JP2014528903A5 - - Google Patents
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- Publication number
- JP2014528903A5 JP2014528903A5 JP2014513549A JP2014513549A JP2014528903A5 JP 2014528903 A5 JP2014528903 A5 JP 2014528903A5 JP 2014513549 A JP2014513549 A JP 2014513549A JP 2014513549 A JP2014513549 A JP 2014513549A JP 2014528903 A5 JP2014528903 A5 JP 2014528903A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- coor
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(Cc1c(*)cccc1)NC(I)=O)C(*)=O Chemical compound *C(C(Cc1c(*)cccc1)NC(I)=O)C(*)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161491746P | 2011-05-31 | 2011-05-31 | |
| US61/491,746 | 2011-05-31 | ||
| PCT/US2012/038517 WO2012166389A1 (en) | 2011-05-31 | 2012-05-18 | Neprilysin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015251113A Division JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528903A JP2014528903A (ja) | 2014-10-30 |
| JP2014528903A5 true JP2014528903A5 (enExample) | 2015-04-16 |
| JP5885832B2 JP5885832B2 (ja) | 2016-03-16 |
Family
ID=46172950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513549A Expired - Fee Related JP5885832B2 (ja) | 2011-05-31 | 2012-05-18 | ネプリライシン阻害剤 |
| JP2015251113A Withdrawn JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015251113A Withdrawn JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8686184B2 (enExample) |
| EP (1) | EP2714648B1 (enExample) |
| JP (2) | JP5885832B2 (enExample) |
| CN (1) | CN103748070B (enExample) |
| CA (1) | CA2835281A1 (enExample) |
| ES (1) | ES2642883T3 (enExample) |
| WO (1) | WO2012166389A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ611528A (en) | 2010-12-15 | 2015-06-26 | Theravance Biopharma R & D Ip Llc | Neprilysin inhibitors |
| US8586536B2 (en) | 2010-12-15 | 2013-11-19 | Theravance, Inc. | Neprilysin inhibitors |
| CA2825737C (en) | 2011-02-17 | 2018-11-13 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
| US8449890B2 (en) | 2011-02-17 | 2013-05-28 | Theravance, Inc. | Neprilysin inhibitors |
| US8513244B2 (en) | 2011-05-31 | 2013-08-20 | Theravance, Inc. | Neprilysin inhibitors |
| CA2835220A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| US9210438B2 (en) | 2012-01-20 | 2015-12-08 | Sony Corporation | Logical intra mode naming in HEVC video coding |
| US9045443B2 (en) | 2012-05-31 | 2015-06-02 | Theravance Biopharma R&D Ip, Llc | Nitric oxide donor neprilysin inhibitors |
| EP2858650B1 (en) | 2012-06-08 | 2018-11-14 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| JP6162230B2 (ja) | 2012-06-08 | 2017-07-12 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤 |
| AU2013299642B2 (en) | 2012-08-08 | 2017-06-08 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| EP2964616B1 (en) | 2013-03-05 | 2017-05-03 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| EP3099678B1 (en) | 2014-01-30 | 2018-12-12 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| US9585882B2 (en) | 2014-01-30 | 2017-03-07 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| ES2923002T3 (es) | 2015-02-11 | 2022-09-22 | Theravance Biopharma R&D Ip Llc | Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina |
| RU2715241C2 (ru) | 2015-02-19 | 2020-02-26 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота |
| PT3408260T (pt) | 2016-03-08 | 2021-07-23 | Theravance Biopharma R&D Ip Llc | Ácido (2s,4r)-5-(5¿-cloro-2¿-fluoro-[1,1¿-bifenil]-4-il)-2- (etoximetil)-4-(3-hidroxi-isoxazole-5-carboxamido)-2- metilpentanoico cristalino e suas utilizações |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| CN113166101A (zh) | 2018-11-27 | 2021-07-23 | 诺华股份有限公司 | 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状五聚体化合物 |
| TW202333563A (zh) | 2021-11-12 | 2023-09-01 | 瑞士商諾華公司 | 用於治療疾病或障礙之二胺基環戊基吡啶衍生物 |
| CN119421876A (zh) * | 2022-04-25 | 2025-02-11 | 日本新药株式会社 | 作为ddr1激酶抑制剂的化合物和药物 |
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| US4189604A (en) | 1975-07-22 | 1980-02-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin |
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| FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
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| US5294632A (en) | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
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| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| DE19510566A1 (de) | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JPH11505522A (ja) | 1995-04-21 | 1999-05-21 | ノバルティス・アクチエンゲゼルシャフト | エンドセリン阻害剤としてのｎ−アロイルアミノ酸アミド |
| FI974437A0 (fi) | 1995-06-06 | 1997-12-05 | Pfizer | Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina |
| JP3408379B2 (ja) * | 1995-06-30 | 2003-05-19 | 株式会社ジャパンエナジー | 新規なジペプチド化合物又はその薬理的に許容される塩及びその医薬用途 |
| US5932550A (en) | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| WO1999050249A2 (en) * | 1998-04-01 | 1999-10-07 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| US6660756B2 (en) | 2001-03-28 | 2003-12-09 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
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| JP2004256435A (ja) * | 2003-02-26 | 2004-09-16 | Sankyo Co Ltd | ３−置換アミノ−２−ヒドロキシ−４−フェニル酪酸類 |
| JP2006528702A (ja) | 2003-05-21 | 2006-12-21 | プロシディオン・リミテッド | グリコーゲンホスホリラーゼのピロロピリジン−２−カルボン酸アミドインヒビター |
| EP1493739A1 (fr) | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
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| WO2007106708A2 (en) | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| RU2530900C2 (ru) | 2007-01-12 | 2014-10-20 | Новартис Аг | Способ получения 5-бифенил-4-амино-2-метилпентановой кислоты |
| TWI448284B (zh) * | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| US8212052B2 (en) | 2007-12-11 | 2012-07-03 | Theravance, Inc. | Dual-acting benzoimidazole antihypertensive agents |
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| US7863309B2 (en) * | 2008-07-24 | 2011-01-04 | Theravance, Inc. | Dual-acting antihypertensive agents |
| KR101096427B1 (ko) * | 2008-10-20 | 2011-12-20 | 주식회사 이큐스앤자루 | 신규한 4-아릴-4-옥소부탄산 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
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| JP5420761B2 (ja) | 2009-05-28 | 2014-02-19 | ノバルティス アーゲー | ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体 |
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| SI2526088T1 (sl) | 2010-01-22 | 2015-12-31 | Novartis Ag | Intermediati nevtralnih endopeptidaznih inhibitorjev in metoda za njihovo pripravo |
| TWI532725B (zh) | 2010-01-26 | 2016-05-11 | 賽諾菲阿凡提斯公司 | 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途 |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| CA2835220A1 (en) * | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
-
2012
- 2012-05-18 WO PCT/US2012/038517 patent/WO2012166389A1/en not_active Ceased
- 2012-05-18 EP EP12724046.3A patent/EP2714648B1/en active Active
- 2012-05-18 CN CN201280026853.1A patent/CN103748070B/zh not_active Expired - Fee Related
- 2012-05-18 ES ES12724046.3T patent/ES2642883T3/es active Active
- 2012-05-18 US US13/475,017 patent/US8686184B2/en not_active Expired - Fee Related
- 2012-05-18 CA CA2835281A patent/CA2835281A1/en not_active Abandoned
- 2012-05-18 JP JP2014513549A patent/JP5885832B2/ja not_active Expired - Fee Related
-
2015
- 2015-12-24 JP JP2015251113A patent/JP2016047846A/ja not_active Withdrawn
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