JP2014521653A5 - - Google Patents
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- JP2014521653A5 JP2014521653A5 JP2014523015A JP2014523015A JP2014521653A5 JP 2014521653 A5 JP2014521653 A5 JP 2014521653A5 JP 2014523015 A JP2014523015 A JP 2014523015A JP 2014523015 A JP2014523015 A JP 2014523015A JP 2014521653 A5 JP2014521653 A5 JP 2014521653A5
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- JP
- Japan
- Prior art keywords
- nitrogen
- sulfur
- oxygen
- ring
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*(C)N1CCNCC1 Chemical compound C*(C)N1CCNCC1 0.000 description 1
- WQEBYNUXWYRLCB-UHFFFAOYSA-N CCN1CC2(CNC2)CC1 Chemical compound CCN1CC2(CNC2)CC1 WQEBYNUXWYRLCB-UHFFFAOYSA-N 0.000 description 1
- YSRSYYHGSQMAFV-UHFFFAOYSA-N CN(CC12)CC1C2N Chemical compound CN(CC12)CC1C2N YSRSYYHGSQMAFV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161513428P | 2011-07-29 | 2011-07-29 | |
| US201161513432P | 2011-07-29 | 2011-07-29 | |
| US61/513,432 | 2011-07-29 | ||
| US61/513,428 | 2011-07-29 | ||
| US201261653588P | 2012-05-31 | 2012-05-31 | |
| US61/653,588 | 2012-05-31 | ||
| PCT/US2012/048368 WO2013019561A1 (en) | 2011-07-29 | 2012-07-26 | Nuclear transport modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016176098A Division JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521653A JP2014521653A (ja) | 2014-08-28 |
| JP2014521653A5 true JP2014521653A5 (enrdf_load_stackoverflow) | 2015-08-20 |
| JP6006794B2 JP6006794B2 (ja) | 2016-10-12 |
Family
ID=46682903
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014523015A Active JP6006794B2 (ja) | 2011-07-29 | 2012-07-26 | 核内輸送調節因子およびその使用 |
| JP2016176098A Withdrawn JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
| JP2018006773A Active JP6752235B2 (ja) | 2011-07-29 | 2018-01-18 | 核内輸送調節因子およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016176098A Withdrawn JP2016199604A (ja) | 2011-07-29 | 2016-09-09 | 核内輸送調節因子およびその使用 |
| JP2018006773A Active JP6752235B2 (ja) | 2011-07-29 | 2018-01-18 | 核内輸送調節因子およびその使用 |
Country Status (15)
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103002742B (zh) | 2010-03-05 | 2016-07-13 | 卡尔约药物治疗公司 | 核转运调节剂及其应用 |
| AU2012207565B2 (en) | 2011-01-17 | 2016-04-07 | Karyopharm Therapeutics Inc. | Olefin containing nuclear transport modulators and uses thereof |
| PE20141003A1 (es) * | 2011-07-29 | 2014-09-02 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear y usos de los mismos |
| CN110372673B (zh) | 2011-07-29 | 2023-10-03 | 卡尔约药物治疗公司 | 含酰肼的核运输调节剂及其用途 |
| KR102095429B1 (ko) | 2012-05-09 | 2020-03-31 | 바이오젠 엠에이 인코포레이티드 | 핵 수송 조절인자 및 이의 용도 |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
| EP2968278B8 (en) | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| JP6730922B2 (ja) | 2013-06-21 | 2020-07-29 | カリオファーム セラピューティクス，インコーポレイテッド | 核内輸送調節因子およびその使用 |
| WO2014205393A1 (en) * | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EA035256B1 (ru) | 2013-07-18 | 2020-05-21 | Новартис Аг | Ингибиторы аутотаксинов, содержащие гетероарил-бензил-амидное ядро |
| US9487536B2 (en) | 2013-11-08 | 2016-11-08 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide B derivatives |
| US9469650B2 (en) | 2013-11-08 | 2016-10-18 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide B derivatives |
