JP2014520529A5 - - Google Patents
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- JP2014520529A5 JP2014520529A5 JP2014518915A JP2014518915A JP2014520529A5 JP 2014520529 A5 JP2014520529 A5 JP 2014520529A5 JP 2014518915 A JP2014518915 A JP 2014518915A JP 2014518915 A JP2014518915 A JP 2014518915A JP 2014520529 A5 JP2014520529 A5 JP 2014520529A5
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- 108091070501 miRNA Proteins 0.000 claims description 145
- 239000002679 microRNA Substances 0.000 claims description 144
- 238000000034 method Methods 0.000 claims description 99
- 108091031326 miR-15b stem-loop Proteins 0.000 claims description 39
- 108091040490 miR-545 stem-loop Proteins 0.000 claims description 38
- 108091029203 miR-301 stem-loop Proteins 0.000 claims description 36
- 108091026505 miR-301a stem-loop Proteins 0.000 claims description 36
- 208000024827 Alzheimer disease Diseases 0.000 claims description 35
- 108091033433 MiR-191 Proteins 0.000 claims description 28
- 108091007427 let-7g Proteins 0.000 claims description 26
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 15
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 12
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 12
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 5
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 229960003530 donepezil Drugs 0.000 claims description 4
- 229960003980 galantamine Drugs 0.000 claims description 4
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 4
- 108091043994 let-7g stem-loop Proteins 0.000 claims description 4
- 108091053972 let-7g-1 stem-loop Proteins 0.000 claims description 4
- 108091024867 let-7g-2 stem-loop Proteins 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 229960004136 rivastigmine Drugs 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 208000031124 Dementia Alzheimer type Diseases 0.000 claims description 2
- 230000003321 amplification Effects 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 210000002751 lymph Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 15
- 208000010877 cognitive disease Diseases 0.000 claims 14
- 208000027061 mild cognitive impairment Diseases 0.000 claims 10
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 208000028698 Cognitive impairment Diseases 0.000 claims 4
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 108091083267 miR-142 stem-loop Proteins 0.000 claims 1
- 108091070626 miR-142a stem-loop Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 description 5
- 108091007420 miR‐142 Proteins 0.000 description 2
- 230000006996 mental state Effects 0.000 description 1
- 108091069297 miR-35 stem-loop Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501720P | 2011-06-27 | 2011-06-27 | |
| US61/501,720 | 2011-06-27 | ||
| PCT/US2012/044202 WO2013003350A2 (en) | 2011-06-27 | 2012-06-26 | Microrna biomarkers indicative of alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016150989A Division JP2016214256A (ja) | 2011-06-27 | 2016-08-01 | アルツハイマー病を示すマイクロｒｎａバイオマーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520529A JP2014520529A (ja) | 2014-08-25 |
| JP2014520529A5 true JP2014520529A5 (https=) | 2015-08-13 |
| JP6154809B2 JP6154809B2 (ja) | 2017-06-28 |
Family
ID=46724591
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518915A Active JP6154809B2 (ja) | 2011-06-27 | 2012-06-26 | アルツハイマー病を示すマイクロｒｎａバイオマーカー |
| JP2016150989A Pending JP2016214256A (ja) | 2011-06-27 | 2016-08-01 | アルツハイマー病を示すマイクロｒｎａバイオマーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016150989A Pending JP2016214256A (ja) | 2011-06-27 | 2016-08-01 | アルツハイマー病を示すマイクロｒｎａバイオマーカー |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9771617B2 (https=) |
| EP (1) | EP2723894B1 (https=) |
| JP (2) | JP6154809B2 (https=) |
| KR (1) | KR102082016B1 (https=) |
| CN (1) | CN103781919B9 (https=) |
| AU (1) | AU2012275556B2 (https=) |
| BR (1) | BR112013033488B8 (https=) |
| CA (1) | CA2840196C (https=) |
| ES (1) | ES2580379T3 (https=) |
| IL (1) | IL230034B (https=) |
| MX (1) | MX341840B (https=) |
| RU (1) | RU2639509C2 (https=) |
