JP2014523742A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014523742A5 JP2014523742A5 JP2014519581A JP2014519581A JP2014523742A5 JP 2014523742 A5 JP2014523742 A5 JP 2014523742A5 JP 2014519581 A JP2014519581 A JP 2014519581A JP 2014519581 A JP2014519581 A JP 2014519581A JP 2014523742 A5 JP2014523742 A5 JP 2014523742A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- tau
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1112056.5 | 2011-07-14 | ||
| GBGB1112056.5A GB201112056D0 (en) | 2011-07-14 | 2011-07-14 | Antibodies |
| PCT/EP2012/063924 WO2013007839A1 (en) | 2011-07-14 | 2012-07-16 | Antibodies to phosphorylated tau aggregates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523742A JP2014523742A (ja) | 2014-09-18 |
| JP2014523742A5 true JP2014523742A5 (enExample) | 2015-09-03 |
| JP6168364B2 JP6168364B2 (ja) | 2017-07-26 |
Family
ID=44586547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519581A Active JP6168364B2 (ja) | 2011-07-14 | 2012-07-16 | リン酸化タウ凝集体に対する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9447179B2 (enExample) |
| EP (1) | EP2731969B1 (enExample) |
| JP (1) | JP6168364B2 (enExample) |
| AU (1) | AU2012282402B2 (enExample) |
| GB (1) | GB201112056D0 (enExample) |
| WO (1) | WO2013007839A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| US9801957B2 (en) | 2011-04-06 | 2017-10-31 | Ananth Annapragada | Lipid-based nanoparticles |
| EP2756459B1 (en) | 2012-01-20 | 2020-12-09 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| EP2870176A4 (en) | 2012-07-03 | 2016-09-28 | Univ Washington | ANTIBODIES DIRECTED AGAINST TAU |
| EP2885010B1 (en) * | 2012-08-16 | 2020-01-01 | Ipierian, Inc. | Methods of treating a tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| WO2014165271A2 (en) * | 2013-03-13 | 2014-10-09 | Neotope Biosciences Limited | Tau immunotherapy |
| SMT202000401T1 (it) * | 2013-06-10 | 2020-11-10 | Ipierian Inc | Metodi di trattamento di una taupatia |
| BR112016010454A2 (pt) * | 2013-11-27 | 2017-12-05 | Ipierian Inc | métodos para tratar uma taupatia |
| CR20160270A (es) | 2013-12-20 | 2016-09-05 | Hoffmann La Roche | ANTICUERPOS ANTI-TAU (pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN |
| EP2899208A1 (en) * | 2014-01-28 | 2015-07-29 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof |
| CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽，抗Tau抗体，及其使用方法 |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TWI734975B (zh) | 2014-06-27 | 2021-08-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| EP3542828A1 (en) | 2014-10-08 | 2019-09-25 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
| CA3001724A1 (en) * | 2014-10-10 | 2016-04-14 | National Research Council Of Canada | Anti-tau antibody and uses thereof |
| AR103713A1 (es) | 2015-02-26 | 2017-05-31 | Lilly Co Eli | Anticuerpos contra tau y sus usos |
| GB201509134D0 (en) * | 2015-05-28 | 2015-07-15 | Electrophoretics Ltd | Biomolecules involved in Alzheimer's disease |
| NZ775762A (en) * | 2015-06-05 | 2025-02-28 | Genentech Inc | Anti-tau antibodies and methods of use |
| ES2809728T3 (es) * | 2015-06-24 | 2021-03-05 | Hoffmann La Roche | Anticuerpos anti-tau(pS422) humanizados y procedimientos de uso |
| CA2991264C (en) | 2015-07-06 | 2023-10-10 | Ucb Biopharma Sprl | Tau-binding antibodies |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US10906964B2 (en) | 2016-05-02 | 2021-02-02 | Prothena Biosciences Limited | Antibodies recognizing tau |
