JP2014528903A5 - - Google Patents
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- Publication number
- JP2014528903A5 JP2014528903A5 JP2014513549A JP2014513549A JP2014528903A5 JP 2014528903 A5 JP2014528903 A5 JP 2014528903A5 JP 2014513549 A JP2014513549 A JP 2014513549A JP 2014513549 A JP2014513549 A JP 2014513549A JP 2014528903 A5 JP2014528903 A5 JP 2014528903A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- coor
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(Cc1c(*)cccc1)NC(I)=O)C(*)=O Chemical compound *C(C(Cc1c(*)cccc1)NC(I)=O)C(*)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161491746P | 2011-05-31 | 2011-05-31 | |
| US61/491,746 | 2011-05-31 | ||
| PCT/US2012/038517 WO2012166389A1 (en) | 2011-05-31 | 2012-05-18 | Neprilysin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015251113A Division JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528903A JP2014528903A (ja) | 2014-10-30 |
| JP2014528903A5 true JP2014528903A5 (enExample) | 2015-04-16 |
| JP5885832B2 JP5885832B2 (ja) | 2016-03-16 |
Family
ID=46172950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513549A Expired - Fee Related JP5885832B2 (ja) | 2011-05-31 | 2012-05-18 | ネプリライシン阻害剤 |
| JP2015251113A Withdrawn JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015251113A Withdrawn JP2016047846A (ja) | 2011-05-31 | 2015-12-24 | ネプリライシン阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8686184B2 (enExample) |
| EP (1) | EP2714648B1 (enExample) |
| JP (2) | JP5885832B2 (enExample) |
| CN (1) | CN103748070B (enExample) |
| CA (1) | CA2835281A1 (enExample) |
| ES (1) | ES2642883T3 (enExample) |
| WO (1) | WO2012166389A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2651896T3 (en) | 2010-12-15 | 2015-10-05 | Theravance Biopharma R & D Ip Llc | Neprilysininhibitorer |
| AU2011343903B2 (en) | 2010-12-15 | 2016-06-30 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| JP5959066B2 (ja) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| JP5959065B2 (ja) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
| US8513244B2 (en) | 2011-05-31 | 2013-08-20 | Theravance, Inc. | Neprilysin inhibitors |
| ES2699773T3 (es) | 2011-05-31 | 2019-02-12 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| US9210438B2 (en) | 2012-01-20 | 2015-12-08 | Sony Corporation | Logical intra mode naming in HEVC video coding |
| WO2013181332A1 (en) | 2012-05-31 | 2013-12-05 | Theravance, Inc. | Nitric oxide donor neprilysin inhibitors |
| JP6162229B2 (ja) | 2012-06-08 | 2017-07-12 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤 |
| PT2864292T (pt) | 2012-06-08 | 2017-07-10 | Theravance Biopharma R&D Ip Llc | Inibidores de neprisilina |
| SG11201500845UA (en) | 2012-08-08 | 2015-03-30 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| HUE034210T2 (hu) | 2013-03-05 | 2018-02-28 | Theravance Biopharma R&D Ip Llc | Neprilizininhibitorok |
| WO2015116786A1 (en) | 2014-01-30 | 2015-08-06 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| US9585882B2 (en) | 2014-01-30 | 2017-03-07 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| MY187899A (en) | 2015-02-11 | 2021-10-27 | Theravance Biopharma R&D Ip Llc | (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor |
| AU2016220348B2 (en) | 2015-02-19 | 2019-10-17 | Theravance Biopharma R&D Ip, Llc | (2R,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid |
| SG11201807591VA (en) | 2016-03-08 | 2018-10-30 | Theravance Biopharma R&D Ip Llc | Crystalline(2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| US20230089867A1 (en) | 2018-11-27 | 2023-03-23 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
| TW202333563A (zh) | 2021-11-12 | 2023-09-01 | 瑞士商諾華公司 | 用於治療疾病或障礙之二胺基環戊基吡啶衍生物 |
| JPWO2023210599A1 (enExample) * | 2022-04-25 | 2023-11-02 |
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| CA2333927A1 (en) * | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| US6660756B2 (en) | 2001-03-28 | 2003-12-09 | Pfizer Inc. | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
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| MXPA05012547A (es) | 2003-05-21 | 2006-05-25 | Prosidion Ltd | Inhibidores de amida de acido pirrolopiridina-2-carboxilico de fosforilasa de glucogeno. |
| EP1493739A1 (fr) | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
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| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| CN101896470B (zh) | 2007-12-11 | 2013-04-10 | 施万制药 | 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途 |
| PE20091364A1 (es) | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| WO2010011821A2 (en) * | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| KR101096427B1 (ko) * | 2008-10-20 | 2011-12-20 | 주식회사 이큐스앤자루 | 신규한 4-아릴-4-옥소부탄산 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
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| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
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| ES2699773T3 (es) * | 2011-05-31 | 2019-02-12 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
-
2012
- 2012-05-18 CN CN201280026853.1A patent/CN103748070B/zh not_active Expired - Fee Related
- 2012-05-18 WO PCT/US2012/038517 patent/WO2012166389A1/en not_active Ceased
- 2012-05-18 ES ES12724046.3T patent/ES2642883T3/es active Active
- 2012-05-18 US US13/475,017 patent/US8686184B2/en active Active
- 2012-05-18 JP JP2014513549A patent/JP5885832B2/ja not_active Expired - Fee Related
- 2012-05-18 CA CA2835281A patent/CA2835281A1/en not_active Abandoned
- 2012-05-18 EP EP12724046.3A patent/EP2714648B1/en active Active
-
2015
- 2015-12-24 JP JP2015251113A patent/JP2016047846A/ja not_active Withdrawn
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