| WO (1) | WO2013003350A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2838562A1 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| WO2015050835A1 (en) * | 2013-10-01 | 2015-04-09 | Advanced Genomic Technology, Llc | Circulating biomarkers for alzheimer's disease and/or mild cognitive impairment |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| KR101583450B1 (ko) * | 2014-12-01 | 2016-01-11 | 전주대학교 산학협력단 | 마이크로 rna id의 분석방법 및 이를 통해 도출한 대장암의 바이오마커 |
| ES2741591T3 (es) | 2015-03-13 | 2020-02-11 | Univ Hiroshima | Método para ayudar a la detección de la enfermedad de Alzheimer o una discapacidad cognitiva moderada |
| US10358676B2 (en) * | 2015-04-03 | 2019-07-23 | Kaohsiung Chang Gung Memorial Hospital | Methods and kits for detecting Kawasaki disease |
| KR101734645B1 (ko) * | 2015-05-18 | 2017-05-11 | (주)에이엔티랩스 | 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법 |
| EP3598137B1 (en) | 2015-09-16 | 2025-04-16 | Shimadzu Corporation | Multiplex biomarker for use in evaluation of state of accumulation of amyloid b in brain, and analysis method for said evaluation |
| ES2734678T3 (es) * | 2015-12-22 | 2019-12-11 | Siemens Ag | Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos |
| US10262423B2 (en) * | 2016-03-29 | 2019-04-16 | Verily Life Sciences Llc | Disease and fall risk assessment using depth mapping systems |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| KR101998457B1 (ko) * | 2016-05-10 | 2019-07-10 | 조선대학교산학협력단 | 알츠하이머 질병의 진단을 위한 바이오마커 |
| KR101992539B1 (ko) * | 2016-10-21 | 2019-09-30 | 서울대학교산학협력단 | miRNA 기반의 인지장애 질환 진단용 조성물 및 방법 |
| WO2018228875A1 (en) * | 2017-06-15 | 2018-12-20 | Nestec S.A. | Micro-rna biomarkers of blood-brain barrier dysfunction |
| JP2020524509A (ja) * | 2017-06-19 | 2020-08-20 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 |
| MX2020000293A (es) * | 2017-07-12 | 2020-07-22 | Univ Texas Tech System | Microrna-455-3p como un marcador bioperiferico para la enfermedad de alzheimer. |
| US11078535B2 (en) | 2017-07-18 | 2021-08-03 | The Trustees Of Indiana University | Presymptomatic micro RNA targets for treatment of neurodegeneration pathology |
| US20200308647A1 (en) * | 2017-10-25 | 2020-10-01 | Hummingbird Diagnostics Gmbh | Mirnas as biomarkers for alzheimer's disease |
| CA3082391A1 (en) * | 2017-11-12 | 2019-05-16 | The Regents Of The University Of California | Non-coding rna for detection of cancer |
| JPWO2019117306A1 (ja) * | 2017-12-14 | 2021-01-28 | 国立大学法人広島大学 | アルツハイマー病の検出を補助する方法 |
| CN108277271A (zh) * | 2018-02-05 | 2018-07-13 | 范瑶飞 | 一种辅助检测阿兹海默疾病的miRNA |
| KR20200120627A (ko) | 2018-02-13 | 2020-10-21 | 도레이 카부시키가이샤 | 인지증 검출을 위한 키트 또는 디바이스 및 방법 |
| EP3807422B1 (en) | 2018-06-15 | 2025-12-03 | Universitat Autònoma de Barcelona | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease |
| KR20210038585A (ko) * | 2018-07-25 | 2021-04-07 | 에스알엔에이리틱스, 인크. | 알츠하이머병에 대한 작은 rna 예측인자 |
| JP6884810B2 (ja) * | 2019-05-08 | 2021-06-09 | キユーピー株式会社 | 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法 |
| CN116171332A (zh) * | 2020-07-24 | 2023-05-26 | 奥塔哥创新有限公司 | 用于认知疾病的生物标志物 |
| US12505927B2 (en) | 2021-01-29 | 2025-12-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and methods for diagnosing neurodegenerative diseases via machine learning and blood RNA |
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-
2012
- 2012-06-26 BR BR112013033488A patent/BR112013033488B8/pt active IP Right Grant
- 2012-06-26 RU RU2014102357A patent/RU2639509C2/ru active
- 2012-06-26 MX MX2013015392A patent/MX341840B/es active IP Right Grant
- 2012-06-26 US US14/128,888 patent/US9771617B2/en active Active
- 2012-06-26 ES ES12750628.5T patent/ES2580379T3/es active Active
- 2012-06-26 CN CN201280041358.8A patent/CN103781919B9/zh active Active
- 2012-06-26 JP JP2014518915A patent/JP6154809B2/ja active Active
- 2012-06-26 KR KR1020147001923A patent/KR102082016B1/ko active Active
- 2012-06-26 AU AU2012275556A patent/AU2012275556B2/en active Active
- 2012-06-26 WO PCT/US2012/044202 patent/WO2013003350A2/en not_active Ceased
- 2012-06-26 CA CA2840196A patent/CA2840196C/en active Active
- 2012-06-26 EP EP12750628.5A patent/EP2723894B1/en active Active
-
2013
- 2013-12-19 IL IL230034A patent/IL230034B/en active IP Right Grant
-
2016
- 2016-08-01 JP JP2016150989A patent/JP2016214256A/ja active Pending
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