ES470296A1 - Fluorinated amino acids - Google Patents
Fluorinated amino acidsInfo
- Publication number
- ES470296A1 ES470296A1 ES470296A ES470296A ES470296A1 ES 470296 A1 ES470296 A1 ES 470296A1 ES 470296 A ES470296 A ES 470296A ES 470296 A ES470296 A ES 470296A ES 470296 A1 ES470296 A1 ES 470296A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- amino acids
- acid addition
- addition salts
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Novel alpha -fluoromethyl- alpha -amino acids and esters have the following formula < IMAGE > in which R is a substituted C1-C4-alkyl group and R1 has the meaning of H or C1-C18-alkyl. The compounds can be present as acid addition salts. The compounds of the formula I, as well as their pharmaceutically acceptable acid addition salts, are used as active compounds in medicaments which have a decarboxylase-inhibiting effect. Processes for preparing the novel compounds are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80238977A | 1977-06-01 | 1977-06-01 | |
US05/802,391 US4325961A (en) | 1977-06-01 | 1977-06-01 | Fluorinated amino acids |
Publications (1)
Publication Number | Publication Date |
---|---|
ES470296A1 true ES470296A1 (en) | 1979-09-16 |
Family
ID=27122442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES470296A Expired ES470296A1 (en) | 1977-06-01 | 1978-05-29 | Fluorinated amino acids |
Country Status (26)
Country | Link |
---|---|
JP (1) | JPS5416423A (en) |
AR (1) | AR223463A1 (en) |
AT (1) | AT360509B (en) |
AU (1) | AU518479B2 (en) |
CA (1) | CA1120040A (en) |
CH (1) | CH639639A5 (en) |
DD (1) | DD138651A5 (en) |
DE (1) | DE2824116A1 (en) |
DK (1) | DK149841C (en) |
ES (1) | ES470296A1 (en) |
FI (1) | FI66840C (en) |
FR (1) | FR2392958A1 (en) |
GB (1) | GB1602525A (en) |
GR (1) | GR64495B (en) |
HK (1) | HK18184A (en) |
HU (1) | HU181911B (en) |
IE (1) | IE46983B1 (en) |
IT (1) | IT1104709B (en) |
LU (1) | LU79750A1 (en) |
NL (1) | NL190485C (en) |
NO (1) | NO147382C (en) |
NZ (1) | NZ187377A (en) |
PL (1) | PL115731B1 (en) |
PT (1) | PT68102B (en) |
SE (1) | SE7806440L (en) |
YU (1) | YU129178A (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA783273B (en) * | 1977-07-11 | 1979-06-27 | Merrell Toraude & Co | A-halomethyl amino acids |
CA1091661A (en) * | 1977-07-11 | 1980-12-16 | Philippe Bey | .alpha.-HALOMETHYL DERIVATIVES OF .alpha.-AMINO ACIDS |
IL59481A0 (en) * | 1977-07-11 | 1980-05-30 | Merrell Toraude & Co | -halomethyl amino acids |
US4315095A (en) * | 1977-07-28 | 1982-02-09 | Merrell Toraude Et Compagnie | α-Halomethyl derivatives of amino acids |
EP0007600B1 (en) * | 1978-07-24 | 1983-05-11 | Merck & Co. Inc. | Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same |
IE49522B1 (en) * | 1979-04-26 | 1985-10-16 | Merrell Toraude & Co | Alpha-halomethylaminoacids |
CA1158657A (en) * | 1979-07-26 | 1983-12-13 | Philippe Bey | Preparation of fluorinated methyl aminoalkanoic acids and novel process intermediates |
ZA813018B (en) * | 1980-05-09 | 1982-05-26 | Merrell Toraude & Co | Fluoromethylated tyrosine methyl ester |
NZ197394A (en) * | 1980-06-16 | 1984-09-28 | Merrell Dow Pharma | Inhibition of protozoal growth in animals with certain-substituted-amines or amino acids |
US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
GB9325368D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Bristol | Organic compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3046300A (en) * | 1960-10-21 | 1962-07-24 | Merck & Co Inc | alpha-trifluoromethyloxyphenylalanines |
-
1978
- 1978-05-25 FR FR7815567A patent/FR2392958A1/en active Granted
- 1978-05-25 NZ NZ187377A patent/NZ187377A/en unknown
- 1978-05-25 GR GR56328A patent/GR64495B/en unknown
- 1978-05-26 AR AR272336A patent/AR223463A1/en active
- 1978-05-26 FI FI781674A patent/FI66840C/en not_active IP Right Cessation
- 1978-05-29 AU AU36586/78A patent/AU518479B2/en not_active Expired
- 1978-05-29 ES ES470296A patent/ES470296A1/en not_active Expired
- 1978-05-29 CA CA000304318A patent/CA1120040A/en not_active Expired
- 1978-05-30 AT AT393278A patent/AT360509B/en not_active IP Right Cessation
- 1978-05-30 PT PT68102A patent/PT68102B/en unknown
- 1978-05-30 DD DD78205669A patent/DD138651A5/en unknown
- 1978-05-30 GB GB24330/78A patent/GB1602525A/en not_active Expired
- 1978-05-30 IE IE1078/78A patent/IE46983B1/en unknown
- 1978-05-30 YU YU01291/78A patent/YU129178A/en unknown
- 1978-05-30 DK DK237978A patent/DK149841C/en not_active IP Right Cessation
- 1978-05-30 HU HU78ME2169A patent/HU181911B/en unknown
- 1978-05-31 NO NO781892A patent/NO147382C/en unknown
- 1978-05-31 PL PL1978207242A patent/PL115731B1/en unknown
- 1978-05-31 CH CH597978A patent/CH639639A5/en not_active IP Right Cessation
- 1978-05-31 IT IT49637/78A patent/IT1104709B/en active
- 1978-06-01 JP JP6501678A patent/JPS5416423A/en active Granted
- 1978-06-01 LU LU79750A patent/LU79750A1/en unknown
- 1978-06-01 SE SE7806440A patent/SE7806440L/en unknown
- 1978-06-01 DE DE19782824116 patent/DE2824116A1/en active Granted
- 1978-06-01 NL NLAANVRAGE7805981,A patent/NL190485C/en not_active IP Right Cessation
-
1984
- 1984-03-01 HK HK181/84A patent/HK18184A/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980202 |