JP2014503534A5 - - Google Patents

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Publication number
JP2014503534A5
JP2014503534A5 JP2013544730A JP2013544730A JP2014503534A5 JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5 JP 2013544730 A JP2013544730 A JP 2013544730A JP 2013544730 A JP2013544730 A JP 2013544730A JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5
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JP
Japan
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alkyl
alkylene
halo
phenyl
och
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JP2013544730A
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English (en)
Japanese (ja)
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JP2014503534A (ja
JP5944921B2 (ja
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Priority claimed from PCT/US2011/064829 external-priority patent/WO2012082853A1/en
Publication of JP2014503534A publication Critical patent/JP2014503534A/ja
Publication of JP2014503534A5 publication Critical patent/JP2014503534A5/ja
Application granted granted Critical
Publication of JP5944921B2 publication Critical patent/JP5944921B2/ja
Active legal-status Critical Current
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JP2013544730A 2010-12-15 2011-12-14 ネプリライシン阻害剤 Active JP5944921B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42318010P 2010-12-15 2010-12-15
US61/423,180 2010-12-15
PCT/US2011/064829 WO2012082853A1 (en) 2010-12-15 2011-12-14 Neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015186389A Division JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Publications (3)

Publication Number Publication Date
JP2014503534A JP2014503534A (ja) 2014-02-13
JP2014503534A5 true JP2014503534A5 (enExample) 2014-11-20
JP5944921B2 JP5944921B2 (ja) 2016-07-05

Family

ID=45478501

Family Applications (2)

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JP2013544730A Active JP5944921B2 (ja) 2010-12-15 2011-12-14 ネプリライシン阻害剤
JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Country Status (28)

