JP2014503534A5 - - Google Patents

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Publication number
JP2014503534A5
JP2014503534A5 JP2013544730A JP2013544730A JP2014503534A5 JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5 JP 2013544730 A JP2013544730 A JP 2013544730A JP 2013544730 A JP2013544730 A JP 2013544730A JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5
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JP
Japan
Prior art keywords
alkyl
alkylene
halo
phenyl
och
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JP2013544730A
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English (en)
Japanese (ja)
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JP5944921B2 (ja
JP2014503534A (ja
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Priority claimed from PCT/US2011/064829 external-priority patent/WO2012082853A1/en
Publication of JP2014503534A publication Critical patent/JP2014503534A/ja
Publication of JP2014503534A5 publication Critical patent/JP2014503534A5/ja
Application granted granted Critical
Publication of JP5944921B2 publication Critical patent/JP5944921B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013544730A 2010-12-15 2011-12-14 ネプリライシン阻害剤 Expired - Fee Related JP5944921B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42318010P 2010-12-15 2010-12-15
US61/423,180 2010-12-15
PCT/US2011/064829 WO2012082853A1 (en) 2010-12-15 2011-12-14 Neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015186389A Division JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Publications (3)

Publication Number Publication Date
JP2014503534A JP2014503534A (ja) 2014-02-13
JP2014503534A5 true JP2014503534A5 (enExample) 2014-11-20
JP5944921B2 JP5944921B2 (ja) 2016-07-05

Family

ID=45478501

Family Applications (2)

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JP2013544730A Expired - Fee Related JP5944921B2 (ja) 2010-12-15 2011-12-14 ネプリライシン阻害剤
JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Country Status (28)

Country Link
US (9) US8586536B2 (enExample)
EP (1) EP2651896B1 (enExample)
JP (2) JP5944921B2 (enExample)
KR (1) KR101892500B1 (enExample)
CN (2) CN105061314A (enExample)
AU (1) AU2011343899B2 (enExample)
BR (1) BR112013016595B1 (enExample)
CA (1) CA2817368C (enExample)
CO (1) CO6741228A2 (enExample)
DK (1) DK2651896T3 (enExample)
ES (1) ES2550324T3 (enExample)
HR (1) HRP20151115T1 (enExample)
HU (1) HUE028051T2 (enExample)
IL (1) IL226327A (enExample)
ME (1) ME02295B (enExample)
MX (1) MX2013006805A (enExample)
MY (1) MY170935A (enExample)
NZ (1) NZ610983A (enExample)
PH (1) PH12013501240A1 (enExample)
PL (1) PL2651896T3 (enExample)
PT (1) PT2651896E (enExample)
RS (1) RS54348B1 (enExample)
RU (1) RU2622288C2 (enExample)
SG (2) SG10201510244TA (enExample)
SI (1) SI2651896T1 (enExample)
SM (1) SMT201500271B (enExample)
WO (1) WO2012082853A1 (enExample)
ZA (1) ZA201304205B (enExample)

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MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
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LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
PY1998404A (es) 2018-11-27 2021-06-17 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) para el tratamiento de trastornos metabólicos
JP7657151B2 (ja) 2018-11-27 2025-04-04 ノバルティス アーゲー 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド
JP2022507958A (ja) 2018-11-27 2022-01-18 ノバルティス アーゲー 代謝障害の治療用のプロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）阻害薬としての環状四量体化合物
CN112592294B (zh) * 2020-12-22 2022-05-13 江苏阿尔法药业股份有限公司 一种沙库巴曲药物中间体的合成方法
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CN119306633B (zh) * 2024-09-24 2025-04-25 深圳市第二人民医院(深圳市转化医学研究院) 一种β3-氨基酸衍生物的合成方法

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JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
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CN103582630B (zh) 2011-05-31 2016-08-17 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
CN103748070B (zh) 2011-05-31 2015-06-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
SMT201700306T1 (it) 2012-06-08 2017-07-18 Theravance Biopharma R&D Ip Llc Inibitori di neprilisina
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MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.

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