en) | 2003-04-25 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| EP2359833A1 (en) | 2003-04-25 | 2011-08-24 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| JP4692283B2 (ja) * | 2003-12-12 | 2011-06-01 | アステラス製薬株式会社 | 悪性黒色腫治療剤 |
| WO2005063751A1 (en) | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | 4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity |
| WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| WO2006076015A2 (en) * | 2004-04-30 | 2006-07-20 | The Regents Of The University Of California | 1-[2-(phosphonomethoxy)ethyl]-cytosine and analogs thereof |
| ME03423B (me) | 2004-07-27 | 2020-01-20 | Gilead Sciences Inc | Fosfonatni analozi jedinjenja hiv inhibitora |
| CN101094677A (zh) * | 2004-11-15 | 2007-12-26 | 塞普泰尔公司 | 蛋白酪氨酸磷酸酶抑制剂及其使用方法 |
| WO2006066074A2 (en) | 2004-12-16 | 2006-06-22 | The Regents Of The University Of California | Lung-targeted drugs |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| US20060219637A1 (en) * | 2005-03-29 | 2006-10-05 | Killeen Kevin P | Devices, systems and methods for liquid chromatography |
| US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
| JP2008538354A (ja) * | 2005-04-08 | 2008-10-23 | キメリクス，インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
| JP2008535862A (ja) * | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| WO2006114064A2 (en) * | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
| US7914810B2 (en) * | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
| US8114843B2 (en) | 2005-11-18 | 2012-02-14 | The Regents Of The University Of California | Photoreactive regulator of protein function and methods of use thereof |
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| JP2011508740A (ja) * | 2007-12-27 | 2011-03-17 | エピファニー バイオサイエンシズ， インク． | 抗ウイルス化合物 |
| EP2254582B1 (en) | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| UA103329C2 (ru) | 2008-07-08 | 2013-10-10 | Гилиад Сайенсиз, Инк. | Соли соединений-ингибиторов вич |
| US8628812B2 (en) * | 2008-12-30 | 2014-01-14 | Pepsico, Inc. | Preservative system for acidic beverages based on sequestrants |
| EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
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| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| WO2011017253A1 (en) | 2009-08-03 | 2011-02-10 | Chimerix, Inc. | Composition and methods of treating viral infections and viral induced tumors |
| ES2533799T3 (es) * | 2009-10-02 | 2015-04-14 | Straitmark Holding Ag | Procedimiento de fabricación de ácidos aminohidroxi difosfónicos |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| EP2558466A4 (en) | 2010-04-14 | 2013-11-13 | Univ California | PHOSPHONATES WITH REDUCED TOXICITY FOR THE TREATMENT OF VIRUS INFECTIONS |
| US9278135B2 (en) | 2010-04-26 | 2016-03-08 | Chimerix Inc. | Methods of treating retroviral infections and related dosage regimes |
| ES2604137T3 (es) * | 2010-08-31 | 2017-03-03 | Chimerix, Inc. | Derivados de éster de fosfonato y métodos de síntesis de los mismos |
| AU2015201895B2 (en) * | 2010-08-31 | 2016-11-17 | Emergent Biodefence Operations Lansing Llc | Phosphonate ester derivatives and methods of synthesis thereof |
| US8884027B2 (en) | 2010-10-22 | 2014-11-11 | University Of Rochester | Melampomagnolide B derivatives as antileukemic and cytotoxic agents |
| JP2014525459A (ja) * | 2011-08-31 | 2014-09-29 | マリンクロッド エルエルシー | Ｈ−ホスホネート−エン／ｈ−ホスホネート−インヒドロホスホニル化反応を用いた標的化ナノ粒子のリモートアセンブリ |
| ES2874774T3 (es) | 2011-12-22 | 2021-11-05 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
| US20150209273A1 (en) * | 2012-08-28 | 2015-07-30 | Glaxosmithkline Llc | Pharmaceutical Compositions |
| EA201892769A3 (ru) * | 2013-03-15 | 2019-08-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Сложные диэфиры ациклических нуклеозидфосфонатов |
| DK2999476T3 (en) | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| JP2017512183A (ja) | 2014-02-13 | 2017-05-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
| RU2665135C2 (ru) | 2014-03-14 | 2018-08-28 | Олтек, Инк. | Композиции селеноорганических соединений и способы их применения |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| BR112017005111B1 (pt) | 2014-09-15 | 2023-02-14 | The Regents Of The University Of California | Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus |
| EP3212656B1 (en) | 2014-10-27 | 2019-06-05 | Concert Pharmaceuticals Inc. | Pyrimidine phosphonic acid esters bearing at least one deuterium atom |
| CA3182565A1 (en) | 2015-03-06 | 2016-09-15 | Atea Pharmaceuticals, Inc. | .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| CA2986202C (en) * | 2015-04-27 | 2023-08-22 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions |
| WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
| WO2017048252A1 (en) | 2015-09-15 | 2017-03-23 | Alltech, Inc. | Compositions of selenoorganic compounds and methods of use thereof |
| EP4295853A3 (en) | 2016-06-28 | 2024-03-06 | Emergent BioDefense Operations Lansing LLC | Formulations of brincidofovir |
| RU2628456C1 (ru) * | 2016-06-29 | 2017-08-17 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Новые пиримидиновые ингибиторы репликации аденовируса человека |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| DK3512863T3 (da) | 2016-09-07 | 2022-03-07 | Atea Pharmaceuticals Inc | 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| RU2670204C1 (ru) * | 2017-12-01 | 2018-10-19 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Производные 2-тиоурацила, обладающие противоаденовирусной активностью |
| WO2019120084A1 (zh) * | 2017-12-21 | 2019-06-27 | 深圳市塔吉瑞生物医药有限公司 | 用于抗病毒的核苷类逆转录酶抑制剂 |
| RU2020126177A (ru) | 2018-01-09 | 2022-02-10 | Лиганд Фармасьютикалз, Инк. | Ацетальные соединения и их терапевтическое применение |
| AU2020334152A1 (en) | 2019-08-22 | 2022-03-24 | Emory University | Nucleoside prodrugs and uses related thereto |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| AU2021330835B2 (en) | 2020-08-24 | 2023-12-14 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
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| US1944530A (en) | 1929-04-08 | 1934-01-23 | Ig Farbenindustrie Ag | Phosphoric acid esters |
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-
2000
- 2000-12-04 DE DE60038038T patent/DE60038038T2/de not_active Expired - Lifetime
- 2000-12-04 AT AT00982468T patent/ATE385797T1/de active
- 2000-12-04 AU AU19497/01A patent/AU785355B2/en not_active Ceased
- 2000-12-04 ES ES00982468T patent/ES2300281T3/es not_active Expired - Lifetime
- 2000-12-04 PT PT00982468T patent/PT1233770E/pt unknown
- 2000-12-04 EP EP00982468A patent/EP1233770B1/en not_active Expired - Lifetime
- 2000-12-04 ES ES08001408.7T patent/ES2498046T3/es not_active Expired - Lifetime
- 2000-12-04 MX MXPA02005490A patent/MXPA02005490A/es active IP Right Grant
- 2000-12-04 CA CA2747954A patent/CA2747954C/en not_active Expired - Lifetime
- 2000-12-04 CA CA2393410A patent/CA2393410C/en not_active Expired - Lifetime
- 2000-12-04 HK HK03101480.2A patent/HK1050627B/en not_active IP Right Cessation
- 2000-12-04 US US10/148,374 patent/US6716825B2/en not_active Expired - Lifetime
- 2000-12-04 CN CN00818111.XA patent/CN1414854B/zh not_active Expired - Lifetime
- 2000-12-04 PT PT80014087T patent/PT1914237E/pt unknown
- 2000-12-04 JP JP2001541459A patent/JP4993649B2/ja not_active Expired - Lifetime
- 2000-12-04 WO PCT/US2000/033079 patent/WO2001039724A2/en not_active Ceased
- 2000-12-04 BR BR0016058-0A patent/BR0016058A/pt not_active Application Discontinuation
- 2000-12-04 DK DK08001408.7T patent/DK1914237T3/da active
- 2000-12-04 DK DK00982468T patent/DK1233770T3/da active
- 2000-12-04 RU RU2002118327/04A patent/RU2258707C2/ru active
- 2000-12-04 KR KR1020027007074A patent/KR20020073342A/ko not_active Ceased
-
2004
- 2004-01-15 US US10/759,345 patent/US7034014B2/en not_active Expired - Lifetime
-
2005
- 2005-04-06 US US11/100,882 patent/US7094772B2/en not_active Expired - Lifetime
- 2005-04-06 US US11/101,259 patent/US7098197B2/en not_active Expired - Lifetime
-
2006
- 2006-08-17 US US11/506,292 patent/US7452898B2/en not_active Expired - Lifetime
- 2006-12-15 AU AU2006252074A patent/AU2006252074B2/en not_active Ceased
-
2007
- 2007-03-07 US US11/715,604 patent/US7790703B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/925,309 patent/US7687480B2/en not_active Expired - Fee Related
-
2008
- 2008-04-30 CY CY20081100465T patent/CY1107927T1/el unknown
-
2010
- 2010-02-05 US US12/701,410 patent/US8008308B2/en not_active Expired - Fee Related
- 2010-12-20 AU AU2010257309A patent/AU2010257309B2/en not_active Ceased
-
2011
- 2011-07-12 JP JP2011153911A patent/JP2011246475A/ja not_active Withdrawn
- 2011-08-29 US US13/220,548 patent/US8309565B2/en not_active Expired - Fee Related
-
2012
- 2012-10-04 US US13/645,105 patent/US8710030B2/en not_active Expired - Fee Related
-
2013
- 2013-10-21 US US14/059,365 patent/US8889658B2/en not_active Expired - Fee Related
-
2014
- 2014-01-10 JP JP2014002881A patent/JP5963787B2/ja not_active Expired - Lifetime
- 2014-10-29 US US14/527,156 patent/US9206208B2/en not_active Expired - Fee Related
-
2015
- 2015-01-15 JP JP2015006124A patent/JP5963894B2/ja not_active Expired - Lifetime
- 2015-11-16 US US14/942,926 patent/US9649321B2/en not_active Expired - Fee Related
-
2017
- 2017-05-15 US US15/595,496 patent/US10071110B2/en not_active Expired - Fee Related
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