JP2015500225A5 - - Google Patents
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- Publication number
- JP2015500225A5 JP2015500225A5 JP2014543977A JP2014543977A JP2015500225A5 JP 2015500225 A5 JP2015500225 A5 JP 2015500225A5 JP 2014543977 A JP2014543977 A JP 2014543977A JP 2014543977 A JP2014543977 A JP 2014543977A JP 2015500225 A5 JP2015500225 A5 JP 2015500225A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- combination
- treatment
- acceptable salt
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 8
- JDUBGYFRJFOXQC-KRWDZBQOSA-N 4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide Chemical compound C1([C@H](CCO)NC(=O)C2(CCN(CC2)C=2C=3C=CNC=3N=CN=2)N)=CC=C(Cl)C=C1 JDUBGYFRJFOXQC-KRWDZBQOSA-N 0.000 claims 7
- 206010060862 Prostate cancer Diseases 0.000 claims 7
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 6
- 238000011284 combination treatment Methods 0.000 claims 5
- 229960000853 abiraterone Drugs 0.000 claims 4
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical compound C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 229960004671 enzalutamide Drugs 0.000 claims 4
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 claims 4
- 229960004103 abiraterone acetate Drugs 0.000 claims 3
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 claims 3
- 102000001307 androgen receptors Human genes 0.000 claims 3
- 108010080146 androgen receptors Proteins 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 1
- JMEYDSHPKCSIJC-UHFFFAOYSA-N 1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone Chemical compound C1CN(C(=O)C)CCN1CCOC1=CC=C(C2CCN(CC2)C=2CCC=3N(C(=NN=3)C(F)(F)F)N=2)C=C1 JMEYDSHPKCSIJC-UHFFFAOYSA-N 0.000 claims 1
- 229960000997 bicalutamide Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564975P | 2011-11-30 | 2011-11-30 | |
| US61/564,975 | 2011-11-30 | ||
| PCT/GB2012/052969 WO2013079964A1 (en) | 2011-11-30 | 2012-11-30 | Combination treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500225A JP2015500225A (ja) | 2015-01-05 |
| JP2015500225A5 true JP2015500225A5 (https=) | 2016-01-21 |
| JP6309454B2 JP6309454B2 (ja) | 2018-04-11 |
Family
ID=47295082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543977A Active JP6309454B2 (ja) | 2011-11-30 | 2012-11-30 | 癌の併用処置 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20140329786A1 (https=) |
| EP (1) | EP2785349B2 (https=) |
| JP (1) | JP6309454B2 (https=) |
| KR (1) | KR102035361B1 (https=) |
| CN (1) | CN103945849B (https=) |
| AU (2) | AU2013205648B2 (https=) |
| CA (1) | CA2856646C (https=) |
| CY (1) | CY1122624T1 (https=) |
| DK (1) | DK2785349T4 (https=) |
| ES (1) | ES2762250T5 (https=) |
| FI (1) | FI2785349T4 (https=) |
| HR (1) | HRP20191982T4 (https=) |
| HU (1) | HUE046667T2 (https=) |
| IL (1) | IL232530B (https=) |
| LT (1) | LT2785349T (https=) |
| MX (1) | MX367640B (https=) |
| MY (1) | MY175800A (https=) |
| PH (1) | PH12014500943A1 (https=) |
| PL (1) | PL2785349T5 (https=) |
| PT (1) | PT2785349T (https=) |
| RS (1) | RS59493B2 (https=) |
| RU (1) | RU2640485C2 (https=) |
| SG (1) | SG11201401471PA (https=) |
| SI (1) | SI2785349T2 (https=) |
| SM (1) | SMT201900708T1 (https=) |
| WO (1) | WO2013079964A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| HRP20200284T1 (hr) | 2008-10-02 | 2020-07-10 | Salix Pharmaceuticals, Ltd. | Postupci liječenja hepatičke encefalopatije |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| AU2011218173C1 (en) | 2010-02-16 | 2015-04-16 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| SG10201600077RA (en) | 2011-01-11 | 2016-02-26 | Glaxosmithkline Llc | Combination |
| US20150005265A1 (en) * | 2011-12-22 | 2015-01-01 | Susan Stewart | Methods and compositions for combination therapy using p13k/mtor inhibitores |
