BR112013033488B8 - Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit - Google Patents
Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kitInfo
- Publication number
- BR112013033488B8 BR112013033488B8 BR112013033488A BR112013033488A BR112013033488B8 BR 112013033488 B8 BR112013033488 B8 BR 112013033488B8 BR 112013033488 A BR112013033488 A BR 112013033488A BR 112013033488 A BR112013033488 A BR 112013033488A BR 112013033488 B8 BR112013033488 B8 BR 112013033488B8
- Authority
- BR
- Brazil
- Prior art keywords
- cognitive impairment
- methods
- disease
- alzheimer
- mci
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 7
- 208000010877 cognitive disease Diseases 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 208000027061 mild cognitive impairment Diseases 0.000 title abstract 4
- 208000028698 Cognitive impairment Diseases 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000012544 monitoring process Methods 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501720P | 2011-06-27 | 2011-06-27 | |
| US61/501,720 | 2011-06-27 | ||
| PCT/US2012/044202 WO2013003350A2 (en) | 2011-06-27 | 2012-06-26 | Microrna biomarkers indicative of alzheimer's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112013033488A2 BR112013033488A2 (pt) | 2017-03-01 |
| BR112013033488B1 BR112013033488B1 (pt) | 2022-03-03 |
| BR112013033488B8 true BR112013033488B8 (pt) | 2022-11-22 |
Family
ID=46724591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013033488A BR112013033488B8 (pt) | 2011-06-27 | 2012-06-26 | Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9771617B2 (https=) |
| EP (1) | EP2723894B1 (https=) |
| JP (2) | JP6154809B2 (https=) |
| KR (1) | KR102082016B1 (https=) |
| CN (1) | CN103781919B9 (https=) |
| AU (1) | AU2012275556B2 (https=) |
| BR (1) | BR112013033488B8 (https=) |
| CA (1) | CA2840196C (https=) |
| ES (1) | ES2580379T3 (https=) |
| IL (1) | IL230034B (https=) |
| MX (1) | MX341840B (https=) |
| RU (1) | RU2639509C2 (https=) |
| WO (1) | WO2013003350A2 (https=) |
Families Citing this family (27)
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| CA2838562A1 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| WO2015050835A1 (en) * | 2013-10-01 | 2015-04-09 | Advanced Genomic Technology, Llc | Circulating biomarkers for alzheimer's disease and/or mild cognitive impairment |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| KR101583450B1 (ko) * | 2014-12-01 | 2016-01-11 | 전주대학교 산학협력단 | 마이크로 rna id의 분석방법 및 이를 통해 도출한 대장암의 바이오마커 |
| ES2741591T3 (es) | 2015-03-13 | 2020-02-11 | Univ Hiroshima | Método para ayudar a la detección de la enfermedad de Alzheimer o una discapacidad cognitiva moderada |
| US10358676B2 (en) * | 2015-04-03 | 2019-07-23 | Kaohsiung Chang Gung Memorial Hospital | Methods and kits for detecting Kawasaki disease |
| KR101734645B1 (ko) * | 2015-05-18 | 2017-05-11 | (주)에이엔티랩스 | 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법 |
| EP3598137B1 (en) | 2015-09-16 | 2025-04-16 | Shimadzu Corporation | Multiplex biomarker for use in evaluation of state of accumulation of amyloid b in brain, and analysis method for said evaluation |
| ES2734678T3 (es) * | 2015-12-22 | 2019-12-11 | Siemens Ag | Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos |
| US10262423B2 (en) * | 2016-03-29 | 2019-04-16 | Verily Life Sciences Llc | Disease and fall risk assessment using depth mapping systems |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| KR101998457B1 (ko) * | 2016-05-10 | 2019-07-10 | 조선대학교산학협력단 | 알츠하이머 질병의 진단을 위한 바이오마커 |
| KR101992539B1 (ko) * | 2016-10-21 | 2019-09-30 | 서울대학교산학협력단 | miRNA 기반의 인지장애 질환 진단용 조성물 및 방법 |