| WO2015079031A1 (en) * | 2013-11-28 | 2015-06-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of beta-thalassemias |
| AU2015229188A1 (en) | 2014-03-13 | 2016-09-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| WO2015138934A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| CA2952862A1 (en) | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| CN111481553B (zh) | 2014-08-15 | 2023-09-01 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| WO2016090166A1 (en) | 2014-12-03 | 2016-06-09 | Board Of Trustees Of The University Of Arkansas | Melampomagnolide b dimers |
| US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| CA2971855A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| WO2017019589A1 (en) | 2015-07-24 | 2017-02-02 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| EP3353145B1 (en) | 2015-09-23 | 2022-09-28 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| RU2752567C2 (ru) | 2015-10-06 | 2021-07-29 | Протеостазис Терапьютикс, Инк. | Соединения, композиции и способы для модуляции cftr |
| CN105384673B (zh) * | 2015-11-09 | 2017-11-14 | 南京富润凯德生物医药有限公司 | 3‑氟代‑氮杂环丁烷衍生物的合成方法 |
| WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10709706B2 (en) * | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| CA3012179A1 (en) * | 2016-01-29 | 2017-08-03 | Bioventures, Llc | Triazole derivatives of melampomagnolide b and methods of use thereof |
| US10662207B2 (en) | 2016-04-07 | 2020-05-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
| KR20190015492A (ko) * | 2016-06-08 | 2019-02-13 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화학적 화합물 |
| WO2017223188A1 (en) | 2016-06-21 | 2017-12-28 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| EP3512515A1 (en) | 2016-09-16 | 2019-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of systemic mastocytosis |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| CN106831731B (zh) * | 2017-01-17 | 2019-11-08 | 广州市闻皓生物科技有限公司 | 一种Selinexor原料药的合成方法 |
| RU2725886C1 (ru) | 2017-03-30 | 2020-07-07 | ЭксДабл-Ю ЛЭБОРЕТРИЗ ИНК. | Бициклические гетероарильные производные и их получение и применение |
| KR20230110828A (ko) | 2018-01-10 | 2023-07-25 | 엑스더블유파마 리미티드 | 케타민의 전구약물, 및 이의 조성물 및 용도 |
| WO2019232724A1 (en) * | 2018-06-06 | 2019-12-12 | Xw Laboratories, Inc. | Compounds as nuclear transport modulators and uses thereof |
| CN110592141B (zh) * | 2018-06-13 | 2023-07-07 | 中国科学院上海有机化学研究所 | 用于调控基因编辑效率的化合物及其应用 |
| EP3856719B1 (en) | 2018-09-30 | 2023-06-07 | XWPharma Ltd. | Compounds as neuronal histamine receptor-3 antagonists and uses thereof |
| CN111606890A (zh) | 2019-02-26 | 2020-09-01 | 微境生物医药科技(上海)有限公司 | 含丙烯酰基的核转运调节剂及其用途 |
| US12479806B2 (en) | 2019-05-01 | 2025-11-25 | Karyopharm Therapeutics Inc. | Process for preparing XPO1 inhibitors and intermediates for use in the preparation of XPO1 inhibitors |
| CN115244028A (zh) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | 4-缬氨酰氧基丁酸的合成方法 |
| KR20230011359A (ko) | 2020-06-18 | 2023-01-20 | 엑스더블유파마 리미티드 | 수용성 활성 약제 성분의 제어 방출 과립화물 |
| CN115803017A (zh) | 2020-06-18 | 2023-03-14 | 凯瑞康宁生物工程有限公司 | 水溶性活性药物成分的药物造粒物 |
| WO2022020621A1 (en) | 2020-07-24 | 2022-01-27 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
| TW202228665A (zh) | 2020-10-05 | 2022-08-01 | 凱瑞康寧生技股份有限公司 | γ－羥基丁酸衍生物之修飾釋放組合物 |
| WO2022143779A1 (zh) * | 2020-12-29 | 2022-07-07 | 南京明德新药研发有限公司 | 含烯基类化合物及其应用 |
