IN2014MN00987A - - Google Patents

Info

Publication number
IN2014MN00987A
IN2014MN00987A IN987MUN2014A IN2014MN00987A IN 2014MN00987 A IN2014MN00987 A IN 2014MN00987A IN 987MUN2014 A IN987MUN2014 A IN 987MUN2014A IN 2014MN00987 A IN2014MN00987 A IN 2014MN00987A
Authority
IN
India
Prior art keywords
compounds
cancer
diseases
processes
preparation
Prior art date
Application number
Inventor
Patrick René Angibaud
Michel Obringer
Julien Jérémie Joseph Marin
Matthieu Jeanty
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of IN2014MN00987A publication Critical patent/IN2014MN00987A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to new naphthyridine derivative compounds to pharmaceutical compositions comprising said compounds to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases e.g. cancer.
IN987MUN2014 2011-10-28 2012-10-26 IN2014MN00987A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552883P 2011-10-28 2011-10-28
GBGB1118675.6A GB201118675D0 (en) 2011-10-28 2011-10-28 New compounds
PCT/GB2012/052669 WO2013061077A1 (en) 2011-10-28 2012-10-26 New compounds

Publications (1)

Publication Number Publication Date
IN2014MN00987A true IN2014MN00987A (en) 2015-04-24

Family

ID=45375501

Family Applications (1)

Application Number Title Priority Date Filing Date
IN987MUN2014 IN2014MN00987A (en) 2011-10-28 2012-10-26

Country Status (19)

Country Link
US (3) US9309241B2 (en)
EP (1) EP2776436B1 (en)
JP (1) JP6022588B2 (en)
KR (1) KR102027602B1 (en)
CN (1) CN104011052B (en)
AU (1) AU2012328167B9 (en)
BR (1) BR112014010179B1 (en)
CA (1) CA2853367C (en)
DK (1) DK2776436T3 (en)
ES (1) ES2731216T3 (en)
GB (1) GB201118675D0 (en)
HR (1) HRP20190994T1 (en)
HU (1) HUE044576T2 (en)
IN (1) IN2014MN00987A (en)
LT (1) LT2776436T (en)
MX (1) MX349004B (en)
RU (1) RU2629194C2 (en)
SI (1) SI2776436T1 (en)
WO (1) WO2013061077A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
AR090844A1 (en) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE DERIVATIVES OF NAFTIRIDINE
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
AR094812A1 (en) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd DERIVED FROM MONOCYCLIC PYRIDINE AS AN FGFR INHIBITOR
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
JP6112724B2 (en) * 2013-10-31 2017-04-12 日本化薬株式会社 1,5-naphthyridine derivative and insecticide comprising the same as an active ingredient
LT3122358T (en) 2014-03-26 2021-04-12 Astex Therapeutics Ltd. Combinations of fgfr- and cmet-inhibitors for the treatment of cancer
JO3512B1 (en) 2014-03-26 2020-07-05 Astex Therapeutics Ltd Quinoxaline derivatives useful as fgfr kinase modulators
DK3122359T3 (en) 2014-03-26 2021-03-08 Astex Therapeutics Ltd COMBINATIONS OF AN FGFR INHIBITOR AND AN IGF1R INHIBITOR
EP3125920B1 (en) 2014-04-04 2020-12-23 Del Mar Pharmaceuticals Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer
KR102344105B1 (en) 2014-08-18 2021-12-29 에자이 알앤드디 매니지먼트 가부시키가이샤 Salt of monocyclic pyridine derivative and crystal thereof
JOP20200201A1 (en) 2015-02-10 2017-06-16 Astex Therapeutics Ltd Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2017050865A1 (en) * 2015-09-23 2017-03-30 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
BR112018005637B1 (en) 2015-09-23 2023-11-28 Janssen Pharmaceutica Nv COMPOUNDS DERIVED FROM QUINOXALINE, QUINOLINE AND QUINAZOLINONE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE OF SAID COMPOUNDS
US9855255B1 (en) 2017-05-26 2018-01-02 King Saud University Substituted naphthyridinyl hydrazines as anti-liver cancer agents
AU2019241625A1 (en) 2018-03-28 2020-09-03 Eisai R&D Management Co., Ltd. Therapeutic agent for hepatocellular carcinoma
CN110128505A (en) * 2019-05-21 2019-08-16 梯尔希（南京）药物研发有限公司 A kind of synthetic method of Goserelin impurity
EP4076449A4 (en) * 2020-01-17 2023-12-06 Beta Pharma, Inc. Pyridazine and 1,2,4-triazine derivatives as fgfr kinase inhibitors

