|
US6358932B1
(en)
|
1994-05-31 |
2002-03-19 |
Isis Pharmaceticals, Inc. |
Antisense oligonucleotide inhibition of raf gene expression
|
|
US6391636B1
(en)
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US6037136A
(en)
|
1994-10-24 |
2000-03-14 |
Cold Spring Harbor Laboratory |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
|
|
US5717100A
(en)
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
|
AU754830C
(en)
|
1997-05-22 |
2004-02-12 |
G.D. Searle Llc |
Substituted pyrazoles as p38 kinase inhibitors
|
|
GB9716557D0
(en)
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6022884A
(en)
|
1997-11-07 |
2000-02-08 |
Amgen Inc. |
Substituted pyridine compounds and methods of use
|
|
US6204467B1
(en)
|
1998-03-24 |
2001-03-20 |
Ford Global Technologies, Inc. |
Method and apparatus for resistive welding
|
|
ME00275B
(me)
|
1999-01-13 |
2011-02-10 |
Bayer Corp |
ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
|
|
US6316435B2
(en)
|
1999-02-24 |
2001-11-13 |
Supergen, Inc. |
Combination therapy for lymphoproliferative diseases
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
US20050043409A1
(en)
|
2001-10-25 |
2005-02-24 |
Chen Ying-Nan Pan |
Combinations comprising a selective cyclooxygenase-2 inhibitor
|
|
ATE374753T1
(de)
|
2001-12-21 |
2007-10-15 |
Vernalis Cambridge Ltd |
3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
|
|
US20080085902A1
(en)
|
2003-09-23 |
2008-04-10 |
Guido Bold |
Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent
|
|
CA2545942C
(en)
|
2003-11-14 |
2012-07-10 |
Lorus Therapeutics Inc. |
Aryl imidazoles and their use as anti-cancer agents
|
|
MXPA06007820A
(es)
|
2004-01-09 |
2006-09-01 |
Novartis Ag |
Derivados de fenil-[4-(3-fenil-1h-pirazol-4-il)-pirimidin-2-il]-amina como inhibidores de igf-ir.
|
|
RU2401265C2
(ru)
|
2004-06-10 |
2010-10-10 |
Айрм Ллк |
Соединения и композиции в качестве ингибиторов протеинкиназы
|
|
EP1871773A1
(en)
|
2005-03-17 |
2008-01-02 |
Novartis AG |
N-[3-(1-amino-5,6,7,8-tetrahydro-2,4,4b-triazafluoren-9-yl)-phenyl]benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
|
|
US20070099856A1
(en)
*
|
2005-05-13 |
2007-05-03 |
Gumerlock Paul H |
Combined treatment with docetaxel and an epidermal growth factor receptor kinase inhibitor using an intermittent dosing regimen
|
|
US7608635B2
(en)
|
2005-08-12 |
2009-10-27 |
Synta Pharmaceuticals Corp. |
Pyrazole compounds that modulate HSP90 activity
|
|
EP1919460A2
(en)
|
2005-08-22 |
2008-05-14 |
Novartis AG |
Pharmaceutical compositions comprising a ph-dependent drug, a ph modifier and a retarding agent
|
|
US20080242667A1
(en)
|
2005-08-26 |
2008-10-02 |
Smithkline Beecham Corporation |
Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases
|
|
TWI387592B
(zh)
|
2005-08-30 |
2013-03-01 |
Novartis Ag |
經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
|
|
WO2007105058A2
(en)
|
2006-03-16 |
2007-09-20 |
Pfizer Products Inc. |
Pyrazole compounds
|
|
KR20080108516A
(ko)
|
2006-04-05 |
2008-12-15 |
노파르티스 아게 |
암을 치료하기 위한 치료제의 조합물
|
|
WO2007123892A2
(en)
|
2006-04-17 |
2007-11-01 |
Arqule Inc. |
Raf inhibitors and their uses
|
|
CN103739595A
(zh)
|
2006-10-02 |
2014-04-23 |
Irm责任有限公司 |
作为蛋白激酶抑制剂的化合物和组合物
|
|
JP2010505859A
(ja)
|
2006-10-06 |
2010-02-25 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
タンパク質キナーゼ阻害剤およびそれを使用するための方法
|
|