Country Link
US (9) US8586536B2 (enExample)
EP (1) EP2651896B1 (enExample)
JP (2) JP5944921B2 (enExample)
KR (1) KR101892500B1 (enExample)
CN (2) CN105061314A (enExample)
AU (1) AU2011343899B2 (enExample)
BR (1) BR112013016595B1 (enExample)
CA (1) CA2817368C (enExample)
CO (1) CO6741228A2 (enExample)
DK (1) DK2651896T3 (enExample)
ES (1) ES2550324T3 (enExample)
HR (1) HRP20151115T1 (enExample)
HU (1) HUE028051T2 (enExample)
IL (1) IL226327A (enExample)
ME (1) ME02295B (enExample)
MX (1) MX2013006805A (enExample)
MY (1) MY170935A (enExample)
NZ (1) NZ610983A (enExample)
PH (1) PH12013501240A1 (enExample)
PL (1) PL2651896T3 (enExample)
PT (1) PT2651896E (enExample)
RS (1) RS54348B1 (enExample)
RU (1) RU2622288C2 (enExample)
SG (2) SG10201510244TA (enExample)
SI (1) SI2651896T1 (enExample)
SM (1) SMT201500271B (enExample)
WO (1) WO2012082853A1 (enExample)
ZA (1) ZA201304205B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120041702A (ko) 2009-05-28 2012-05-02 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체
EP2651896B1 (en) 2010-12-15 2015-08-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
SG191175A1 (en) 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
WO2012154249A1 (en) * 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
CN103380119B (zh) 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
US9499487B2 (en) 2011-05-31 2016-11-22 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
WO2013059215A1 (en) 2011-10-17 2013-04-25 Biotheryx, Inc. Substituted biaryl alkyl amides
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
BR112014030743B1 (pt) 2012-06-08 2022-09-06 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processo para a preparação do referido composto, composição farmacêutica e uso do referido composto
KR102104954B1 (ko) 2012-08-08 2020-04-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
US8796305B2 (en) * 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
WO2014126979A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
KR20150119107A (ko) 2013-02-14 2015-10-23 노파르티스 아게 개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
CA2934936A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
MX2016009759A (es) 2014-01-30 2016-11-17 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
CA2970011C (en) * 2014-12-24 2021-08-03 Lg Chem, Ltd. Biaryl derivative as gpr120 agonist
MY187899A (en) 2015-02-11 2021-10-27 Theravance Biopharma R&D Ip Llc (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
KR20220035991A (ko) 2016-03-08 2022-03-22 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 (2s,4r)-5-(5'-클로로-2'-플루오로-[1,1'-비페닐]-4-일)-2-(에톡시메틸)-4-(3-히드록시이속사졸-5-카르복사미도)-2-메틸펜탄산 결정 및 그 용도
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
US20230089867A1 (en) 2018-11-27 2023-03-23 Novartis Ag Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
WO2020110011A1 (en) 2018-11-27 2020-06-04 Novartis Ag Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
CN112592294B (zh) * 2020-12-22 2022-05-13 江苏阿尔法药业股份有限公司 一种沙库巴曲药物中间体的合成方法
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
CN119306633B (zh) * 2024-09-24 2025-04-25 深圳市第二人民医院(深圳市转化医学研究院) 一种β3-氨基酸衍生物的合成方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189604A (en) 1975-07-22 1980-02-19 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin
US4206232A (en) 1976-05-10 1980-06-03 E. R. Squibb & Sons, Inc. Relieving hypertension with carboxyalkylacylamino acids
CH653687A5 (de) * 1978-11-25 1986-01-15 Nippon Kayaku Kk Threo-3-amino-2-hydroxy-butanoylaminoessigsaeure-derivate.
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS5615257A (en) 1979-07-17 1981-02-14 Nippon Hidorajin Kogyo Kk Preparation of methylhydrazine
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4906615A (en) 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
CN1008092B (zh) * 1983-10-03 1990-05-23 E·R·斯奎布父子公司 脑啡肽酶抑制剂的制备方法
US4722810A (en) 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4939261A (en) 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
EP0225292A3 (en) 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US4929641B1 (en) 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
KR880007441A (ko) 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
FR2623498B1 (fr) 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
GB8820844D0 (en) 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
US5599951A (en) 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5155100A (en) 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
DE19510566A1 (de) 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH11505522A (ja) 1995-04-21 1999-05-21 ノバルティス・アクチエンゲゼルシャフト エンドセリン阻害剤としてのｎ−アロイルアミノ酸アミド
US6660756B2 (en) 2001-03-28 2003-12-09 Pfizer Inc. N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
DE60330997D1 (de) * 2002-11-19 2010-03-04 Galderma Res & Dev Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen
CN1566065A (zh) * 2003-06-27 2005-01-19 中国医学科学院药物研究所 α位杂原子取代的γ芳基丁本酮酸衍生物及其制法和其药物组合物与用途
WO2006027680A1 (en) 2004-09-10 2006-03-16 Pfizer Limited 3-(1-carbamoylcyclohexyl) propionic acid derivatives as inhibitors of neutral endopeptidase enzyme
DE602006006418D1 (de) * 2005-02-10 2009-06-04 Medivir Ab Hiv-protease-inhibitoren
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
WO2007106708A2 (en) 2006-03-10 2007-09-20 Novartis Ag Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril
PT2121578T (pt) * 2007-01-12 2016-11-14 Novartis Ag Processo de preparação de ácido 5-bifenil-4-amino-2-metil-pentanoico
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
KR20120041702A (ko) 2009-05-28 2012-05-02 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체
JP5420761B2 (ja) * 2009-05-28 2014-02-19 ノバルティス アーゲー ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
HRP20151061T1 (hr) 2010-01-22 2015-12-04 Novartis Ag Posrednici inhibitora neutralne endopeptidaze i postupak njihove pripreme
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
EP2651896B1 (en) 2010-12-15 2015-08-12 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
SG191175A1 (en) 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
CN103380119B (zh) 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
US9499487B2 (en) 2011-05-31 2016-11-22 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN103596928B (zh) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
CA2835281A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
BR112014030743B1 (pt) 2012-06-08 2022-09-06 Theravance Biopharma R&D Ip, Llc Composto inibidor de neprilisina, processo para a preparação do referido composto, composição farmacêutica e uso do referido composto
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
KR102104954B1 (ko) 2012-08-08 2020-04-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제

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