| MX2018013384A (es) | 2016-05-02 | 2019-02-28 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau. |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| US10570196B2 (en) * | 2016-07-20 | 2020-02-25 | Anahit Ghochikyan | Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| JP6949102B2 (ja) | 2016-08-09 | 2021-10-13 | イーライ リリー アンド カンパニー | 併用療法 |
| KR101876423B1 (ko) | 2016-10-10 | 2018-07-09 | 한국과학기술연구원 | 치매 모델 형질전환 마우스 및 이를 이용한 스크리닝 방법 |
| FR3058143B1 (fr) * | 2016-10-27 | 2021-03-12 | Univ Grenoble Alpes | Nanocorps anti-tau |
| EP3551220B1 (en) | 2016-12-07 | 2025-01-29 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| EP3551655A2 (en) | 2016-12-07 | 2019-10-16 | Genentech, Inc. | Anti-tau antibodies and methods of their use |
| US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| CA3053379A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| SG11201910066QA (en) | 2017-05-02 | 2019-11-28 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| JP6851549B2 (ja) | 2017-10-16 | 2021-03-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗タウ抗体及びその使用 |
| TW202333768A (zh) * | 2017-10-25 | 2023-09-01 | 美商健生醫藥公司 | Tau胜肽之組成物及其用途 |
| TW201946654A (zh) | 2018-03-05 | 2019-12-16 | 比利時商健生藥品公司 | 抗ＰＨＦ－Ｔａｕ抗體及其用途 |
| WO2019171258A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Assays to detect neurodegeneration |
| EP3829634A1 (en) | 2018-07-31 | 2021-06-09 | Eli Lilly and Company | Combination therapy |
| WO2020105700A1 (ja) * | 2018-11-22 | 2020-05-28 | 富士レビオ株式会社 | 抗体コンジュゲート |
| WO2020120644A1 (en) * | 2018-12-13 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
| TWI859197B (zh) | 2019-03-03 | 2024-10-21 | 愛爾蘭商普羅帝納生物科學公司 | 識別ｔａｕ之抗體 |
| WO2021167723A1 (en) * | 2020-02-17 | 2021-08-26 | Board Of Regents, The University Of Texas System | Chimeric scavenger receptors targeted to phosphorylated tau (ptau) and uses thereof |
| CA3231228A1 (en) | 2021-09-09 | 2023-03-16 | Andreas Jeromin | Phospho-tau antibodies and methods of use |
| WO2026102093A1 (en) | 2024-11-07 | 2026-05-15 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| CN119708218B (zh) * | 2024-11-19 | 2025-12-16 | 海南大学 | 分泌抗217位点苏氨酸磷酸化tau单克隆抗体的杂交瘤细胞株 |
| CN119661705B (zh) * | 2024-11-22 | 2025-06-24 | 上海伯杰医疗科技股份有限公司 | 一种抗p-Tau217蛋白单克隆抗体及其制备方法和应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| JPH07503124A (ja) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | 微生物によって生産される抗体断片とそれらの複合体 |
| ATE154642T1 (de) | 1991-10-25 | 1997-07-15 | Innogenetics Nv | Monoklonale antikörper gegen das mikrotubulusassoziierte protein tau. |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DE69334275D1 (de) | 1992-08-21 | 2009-05-20 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
| JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
| ATE335007T1 (de) | 1993-12-21 | 2006-08-15 | Innogenetics Nv | Monoklonale antikörper gegen phf-tau, hybridomen die diese ausscheiden, antigenerkennung durch diesen antikörper und deren verwendungen |
| ES2201097T3 (es) | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| ATE374248T1 (de) | 1996-06-27 | 2007-10-15 | Vlaams Interuniv Inst Biotech | Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren |
| US20030068316A1 (en) | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| US20040110938A1 (en) * | 2000-02-24 | 2004-06-10 | Parekh Rajesh Bhikhu | Proteins, genes and their use for diagnosis and treatment of schizophrenia |
| DE60336848D1 (de) | 2002-09-12 | 2011-06-01 | Univ California | Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz |
| US7238788B2 (en) * | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| EP1769002A1 (en) | 2004-07-02 | 2007-04-04 | Northwestern University | Monolocal antibodies that target pathological assemblies of amyloid beta; (abeta) |