US20100069458A1
(en)
|
2007-02-15 |
2010-03-18 |
Peter Wisdom Atadja |
Combination of lbh589 with other therapeutic agents for treating cancer
|
|
US20090022789A1
(en)
|
2007-07-18 |
2009-01-22 |
Supernus Pharmaceuticals, Inc. |
Enhanced formulations of lamotrigine
|
|
WO2009016460A2
(en)
|
2007-08-01 |
2009-02-05 |
Pfizer Inc. |
Pyrazole compounds and their use as raf inhibitors
|
|
UA100865C2
(ru)
|
2007-10-19 |
2013-02-11 |
Эбботт Гмбх Унд Ко. Кг |
Твердый дисперсный продукт лекарственных средств на основе n-арилмочевины
|
|
CN101861316B
(zh)
|
2007-11-14 |
2013-08-21 |
奥梅-杨森制药有限公司 |
咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
|
|
WO2009115572A2
(en)
|
2008-03-21 |
2009-09-24 |
Novartis Ag |
Novel heterocyclic compounds and uses therof
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
PT2324008E
(pt)
|
2008-07-24 |
2012-06-25 |
Nerviano Medical Sciences Srl |
3,4-diarilpirazoles como inibidores da proteína quinase
|
|
CN102123987A
(zh)
|
2008-07-28 |
2011-07-13 |
吉里德科学公司 |
亚环烷基和亚杂环烷基组蛋白脱乙酰酶抑制剂化合物
|
|
US8778929B2
(en)
|
2008-09-29 |
2014-07-15 |
Boehringer Ingelheim International Gmbh |
Substituted heteroaryl inhibitors of B-RAF
|
|
CA2737400C
(en)
|
2008-10-07 |
2016-11-22 |
Astrazeneca Uk Limited |
Pharmaceutical formulation 514
|
|
WO2010056662A1
(en)
|
2008-11-11 |
2010-05-20 |
University Of Washington |
Activated wnt-beta-catenin signaling in melanoma
|
|
ES2422263T3
(es)
|
2008-12-19 |
2013-09-10 |
Nerviano Medical Sciences Srl |
Pirazoles bicíclicos como inhibidores de la proteinquinasa
|
|
AR075180A1
(es)
|
2009-01-29 |
2011-03-16 |
Novartis Ag |
Formulaciones orales solidas de una pirido-pirimidinona
|
|
RU2402602C1
(ru)
*
|
2009-02-12 |
2010-10-27 |
Государственное учреждение Российский онкологический научный центр им. Н.Н. Блохина РАМН |
КЛЕТОЧНАЯ ЛИНИЯ МЕЛАНОМЫ ЧЕЛОВЕКА mel Rac, ИСПОЛЬЗУЕМАЯ ДЛЯ ПОЛУЧЕНИЯ ПРОТИВООПУХОЛЕВЫХ ВАКЦИН
|
|
WO2010100127A1
(en)
|
2009-03-04 |
2010-09-10 |
Novartis Ag |
Disubstituted imidazole derivatives as modulators of raf kinase
|
|
TWI532484B
(zh)
|
2009-06-08 |
2016-05-11 |
艾伯維有限公司 |
包含凋亡促進劑之固態分散劑
|
|
US8546413B2
(en)
|
2009-06-15 |
2013-10-01 |
Nerviano Medical Sciences S.R.L. |
Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
|
|
KR101256018B1
(ko)
|
2009-08-20 |
2013-04-18 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
|
|
AR077975A1
(es)
|
2009-08-28 |
2011-10-05 |
Irm Llc |
Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
|
|
US8242260B2
(en)
|
2009-08-28 |
2012-08-14 |
Novartis Ag |
Compounds and compositions as protein kinase inhibitors
|
|
CN104958294A
(zh)
|
2010-01-27 |
2015-10-07 |
内尔维安诺医学科学有限公司 |
作为蛋白激酶抑制剂的3,4-二芳基吡唑的亚磺酰氨基衍生物
|
|
CN102918034B
(zh)
|
2010-03-30 |
2015-06-03 |
维颂公司 |
多取代芳族化合物作为凝血酶的抑制剂
|
|
EP2601185B1
(en)
|
2010-08-03 |
2015-10-07 |
Nerviano Medical Sciences S.r.l. |
Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents
|
|
CA2829263C
(en)
|
2011-03-21 |
2020-05-12 |
Valcuria Ab |
A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof.
|
|
PH12013502523A1
(en)
|
2011-06-14 |
2019-10-11 |
Novartis Ag |
Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
|
|
SI2782557T1
(sl)
|
2011-11-23 |
2019-02-28 |
Array Biopharma, Inc., |
Farmacevtske formulacije
|
|
JP2015536964A
(ja)
|
2012-11-08 |
2015-12-24 |
ノバルティス アーゲー |
Ｂ−ｒａｆ阻害剤とヒストン脱アセチル化酵素阻害剤を含む医薬組合せおよび増殖性疾患の治療におけるそれらの使用
|