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
GB9125001D0 (en) 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
CA2744096C (en) 1996-07-31 2013-07-30 Laboratory Corporation Of America Holdings Biomarkers and targets for diagnosis, prognosis and management of prostate disease
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
IL133007A (en) 1997-05-28 2005-06-19 Aventis Pharma Inc Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
EP1147094A1 (en) 1999-01-15 2001-10-24 Novo Nordisk A/S Non-peptide glp-1 agonists
AU777468B2 (en) 1999-09-15 2004-10-21 Warner-Lambert Company Pteridinones as kinase inhibitors
DE10013318A1 (en) 2000-03-17 2001-09-20 Merck Patent Gmbh Quinoxaline derivatives are used as photo-stable UV filters in cosmetic or pharmaceutical sunscreens for the hair or skin
WO2002076985A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
US7569592B2 (en) 2001-12-18 2009-08-04 Merck & Co., Inc. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
AU2002353196B2 (en) 2001-12-24 2008-01-17 Astrazeneca Ab Substituted quinazoline derivatives as inhibitors of aurora kinases
JP2003213463A (en) 2002-01-17 2003-07-30 Sumitomo Chem Co Ltd Metal anticorrosive and cleaning solution
US7265378B2 (en) 2002-07-10 2007-09-04 E. I. Du Pont De Nemours And Company Electronic devices made with electron transport and/or anti-quenching layers
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
CA2500727A1 (en) 2002-10-03 2004-04-15 Targegen, Inc. Vasculostatic agents and methods of use thereof
AR043059A1 (en) 2002-11-12 2005-07-13 Bayer Pharmaceuticals Corp DERIVATIVES OF INDOLIL PIRAZINONA USEFUL FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
MXPA05007503A (en) * 2003-01-17 2005-09-21 Warner Lambert Co 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation.
WO2004098494A2 (en) 2003-04-30 2004-11-18 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004110350A2 (en) 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
DE10323345A1 (en) 2003-05-23 2004-12-16 Zentaris Gmbh New pyridopyrazines and their use as kinase inhibitors
PT1636228E (en) 2003-05-23 2009-02-02 Aeterna Zentaris Gmbh Novel pyridopyrazines and use thereof as kinase modulators
WO2005007099A2 (en) 2003-07-10 2005-01-27 Imclone Systems Incorporated Pkb inhibitors as anti-tumor agents
EP1646383A4 (en) 2003-07-21 2009-03-25 Bethesda Pharmaceuticals Inc Design and synthesis of optimized ligands for ppar
JP2007508355A (en) 2003-10-17 2007-04-05 ４・アー・ゼット・アー・バイオサイエンス・ナムローゼ・フエンノートシャップ Heterocycle-substituted pteridine derivatives and their use in therapy
CA2544186A1 (en) 2003-11-07 2005-05-26 Chiron Corporation Inhibition of fgfr3 and treatment of multiple myeloma with benzimidazole quinolinones
WO2005054201A1 (en) 2003-11-20 2005-06-16 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
RU2377241C2 (en) 2003-11-24 2009-12-27 Ф.Хоффманн-Ля Рош Аг Pirazoloimidazopyrimidine derivatives with antagonist activity to corticotrophin release factor (crf)
JP4928949B2 (en) 2003-12-23 2012-05-09 アステックス、セラピューティックス、リミテッド Pyrazole derivatives as protein kinase modulators
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
US7205316B2 (en) 2004-05-12 2007-04-17 Abbott Laboratories Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
US20090118261A1 (en) 2004-08-31 2009-05-07 Astrazeneca Ab Quinazolinone derivatives and their use as b-raf inhibitors
JP2008516905A (en) * 2004-10-14 2008-05-22 エフ．ホフマン−ラ ロシュ アーゲー 1,5-naphthyridine azolidinone having CDK1 antiproliferative activity
JP4966202B2 (en) 2004-12-24 2012-07-04 スピニフェクス ファーマシューティカルズ ピーティーワイ リミテッド Methods for treatment or prevention
WO2006084338A1 (en) 2005-02-14 2006-08-17 Bionomics Limited Novel tubulin polymerisation inhibitors
EP1853261B1 (en) 2005-03-03 2017-01-11 Universität des Saarlandes Selective inhibitors of human corticosteroid synthases
AU2006247833A1 (en) 2005-05-12 2006-11-23 Merck & Co., Inc. Tyrosine kinase inhibitors
BRPI0611521A2 (en) * 2005-05-18 2010-09-14 Wyeth Corp 4,6-diamino- [1,7] naphthyridine-3-carbonitrile kinase tpl2 inhibitors and methods of manufacture and use thereof
GB0513692D0 (en) 2005-07-04 2005-08-10 Karobio Ab Novel pharmaceutical compositions
CA2628039A1 (en) 2005-11-11 2007-05-18 Aeterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
EP1790342A1 (en) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazine derivatives and their use as signal transduction modulators
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
CA2634721C (en) 2005-12-21 2014-06-17 Janssen Pharmaceutica N.V. Triazolopyridazines as tyrosine kinase modulators
CA2651072A1 (en) * 2006-05-01 2007-11-08 Pfizer Products Inc. Substituted 2-amino-fused heterocyclic compounds
GB0609621D0 (en) 2006-05-16 2006-06-21 Astrazeneca Ab Novel co-crystal
CA2653117A1 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines substituted with a four-membered heterocycle
