AU2012282402B2 - Antibodies to phosphorylated tau aggregates - Google Patents

Antibodies to phosphorylated tau aggregates Download PDF

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Publication number
AU2012282402B2
AU2012282402B2 AU2012282402A AU2012282402A AU2012282402B2 AU 2012282402 B2 AU2012282402 B2 AU 2012282402B2 AU 2012282402 A AU2012282402 A AU 2012282402A AU 2012282402 A AU2012282402 A AU 2012282402A AU 2012282402 B2 AU2012282402 B2 AU 2012282402B2
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AU
Australia
Prior art keywords
antibody
tau
seq
amino acid
acid sequence
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Ceased
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AU2012282402A
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English (en)
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AU2012282402A2 (en
AU2012282402A1 (en
Inventor
Fred Van Leuven
Eugeen Vanmechelen
Joris Winderickx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
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Katholieke Universiteit Leuven
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Publication of AU2012282402A2 publication Critical patent/AU2012282402A2/en
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Publication of AU2012282402B2 publication Critical patent/AU2012282402B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
AU2012282402A 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates Ceased AU2012282402B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1112056.5A GB201112056D0 (en) 2011-07-14 2011-07-14 Antibodies
GB1112056.5 2011-07-14
PCT/EP2012/063924 WO2013007839A1 (en) 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates

Publications (3)

Publication Number Publication Date
AU2012282402A1 AU2012282402A1 (en) 2014-01-30
AU2012282402A2 AU2012282402A2 (en) 2014-05-08
AU2012282402B2 true AU2012282402B2 (en) 2017-03-09

Family

ID=44586547

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012282402A Ceased AU2012282402B2 (en) 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates

Country Status (6)

Country Link
US (1) US9447179B2 (enExample)
EP (1) EP2731969B1 (enExample)
JP (1) JP6168364B2 (enExample)
AU (1) AU2012282402B2 (enExample)
GB (1) GB201112056D0 (enExample)
WO (1) WO2013007839A1 (enExample)

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Also Published As

Publication number Publication date
US9447179B2 (en) 2016-09-20
AU2012282402A2 (en) 2014-05-08
GB201112056D0 (en) 2011-08-31
EP2731969A1 (en) 2014-05-21
US20140161875A1 (en) 2014-06-12
EP2731969B1 (en) 2018-10-17
AU2012282402A1 (en) 2014-01-30
JP6168364B2 (ja) 2017-07-26
JP2014523742A (ja) 2014-09-18
WO2013007839A1 (en) 2013-01-17

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