JP2014521725A - ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 - Google Patents

ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 Download PDF

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Publication number
JP2014521725A
JP2014521725A JP2014525162A JP2014525162A JP2014521725A JP 2014521725 A JP2014521725 A JP 2014521725A JP 2014525162 A JP2014525162 A JP 2014525162A JP 2014525162 A JP2014525162 A JP 2014525162A JP 2014521725 A JP2014521725 A JP 2014521725A
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JP
Japan
Prior art keywords
compound
formula
pharmaceutically acceptable
methyl
alkyl
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JP2014525162A
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English (en)
Japanese (ja)
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JP2014521725A5 (https=
Inventor
アレッサンドロ・エンメ・ヴァンヌッキ
コスタンツァ・ボガーニ
ニッコロ・ヴァルタルッチ
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Novartis Pharma AG
Incyte Corp
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Novartis Pharma AG
Incyte Corp
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Publication of JP2014521725A publication Critical patent/JP2014521725A/ja
Publication of JP2014521725A5 publication Critical patent/JP2014521725A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014525162A 2011-08-10 2012-08-10 ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 Pending JP2014521725A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161522001P 2011-08-10 2011-08-10
US61/522,001 2011-08-10
PCT/US2012/050252 WO2013023119A1 (en) 2011-08-10 2012-08-10 JAK P13K/mTOR COMBINATION THERAPY

Publications (2)

Publication Number Publication Date
JP2014521725A true JP2014521725A (ja) 2014-08-28
JP2014521725A5 JP2014521725A5 (https=) 2015-09-17

Family

ID=46690743

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014525162A Pending JP2014521725A (ja) 2011-08-10 2012-08-10 ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法

Country Status (6)

Country Link
US (1) US9358229B2 (https=)
EP (1) EP2741747A1 (https=)
JP (1) JP2014521725A (https=)
CA (1) CA2844507A1 (https=)
HK (1) HK1198579A1 (https=)
WO (1) WO2013023119A1 (https=)

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JP2014533294A (ja) * 2011-11-15 2014-12-11 ノバルティス アーゲー ホスホイノシチド３−キナーゼ阻害剤およびヤヌスキナーゼ２−シグナル伝達兼転写活性化因子５経路の調節剤の組合せ

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