| AU2013204533B2 (en) * | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| NZ744456A (en) * | 2012-09-26 | 2019-09-27 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| PL2945628T3 (pl) | 2013-01-15 | 2020-09-21 | Aragon Pharmaceuticals, Inc. | Modulator receptorów androgenowych w skojarzeniu z octanem abirateronu i prednizonem do leczenia nowotworu stercza |
| RU2015137617A (ru) | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| CN109806266A (zh) * | 2013-10-01 | 2019-05-28 | 诺华股份有限公司 | 用于癌症治疗的组合及其应用 |
| MX2016004265A (es) * | 2013-10-01 | 2016-07-08 | Novartis Ag | Combinacion. |
| US9566280B2 (en) | 2014-01-28 | 2017-02-14 | Massachusetts Institute Of Technology | Combination therapies and methods of use thereof for treating cancer |
| US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| US11478453B2 (en) | 2016-07-21 | 2022-10-25 | Hadasit Medical Research Services And Development Ltd. | Treatment for glioblastoma |
| KR102368555B1 (ko) * | 2016-12-16 | 2022-02-28 | 강푸 바이오파마슈티칼즈 리미티드 | 조성물, 이의 적용 및 치료 방법 |
| CN107670048B (zh) | 2017-08-30 | 2019-04-26 | 南京明臻医药科技有限公司 | 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用 |
| WO2019060525A1 (en) * | 2017-09-22 | 2019-03-28 | Dispersol Technologies, Llc | PHARMACEUTICAL FORMULATIONS OF CYCLIC OLIGOMER AND ABIRATERONE AND METHODS OF FORMATION AND ADMINISTRATION THEREOF |
| US10702508B2 (en) | 2017-10-16 | 2020-07-07 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| CN108486041A (zh) * | 2018-03-28 | 2018-09-04 | 华南农业大学 | PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法 |
| US10792292B2 (en) | 2019-03-06 | 2020-10-06 | Propella Therapeutics, Inc. | Abiraterone prodrugs |
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-
2012
- 2012-11-30 HR HRP20191982TT patent/HRP20191982T4/hr unknown
- 2012-11-30 FI FIEP12795842.9T patent/FI2785349T4/fi active
- 2012-11-30 PT PT127958429T patent/PT2785349T/pt unknown
- 2012-11-30 RS RS20191392A patent/RS59493B2/sr unknown
- 2012-11-30 AU AU2013205648A patent/AU2013205648B2/en active Active
- 2012-11-30 LT LT12795842T patent/LT2785349T/lt unknown
- 2012-11-30 HU HUE12795842A patent/HUE046667T2/hu unknown
- 2012-11-30 MY MYPI2014701394A patent/MY175800A/en unknown
- 2012-11-30 WO PCT/GB2012/052969 patent/WO2013079964A1/en not_active Ceased
- 2012-11-30 PH PH1/2014/500943A patent/PH12014500943A1/en unknown
- 2012-11-30 EP EP12795842.9A patent/EP2785349B2/en active Active
- 2012-11-30 RU RU2014119713A patent/RU2640485C2/ru active
- 2012-11-30 DK DK12795842.9T patent/DK2785349T4/da active
- 2012-11-30 SG SG11201401471PA patent/SG11201401471PA/en unknown
- 2012-11-30 US US14/361,718 patent/US20140329786A1/en not_active Abandoned
- 2012-11-30 CA CA2856646A patent/CA2856646C/en active Active
- 2012-11-30 JP JP2014543977A patent/JP6309454B2/ja active Active
- 2012-11-30 SI SI201231690T patent/SI2785349T2/sl unknown
- 2012-11-30 SM SM20190708T patent/SMT201900708T1/it unknown
- 2012-11-30 KR KR1020147016680A patent/KR102035361B1/ko active Active
- 2012-11-30 CN CN201280059109.1A patent/CN103945849B/zh active Active
- 2012-11-30 AU AU2012321110A patent/AU2012321110B2/en active Active
- 2012-11-30 PL PL12795842.9T patent/PL2785349T5/pl unknown
- 2012-11-30 ES ES12795842T patent/ES2762250T5/es active Active
- 2012-11-30 MX MX2014006547A patent/MX367640B/es active IP Right Grant
-
2014
- 2014-05-08 IL IL232530A patent/IL232530B/en active IP Right Grant
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2016
- 2016-02-08 US US15/018,157 patent/US9737540B2/en active Active
-
2019
- 2019-12-17 CY CY20191101323T patent/CY1122624T1/el unknown
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