JP2014518199A5 - - Google Patents

Download PDF

Info

Publication number
JP2014518199A5
JP2014518199A5 JP2014513214A JP2014513214A JP2014518199A5 JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5 JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5
Authority
JP
Japan
Prior art keywords
formula
compound
group
alkyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014513214A
Other languages
English (en)
Japanese (ja)
Other versions
JP6425540B2 (ja
JP2014518199A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/060447 external-priority patent/WO2012164096A1/en
Publication of JP2014518199A publication Critical patent/JP2014518199A/ja
Publication of JP2014518199A5 publication Critical patent/JP2014518199A5/ja
Application granted granted Critical
Publication of JP6425540B2 publication Critical patent/JP6425540B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014513214A 2011-06-01 2012-06-01 エステトロール中間体を製造するための方法 Active JP6425540B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161492300P 2011-06-01 2011-06-01
EP11168561 2011-06-01
EP11168561.6 2011-06-01
US61/492,300 2011-06-01
PCT/EP2012/060447 WO2012164096A1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017155801A Division JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Publications (3)

Publication Number Publication Date
JP2014518199A JP2014518199A (ja) 2014-07-28
JP2014518199A5 true JP2014518199A5 (cg-RX-API-DMAC7.html) 2016-02-12
JP6425540B2 JP6425540B2 (ja) 2018-11-21

Family

ID=45003353

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014513214A Active JP6425540B2 (ja) 2011-06-01 2012-06-01 エステトロール中間体を製造するための方法
JP2017155801A Active JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017155801A Active JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Country Status (24)

Country Link
US (1) US11053274B2 (cg-RX-API-DMAC7.html)
EP (1) EP2714710B1 (cg-RX-API-DMAC7.html)
JP (2) JP6425540B2 (cg-RX-API-DMAC7.html)
KR (1) KR101994805B1 (cg-RX-API-DMAC7.html)
CN (2) CN107266514A (cg-RX-API-DMAC7.html)
AU (1) AU2012264602B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013030830B1 (cg-RX-API-DMAC7.html)
CA (1) CA2835981C (cg-RX-API-DMAC7.html)
CY (1) CY1118150T1 (cg-RX-API-DMAC7.html)
DK (1) DK2714710T3 (cg-RX-API-DMAC7.html)
EA (1) EA023991B1 (cg-RX-API-DMAC7.html)
ES (1) ES2579175T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20160692T2 (cg-RX-API-DMAC7.html)
HU (1) HUE029252T2 (cg-RX-API-DMAC7.html)
ME (1) ME02454B (cg-RX-API-DMAC7.html)
MX (1) MX341561B (cg-RX-API-DMAC7.html)
PL (1) PL2714710T3 (cg-RX-API-DMAC7.html)
PT (1) PT2714710T (cg-RX-API-DMAC7.html)
RS (1) RS54880B1 (cg-RX-API-DMAC7.html)
SG (1) SG195118A1 (cg-RX-API-DMAC7.html)
SI (1) SI2714710T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201600206B (cg-RX-API-DMAC7.html)
WO (1) WO2012164096A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201308446B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2714712B1 (en) 2011-06-01 2016-08-24 Estetra S.P.R.L. Process for the production of estetrol intermediates
PL2714710T3 (pl) 2011-06-01 2017-03-31 Estetra S.P.R.L. Sposób wytwarzania estetrolowych związków pośrednich
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
EA024003B1 (ru) 2011-10-07 2016-08-31 Эстетра С.П.Р.Л. Способ получения эстетрола
JP6866561B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠
TN2017000499A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
PT3310333T (pt) 2015-06-18 2020-06-08 Estetra Sprl Dose unitária orodispersível contendo um composto de estetrol
CA2988362C (en) 2015-06-18 2022-07-19 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
CN105837424A (zh) * 2016-03-31 2016-08-10 常州大学 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
JP6935766B2 (ja) 2018-02-15 2021-09-15 日本精工株式会社 スピンドル装置
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
US20220348607A1 (en) 2019-09-27 2022-11-03 Industriale Chimica S.R.L. Process for preparing (15alpha,16alpha,17beta)-estra-1,3,5(10)-triene- 3,15,16,17-tetrol (estetrol) and intermediates of said process
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
CA3232558A1 (en) 2021-10-01 2023-04-06 Roberto Lenna Process for preparing (15alpha,16alpha,17 eta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) monohydrate
DE112023005720T5 (de) 2023-02-02 2025-12-11 Industriale Chimica S.R.L VERFAHREN ZUR HERSTELLUNG VON (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRAT

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE144266C (cg-RX-API-DMAC7.html)
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
US4792620A (en) 1983-10-14 1988-12-20 Bp Chemicals Limited Carbonylation catalysts
US4739078A (en) 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
IE60780B1 (en) 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3710728A1 (de) 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
WO2002094276A1 (en) 2001-05-18 2002-11-28 Pantarhei Bioscience B.V. Pharmaceutical composition for use in hormone replacement therapy
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
ES2296943T3 (es) 2001-05-23 2008-05-01 Pantarhei Bioscience B.V. Sistema de administracion de un medicamento estrogeno tetrahidroxilado destinado a la contracepcion hormonal.
ATE449606T1 (de) 2001-05-23 2009-12-15 Pantarhei Bioscience Bv Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
CA2467222C (en) 2001-11-15 2010-06-08 Herman Jan Tijmen Coelingh Bennink Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
PL209558B1 (pl) 2002-02-21 2011-09-30 Bayer Schering Pharma Ag Zestaw zawierający steroid, składnik tetrahydrofolianowy i witaminę B12 do zastosowania w metodzie hormonalnej antykoncepcji lub hormonalnej terapii zastępczej
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
ES2399423T3 (es) 2002-06-11 2013-04-01 Pantarhei Bioscience B.V. Método para tratar la piel humana y una composición para el cuidado de la piel para su uso en tal método
ATE340579T1 (de) 2002-06-11 2006-10-15 Pantarhei Bioscience Bv Methode zur behandlung oder prävention immunologischer erkrankungen und pharmazeutische zusammensetzung zur solchen anwendung
ES2299730T3 (es) 2002-07-12 2008-06-01 Pantarhei Bioscience B.V. Composicion farmaceutica que comprende derivados de estetrol para el uso en la terapia del cancer.
DE60318092T2 (de) 2002-10-23 2008-11-27 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung enthaltend estetrolderivate und anwendung in der krebsbehandlung
EP1562976B1 (en) * 2002-11-08 2010-05-26 Pantarhei Bioscience B.V. Synthesis of estetrol via estrone derived steroids
DK1624878T3 (da) 2003-05-22 2007-01-08 Pantarhei Bioscience Bv Anvendelse af præparater som omfatter en östrogen komponent til behandling og forebyggelse af muskel-skelet-smerte
CN102796160A (zh) 2005-05-26 2012-11-28 索尔瓦药物有限公司 17β-HSD1和STS抑制剂
DE502006007749D1 (de) 2005-07-25 2010-10-07 Riboxx Gmbh Verfahren und Kit zur Amplifikation von heteropolymerer oder poly(C)- RNA
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
US20090221540A1 (en) 2006-01-09 2009-09-03 Pantarhei Bioscience B.V. Method of Treating An Acute Vascular Disorder
WO2007146805A2 (en) 2006-06-08 2007-12-21 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailabilty
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
EP2086550A2 (en) 2006-11-29 2009-08-12 Wyeth Estrogen/ serm and estrogen/ progestin bi-layer tablets
WO2008079245A2 (en) 2006-12-20 2008-07-03 Duramed Pharmaceuticals, Inc. Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof
DE602008001783D1 (de) * 2007-01-08 2010-08-26 Pantarhei Bioscience Bv Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens
US20080175908A1 (en) 2007-01-12 2008-07-24 Wyeth Tablet-in-tablet compositions
ATE537833T1 (de) 2007-06-21 2012-01-15 Pantarhei Bioscience Bv Behandlung des mekoniumaspirationssyndroms mit östrogenen
US8518923B2 (en) 2007-07-19 2013-08-27 Pantarhei Bioscience B.V. Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation
EP2085373B8 (en) 2007-08-31 2013-06-26 National University Corporation Nagoya University Method for producing carbonyl compound and pro-oxidant used for production of carbonyl compound
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
US20110250274A1 (en) 2008-09-19 2011-10-13 Shaked Ze Ev Estriol formulations
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2714712B1 (en) 2011-06-01 2016-08-24 Estetra S.P.R.L. Process for the production of estetrol intermediates
PL2714710T3 (pl) 2011-06-01 2017-03-31 Estetra S.P.R.L. Sposób wytwarzania estetrolowych związków pośrednich
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
KR102033187B1 (ko) 2011-07-19 2019-10-16 판타레이 바이오사이언스 비.브이. 디하이드로에피안드로스테론(dhea)을 함유하는 정제
US9579329B2 (en) 2011-08-11 2017-02-28 Estetra S.P.R.L. Use of estetrol as emergency contraceptive
US9731018B2 (en) 2011-09-16 2017-08-15 Ferring B.V. Fast dissolving pharmaceutical composition
EA024003B1 (ru) 2011-10-07 2016-08-31 Эстетра С.П.Р.Л. Способ получения эстетрола
US9808470B2 (en) 2012-04-19 2017-11-07 Universite De Liege Estrogenic components for use in the treatment of neurological disorders
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
WO2014159377A1 (en) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
ES2624667T3 (es) 2013-09-18 2017-07-17 Crystal Pharma, S.A.U. Procedimiento para la preparación de estetrol
HRP20180129T1 (hr) 2013-12-12 2018-02-23 Donesta Bioscience B.V. Oralno raspadajuća čvrsta jedinica doze koja sadrži estetrol komponentu
CA2988362C (en) 2015-06-18 2022-07-19 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
PT3310333T (pt) 2015-06-18 2020-06-08 Estetra Sprl Dose unitária orodispersível contendo um composto de estetrol
TN2017000499A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
JP6866561B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠

Similar Documents

Publication Publication Date Title
JP2014518199A5 (cg-RX-API-DMAC7.html)
HRP20160692T2 (hr) Postupak za proizvodnju intermedijera estetrola
RU2012138259A (ru) Способ получения ривароксабана
JP2015507023A5 (cg-RX-API-DMAC7.html)
JP2015042636A5 (ja) 有機化合物
JP2010536802A5 (cg-RX-API-DMAC7.html)
JP2013520495A5 (cg-RX-API-DMAC7.html)
JP2013194257A5 (cg-RX-API-DMAC7.html)
JP2007260659A5 (ja) 液相反応用のポリシラン担持遷移金属触媒
CN103641811A (zh) 一种制备环碳酸酯的方法
JP2013527840A5 (cg-RX-API-DMAC7.html)
JP2007526868A5 (cg-RX-API-DMAC7.html)
JP2014511259A5 (cg-RX-API-DMAC7.html)
JP2014511258A5 (cg-RX-API-DMAC7.html)
JP2013136733A5 (cg-RX-API-DMAC7.html)
JP2013525317A5 (cg-RX-API-DMAC7.html)
CN103566970B (zh) 铬、锌或铜络合共轭微孔高分子催化剂及其制备和应用
JP2008247919A5 (cg-RX-API-DMAC7.html)
JP2014508714A5 (cg-RX-API-DMAC7.html)
JP2013234194A5 (cg-RX-API-DMAC7.html)
JP2004517891A5 (cg-RX-API-DMAC7.html)
JPWO2016035609A1 (ja) 2−アミノ置換ベンズアルデヒド化合物を製造する方法
CN110885341B (zh) 一种烷基溴化物无过渡金属催化的硼酯化反应方法
JP2018505179A5 (cg-RX-API-DMAC7.html)
JP2007045816A5 (ja) カルバゾール誘導体、発光素子用材料として用いられるアントラセン誘導体の作製方法