JP2014518220A5 - - Google Patents
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- Publication number
- JP2014518220A5 JP2014518220A5 JP2014516092A JP2014516092A JP2014518220A5 JP 2014518220 A5 JP2014518220 A5 JP 2014518220A5 JP 2014516092 A JP2014516092 A JP 2014516092A JP 2014516092 A JP2014516092 A JP 2014516092A JP 2014518220 A5 JP2014518220 A5 JP 2014518220A5
- Authority
- JP
- Japan
- Prior art keywords
- difluoro
- pyridin
- difluorophenyl
- tetrazol
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498570P | 2011-06-19 | 2011-06-19 | |
| US61/498,570 | 2011-06-19 | ||
| US201261611897P | 2012-03-16 | 2012-03-16 | |
| US61/611,897 | 2012-03-16 | ||
| PCT/US2012/043147 WO2012177638A1 (en) | 2011-06-19 | 2012-06-19 | Metalloenzyme inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518220A JP2014518220A (ja) | 2014-07-28 |
| JP2014518220A5 true JP2014518220A5 (cg-RX-API-DMAC7.html) | 2015-07-30 |
| JP6247632B2 JP6247632B2 (ja) | 2017-12-13 |
Family
ID=47362418
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517090A Expired - Fee Related JP6158797B2 (ja) | 2011-06-19 | 2012-06-19 | 金属酵素阻害剤化合物 |
| JP2014516092A Expired - Fee Related JP6247632B2 (ja) | 2011-06-19 | 2012-06-19 | メタロ酵素阻害剤化合物 |
| JP2017019006A Pending JP2017132766A (ja) | 2011-06-19 | 2017-02-03 | 金属酵素阻害剤化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517090A Expired - Fee Related JP6158797B2 (ja) | 2011-06-19 | 2012-06-19 | 金属酵素阻害剤化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017019006A Pending JP2017132766A (ja) | 2011-06-19 | 2017-02-03 | 金属酵素阻害剤化合物 |
Country Status (23)
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201490038A1 (ru) | 2011-06-19 | 2014-04-30 | Вайамет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| AU2012273103B2 (en) * | 2011-06-19 | 2017-04-20 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| AU2012273004B2 (en) * | 2011-06-23 | 2017-04-13 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| CN104136427B (zh) * | 2012-01-20 | 2017-03-01 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
| WO2014117090A1 (en) * | 2013-01-28 | 2014-07-31 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| JP2016522800A (ja) | 2013-04-12 | 2016-08-04 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 新規トリアゾリンチオン誘導体 |
| EP2984082B1 (en) * | 2013-04-12 | 2017-08-02 | Bayer CropScience Aktiengesellschaft | Novel triazole derivatives |
| WO2014167009A1 (en) | 2013-04-12 | 2014-10-16 | Bayer Cropscience Ag | Novel triazole derivatives |
| JP6387401B2 (ja) * | 2013-05-28 | 2018-09-05 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 殺真菌組成物 |
| CA2915054A1 (en) * | 2013-06-12 | 2014-12-18 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EP3040073B1 (en) * | 2013-08-27 | 2020-07-08 | Sinochem Corporation | Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs |
| CA2942972A1 (en) | 2014-03-19 | 2015-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antifungal compound process |
| EP3119756B9 (en) | 2014-03-19 | 2021-08-25 | Dow AgroSciences LLC | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| JP2017507991A (ja) | 2014-03-19 | 2017-03-23 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| KR102151082B1 (ko) * | 2014-03-19 | 2020-09-03 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스 | 항진균 화합물 제조방법 |
| BR112016021257B1 (pt) * | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| AU2015231216B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231270B2 (en) | 2014-03-19 | 2019-03-07 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compound process |
| EA201691648A1 (ru) | 2014-03-19 | 2017-01-30 | Ваймет Фармасьютикалс, Инк. | Способ получения противогрибковых соединений |
| US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP6623015B2 (ja) * | 2014-09-29 | 2019-12-18 | 国立研究開発法人理化学研究所 | 植物の耐塩性向上剤 |
| EP3201188A1 (en) | 2014-10-02 | 2017-08-09 | Bayer CropScience Aktiengesellschaft | Novel triazole derivatives useful as fungicides |
| EP3277674B1 (en) | 2015-04-02 | 2019-09-11 | Bayer CropScience Aktiengesellschaft | Triazol derivatives as fungicides |
| EP3702353B1 (en) * | 2015-05-18 | 2023-07-05 | Mycovia Pharmaceuticals, Inc. | Antifungal compositions |