US20100016293A1 (en) 2006-07-03 2010-01-21 Rogier Adriaan Smits Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use
JP2008127446A (en) 2006-11-20 2008-06-05 Canon Inc 1,5-naphthyridine compound and organic light emitting device
NZ578329A (en) 2006-12-13 2012-05-25 Schering Corp Igf1r inhibitors for treating cancer
WO2008080001A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
BRPI0720563A2 (en) * 2006-12-22 2014-02-04 Novartis Ag PDK1 INHIBIT QUINAZOLINS
CA2672172C (en) 2006-12-22 2016-05-03 Astex Therapeutics Limited Bicyclic heterocyclic compounds as fgfr inhibitors
KR20080062876A (en) 2006-12-29 2008-07-03 주식회사 대웅제약 Novel antifungal triazole derivatives
EP1990342A1 (en) 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
PE20090288A1 (en) 2007-05-10 2009-04-03 Smithkline Beecham Corp QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
JP2010529031A (en) 2007-05-29 2010-08-26 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Naphthyridine derivatives as PI3 kinase inhibitors
AR066879A1 (en) 2007-06-08 2009-09-16 Novartis Ag DERIVATIVES OF QUINOXALINE AS INHIBITORS OF THE TYPOSINE CINASA ACTIVITY OF THE JANUS CINASES
US8629144B2 (en) 2007-06-21 2014-01-14 Janssen Pharmaceutica Nv Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline
WO2009019518A1 (en) 2007-08-09 2009-02-12 Astrazeneca Ab Pyrimidine compounds having a fgfr inhibitory effect
JP2010535804A (en) 2007-08-09 2010-11-25 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Quinoxaline derivatives as PI3 kinase inhibitors
US20090054304A1 (en) 2007-08-23 2009-02-26 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
CN101910152B (en) 2007-11-16 2014-08-06 因塞特公司 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors
MX2010012064A (en) 2008-05-05 2010-12-06 Schering Corp Sequential administration of chemotherapeutic agents for treatment of cancer.
WO2009141386A1 (en) 2008-05-23 2009-11-26 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
JP2012509342A (en) 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド Substituted pyrrolo [2,3-B] -pyridine and -pyrazine
JP5662346B2 (en) 2009-01-21 2015-01-28 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ New bicyclic antibiotics
JP2012516847A (en) * 2009-02-02 2012-07-26 メルク・シャープ・エンド・ドーム・コーポレイション Inhibitor of AKT activity
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
KR101973348B1 (en) 2009-06-12 2019-04-26 아비박스 Compounds useful for treating premature aging in particular progeria
JP5696856B2 (en) 2009-09-03 2015-04-08 バイオエナジェニックス Heterocyclic compounds for inhibition of PASK
CN102596932A (en) 2009-09-04 2012-07-18 拜耳医药股份有限公司 Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
EP2332939A1 (en) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
RU2017144535A (en) 2010-03-30 2019-02-18 Версеон Корпорейшн MULTI-DISPLACED AROMATIC COMPOUNDS AS THROMBINE INHIBITORS
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
WO2011146591A1 (en) 2010-05-19 2011-11-24 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
JP5894980B2 (en) 2010-05-24 2016-03-30 インテリカイン， エルエルシー Heterocyclic compounds and uses thereof
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
CN102532141A (en) 2010-12-08 2012-07-04 中国科学院上海药物研究所 (1,2,4)-triazolo-(4,3-b) (1,2,4)-triazine compounds, as well as preparation method and use thereof
ES2611885T3 (en) 2011-01-31 2017-05-11 Novartis Ag Novel Heterocyclic Derivatives
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
WO2012118492A1 (en) 2011-03-01 2012-09-07 Array Biopharma Inc. Heterocyclic sulfonamides as raf inhibitors
ES2725790T3 (en) 2011-08-26 2019-09-27 Neupharma Inc Some chemical entities, compositions, and methods
EP3332785B1 (en) 2011-09-14 2020-05-06 Neupharma, Inc. Certain chemical entities, compositions, and methods
WO2013043935A1 (en) 2011-09-21 2013-03-28 Neupharma, Inc. Certain chemical entites, compositions, and methods
WO2013052699A2 (en) 2011-10-04 2013-04-11 Gilead Calistoga Llc Novel quinoxaline inhibitors of pi3k
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
PL2771342T3 (en) 2011-10-28 2016-11-30 Purine derivatives and their use in the treatment of disease
JO3210B1 (en) 2011-10-28 2018-03-08 Merck Sharp & Dohme Fused bicyclic oxazolidinone cetp inhibitor
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
JO3512B1 (en) 2014-03-26 2020-07-05 Astex Therapeutics Ltd Quinoxaline derivatives useful as fgfr kinase modulators
LT3122358T (en) 2014-03-26 2021-04-12 Astex Therapeutics Ltd. Combinations of fgfr- and cmet-inhibitors for the treatment of cancer
DK3122359T3 (en) 2014-03-26 2021-03-08 Astex Therapeutics Ltd COMBINATIONS OF AN FGFR INHIBITOR AND AN IGF1R INHIBITOR
JOP20200201A1 (en) 2015-02-10 2017-06-16 Astex Therapeutics Ltd Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine

