JP2014524477A - ペプチドナノ粒子およびその使用 - Google Patents

ペプチドナノ粒子およびその使用 Download PDF

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Publication number
JP2014524477A
JP2014524477A JP2014527288A JP2014527288A JP2014524477A JP 2014524477 A JP2014524477 A JP 2014524477A JP 2014527288 A JP2014527288 A JP 2014527288A JP 2014527288 A JP2014527288 A JP 2014527288A JP 2014524477 A JP2014524477 A JP 2014524477A
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Japan
Prior art keywords
peptide
leu
trp
amphiphilic
amino acid
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JP2014527288A
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Japanese (ja)
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JP2014524477A5 (enExample
Inventor
クリスティアン ディットリッチ
ガウデンツ ダヌセール
Original Assignee
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
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Publication of JP2014524477A publication Critical patent/JP2014524477A/ja
Publication of JP2014524477A5 publication Critical patent/JP2014524477A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014527288A 2011-08-23 2012-08-23 ペプチドナノ粒子およびその使用 Ceased JP2014524477A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161526526P 2011-08-23 2011-08-23
US61/526,526 2011-08-23
PCT/US2012/052027 WO2013028843A1 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and uses thereof

Publications (2)

Publication Number Publication Date
JP2014524477A true JP2014524477A (ja) 2014-09-22
JP2014524477A5 JP2014524477A5 (enExample) 2014-10-30

Family

ID=46826904

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014527288A Ceased JP2014524477A (ja) 2011-08-23 2012-08-23 ペプチドナノ粒子およびその使用

Country Status (19)

Country Link
US (1) US8828928B2 (enExample)
EP (1) EP2748182B1 (enExample)
JP (1) JP2014524477A (enExample)
KR (1) KR20140068087A (enExample)
CN (1) CN104011065B (enExample)
AU (1) AU2012298824B2 (enExample)
BR (1) BR112014004014A2 (enExample)
CA (1) CA2845886A1 (enExample)
CL (1) CL2014000418A1 (enExample)
DK (1) DK2748182T3 (enExample)
ES (1) ES2610779T3 (enExample)
HU (1) HUE031511T2 (enExample)
IL (1) IL231005A0 (enExample)
MX (1) MX2014002062A (enExample)
PT (1) PT2748182T (enExample)
RU (1) RU2014110901A (enExample)
SG (1) SG11201400073SA (enExample)
WO (1) WO2013028843A1 (enExample)
ZA (1) ZA201401210B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220356303A1 (en) * 2021-04-08 2022-11-10 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures
US12509552B2 (en) * 2022-04-08 2025-12-30 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures

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* Cited by examiner, † Cited by third party
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US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
WO2017139746A1 (en) * 2016-02-11 2017-08-17 Mark Daniels Posh inhibitor complex biomolecules and amphiphile micelles
EP3432908A4 (en) 2016-03-21 2020-07-29 Rhode Island Council on Postsecondary Education PEPTIDES SENSITIVE TO PH
ES2914787T3 (es) * 2016-12-16 2022-06-16 Brigham & Womens Hospital Inc Método para matriz de sensores de corona de proteínas para la detección temprana de enfermedades
CN106832003B (zh) * 2017-02-15 2021-01-05 中国药科大学 一种酸敏性多肽及其应用
WO2019195766A1 (en) 2018-04-06 2019-10-10 AMMA Therapeutics, Inc. Composition for controlled release of therapeutic agents
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
WO2023244536A2 (en) * 2022-06-13 2023-12-21 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

Family Cites Families (17)

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US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3872925A (en) 1973-04-24 1975-03-25 Gearhart Owen Industries Through-tubing bridge plug
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (enExample) 1974-03-08 1982-06-04
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4511390A (en) 1983-06-10 1985-04-16 E. I. Du Pont De Nemours And Company Aralkylcarbamoyl peptide alcohols
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
FR2736642B1 (fr) 1995-07-10 1997-09-12 Pasteur Institut Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
AU776832B2 (en) 1999-08-02 2004-09-23 Synt:Em (S.A.) Computational design methods for making molecular mimetics
JP4215512B2 (ja) 2001-02-26 2009-01-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非オリゴマー化タンデム蛍光性タンパク質
CA2572964C (en) 2004-07-06 2018-03-06 3D Matrix, Inc. Purified amphiphilic peptide compositions and uses thereof
JP6088123B2 (ja) * 2008-02-01 2017-03-01 アルファ−オー・ペプチドズ・アーゲーＡｌｐｈａ−Ｏ Ｐｅｐｔｉｄｅｓ Ａｇ ワクチンとして有用な自己会合ペプチドナノ粒子
EP2297182A4 (en) * 2008-04-28 2012-08-15 Harvard College HIGHLY CHARGED PROTEINS USED FOR CELL PENETRATION

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.PHYS.CHEM.C, vol. Vol.115, JPN6016015298, 13 July 2011 (2011-07-13), pages 14583 - 14590 *
MACROMOL. BIOSCI., vol. Vol.10, JPN6016015297, 2010, pages 1406 - 1415 *
SOFT MATTER, vol. vol.6, JPN6016015299, 2010, pages 5596 - 5604 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220356303A1 (en) * 2021-04-08 2022-11-10 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures
US12509552B2 (en) * 2022-04-08 2025-12-30 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures

Also Published As

Publication number Publication date
AU2012298824A1 (en) 2014-03-20
RU2014110901A (ru) 2015-09-27
MX2014002062A (es) 2014-05-28
KR20140068087A (ko) 2014-06-05
AU2012298824B2 (en) 2017-06-01
HUE031511T2 (en) 2017-07-28
US20130064895A1 (en) 2013-03-14
DK2748182T3 (en) 2017-02-06
NZ622045A (en) 2016-02-26
ZA201401210B (en) 2015-12-23
SG11201400073SA (en) 2014-03-28
WO2013028843A1 (en) 2013-02-28
EP2748182B1 (en) 2016-10-19
CN104011065A (zh) 2014-08-27
CA2845886A1 (en) 2013-02-28
CN104011065B (zh) 2017-06-30
US8828928B2 (en) 2014-09-09
CL2014000418A1 (es) 2014-07-25
EP2748182A1 (en) 2014-07-02
PT2748182T (pt) 2017-01-20
IL231005A0 (en) 2014-03-31
ES2610779T3 (es) 2017-05-03
BR112014004014A2 (pt) 2020-10-27

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