JPS55355A - Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative - Google Patents
Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivativeInfo
- Publication number
- JPS55355A JPS55355A JP2663279A JP2663279A JPS55355A JP S55355 A JPS55355 A JP S55355A JP 2663279 A JP2663279 A JP 2663279A JP 2663279 A JP2663279 A JP 2663279A JP S55355 A JPS55355 A JP S55355A
- Authority
- JP
- Japan
- Prior art keywords
- isomer
- phenyl
- amino
- hyroxypropionic
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: Thionyl chloride is made to act on (2R,3R) isomer and (2R,3S) isomer, which are useless because they have no enzyme inhibition activity, and the hydrolysis is effected to produce title compound used for synthetic intermediate of immunologically activated carcinostatics.
CONSTITUTION: Thionyl chloride or sulfonyl chloride is made to act on (2R,3R) or (2R,3S)-3-amino-2-hydroxypropionic ester derivative of the formula [R1 is cycloalkyl, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl; R2 is lower alkyl, phenyl, substituted phenyl; R3 is residue of ester] in such an amount that thionyl chlride or sulfonyl chloride can be used also as the solvent, 5W10 times equivalent at -10W10°C. The resulting product is hydrolyzed with acid or alkali to produce the objective (2S,3R) or (2S,3S) isomer.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2663279A JPS55355A (en) | 1979-03-09 | 1979-03-09 | Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2663279A JPS55355A (en) | 1979-03-09 | 1979-03-09 | Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53049941 Division |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55355A true JPS55355A (en) | 1980-01-05 |
JPS62906B2 JPS62906B2 (en) | 1987-01-10 |
Family
ID=12198816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2663279A Granted JPS55355A (en) | 1979-03-09 | 1979-03-09 | Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55355A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4517961A (en) * | 1982-11-09 | 1985-05-21 | Bloor Trevor J | Solar water heating apparatus |
US20120308588A1 (en) * | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
-
1979
- 1979-03-09 JP JP2663279A patent/JPS55355A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4517961A (en) * | 1982-11-09 | 1985-05-21 | Bloor Trevor J | Solar water heating apparatus |
US20120308588A1 (en) * | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
US8686184B2 (en) * | 2011-05-31 | 2014-04-01 | Theravance, Inc. | Neprilysin inhibitors |
Also Published As
Publication number | Publication date |
---|---|
JPS62906B2 (en) | 1987-01-10 |
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