Also Published As

Publication number Publication date
WO2013061077A1 (en) 2013-05-02
AU2012328167A1 (en) 2014-05-22
MX2014004859A (en) 2014-08-26
US20170105978A1 (en) 2017-04-20
LT2776436T (en) 2019-06-10
ES2731216T3 (en) 2019-11-14
US9527844B2 (en) 2016-12-27
US9757364B2 (en) 2017-09-12
KR102027602B1 (en) 2019-10-01
BR112014010179A2 (en) 2017-04-25
HUE044576T2 (en) 2019-11-28
AU2012328167B9 (en) 2017-09-28
EP2776436B1 (en) 2019-03-13
CA2853367A1 (en) 2013-05-02
CN104011052A (en) 2014-08-27
HRP20190994T1 (en) 2019-11-29
CA2853367C (en) 2021-05-25
RU2629194C2 (en) 2017-08-25
BR112014010179A8 (en) 2018-01-09
SI2776436T1 (en) 2019-08-30
KR20140096033A (en) 2014-08-04
BR112014010179B1 (en) 2020-12-08
US9309241B2 (en) 2016-04-12
DK2776436T3 (en) 2019-06-11
CN104011052B (en) 2016-06-08
AU2012328167B2 (en) 2017-08-24
RU2014121496A (en) 2015-12-10
EP2776436A1 (en) 2014-09-17
JP6022588B2 (en) 2016-11-09
US20150057293A1 (en) 2015-02-26
US20160108034A1 (en) 2016-04-21
MX349004B (en) 2017-07-06
GB201118675D0 (en) 2011-12-14
JP2014530897A (en) 2014-11-20

Similar Documents

Publication Publication Date Title
IN2014MN00987A (en)
IN2014MN00948A (en)
IN2014MN02049A (en)
IN2014MN00986A (en)
IN2014MN00988A (en)
IN2014MN02069A (en)
IN2012MN02591A (en)
PH12016501139B1 (en) Bicyclic heterocycle compounds and their uses in therapy
PH12015500274B1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
IL236221A (en) Thienopyridone derivatives and pharmaceutical compositions comprising them for the treatment of diseases
EP2872151A4 (en) Acellular pro-tolerogenic compositions for the treatment/prevention of auto-immune diseases
PH12015500713B1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
LT2925757T (en) Compounds and compositions for the treatment of parasitic diseases
IL231926A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases and pharmaceutical compositions comprising them
MX349224B (en) Pharmaceutical composition for use in the treatment of a neurodegenerative disease.
EP2709632A4 (en) Compositions and methods for the treatment of skin diseases
IN2014DN03010A (en)
HUP1100290A2 (en) Combination compositions for the treatment of proliferative diseases
HK1157189A1 (en) Pharmaceutical composition for the treatment of tumor diseases
AU2011900519A0 (en) Drug compositions for the treatment of insomnia
TN2013000202A1 (en) Spiro-oxindole mdm2 antagonists