| CA2576405A1 (en) | 2004-08-11 | 2006-02-16 | Mitsubishi Chemical Corporation | Antibody and utilization of the same |
| KR20070094890A (ko) | 2004-10-25 | 2007-09-27 | 머크 앤드 캄파니 인코포레이티드 | 안티 ａｄｄｌ 항체 및 그 용도 |
| WO2007062088A1 (en) | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of alzheimer's and related diseases |
| BRPI0706818A2 (pt) | 2006-02-24 | 2011-04-05 | Chiesi Farma Spa | composições, métodos e usos de imunogênicos antiamilóides |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| WO2008070229A2 (en) | 2006-08-28 | 2008-06-12 | Case Western Reserve University | Detection of pathogenic aggregates of protein in a sample by homologous elisa |
| ES2610474T3 (es) | 2007-01-11 | 2017-04-27 | Michael Bacher | Diagnóstico y tratamiento de la enfermedad de Alzheimer y otras enfermedades neurodegenerativas causantes de demencia |
| HRP20150086T1 (xx) | 2007-06-12 | 2015-02-27 | Ac Immune S.A. | Humanizirana antitijela za beta amiloid |
| US8932558B2 (en) * | 2007-10-05 | 2015-01-13 | Plaxgen Inc | Multi-subunit biological complexes for treatment of plaque-associated diseases |
| US20110294144A1 (en) * | 2008-02-12 | 2011-12-01 | Kenichi Noguchi | Screening method |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) * | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| WO2012045882A2 (en) | 2010-10-07 | 2012-04-12 | Ac Immune S.A. | Pharmaceutical composition |
-
2011
- 2011-07-14 GB GBGB1112056.5A patent/GB201112056D0/en not_active Ceased
-
2012
- 2012-07-16 US US14/232,659 patent/US9447179B2/en active Active
- 2012-07-16 AU AU2012282402A patent/AU2012282402B2/en not_active Ceased
- 2012-07-16 JP JP2014519581A patent/JP6168364B2/ja active Active
- 2012-07-16 EP EP12743696.2A patent/EP2731969B1/en active Active
- 2012-07-16 WO PCT/EP2012/063924 patent/WO2013007839A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI719894B (zh) | 抗原結合分子類和使用彼等之方法 | |
| CA3109036C (en) | Human immunodeficiency virus (hiv)-neutralizing antibodies | |
| Zhou et al. | Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 | |
| JP2024156662A (ja) | 抗可変ｍｕｃ１＊抗体およびその使用 | |
| CN111978398B (zh) | 针对冠状病毒sars-cov-2的抗体及其医学用途 | |
| JP2022516039A (ja) | 抗ｃｄ１９抗体のモノクローナル抗体及びその使用 | |
| KR20220018479A (ko) | 동종이계 car-t 세포, 이의 제조 및 응용 | |
| JP2024514477A (ja) | Ｓａｒｓ－ｃｏｖ－２抗原を標的とするペプチドおよび操作されたｔ細胞受容体ならびに使用の方法 | |
| WO2022162192A2 (en) | Therapeutic and diagnostic agents and uses thereof | |
| WO2025015726A9 (zh) | 抗cd19抗体的抗体、抗cd22抗体的抗体及其应用 | |
| KR20220129026A (ko) | 아밀로이드 제거를 위한 키메라 항원 수용체 | |
| WO2023026207A1 (en) | Potently neutralizing novel human monoclonal antibodies against sars-cov-2 (covid-19) | |
| WO2015199618A1 (en) | Epstein-barr virus lmp2 specific antibody and uses thereof | |
| CN113667011A (zh) | 制备抗原结合单元的方法 | |
| WO2024036204A2 (en) | Modified antibodies and methods of use thereof | |
| US9340601B2 (en) | Splice variants of the EGF receptor | |
| EP4472663A1 (en) | Therapeutic and diagnostic agents and uses thereof | |
| CN110878126A (zh) | Tcr样嵌合抗原受体及其应用 | |
| CN119421953A (zh) | 具有突变株交叉性的抗SARS－CoV－2人中和抗体及其抗原结合片段 | |
| CN118667005A (zh) | 抗pd-l1的纳米抗体及其用途 | |
| JP2018150260A (ja) | インフルエンザウイルスの増殖を阻害するモノクローナル抗体 | |
| TW202041862A (zh) | 用於檢測米田堡血型抗原的抗體及其片段、試劑盒及方法 | |
| Brackenridge et al. | Mapping the epitopes of the Human Leukocyte Antigen E antibodies 3D12 and 4D12 | |
| Dorgham et al. | Identification of the single immunodominant region of the native human CC chemokine receptor 6 recognized by mouse monoclonal antibodies | |
| HK40064555A (en) | Method for providing antigen binding units |