| KR102798709B1 (ko) * | 2015-09-18 | 2025-04-23 | 마이코비아 파마슈티컬즈, 인코포레이티드 | 항진균 화합물 제조 방법 |
| US10414735B2 (en) | 2015-11-09 | 2019-09-17 | Forge Therapeutics, Inc. | Substituted hydroxypyrimidinones for treating bacterial infections |
| US10611747B2 (en) | 2015-11-09 | 2020-04-07 | Forge Therapeutics, Inc. | Pyrone based compounds for treating bacterial infections |
| US20180370946A1 (en) | 2015-11-17 | 2018-12-27 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| CA3005738C (en) * | 2015-11-17 | 2023-10-31 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| TWI636045B (zh) | 2015-11-17 | 2018-09-21 | 美商維愛美製藥公司 | ４－（（６－（２－（２，４－二氟苯基）－１，１－二氟－２－氧代乙基）吡啶－３－基）氧基）苄腈以及其製造方法 |
| WO2017087592A1 (en) * | 2015-11-17 | 2017-05-26 | Viamet Pharmaceuticals, Inc. | 4-((6-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| HUE057289T2 (hu) | 2016-08-31 | 2022-05-28 | Jiangsu Hengrui Medicine Co | Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása |
| JP2018048090A (ja) * | 2016-09-21 | 2018-03-29 | 大阪ガスケミカル株式会社 | 工業用保存剤 |
| BR112019009793A2 (pt) * | 2016-11-18 | 2019-08-06 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidróxi-3-(5-mercapto-1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação |
| US20190330184A1 (en) * | 2016-11-18 | 2019-10-31 | Dow Agrosciences Llc | 4-((6-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| BR112019009801A2 (pt) * | 2016-11-18 | 2019-08-06 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidróxi-3-(5-mercapto-1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação |
| CN109983005A (zh) * | 2016-11-18 | 2019-07-05 | 美国陶氏益农公司 | 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(5-巯基-1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈及制备方法 |
| CN110291078A (zh) * | 2016-11-18 | 2019-09-27 | 美国陶氏益农公司 | 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(5-巯基-1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈及制备方法 |
| US20190284161A1 (en) * | 2016-11-18 | 2019-09-19 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| WO2018094138A1 (en) * | 2016-11-18 | 2018-05-24 | Vps-3, Inc. | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| EP3541799A4 (en) * | 2016-11-18 | 2020-04-01 | Dow Agrosciences Llc | PROCESSES FOR THE PREPARATION OF 4 - ((6- (2- (2,4-DIFLUOROPHENYL) -1,1-DIFLUORO-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1- YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE |
| AR110210A1 (es) * | 2016-11-22 | 2019-03-06 | Viamet Pharmaceuticals Inc | Uso de un compuesto de difluoro-(2-hidroxipropil)piridina como fungicida para el control de la mancha foliar en remolacha azucarera |
| BR112019010138A2 (pt) * | 2016-11-22 | 2019-08-20 | Dow Agrosciences Llc | compostos fungicidas e misturas para controle de fungos em cereais |
| AR110213A1 (es) * | 2016-11-22 | 2019-03-06 | Viamet Pharmaceuticals Inc | Compuestos y mezclas fungicidas para el control de hongos en cereales |
| US20190284162A1 (en) * | 2016-11-22 | 2019-09-19 | Dow Agrosciences Llc | Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of corn |
| AR110207A1 (es) * | 2016-11-22 | 2019-03-06 | Viamet Pharmaceuticals Inc | Compuestos y mezclas fungicidas para el control de hongos en cereales |
| AR110206A1 (es) * | 2016-11-22 | 2019-03-06 | Viamet Pharmaceuticals Inc | Uso de un compuesto de difluoro-(2-hidroxipropil)piridina como fungicida para el control de hongos fitopatógenos en trigo |
| RU2019118631A (ru) * | 2016-11-22 | 2020-12-24 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Применение соединения дифтор-(2-гидроксипропил)пиридина в качестве фунгицида для борьбы с фитопатогенным грибком ячменя |
| US20190297889A1 (en) * | 2016-11-22 | 2019-10-03 | Dow Agrossciences Llc | Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of rice |
| CN109996442A (zh) * | 2016-11-22 | 2019-07-09 | 美国陶氏益农公司 | 用于谷物的真菌防治的杀真菌化合物和混合物 |
| AU2017365173A1 (en) * | 2016-11-22 | 2019-06-20 | Corteva Agriscience Llc | Fungicidal compounds and mixtures for fungal control in cereals |
| SG10201911243WA (en) | 2016-12-22 | 2020-02-27 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
| US11021471B2 (en) | 2017-05-10 | 2021-06-01 | Forge Therapeutics, Inc. | Antibacterial compounds |
| JP2021502402A (ja) | 2017-11-13 | 2021-01-28 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | テトラゾリルプロピル誘導体および殺真菌剤としてのそれらの使用 |
