|
US2940972A
(en)
|
1957-06-27 |
1960-06-14 |
Thomae Gmbh Dr K |
Tri-and tetra-substituted pteridine derivatives
|
|
US4666828A
(en)
|
1984-08-15 |
1987-05-19 |
The General Hospital Corporation |
Test for Huntington's disease
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4801531A
(en)
|
1985-04-17 |
1989-01-31 |
Biotechnology Research Partners, Ltd. |
Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
|
|
US5272057A
(en)
|
1988-10-14 |
1993-12-21 |
Georgetown University |
Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
|
|
US5192659A
(en)
|
1989-08-25 |
1993-03-09 |
Genetype Ag |
Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
|
|
GB9125001D0
(en)
|
1991-11-25 |
1992-01-22 |
Ici Plc |
Heterocyclic compounds
|
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
US6331555B1
(en)
|
1995-06-01 |
2001-12-18 |
University Of California |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
US6218529B1
(en)
|
1995-07-31 |
2001-04-17 |
Urocor, Inc. |
Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
|
|
CA2262403C
(en)
|
1995-07-31 |
2011-09-20 |
Urocor, Inc. |
Biomarkers and targets for diagnosis, prognosis and management of prostate disease
|
|
TW472045B
(en)
|
1996-09-25 |
2002-01-11 |
Astra Ab |
Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
|
|
CA2291774A1
(en)
|
1997-05-28 |
1998-12-03 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
|
|
UA71555C2
(en)
|
1997-10-06 |
2004-12-15 |
Zentaris Gmbh |
Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
|
|
AU3033500A
(en)
|
1999-01-15 |
2000-08-01 |
Agouron Pharmaceuticals, Inc. |
Non-peptide glp-1 agonists
|
|
EP1409487A1
(en)
|
1999-09-15 |
2004-04-21 |
Warner-Lambert Company Llc |
Pteridinones as kinase inhibitors
|
|
DE10013318A1
(de)
|
2000-03-17 |
2001-09-20 |
Merck Patent Gmbh |
Formulierung enthaltend Chinoxalinderivate
|
|
WO2002076985A1
(en)
|
2001-03-23 |
2002-10-03 |
Smithkline Beecham Corporation |
Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
|
|
EP1458383B1
(en)
|
2001-12-18 |
2007-11-21 |
Merck & Co., Inc. |
Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
|
|
PT1463506E
(pt)
|
2001-12-24 |
2009-12-10 |
Astrazeneca Ab |
Derivados de quinazolina substituídos como inibidores de aurora cinases
|
|
JP2003213463A
(ja)
|
2002-01-17 |
2003-07-30 |
Sumitomo Chem Co Ltd |
金属腐食防止剤および洗浄液
|
|
US6962995B2
(en)
|
2002-07-10 |
2005-11-08 |
E. I. Du Pont De Nemours And Company |
Charge transport compositions and electronic devices made with such compositions
|
|
US7825132B2
(en)
|
2002-08-23 |
2010-11-02 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibition of FGFR3 and treatment of multiple myeloma
|
|
CA2500727A1
(en)
|
2002-10-03 |
2004-04-15 |
Targegen, Inc. |
Vasculostatic agents and methods of use thereof
|
|
AR043059A1
(es)
|
2002-11-12 |
2005-07-13 |
Bayer Pharmaceuticals Corp |
Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
|
|
US7098332B2
(en)
|
2002-12-20 |
2006-08-29 |
Hoffmann-La Roche Inc. |
5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
|
|
JP2006516561A
(ja)
*
|
2003-01-17 |
2006-07-06 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類
|
|
EP1620413A2
(en)
|
2003-04-30 |
2006-02-01 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
|
MXPA05012281A
(es)
|
2003-05-14 |
2006-05-19 |
Torreypines Therapeutics Inc |
Compuestos y uso de los mismos en la modulacion beta amiloide.