| WO2018228875A1 (en) * | 2017-06-15 | 2018-12-20 | Nestec S.A. | Micro-rna biomarkers of blood-brain barrier dysfunction |
| JP2020524509A (ja) * | 2017-06-19 | 2020-08-20 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 |
| MX2020000293A (es) * | 2017-07-12 | 2020-07-22 | Univ Texas Tech System | Microrna-455-3p como un marcador bioperiferico para la enfermedad de alzheimer. |
| US11078535B2 (en) | 2017-07-18 | 2021-08-03 | The Trustees Of Indiana University | Presymptomatic micro RNA targets for treatment of neurodegeneration pathology |
| US20200308647A1 (en) * | 2017-10-25 | 2020-10-01 | Hummingbird Diagnostics Gmbh | Mirnas as biomarkers for alzheimer's disease |
| CA3082391A1 (en) * | 2017-11-12 | 2019-05-16 | The Regents Of The University Of California | Non-coding rna for detection of cancer |
| JPWO2019117306A1 (ja) * | 2017-12-14 | 2021-01-28 | 国立大学法人広島大学 | アルツハイマー病の検出を補助する方法 |
| CN108277271A (zh) * | 2018-02-05 | 2018-07-13 | 范瑶飞 | 一种辅助检测阿兹海默疾病的miRNA |
| KR20200120627A (ko) | 2018-02-13 | 2020-10-21 | 도레이 카부시키가이샤 | 인지증 검출을 위한 키트 또는 디바이스 및 방법 |
| EP3807422B1 (en) | 2018-06-15 | 2025-12-03 | Universitat Autònoma de Barcelona | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease |
| KR20210038585A (ko) * | 2018-07-25 | 2021-04-07 | 에스알엔에이리틱스, 인크. | 알츠하이머병에 대한 작은 rna 예측인자 |
| JP6884810B2 (ja) * | 2019-05-08 | 2021-06-09 | キユーピー株式会社 | 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法 |
| CN116171332A (zh) * | 2020-07-24 | 2023-05-26 | 奥塔哥创新有限公司 | 用于认知疾病的生物标志物 |
| US12505927B2 (en) | 2021-01-29 | 2025-12-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and methods for diagnosing neurodegenerative diseases via machine learning and blood RNA |
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-
2012
- 2012-06-26 BR BR112013033488A patent/BR112013033488B8/pt active IP Right Grant
- 2012-06-26 RU RU2014102357A patent/RU2639509C2/ru active
- 2012-06-26 MX MX2013015392A patent/MX341840B/es active IP Right Grant
- 2012-06-26 US US14/128,888 patent/US9771617B2/en active Active
- 2012-06-26 ES ES12750628.5T patent/ES2580379T3/es active Active
- 2012-06-26 CN CN201280041358.8A patent/CN103781919B9/zh active Active
- 2012-06-26 JP JP2014518915A patent/JP6154809B2/ja active Active
- 2012-06-26 KR KR1020147001923A patent/KR102082016B1/ko active Active
- 2012-06-26 AU AU2012275556A patent/AU2012275556B2/en active Active
- 2012-06-26 WO PCT/US2012/044202 patent/WO2013003350A2/en not_active Ceased
- 2012-06-26 CA CA2840196A patent/CA2840196C/en active Active
- 2012-06-26 EP EP12750628.5A patent/EP2723894B1/en active Active
-
2013
- 2013-12-19 IL IL230034A patent/IL230034B/en active IP Right Grant
-
2016
- 2016-08-01 JP JP2016150989A patent/JP2016214256A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2723894A2 (en) | 2014-04-30 |
| WO2013003350A2 (en) | 2013-01-03 |
| KR102082016B1 (ko) | 2020-02-26 |
| AU2012275556A1 (en) | 2013-05-02 |
| MX341840B (es) | 2016-09-05 |
| AU2012275556B2 (en) | 2016-02-04 |
| CN103781919B9 (zh) | 2017-09-15 |
| ES2580379T3 (es) | 2016-08-23 |
| KR20140044375A (ko) | 2014-04-14 |
| JP6154809B2 (ja) | 2017-06-28 |
| BR112013033488B1 (pt) | 2022-03-03 |
| JP2014520529A (ja) | 2014-08-25 |
| CN103781919B (zh) | 2017-07-04 |
| IL230034B (en) | 2021-02-28 |
| CA2840196A1 (en) | 2013-01-03 |
| BR112013033488A2 (pt) | 2017-03-01 |
| WO2013003350A3 (en) | 2013-04-11 |
| US9771617B2 (en) | 2017-09-26 |
| MX2013015392A (es) | 2014-07-14 |
| JP2016214256A (ja) | 2016-12-22 |
| CN103781919A (zh) | 2014-05-07 |
| US20140378439A1 (en) | 2014-12-25 |
| EP2723894B1 (en) | 2016-05-11 |
| RU2014102357A (ru) | 2015-08-10 |
| RU2639509C2 (ru) | 2017-12-21 |
| CA2840196C (en) | 2022-09-20 |
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