JPS55355A - Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative - Google Patents

Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative

Info

Publication number
JPS55355A
JPS55355A JP2663279A JP2663279A JPS55355A JP S55355 A JPS55355 A JP S55355A JP 2663279 A JP2663279 A JP 2663279A JP 2663279 A JP2663279 A JP 2663279A JP S55355 A JPS55355 A JP S55355A
Authority
JP
Japan
Prior art keywords
isomer
phenyl
amino
hyroxypropionic
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2663279A
Other languages
Japanese (ja)
Other versions
JPS62906B2 (en
Inventor
Rinzo Nishizawa
Tetsuyuki Saino
Kenji Seya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP2663279A priority Critical patent/JPS55355A/en
Publication of JPS55355A publication Critical patent/JPS55355A/en
Publication of JPS62906B2 publication Critical patent/JPS62906B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: Thionyl chloride is made to act on (2R,3R) isomer and (2R,3S) isomer, which are useless because they have no enzyme inhibition activity, and the hydrolysis is effected to produce title compound used for synthetic intermediate of immunologically activated carcinostatics.
CONSTITUTION: Thionyl chloride or sulfonyl chloride is made to act on (2R,3R) or (2R,3S)-3-amino-2-hydroxypropionic ester derivative of the formula [R1 is cycloalkyl, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl; R2 is lower alkyl, phenyl, substituted phenyl; R3 is residue of ester] in such an amount that thionyl chlride or sulfonyl chloride can be used also as the solvent, 5W10 times equivalent at -10W10°C. The resulting product is hydrolyzed with acid or alkali to produce the objective (2S,3R) or (2S,3S) isomer.
COPYRIGHT: (C)1980,JPO&Japio
JP2663279A 1979-03-09 1979-03-09 Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative Granted JPS55355A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2663279A JPS55355A (en) 1979-03-09 1979-03-09 Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2663279A JPS55355A (en) 1979-03-09 1979-03-09 Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53049941 Division

Publications (2)

Publication Number Publication Date
JPS55355A true JPS55355A (en) 1980-01-05
JPS62906B2 JPS62906B2 (en) 1987-01-10

Family

ID=12198816

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2663279A Granted JPS55355A (en) 1979-03-09 1979-03-09 Preparation of (2s,3r) or (2s,3s)-3-amino-2-hyroxypropionic acid derivative

Country Status (1)

Country Link
JP (1) JPS55355A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517961A (en) * 1982-11-09 1985-05-21 Bloor Trevor J Solar water heating apparatus
US20120308588A1 (en) * 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517961A (en) * 1982-11-09 1985-05-21 Bloor Trevor J Solar water heating apparatus
US20120308588A1 (en) * 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
US8686184B2 (en) * 2011-05-31 2014-04-01 Theravance, Inc. Neprilysin inhibitors

Also Published As

Publication number Publication date
JPS62906B2 (en) 1987-01-10

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