| DK4308086T3 (da) | 2021-03-19 | 2025-11-17 | Xwpharma Ltd | Farmakokinetik af formuleringer med kombineret frigivelse af et gamma-hydroxysmørsyrederivat |
| US11690811B2 (en) | 2021-08-13 | 2023-07-04 | XWPharma Ltd. | Pharmaceutical compositions and oral dosage forms of ketamine derivatives |
| CN121001993A (zh) * | 2023-02-24 | 2025-11-21 | 鲁汶天主教大学 | 核转运调节剂 |
| CN116514773B (zh) * | 2023-04-24 | 2024-12-03 | 重庆汉佩生物科技有限公司 | 一种Verdinexor(KPT-335)及其盐酸盐的合成方法 |
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| PE20141003A1 (es) * | 2011-07-29 | 2014-09-02 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear y usos de los mismos |
| CN110372673B (zh) * | 2011-07-29 | 2023-10-03 | 卡尔约药物治疗公司 | 含酰肼的核运输调节剂及其用途 |
| KR102095429B1 (ko) | 2012-05-09 | 2020-03-31 | 바이오젠 엠에이 인코포레이티드 | 핵 수송 조절인자 및 이의 용도 |
| WO2014152263A1 (en) | 2013-03-15 | 2014-09-25 | Karyopharm Therapeutics Inc. | Exo olefin-containing nuclear transport modulators and uses thereof |
| EP2968278B8 (en) * | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| WO2014205393A1 (en) | 2013-06-21 | 2014-12-24 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| JP6730922B2 (ja) | 2013-06-21 | 2020-07-29 | カリオファーム セラピューティクス，インコーポレイテッド | 核内輸送調節因子およびその使用 |
-
2012
- 2012-07-26 PE PE2014000137A patent/PE20141003A1/es active IP Right Grant
- 2012-07-26 KR KR1020147005649A patent/KR102022715B1/ko active Active
- 2012-07-26 EP EP12748083.8A patent/EP2736883B1/en active Active
- 2012-07-26 JP JP2014523015A patent/JP6006794B2/ja active Active
- 2012-07-26 WO PCT/US2012/048368 patent/WO2013019561A1/en not_active Ceased
- 2012-07-26 US US14/235,342 patent/US9428490B2/en active Active
- 2012-07-26 CA CA2842364A patent/CA2842364A1/en not_active Abandoned
- 2012-07-26 BR BR112014001933A patent/BR112014001933A2/pt not_active Application Discontinuation
- 2012-07-26 MX MX2014001180A patent/MX350442B/es active IP Right Grant
- 2012-07-26 CN CN201280047930.1A patent/CN103842340B/zh active Active
- 2012-07-26 EA EA201490406A patent/EA201490406A1/ru unknown
- 2012-07-26 SG SG10201609097PA patent/SG10201609097PA/en unknown
- 2012-07-26 UA UAA201401884A patent/UA117902C2/uk unknown
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2014
- 2014-01-29 CL CL2014000224A patent/CL2014000224A1/es unknown
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2015
- 2015-05-11 CL CL2015001259A patent/CL2015001259A1/es unknown
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2016
- 2016-07-22 US US15/217,514 patent/US20170137430A1/en not_active Abandoned
- 2016-08-11 AU AU2016213805A patent/AU2016213805A1/en not_active Abandoned
- 2016-09-09 JP JP2016176098A patent/JP2016199604A/ja not_active Withdrawn
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2018
- 2018-01-18 JP JP2018006773A patent/JP6752235B2/ja active Active
- 2018-06-14 AU AU2018204256A patent/AU2018204256A1/en not_active Abandoned
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2019
- 2019-04-25 US US16/394,986 patent/US20200087313A1/en not_active Abandoned
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2021
- 2021-05-04 US US17/307,656 patent/US20220056038A1/en not_active Abandoned
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2023
- 2023-12-01 US US18/526,900 patent/US20240376114A1/en active Pending