| AU2019345150A1 (en) | 2018-09-20 | 2021-05-13 | Blacksmith Medicines, Inc. | Antibacterial compounds |
| WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| CN113278409B (zh) * | 2021-06-22 | 2022-04-29 | 西南石油大学 | 一种高温酸化缓蚀剂 |
| CA3233328A1 (en) | 2021-09-28 | 2023-04-06 | Min Teng | Lpxc inhibitors and uses thereof |
| CN117069693A (zh) * | 2022-05-16 | 2023-11-17 | 上海济煜医药科技有限公司 | 一类含胺基结构化合物的制备方法及作为抗菌剂的应用 |
| AR130569A1 (es) | 2022-09-28 | 2024-12-18 | Syngenta Crop Protection Ag | Composiciones fungicidas |
| WO2024068655A1 (en) | 2022-09-28 | 2024-04-04 | Syngenta Crop Protection Ag | Fungicidal compositions |
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| AU2012273103B2 (en) * | 2011-06-19 | 2017-04-20 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| EA201490038A1 (ru) * | 2011-06-19 | 2014-04-30 | Вайамет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
-
2012
- 2012-06-19 AU AU2012273103A patent/AU2012273103B2/en not_active Ceased
- 2012-06-19 JP JP2014517090A patent/JP6158797B2/ja not_active Expired - Fee Related
- 2012-06-19 CN CN201280040388.7A patent/CN103781775B/zh not_active Expired - Fee Related
- 2012-06-19 EP EP12803318.0A patent/EP2721023B1/en not_active Not-in-force
- 2012-06-19 WO PCT/US2012/043140 patent/WO2012177635A1/en not_active Ceased
- 2012-06-19 EP EP18177072.8A patent/EP3398944A1/en not_active Withdrawn
- 2012-06-19 EA EA201490029A patent/EA025406B1/ru not_active IP Right Cessation
- 2012-06-19 PH PH1/2013/502623A patent/PH12013502623A1/en unknown
- 2012-06-19 KR KR1020187023221A patent/KR20180095109A/ko not_active Ceased
- 2012-06-19 EP EP16164223.6A patent/EP3067350B1/en not_active Not-in-force
- 2012-06-19 ES ES12803318T patent/ES2700250T3/es active Active
- 2012-06-19 KR KR1020147001301A patent/KR101912848B1/ko not_active Expired - Fee Related
- 2012-06-19 CN CN201610244675.XA patent/CN105884743B/zh not_active Expired - Fee Related
- 2012-06-19 AU AU2012273100A patent/AU2012273100B2/en not_active Ceased
- 2012-06-19 CA CA2839691A patent/CA2839691A1/en not_active Abandoned
- 2012-06-19 EP EP12802997.2A patent/EP2721022B1/en active Active
- 2012-06-19 IN IN288DEN2014 patent/IN2014DN00288A/en unknown
- 2012-06-19 BR BR102012015179-0A patent/BR102012015179B1/pt not_active IP Right Cessation
- 2012-06-19 KR KR1020147001300A patent/KR101912844B1/ko not_active Expired - Fee Related
- 2012-06-19 MX MX2013015158A patent/MX351943B/es active IP Right Grant
- 2012-06-19 CA CA2838912A patent/CA2838912C/en active Active
- 2012-06-19 EA EA201490030A patent/EA024789B1/ru unknown
- 2012-06-19 WO PCT/US2012/043147 patent/WO2012177638A1/en not_active Ceased
- 2012-06-19 US US13/527,413 patent/US8796001B2/en active Active
- 2012-06-19 CN CN201280040415.0A patent/CN103764647B/zh not_active Expired - Fee Related
- 2012-06-19 BR BR122020013521-2A patent/BR122020013521B1/pt active IP Right Grant
- 2012-06-19 US US13/527,426 patent/US8748461B2/en active Active
- 2012-06-19 KR KR1020187023218A patent/KR20180095108A/ko not_active Ceased
- 2012-06-19 UA UAA201400361A patent/UA114090C2/uk unknown
- 2012-06-19 AR ARP120102182A patent/AR088130A1/es active IP Right Grant
- 2012-06-19 JP JP2014516092A patent/JP6247632B2/ja not_active Expired - Fee Related
- 2012-06-20 UY UY0001034145A patent/UY34145A/es unknown
- 2012-06-20 UY UY0001039413A patent/UY39413A/es not_active Application Discontinuation
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2013
- 2013-12-17 IL IL229965A patent/IL229965A/en active IP Right Grant
- 2013-12-18 CL CL2013003638A patent/CL2013003638A1/es unknown
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2014
- 2014-01-10 ZA ZA2014/00232A patent/ZA201400232B/en unknown
- 2014-01-15 CO CO14007084A patent/CO6930356A2/es unknown
- 2014-01-16 CR CR20140020A patent/CR20140020A/es unknown
- 2014-01-16 EC ECSP14013152 patent/ECSP14013152A/es unknown
- 2014-06-05 US US14/297,065 patent/US9220265B2/en active Active
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2017
- 2017-02-03 JP JP2017019006A patent/JP2017132766A/ja active Pending
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2022
- 2022-06-29 EC ECSENADI202251489A patent/ECSP22051489A/es unknown