|
|
ME00541B
(me)
|
2003-05-23 |
2011-10-10 |
Zentaris Gmbh |
NOVI PIRIDOPIRAZINI I NJlUHOVA UPOTREBA KAO MODULATORA KlNAZA
|
|
DE10323345A1
(de)
|
2003-05-23 |
2004-12-16 |
Zentaris Gmbh |
Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
|
|
WO2005007099A2
(en)
|
2003-07-10 |
2005-01-27 |
Imclone Systems Incorporated |
Pkb inhibitors as anti-tumor agents
|
|
US7339065B2
(en)
|
2003-07-21 |
2008-03-04 |
Bethesda Pharmaceuticals, Inc. |
Design and synthesis of optimized ligands for PPAR
|
|
PT1673092E
(pt)
|
2003-10-17 |
2007-11-23 |
4 Aza Ip Nv |
''derivados de pteridina substituídos com heterociclos e sua utilização em terapia''
|
|
CA2544186A1
(en)
|
2003-11-07 |
2005-05-26 |
Chiron Corporation |
Inhibition of fgfr3 and treatment of multiple myeloma with benzimidazole quinolinones
|
|
AU2004295058B9
(en)
|
2003-11-20 |
2011-06-30 |
Janssen Pharmaceutica N.V. |
6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
|
|
CA2545992A1
(en)
|
2003-11-24 |
2005-06-16 |
F. Hoffmann-La Roche Ag |
Pyrazolyl and imidazolyl pyrimidines
|
|
BRPI0418078A8
(pt)
|
2003-12-23 |
2018-01-02 |
Astex Therapeutics Ltd |
composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto
|
|
US7098222B2
(en)
|
2004-05-12 |
2006-08-29 |
Abbott Laboratories |
Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
|
|
US7205316B2
(en)
|
2004-05-12 |
2007-04-17 |
Abbott Laboratories |
Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
|
|
EP1789399A1
(en)
|
2004-08-31 |
2007-05-30 |
AstraZeneca AB |
Quinazolinone derivatives and their use as b-raf inhibitors
|
|
CN101039944B
(zh)
*
|
2004-10-14 |
2010-05-05 |
霍夫曼-拉罗奇有限公司 |
具有cdk1抗增殖活性的1,5-二氮杂萘唑烷酮类
|
|
WO2006066361A1
(en)
|
2004-12-24 |
2006-06-29 |
The University Of Queensland |
Method of treatment or prophylaxis
|
|
US8278290B2
(en)
|
2005-02-14 |
2012-10-02 |
Biononics Limited |
Tubulin polymerisation inhibitors
|
|
EP1853261B1
(de)
|
2005-03-03 |
2017-01-11 |
Universität des Saarlandes |
Selektive hemmstoffe humaner corticoidsynthasen
|
|
JP2008540535A
(ja)
|
2005-05-12 |
2008-11-20 |
メルク エンド カムパニー インコーポレーテッド |
チロシンキナーゼ阻害剤
|
|
MX2007014258A
(es)
*
|
2005-05-18 |
2008-01-22 |
Wyeth Corp |
Inhibidores de 4,6-diamino-[1,7]naftiridin-3-carbonitrilo de la tpl2 cinasa y metodos de fabricacion y uso de los mismos.
|
|
GB0513692D0
(en)
|
2005-07-04 |
2005-08-10 |
Karobio Ab |
Novel pharmaceutical compositions
|
|
EP1790342A1
(de)
|
2005-11-11 |
2007-05-30 |
Zentaris GmbH |
Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
|
|
EP1957487A1
(de)
|
2005-11-11 |
2008-08-20 |
AEterna Zentaris GmbH |
Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
|
|
US8217042B2
(en)
|
2005-11-11 |
2012-07-10 |
Zentaris Gmbh |
Pyridopyrazines and their use as modulators of kinases
|
|
JP5292102B2
(ja)
|
2005-12-21 |
2013-09-18 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
チロシンキナーゼ調節剤としてのトリアゾロピリダジン類
|
|
JP2009535393A
(ja)
*
|
2006-05-01 |
2009-10-01 |
ファイザー・プロダクツ・インク |
置換２−アミノ縮合複素環式化合物
|
|
GB0609621D0
(en)
|
2006-05-16 |
2006-06-21 |
Astrazeneca Ab |
Novel co-crystal
|
|
US20100234347A1
(en)
|
2006-05-24 |
2010-09-16 |
Boehringer Ingelheim Internationl Gmbh |
Substituted Pteridines substituted with a Four-Membered Heterocycle
|
|
EP2044027A2
(en)
|
2006-07-03 |
2009-04-08 |
Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg |
Fused bicyclic compounds interacting with the histamine h4 receptor
|
|
JP2008127446A
(ja)
|
2006-11-20 |
2008-06-05 |
Canon Inc |
１，５−ナフチリジン化合物及び有機発光素子
|
|
NZ578329A
(en)
|
2006-12-13 |
2012-05-25 |
Schering Corp |
Igf1r inhibitors for treating cancer
|
|
AU2007336811A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN101652352A
(zh)
*
|
2006-12-22 |
2010-02-17 |
诺瓦提斯公司 |
用于抑制pdk1的喹唑啉类
|
|
CA2672172C
(en)
|
2006-12-22 |
2016-05-03 |
Astex Therapeutics Limited |
Bicyclic heterocyclic compounds as fgfr inhibitors
|
|
KR20080062876A
(ko)
|
2006-12-29 |
2008-07-03 |
주식회사 대웅제약 |
신규한 항진균성 트리아졸 유도체
|
|
PE20090288A1
(es)
|
2007-05-10 |
2009-04-03 |
Smithkline Beecham Corp |
Derivados de quinoxalina como inhibidores de la pi3 quinasa
|
|
EP1990342A1
(en)
|
2007-05-10 |
2008-11-12 |
AEterna Zentaris GmbH |
Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
|
|
WO2008150827A1
(en)
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
AR066879A1
(es)
|
2007-06-08 |
2009-09-16 |
Novartis Ag |
Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus
|
|
EP2170894A1
(en)
|
2007-06-21 |
2010-04-07 |
Janssen Pharmaceutica N.V. |
Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline
|
|
WO2009019518A1
(en)
|
2007-08-09 |
2009-02-12 |
Astrazeneca Ab |
Pyrimidine compounds having a fgfr inhibitory effect
|
|
EP2173354A4
(en)
|
2007-08-09 |
2011-10-05 |
Glaxosmithkline Llc |
CHINOXALIN DERIVATIVES AS PI3 KINASE INHIBITORS
|
|
US20090054304A1
(en)
|
2007-08-23 |
2009-02-26 |
Kalypsys, Inc. |
Heterocyclic modulators of tgr5 for treatment of disease
|
|
KR101580482B1
(ko)
|
2007-11-16 |
2015-12-28 |
인사이트 홀딩스 코포레이션 |
야누스 키나제 억제제로서의 ４－피라졸릴－ｎ－아릴피리미딘－２－아민 및 ４－피라졸릴－ｎ－헤테로아릴피리미딘－２－아민
|
|
US20110129456A1
(en)
|
2008-05-05 |
2011-06-02 |
Yaolin Wang |
Sequential Administration of Chemotherapeutic Agents for Treatment of Cancer
|
|
KR101257158B1
(ko)
|
2008-05-23 |
2013-04-23 |
노파르티스 아게 |
단백질 티로신 키나제 억제제로서의 퀴놀린 및 퀴녹살린의 유도체
|
|
EP2356116A1
(en)
|
2008-11-20 |
2011-08-17 |
OSI Pharmaceuticals, Inc. |
Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
|
|
CA2750047A1
(en)
|
2009-01-21 |
2010-07-29 |
Basilea Pharmaceutica Ag |
Novel bicyclic antibiotics
|
|
JP2012516847A
(ja)
*
|
2009-02-02 |
2012-07-26 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Ａｋｔ活性の阻害剤
|
|
TW201041888A
(en)
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
CU24245B1
(es)
|
2009-06-12 |
2017-02-02 |
Centre Nat Rech Scient |
QUINOLIN-6 AMINA Y QUINOLINA-7-AMINA DERIVADOS DE LA FÓRMULA (Id) y (Ir), Y SALES DERIVADAS
|
|
NZ598294A
(en)
|
2009-09-03 |
2013-07-26 |
Bioenergenix |
Heterocyclic compounds for the inhibition of pask
|
|
US9340528B2
(en)
|
2009-09-04 |
2016-05-17 |
Bayer Pharma Aktiengesellschaft |
Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
|
|
EP2332939A1
(en)
|
2009-11-26 |
2011-06-15 |
Æterna Zentaris GmbH |
Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
|
|
KR102113960B1
(ko)
|
2010-03-30 |
2020-05-21 |
베르선 코포레이션 |
트롬빈 억제제로서의 다중치환된 방향족 화합물
|
|
GB201007286D0
(en)
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
WO2011146591A1
(en)
|
2010-05-19 |
2011-11-24 |
Millennium Pharmaceuticals, Inc. |
Substituted hydroxamic acids and uses thereof
|
|
WO2011149937A1
(en)
|
2010-05-24 |
2011-12-01 |
Intellikine, Inc. |
Heterocyclic compounds and uses thereof
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
CN102532141A
(zh)
|
2010-12-08 |
2012-07-04 |
中国科学院上海药物研究所 |
[1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途
|
|
EP2670753B1
(en)
|
2011-01-31 |
2016-10-19 |
Novartis AG |
Novel heterocyclic derivatives
|
|
JP6130305B2
(ja)
|
2011-02-23 |
2017-05-17 |
インテリカイン， エルエルシー |
キナーゼ阻害剤の組み合わせおよびそれらの使用
|
|
WO2012118492A1
(en)
|
2011-03-01 |
2012-09-07 |
Array Biopharma Inc. |
Heterocyclic sulfonamides as raf inhibitors
|
|
CN104053442B
(zh)
|
2011-08-26 |
2017-06-23 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
AU2012308238B2
(en)
|
2011-09-14 |
2017-05-25 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
WO2013043935A1
(en)
|
2011-09-21 |
2013-03-28 |
Neupharma, Inc. |
Certain chemical entites, compositions, and methods
|
|
CN104024257A
(zh)
|
2011-10-04 |
2014-09-03 |
吉利德卡利斯托加有限责任公司 |
Pi3k的新的喹喔啉抑制剂
|
|
JO3210B1
(ar)
|
2011-10-28 |
2018-03-08 |
Merck Sharp & Dohme |
مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
|
|
EA023935B1
(ru)
|
2011-10-28 |
2016-07-29 |
Новартис Аг |
Производные пурина и их применение для лечения заболевания
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
US9221804B2
(en)
|
2013-10-15 |
2015-12-29 |
Janssen Pharmaceutica Nv |
Secondary alcohol quinolinyl modulators of RORγt
|
|
KR102479693B1
(ko)
|
2014-03-26 |
2022-12-22 |
아스텍스 테라퓨틱스 리미티드 |
조합물
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
RU2715893C2
(ru)
|
2014-03-26 |
2020-03-04 |
Астекс Терапьютикс Лтд |
Комбинации ингибитора fgfr и ингибитора igf1r
|
|
JOP20200201A1
(ar)
|
2015-02-10 |
2017-06-16 |
Astex Therapeutics Ltd |
تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
|